SI1094839T1 - Farnesyl protein transferase inhibitors with (in vivo) radiosensitizing properties - Google Patents

Farnesyl protein transferase inhibitors with (in vivo) radiosensitizing properties

Info

Publication number: SI1094839T1
Authority: SI; Slovenia
Prior art keywords: vivo; protein transferase; transferase inhibitors; farnesyl protein; radiosensitizing properties
Prior art date: 1998-07-06

Application number

SI9930332T

Other languages

English (en)

Slovenian (sl)

Inventor

Ginckel Robert Franciscus Van

Wim Joanna Janssen Pharmaceutica N.V. FLOREN

David William Janssen Research Foundation END

Walter Boudewijn Leopold Wouters

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-06

Filing date

1999-06-30

Publication date

2003-12-31

1999-06-30 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2003-12-31 Publication of SI1094839T1 publication Critical patent/SI1094839T1/xx

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

SI9930332T 1998-07-06 1999-06-30 Farnesyl protein transferase inhibitors with (in vivo) radiosensitizing properties SI1094839T1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP98202257		1998-07-06
EP98204330		1998-12-18
EP99931229A EP1094839B1 (en)	1998-07-06	1999-06-30	Farnesyl protein transferase inhibitors with (in vivo) radiosensitizing properties
PCT/EP1999/004545 WO2000001411A1 (en)	1998-07-06	1999-06-30	Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (1)

Publication Number	Publication Date
SI1094839T1 true SI1094839T1 (en)	2003-12-31

Family

ID=26150503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9930332T SI1094839T1 (en)	1998-07-06	1999-06-30	Farnesyl protein transferase inhibitors with (in vivo) radiosensitizing properties

Country Status (31)

Country	Link
US (1)	US6545020B1 (xx)
EP (1)	EP1094839B1 (xx)
JP (1)	JP4530537B2 (xx)
KR (1)	KR100591603B1 (xx)
CN (1)	CN1152716C (xx)
AP (1)	AP1599A (xx)
AT (1)	ATE238811T1 (xx)
AU (1)	AU762423B2 (xx)
BG (1)	BG64941B1 (xx)
BR (1)	BR9911861A (xx)
CA (1)	CA2336624C (xx)
CZ (1)	CZ300968B6 (xx)
DE (1)	DE69907461T2 (xx)
DK (1)	DK1094839T3 (xx)
EA (1)	EA003877B1 (xx)
EE (1)	EE04582B1 (xx)
ES (1)	ES2199579T3 (xx)
HK (1)	HK1034451A1 (xx)
HR (1)	HRP20000903A2 (xx)
HU (1)	HU229076B1 (xx)
ID (1)	ID26987A (xx)
IL (2)	IL140721A0 (xx)
MY (1)	MY126519A (xx)
NO (1)	NO328178B1 (xx)
PL (1)	PL193464B1 (xx)
PT (1)	PT1094839E (xx)
SI (1)	SI1094839T1 (xx)
SK (1)	SK284723B6 (xx)
TR (1)	TR200003879T2 (xx)
TW (1)	TW586937B (xx)
WO (1)	WO2000001411A1 (xx)

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UA64797C2 (uk)	1998-07-06	2004-03-15	Янссен Фармацевтика Н.В.	Інгібітори фарнезил білок трансферази як засіб для лікування артропатії
WO2001056552A2 (en) *	2000-02-04	2001-08-09	Janssen Pharmaceutica N.V.	Farnesyl protein transferase inhibitors for treating breast cancer
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ES2313991T3 (es)	2000-09-25	2009-03-16	Janssen Pharmaceutica Nv	Derivados de 6-heterociclilmetil-quinolina y quinazolina que inhiben la farnesil transferasa.
EP1322636A1 (en)	2000-09-25	2003-07-02	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6- (substituted phenyl)methyl]-quinoline and quinazoline derivatives
EP1322644A1 (en)	2000-09-25	2003-07-02	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
US7153958B2 (en)	2000-11-21	2006-12-26	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting benzoheterocyclic derivatives
US7129356B2 (en)	2000-12-27	2006-10-31	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 4-substituted quinoline and quinazoline derivatives
DE60119383T2 (de) *	2000-12-27	2007-04-19	Janssen Pharmaceutica N.V.	Farnesyltransferasehemmende 4-heterocyclylchinolin- und chinazolinderivate
WO2003000266A1 (en)	2001-06-21	2003-01-03	Ariad Pharmaceuticals, Inc.	Novel quinolines and uses thereof
ES2323265T3 (es)	2001-12-19	2009-07-10	Janssen Pharmaceutica Nv	Derivados de quinolina condensados en 1,8 sustituidos con triazoles unidos por el carbono como inhibidores de la farnesil-transferasa.
WO2003080058A1 (en)	2002-03-22	2003-10-02	Janssen Pharmaceutica. N.V.	Benzylimidazolyl substituted 2-quinoline and quinazoline derivatives for use as farnesyl transferase inhibitors
DE60307616T2 (de)	2002-04-15	2007-10-04	Janssen Pharmaceutica N.V.	Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen
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EP1732549A4 (en) *	2004-03-18	2009-11-11	Brigham & Womens Hospital	METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES
US20050272722A1 (en) *	2004-03-18	2005-12-08	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
WO2005089518A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Uch-l1 expression and cancer therapy
US20060194821A1 (en) *	2005-02-18	2006-08-31	The Brigham And Women's Hospital, Inc.	Compounds inhibiting the aggregation of superoxide dismutase-1
US7826982B2 (en)	2005-07-29	2010-11-02	Children's Hospital Medical Center	Method of identifying inhibitors using a 3-D structure of RAC-1 GTPASE
CA2634598A1 (en)	2005-12-23	2007-07-05	Link Medicine Corporation	Treatment of synucleinopathies
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WO2009151683A2 (en) *	2008-03-12	2009-12-17	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2138844B1 (en)	2008-06-26	2012-04-25	SpheroTec GmbH	Method for testing the response of cells to exposures with therapeutics
US20110060005A1 (en) *	2008-11-13	2011-03-10	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20100331363A1 (en) *	2008-11-13	2010-12-30	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
NZ593090A (en) *	2008-11-13	2013-06-28	Link Medicine Corp	Azaquinolinone derivatives and uses thereof
US9980942B2 (en)	2012-05-02	2018-05-29	Children's Hospital Medical Center	Rejuvenation of precursor cells
US9309222B2 (en)	2012-10-16	2016-04-12	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
SI2909192T1 (sl)	2012-10-16	2017-08-31	Janssen Pharmaceutica Nv	Metilensko vezani kinolinilni modulatorji za ROR-gama-t
US9303015B2 (en)	2012-10-16	2016-04-05	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORγt
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
JP6423423B2 (ja)	2013-10-15	2018-11-14	ヤンセンファーマシューティカエヌ．ベー．	Ｒｏｒγｔのアルキル結合キノリニルモジュレーター
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt
US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
AU2014334616A1 (en)	2013-10-15	2016-04-28	Janssen Pharmaceutica Nv	Quinolinyl modulators of RORyt
US10028503B2 (en)	2014-06-18	2018-07-24	Children's Hospital Medical Center	Platelet storage methods and compositions for same
JP6630742B2 (ja)	2015-08-17	2020-01-15	クラオンコロジー，インコーポレイテッド	ファルネシルトランスフェラーゼ阻害剤を用いて癌患者を治療する方法
US20190119758A1 (en)	2016-04-22	2019-04-25	Kura Oncology, Inc.	Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
JP2019534290A (ja)	2016-11-03	2019-11-28	クラオンコロジー，インコーポレイテッド	癌の治療方法において使用するためのファルネシルトランスフェラーゼ阻害剤
CN109999037A (zh)	2017-02-21	2019-07-12	库拉肿瘤学公司	使用法尼基转移酶抑制剂治疗癌症的方法
US9956215B1 (en)	2017-02-21	2018-05-01	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US10806730B2 (en)	2017-08-07	2020-10-20	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
TW201919628A (zh)	2017-08-07	2019-06-01	美商庫拉腫瘤技術股份有限公司	以法尼基轉移酶(farnesyltransferase)抑制劑治療癌症之方法
WO2019113269A1 (en)	2017-12-08	2019-06-13	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
US20220002396A1 (en)	2018-11-01	2022-01-06	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US20220142983A1 (en)	2019-03-01	2022-05-12	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2020190604A1 (en)	2019-03-15	2020-09-24	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
WO2020205486A1 (en)	2019-03-29	2020-10-08	Kura Oncology, Inc.	Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors
US20220168296A1 (en)	2019-04-01	2022-06-02	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US20220305001A1 (en)	2019-05-02	2022-09-29	Kura Oncology, Inc.	Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors

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1999
- 1999-06-30 EA EA200100111A patent/EA003877B1/ru not_active IP Right Cessation
- 1999-06-30 EP EP99931229A patent/EP1094839B1/en not_active Expired - Lifetime
- 1999-06-30 CA CA002336624A patent/CA2336624C/en not_active Expired - Lifetime
- 1999-06-30 AT AT99931229T patent/ATE238811T1/de active
- 1999-06-30 CZ CZ20004777A patent/CZ300968B6/cs not_active IP Right Cessation
- 1999-06-30 IL IL14072199A patent/IL140721A0/xx active IP Right Grant
- 1999-06-30 WO PCT/EP1999/004545 patent/WO2000001411A1/en active IP Right Grant
- 1999-06-30 DK DK99931229T patent/DK1094839T3/da active
- 1999-06-30 AP APAP/P/2001/002057A patent/AP1599A/en active
- 1999-06-30 AU AU47805/99A patent/AU762423B2/en not_active Expired
- 1999-06-30 CN CNB998082678A patent/CN1152716C/zh not_active Expired - Lifetime
- 1999-06-30 TR TR2000/03879T patent/TR200003879T2/xx unknown
- 1999-06-30 PT PT99931229T patent/PT1094839E/pt unknown
- 1999-06-30 SI SI9930332T patent/SI1094839T1/xx unknown
- 1999-06-30 HU HU0103689A patent/HU229076B1/hu unknown
- 1999-06-30 KR KR1020007014066A patent/KR100591603B1/ko not_active IP Right Cessation
- 1999-06-30 ES ES99931229T patent/ES2199579T3/es not_active Expired - Lifetime
- 1999-06-30 BR BR9911861-0A patent/BR9911861A/pt not_active Application Discontinuation
- 1999-06-30 JP JP2000557857A patent/JP4530537B2/ja not_active Expired - Lifetime
- 1999-06-30 ID IDW20010020A patent/ID26987A/id unknown
- 1999-06-30 EE EEP200000794A patent/EE04582B1/xx unknown
- 1999-06-30 PL PL99347979A patent/PL193464B1/pl unknown
- 1999-06-30 US US09/743,130 patent/US6545020B1/en not_active Expired - Lifetime
- 1999-06-30 DE DE69907461T patent/DE69907461T2/de not_active Expired - Lifetime
- 1999-06-30 SK SK1986-2000A patent/SK284723B6/sk not_active IP Right Cessation
- 1999-07-01 MY MYPI99002794A patent/MY126519A/en unknown
- 1999-07-05 TW TW088111346A patent/TW586937B/zh not_active IP Right Cessation
2000
- 2000-12-28 HR HR20000903A patent/HRP20000903A2/hr not_active Application Discontinuation
2001
- 2001-01-03 BG BG105108A patent/BG64941B1/bg unknown
- 2001-01-04 IL IL140721A patent/IL140721A/en not_active IP Right Cessation
- 2001-01-05 NO NO20010082A patent/NO328178B1/no not_active IP Right Cessation
- 2001-07-18 HK HK01105023A patent/HK1034451A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
BG64941B1 (bg)	2006-10-31
BR9911861A (pt)	2001-03-20
DE69907461T2 (de)	2004-02-19
JP4530537B2 (ja)	2010-08-25
US6545020B1 (en)	2003-04-08
SK284723B6 (sk)	2005-10-06
KR100591603B1 (ko)	2006-06-20
TW586937B (en)	2004-05-11
JP2002519389A (ja)	2002-07-02
AU4780599A (en)	2000-01-24
ATE238811T1 (de)	2003-05-15
CN1152716C (zh)	2004-06-09
EE04582B1 (et)	2006-02-15
CN1311692A (zh)	2001-09-05
HRP20000903A2 (en)	2001-12-31
EA200100111A1 (ru)	2001-06-25
HUP0103689A3 (en)	2003-01-28
EP1094839A1 (en)	2001-05-02
WO2000001411A1 (en)	2000-01-13
EE200000794A (et)	2002-06-17
PL193464B1 (pl)	2007-02-28
DK1094839T3 (da)	2003-08-18
HK1034451A1 (en)	2001-10-26
IL140721A (en)	2008-11-26
AU762423B2 (en)	2003-06-26
IL140721A0 (en)	2002-02-10
NO20010082D0 (no)	2001-01-05
NO328178B1 (no)	2009-12-28
CZ20004777A3 (en)	2001-05-16
HUP0103689A2 (hu)	2002-02-28
DE69907461D1 (de)	2003-06-05
PT1094839E (pt)	2003-09-30
HU229076B1 (en)	2013-07-29
EP1094839B1 (en)	2003-05-02
TR200003879T2 (tr)	2007-01-22
CA2336624C (en)	2008-10-21
ES2199579T3 (es)	2004-02-16
BG105108A (en)	2001-11-30
CA2336624A1 (en)	2000-01-13
AP1599A (en)	2006-04-27
AP2001002057A0 (en)	2001-03-31
CZ300968B6 (cs)	2009-09-30
NO20010082L (no)	2001-01-05
KR20010052770A (ko)	2001-06-25
EA003877B1 (ru)	2003-10-30
ID26987A (id)	2001-02-22
SK19862000A3 (sk)	2001-12-03
PL347979A1 (en)	2002-05-06
MY126519A (en)	2006-10-31

Publication	Publication Date	Title
HK1034451A1 (en)	2001-10-26	Farnesyl protein transferase inhibitors with (in vivo) radiosensitizing properties
HUS1700048I1 (hu)	2017-12-28	Szubsztituált 3-cianokinolinok mint protein tirozin kinázok inhibitorai
ZA985778B (en)	2000-01-20	Inhibitors of farnesyl protein transferase.
PL346934A1 (en)	2002-03-11	Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
EP1066286A4 (en)	2004-02-11	PROTEIN TYROSINE KINASE INHIBITORS, BASED ON IMIDAZOPYRAZINE WITH HETEROCYCLO SUBSTITUTION
PL348294A1 (en)	2002-05-20	Farnesyl protein transferase inhibitors
IL146094A0 (en)	2002-07-25	Diaminothiazoles and their use for inhibiting protein kinases
EE04309B1 (et)	2004-06-15	Farnesüül-proteiini transferaasi inhibiitorid
EE9800408A (et)	1999-06-15	Proteiinfarnesüültransferaasi inhibiitorid
AU2001246477A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with platinum compounds
AU2001235496A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents
AU4020897A (en)	1998-03-06	3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
HUP0202152A2 (en)	2002-10-28	Tricyclyc farnesyl protein transferase inhibitors
PL355887A1 (en)	2004-05-31	Farnesyl transferase inhibitors
AU3514302A (en)	2002-06-11	0ovel farnesyl protein transferase inhibitors
HK1032002A1 (en)	2001-07-06	Prenyl transferase inhibitors
IL149870A0 (en)	2002-11-10	Inhibitors of farnesyl protein transferase
ZA996763B (en)	2000-05-15	Inhibitors of protein isoprenyl transferases.