SK284723B6 - Použitie inhibítora farnesyl-proteín transferázy na prípravu farmaceutickej kompozície, majúcej rádiosenzibilizačné vlastnosti - Google Patents

Použitie inhibítora farnesyl-proteín transferázy na prípravu farmaceutickej kompozície, majúcej rádiosenzibilizačné vlastnosti Download PDF

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Publication number
SK284723B6
SK284723B6 SK1986-2000A SK19862000A SK284723B6 SK 284723 B6 SK284723 B6 SK 284723B6 SK 19862000 A SK19862000 A SK 19862000A SK 284723 B6 SK284723 B6 SK 284723B6
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SK
Slovakia
Prior art keywords
alkyl
methyl
hydrogen
formula
alkoxy
Prior art date
Application number
SK1986-2000A
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English (en)
Slovak (sk)
Other versions
SK19862000A3 (sk
Inventor
Ginckel Robert Franciscus Van
Wim Joanna Floren
David William End
Walter Boudewijn Leopold Wouters
Original Assignee
Janssen Pharmaceutica N. V.
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Publication date
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of SK19862000A3 publication Critical patent/SK19862000A3/sk
Publication of SK284723B6 publication Critical patent/SK284723B6/sk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK1986-2000A 1998-07-06 1999-06-30 Použitie inhibítora farnesyl-proteín transferázy na prípravu farmaceutickej kompozície, majúcej rádiosenzibilizačné vlastnosti SK284723B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98202257 1998-07-06
EP98204330 1998-12-18
PCT/EP1999/004545 WO2000001411A1 (en) 1998-07-06 1999-06-30 Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (2)

Publication Number Publication Date
SK19862000A3 SK19862000A3 (sk) 2001-12-03
SK284723B6 true SK284723B6 (sk) 2005-10-06

Family

ID=26150503

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1986-2000A SK284723B6 (sk) 1998-07-06 1999-06-30 Použitie inhibítora farnesyl-proteín transferázy na prípravu farmaceutickej kompozície, majúcej rádiosenzibilizačné vlastnosti

Country Status (31)

Country Link
US (1) US6545020B1 (xx)
EP (1) EP1094839B1 (xx)
JP (1) JP4530537B2 (xx)
KR (1) KR100591603B1 (xx)
CN (1) CN1152716C (xx)
AP (1) AP1599A (xx)
AT (1) ATE238811T1 (xx)
AU (1) AU762423B2 (xx)
BG (1) BG64941B1 (xx)
BR (1) BR9911861A (xx)
CA (1) CA2336624C (xx)
CZ (1) CZ300968B6 (xx)
DE (1) DE69907461T2 (xx)
DK (1) DK1094839T3 (xx)
EA (1) EA003877B1 (xx)
EE (1) EE04582B1 (xx)
ES (1) ES2199579T3 (xx)
HK (1) HK1034451A1 (xx)
HR (1) HRP20000903A2 (xx)
HU (1) HU229076B1 (xx)
ID (1) ID26987A (xx)
IL (2) IL140721A0 (xx)
MY (1) MY126519A (xx)
NO (1) NO328178B1 (xx)
PL (1) PL193464B1 (xx)
PT (1) PT1094839E (xx)
SI (1) SI1094839T1 (xx)
SK (1) SK284723B6 (xx)
TR (1) TR200003879T2 (xx)
TW (1) TW586937B (xx)
WO (1) WO2000001411A1 (xx)

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CN1152716C (zh) 1998-07-06 2004-06-09 詹森药业有限公司 具体***线感受性的法呢基蛋白质转移酶抑制剂
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JO2361B1 (en) 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl
DE60118225T2 (de) 2000-09-25 2007-05-03 Janssen Pharmaceutica N.V. Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren
WO2002024686A2 (en) 2000-09-25 2002-03-28 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
EP1322644A1 (en) 2000-09-25 2003-07-02 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
EP1322636A1 (en) 2000-09-25 2003-07-02 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6- (substituted phenyl)methyl]-quinoline and quinazoline derivatives
ATE434615T1 (de) 2000-11-21 2009-07-15 Janssen Pharmaceutica Nv Farnesyltransferase hemmende benzoheterocyclische derivate
ES2260316T3 (es) 2000-12-27 2006-11-01 Janssen Pharmaceutica N.V. Derivados de quinazolina y quinolina 4-sustituidos que inhiben la farnesil transferasa.
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US7408063B2 (en) 2001-12-19 2008-08-05 Janssen Pharmaceutica, N.V. 1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
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ATE336496T1 (de) 2002-04-15 2006-09-15 Janssen Pharmaceutica Nv Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen
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WO2005089515A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
AU2006275528B2 (en) 2005-07-29 2012-03-08 Children's Hospital Medical Center GTPase inhibitors and methods of use and crystal structure of Rac-1 GTPase
EP2545919A1 (en) 2005-12-23 2013-01-16 Link Medicine Corporation Treatment of synucleinopathies
DK2160386T3 (da) * 2007-05-23 2012-08-27 Allergan Inc Terapeutiske ((phenyl)imidazolyl)methylquinolinylforbindelser
US8232402B2 (en) * 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
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US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
BRPI0920927A2 (pt) * 2008-11-13 2019-09-24 Link Medicine Corp derivados de azaquinolinona e usos dos mesmos
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US9980942B2 (en) 2012-05-02 2018-05-29 Children's Hospital Medical Center Rejuvenation of precursor cells
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RS56283B1 (sr) 2012-10-16 2017-12-29 Janssen Pharmaceutica Nv Metilen vezani hinolinil modulatori ror-gama-t
EP2909189B8 (en) 2012-10-16 2017-04-19 Janssen Pharmaceutica NV Heteroaryl linked quinolinyl modulators of ror-gamma-t
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US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
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US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
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US20220142983A1 (en) 2019-03-01 2022-05-12 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
TW202108170A (zh) 2019-03-15 2021-03-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症患者之方法
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Also Published As

Publication number Publication date
ATE238811T1 (de) 2003-05-15
PL347979A1 (en) 2002-05-06
SK19862000A3 (sk) 2001-12-03
DE69907461D1 (de) 2003-06-05
ID26987A (id) 2001-02-22
EE04582B1 (et) 2006-02-15
CA2336624C (en) 2008-10-21
NO328178B1 (no) 2009-12-28
CA2336624A1 (en) 2000-01-13
EA200100111A1 (ru) 2001-06-25
CZ300968B6 (cs) 2009-09-30
AP1599A (en) 2006-04-27
AU762423B2 (en) 2003-06-26
AU4780599A (en) 2000-01-24
IL140721A0 (en) 2002-02-10
HRP20000903A2 (en) 2001-12-31
JP4530537B2 (ja) 2010-08-25
US6545020B1 (en) 2003-04-08
HUP0103689A2 (hu) 2002-02-28
MY126519A (en) 2006-10-31
HUP0103689A3 (en) 2003-01-28
EA003877B1 (ru) 2003-10-30
IL140721A (en) 2008-11-26
EP1094839A1 (en) 2001-05-02
SI1094839T1 (en) 2003-12-31
NO20010082L (no) 2001-01-05
DE69907461T2 (de) 2004-02-19
KR20010052770A (ko) 2001-06-25
EP1094839B1 (en) 2003-05-02
ES2199579T3 (es) 2004-02-16
WO2000001411A1 (en) 2000-01-13
AP2001002057A0 (en) 2001-03-31
PL193464B1 (pl) 2007-02-28
PT1094839E (pt) 2003-09-30
JP2002519389A (ja) 2002-07-02
BG105108A (en) 2001-11-30
CN1311692A (zh) 2001-09-05
KR100591603B1 (ko) 2006-06-20
DK1094839T3 (da) 2003-08-18
HK1034451A1 (en) 2001-10-26
BR9911861A (pt) 2001-03-20
CZ20004777A3 (en) 2001-05-16
EE200000794A (et) 2002-06-17
TW586937B (en) 2004-05-11
BG64941B1 (bg) 2006-10-31
HU229076B1 (en) 2013-07-29
CN1152716C (zh) 2004-06-09
NO20010082D0 (no) 2001-01-05
TR200003879T2 (tr) 2007-01-22

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Expiry date: 20190630