HRP20000903A2 - Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties - Google Patents

Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties Download PDF

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Publication number
HRP20000903A2
HRP20000903A2 HR20000903A HRP20000903A HRP20000903A2 HR P20000903 A2 HRP20000903 A2 HR P20000903A2 HR 20000903 A HR20000903 A HR 20000903A HR P20000903 A HRP20000903 A HR P20000903A HR P20000903 A2 HRP20000903 A2 HR P20000903A2
Authority
HR
Croatia
Prior art keywords
alkyl
alkyloxy
amino
methyl
hydroxy
Prior art date
Application number
HR20000903A
Other languages
English (en)
Croatian (hr)
Inventor
Robert
Wim
David
Walter
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HRP20000903A2 publication Critical patent/HRP20000903A2/hr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20000903A 1998-07-06 2000-12-28 Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties HRP20000903A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98202257 1998-07-06
EP98204330 1998-12-18
PCT/EP1999/004545 WO2000001411A1 (en) 1998-07-06 1999-06-30 Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (1)

Publication Number Publication Date
HRP20000903A2 true HRP20000903A2 (en) 2001-12-31

Family

ID=26150503

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000903A HRP20000903A2 (en) 1998-07-06 2000-12-28 Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Country Status (31)

Country Link
US (1) US6545020B1 (xx)
EP (1) EP1094839B1 (xx)
JP (1) JP4530537B2 (xx)
KR (1) KR100591603B1 (xx)
CN (1) CN1152716C (xx)
AP (1) AP1599A (xx)
AT (1) ATE238811T1 (xx)
AU (1) AU762423B2 (xx)
BG (1) BG64941B1 (xx)
BR (1) BR9911861A (xx)
CA (1) CA2336624C (xx)
CZ (1) CZ300968B6 (xx)
DE (1) DE69907461T2 (xx)
DK (1) DK1094839T3 (xx)
EA (1) EA003877B1 (xx)
EE (1) EE04582B1 (xx)
ES (1) ES2199579T3 (xx)
HK (1) HK1034451A1 (xx)
HR (1) HRP20000903A2 (xx)
HU (1) HU229076B1 (xx)
ID (1) ID26987A (xx)
IL (2) IL140721A0 (xx)
MY (1) MY126519A (xx)
NO (1) NO328178B1 (xx)
PL (1) PL193464B1 (xx)
PT (1) PT1094839E (xx)
SI (1) SI1094839T1 (xx)
SK (1) SK284723B6 (xx)
TR (1) TR200003879T2 (xx)
TW (1) TW586937B (xx)
WO (1) WO2000001411A1 (xx)

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CN1152716C (zh) 1998-07-06 2004-06-09 詹森药业有限公司 具体***线感受性的法呢基蛋白质转移酶抑制剂
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JO2361B1 (en) 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl
DE60118225T2 (de) 2000-09-25 2007-05-03 Janssen Pharmaceutica N.V. Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren
WO2002024686A2 (en) 2000-09-25 2002-03-28 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
EP1322644A1 (en) 2000-09-25 2003-07-02 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
EP1322636A1 (en) 2000-09-25 2003-07-02 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6- (substituted phenyl)methyl]-quinoline and quinazoline derivatives
ATE434615T1 (de) 2000-11-21 2009-07-15 Janssen Pharmaceutica Nv Farnesyltransferase hemmende benzoheterocyclische derivate
ES2260316T3 (es) 2000-12-27 2006-11-01 Janssen Pharmaceutica N.V. Derivados de quinazolina y quinolina 4-sustituidos que inhiben la farnesil transferasa.
ES2263684T3 (es) * 2000-12-27 2006-12-16 Janssen Pharmaceutica N.V. Derivados de 4-heterociclil-quinolina y -quinazolina que inhiben la farnesil transferasa.
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US7408063B2 (en) 2001-12-19 2008-08-05 Janssen Pharmaceutica, N.V. 1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
ATE364384T1 (de) 2002-03-22 2007-07-15 Janssen Pharmaceutica Nv Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren
ATE336496T1 (de) 2002-04-15 2006-09-15 Janssen Pharmaceutica Nv Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen
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SG150533A1 (en) * 2003-11-20 2009-03-30 Janssen Pharmaceutica Nv 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2- quinoxalinones as poly(adp-ribose) polymerase inhibitors
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CA2559221A1 (en) * 2004-03-18 2005-09-29 Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
JP2007529555A (ja) * 2004-03-18 2007-10-25 ザ ブライハム アンド ウイメンズ ホスピタル, インコーポレイテッド シヌクレイノパチーを治療する方法
WO2005089502A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20050272068A1 (en) * 2004-03-18 2005-12-08 The Brigham And Women's Hospital, Inc. UCH-L1 expression and cancer therapy
WO2005089515A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
AU2006275528B2 (en) 2005-07-29 2012-03-08 Children's Hospital Medical Center GTPase inhibitors and methods of use and crystal structure of Rac-1 GTPase
EP2545919A1 (en) 2005-12-23 2013-01-16 Link Medicine Corporation Treatment of synucleinopathies
DK2160386T3 (da) * 2007-05-23 2012-08-27 Allergan Inc Terapeutiske ((phenyl)imidazolyl)methylquinolinylforbindelser
US8232402B2 (en) * 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2138844B1 (en) 2008-06-26 2012-04-25 SpheroTec GmbH Method for testing the response of cells to exposures with therapeutics
US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
BRPI0920927A2 (pt) * 2008-11-13 2019-09-24 Link Medicine Corp derivados de azaquinolinona e usos dos mesmos
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US9980942B2 (en) 2012-05-02 2018-05-29 Children's Hospital Medical Center Rejuvenation of precursor cells
CA2888485C (en) 2012-10-16 2021-01-26 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of ror.gamma.t
RS56283B1 (sr) 2012-10-16 2017-12-29 Janssen Pharmaceutica Nv Metilen vezani hinolinil modulatori ror-gama-t
EP2909189B8 (en) 2012-10-16 2017-04-19 Janssen Pharmaceutica NV Heteroaryl linked quinolinyl modulators of ror-gamma-t
ES2742843T3 (es) 2013-10-15 2020-02-17 Janssen Pharmaceutica Nv Moduladores de quinolinilo de ROR(gamma)t
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
AU2014334619A1 (en) 2013-10-15 2016-04-21 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORyt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US10028503B2 (en) 2014-06-18 2018-07-24 Children's Hospital Medical Center Platelet storage methods and compositions for same
PT3277842T (pt) 2015-08-17 2019-09-05 Kura Oncology Inc Métodos de tratamento de doentes com cancro usando inibidores da farnesiltransferase
WO2017184968A1 (en) 2016-04-22 2017-10-26 Kura Oncology, Inc. Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
LT3534885T (lt) 2016-11-03 2021-07-12 Kura Oncology, Inc. Farneziltransferazės inhibitoriai, skirti naudoti vėžio gydymui
US9956215B1 (en) 2017-02-21 2018-05-01 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2018156609A1 (en) 2017-02-21 2018-08-30 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
MX2020001207A (es) 2017-08-07 2020-03-20 Kura Oncology Inc Metodos de tratamiento del cancer con inhibidores de farnesiltransferasa.
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2019113269A1 (en) 2017-12-08 2019-06-13 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
CN113286591A (zh) 2018-11-01 2021-08-20 库拉肿瘤学公司 用法尼基转移酶抑制剂治疗癌症的方法
US20220142983A1 (en) 2019-03-01 2022-05-12 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
TW202108170A (zh) 2019-03-15 2021-03-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症患者之方法
TW202043487A (zh) 2019-03-29 2020-12-01 美商庫拉腫瘤技術股份有限公司 以法尼基轉移酶(farnesyltransferase)抑制劑治療鱗狀細胞癌之方法
WO2020205387A1 (en) 2019-04-01 2020-10-08 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US20220305001A1 (en) 2019-05-02 2022-09-29 Kura Oncology, Inc. Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors

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US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
US6083917A (en) * 1990-04-18 2000-07-04 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
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Also Published As

Publication number Publication date
ATE238811T1 (de) 2003-05-15
PL347979A1 (en) 2002-05-06
SK19862000A3 (sk) 2001-12-03
DE69907461D1 (de) 2003-06-05
ID26987A (id) 2001-02-22
EE04582B1 (et) 2006-02-15
CA2336624C (en) 2008-10-21
NO328178B1 (no) 2009-12-28
CA2336624A1 (en) 2000-01-13
EA200100111A1 (ru) 2001-06-25
CZ300968B6 (cs) 2009-09-30
AP1599A (en) 2006-04-27
AU762423B2 (en) 2003-06-26
AU4780599A (en) 2000-01-24
IL140721A0 (en) 2002-02-10
JP4530537B2 (ja) 2010-08-25
US6545020B1 (en) 2003-04-08
HUP0103689A2 (hu) 2002-02-28
SK284723B6 (sk) 2005-10-06
MY126519A (en) 2006-10-31
HUP0103689A3 (en) 2003-01-28
EA003877B1 (ru) 2003-10-30
IL140721A (en) 2008-11-26
EP1094839A1 (en) 2001-05-02
SI1094839T1 (en) 2003-12-31
NO20010082L (no) 2001-01-05
DE69907461T2 (de) 2004-02-19
KR20010052770A (ko) 2001-06-25
EP1094839B1 (en) 2003-05-02
ES2199579T3 (es) 2004-02-16
WO2000001411A1 (en) 2000-01-13
AP2001002057A0 (en) 2001-03-31
PL193464B1 (pl) 2007-02-28
PT1094839E (pt) 2003-09-30
JP2002519389A (ja) 2002-07-02
BG105108A (en) 2001-11-30
CN1311692A (zh) 2001-09-05
KR100591603B1 (ko) 2006-06-20
DK1094839T3 (da) 2003-08-18
HK1034451A1 (en) 2001-10-26
BR9911861A (pt) 2001-03-20
CZ20004777A3 (en) 2001-05-16
EE200000794A (et) 2002-06-17
TW586937B (en) 2004-05-11
BG64941B1 (bg) 2006-10-31
HU229076B1 (en) 2013-07-29
CN1152716C (zh) 2004-06-09
NO20010082D0 (no) 2001-01-05
TR200003879T2 (tr) 2007-01-22

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