SG11201700874SA - Method for proliferation of pancreatic progenitor cells - Google Patents

Method for proliferation of pancreatic progenitor cells

Info

Publication number
SG11201700874SA
SG11201700874SA SG11201700874SA SG11201700874SA SG11201700874SA SG 11201700874S A SG11201700874S A SG 11201700874SA SG 11201700874S A SG11201700874S A SG 11201700874SA SG 11201700874S A SG11201700874S A SG 11201700874SA SG 11201700874S A SG11201700874S A SG 11201700874SA
Authority
SG
Singapore
Prior art keywords
proliferation
progenitor cells
pancreatic progenitor
pancreatic
cells
Prior art date
Application number
SG11201700874SA
Other languages
English (en)
Inventor
Yuya Kunisada
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of SG11201700874SA publication Critical patent/SG11201700874SA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
SG11201700874SA 2014-08-04 2015-08-03 Method for proliferation of pancreatic progenitor cells SG11201700874SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014158470 2014-08-04
PCT/JP2015/072591 WO2016021734A1 (fr) 2014-08-04 2015-08-03 Procédé de multiplication de cellules progénitrices pancréatiques

Publications (1)

Publication Number Publication Date
SG11201700874SA true SG11201700874SA (en) 2017-03-30

Family

ID=55263991

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201700874SA SG11201700874SA (en) 2014-08-04 2015-08-03 Method for proliferation of pancreatic progenitor cells

Country Status (9)

Country Link
US (1) US10655105B2 (fr)
EP (1) EP3178924B1 (fr)
JP (1) JP6678107B2 (fr)
KR (1) KR102416647B1 (fr)
CN (1) CN106795487B (fr)
AU (1) AU2015300020B2 (fr)
CA (1) CA2957000C (fr)
SG (1) SG11201700874SA (fr)
WO (1) WO2016021734A1 (fr)

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* Cited by examiner, † Cited by third party
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KR102580225B1 (ko) 2013-06-11 2023-09-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
US10190096B2 (en) 2014-12-18 2019-01-29 President And Fellows Of Harvard College Methods for generating stem cell-derived β cells and uses thereof
US10443042B2 (en) 2014-12-18 2019-10-15 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
CN107614678B (zh) 2014-12-18 2021-04-30 哈佛学院校长同事会 干细胞来源的β细胞的产生方法及其使用方法
TWI710636B (zh) * 2016-04-28 2020-11-21 日商武田藥品工業股份有限公司 源自多能性幹細胞之胰前驅細胞的純化法及其擴增法
CN110392735A (zh) * 2017-01-17 2019-10-29 新加坡科技研究局 胰腺祖细胞的维持和扩增
EP3710021A4 (fr) 2017-11-15 2021-08-11 Semma Therapeutics, Inc. Compositions pour la fabrication de cellules d'ilôts et procédés d'utilisation
CA3092842A1 (fr) * 2018-03-02 2019-09-06 Vertex Pharmaceuticals Incorporated Procedes d'amelioration de la differenciation de cellules souches en cellules beta
TW201945536A (zh) 2018-03-19 2019-12-01 國立大學法人京都大學 水凝膠膠囊
US20210254014A1 (en) 2018-04-23 2021-08-19 Kyoto University Growth inhibitor
US20210198633A1 (en) * 2018-05-31 2021-07-01 University Health Network Methods and compositions comprising tankyrase inhibitors for generating insulin producing cells
CN112912490B (zh) 2018-08-03 2023-12-26 千纸鹤治疗公司 细胞制造方法
CA3108275A1 (fr) 2018-08-10 2020-02-13 Vertex Pharmaceuticals Incorporated Differenciation d'ilot derive de cellules souches
JP7295576B2 (ja) 2018-09-19 2023-06-21 オリヅルセラピューティクス株式会社 インスリン産生細胞
CA3116184A1 (fr) * 2018-10-15 2020-04-23 Cynity Co., Ltd. Procede de production de cellules souches/precurseurs, a l'aide d'un compose de faible poids moleculaire, a partir de cellules derivees de tissu ou d'organe endodermique
CN109749986B (zh) * 2019-03-13 2021-04-02 武汉大学 一种由人多能干细胞分化获得胰腺前体细胞及胰岛β细胞的方法
EP3954436A4 (fr) 2019-04-10 2023-01-11 Orizuru Therapeutics, Inc. Procédé de production d'une structure de type tissu biologique
JP7385244B2 (ja) * 2019-06-27 2023-11-22 国立大学法人 東京大学 膵前駆細胞の分離方法
WO2021079874A1 (fr) 2019-10-21 2021-04-29 武田薬品工業株式会社 Inhibiteur de prolifération
US20230227787A1 (en) 2020-05-28 2023-07-20 Orizuru Therapeutics, Inc. Mass production method of uniform size cell aggregates
US20230399607A1 (en) 2020-11-20 2023-12-14 Orizuru Therapeutics, Inc. Maturation agent
CN115023495B (zh) * 2020-12-04 2024-04-23 奥赛金生物科技公司 用于长期离体维持或扩增人成红细胞、人巨核细胞-红系祖细胞或人普通髓系祖细胞的方法及其应用
WO2022172960A1 (fr) 2021-02-09 2022-08-18 オリヅルセラピューティクス株式会社 Agent de maturation
CN113234664A (zh) * 2021-05-11 2021-08-10 澳门大学 一种胰腺祖细胞的制备方法及其应用
WO2024070494A1 (fr) * 2022-09-26 2024-04-04 国立大学法人京都大学 Procédé de production de cellules endodermiques pancréatiques

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
EP1175487A2 (fr) * 1999-02-10 2002-01-30 Curis, Inc. Cellules progenitrices de pancreas et procedes et utilisations associees
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
EP1994140B1 (fr) 2006-01-20 2010-12-22 ReNeuron, Inc. Procédé permettant d'améliorer la prolifération cellulaire des cellules progénitrices pancréatiques dans une culture de cellules pancréatiques
WO2010053472A1 (fr) 2008-11-04 2010-05-14 Novocell, Inc. Compositions de suspension d'agrégats de cellules souches et procédés pour leur différenciation
US8008075B2 (en) * 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
US9109245B2 (en) * 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
CA2785966C (fr) 2009-12-29 2020-10-27 Takeda Pharmaceutical Company Limited Procede pour la fabrication de cellules de production d'hormones pancreatiques
WO2014062138A1 (fr) * 2012-10-19 2014-04-24 Agency For Science, Technology And Research Procédés de différenciation de cellules souches en un ou plusieurs lignages cellulaires
RU2675928C2 (ru) 2013-02-06 2018-12-25 Виасайт, Инк. Композиции клеток, полученные из дедифференцированных перепрограммированных клеток
WO2015125926A1 (fr) * 2014-02-21 2015-08-27 国立研究開発法人理化学研究所 Procédé permettant la création et le maintien de cellules souches trophoblastiques

Also Published As

Publication number Publication date
JPWO2016021734A1 (ja) 2017-05-18
AU2015300020A1 (en) 2017-02-23
CA2957000A1 (fr) 2016-02-11
AU2015300020B2 (en) 2021-04-08
CN106795487A (zh) 2017-05-31
KR20170031254A (ko) 2017-03-20
WO2016021734A1 (fr) 2016-02-11
JP6678107B2 (ja) 2020-04-08
CA2957000C (fr) 2023-08-01
CN106795487B (zh) 2021-11-19
EP3178924A1 (fr) 2017-06-14
US20170233700A1 (en) 2017-08-17
US10655105B2 (en) 2020-05-19
KR102416647B1 (ko) 2022-07-05
EP3178924B1 (fr) 2019-12-25
EP3178924A4 (fr) 2018-01-24

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