SE8005647L - Sett att framstella nya terapeitiska foreningar - Google Patents
Sett att framstella nya terapeitiska foreningarInfo
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- SE8005647L SE8005647L SE8005647A SE8005647A SE8005647L SE 8005647 L SE8005647 L SE 8005647L SE 8005647 A SE8005647 A SE 8005647A SE 8005647 A SE8005647 A SE 8005647A SE 8005647 L SE8005647 L SE 8005647L
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
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- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
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- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
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- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/86—Ketones containing a keto group bound to a six-membered aromatic ring containing —CHO groups
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- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
- C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
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- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
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- C07D333/28—Halogen atoms
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- Chemical & Material Sciences (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
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Claims (5)
1. FOrfarande for framstEllning av en forening med den all-manna formeln: (I) X4 van i A betecknar metyl, etyl, n-propyl, isopropyl, n-butyl, isobutyl, cyklohexyl eller en grupp med nAson av formlerna: van i XI, X2 och x3 Or lika eller olika och vardera betecknar vdte, klor, brom, fluor, triflazmetyl, nitro, amino, hydroxyl, alkyl med 1-4 kolatomer, alkoxi m,-4 ko1etomersyloxi, acetylamino. formeln A-CO-Hal1 van i A bar tidigare angiven betydelse och Hall betecknar en halogen, fdretrtidesvis klor, och en fenoxialkylkarbonsyraftirening and formeln: 3,( CH l• 3 ---0-C-CO-Yo X4 van i X4, x och R bar tidigare angiven betydelse och Yo bar samma betydelse som Y med undantag nil'. hydroxyl, (b) reaktion enligt Friedel-Crafts mellan ett bensenderivat med formeln xi X3 verb XI, X2 och Xy)zar tidigare aniayen betydelse, och en p-klor- karbonylfenoxiallatnsyraforemed formeln: CH 3 acetoxi, formyl, karboxyl, en grupp med formeln -0-C-COY van i Y
2. 81. 13 betecknar hydroxyl eller fdretradesvis alkoxi med 1-4 kolatomer, X6 syre eller Evavel och X7 betecknar vate, klor eller brom, och R, X4 och X ar lika eller olika och vardera betecknar %tate eller alkyl med 1-4 kolatomer, Y beteclalar H, OH, OM, van l M betecknar en metallisk rest, eller alkoxi med 1-12 kolatomer, vari kolvatedelen bar linjdr eller grenad kedja, cykloalkyloxi med 3-8 kolatomer, alkyltio med 1-4 kolatomer, 2,3-dihydroxipropyloxi, en 4-(2,2-dimety1-1,3- dioxolany1)-metylenoxigrupp, avledd frAn den fdregaende och med formelnt -CH2 0 CH t 3 C-CO-Yo' X4 marl X4, X, R och Yo her tidigare angiven betydelse, (c) reaktion mellan ett cyanobensenderivat med formeln: A-ON marl A bar tidigare angiven betydelse och joke innehAller flagon substituent morn dr reaktiv mot metal lorganiska reagens, och en magnesiumorganisk fdrening med formeln: Cl -CO H3CCH3 fenoxi, substituerad fenoxi, speciellt d& p-klorfenoxi, 3-pyridylmetylenoxi, 5-(2-mety1-3-hydroxi-4-hydroximetylpyridy1)-metylenoxi med formeln: X -Mg — CH
3. -C-CO-Y 1 CH2OH OH -0-CH2 ---- H3 en grupp med nAgon av formlerna Ny2, NNCH2CH2Ny2, OCH2CM2N2122 eller 0(cd2)0cONz1Z2 , marl m bar vardet 1-4 och Zl och Z2 be- tecknar alkyl med 1-4 kolatomer eller tillsammans med den kvaveatom, till vilken de Kr bundna kan bilda en N-heterocyklisk grupp med 5-7 ringled och mom kan innehAlla en andra heteroatom, sAsom 0 eller N och som kan vara substltuerad, eller en grupp med for-mein CH3 z 0-AC12)3-02C+0(" V _ -/ :)----C1 CH sent less syraadditionssalter, kannetecknat ddrav, att let utgbres av n&gon av fdljande reaktionsvagar: (a) reaktion en:e.' Friedel-Crati",mellan en halogenid med X4 marl X4' Xoch R her tidigare angiven betydelse, X betecknar brom eller jod och Yibetecknar metal', OMgHr eller 0MgI, samt Y1 kan beteckna OH, OCH3 eller 0C2H ndr X betecknar I,
4. reaktion mellan en halogenid med formeln A-CO-Hal 1 van i A har tidigare angiven betydelse och icke innehAller nAgon substituent som dr reaktiv mot metallOrganiska reagens, och en magnesiumorganisk forening med formeln: qH .O-Y1 vari X, X4, x, R och Y1 has- under (c) angiven betydelse,
5. reaktion mellan en hydroxiketon med formeln Forts. nosto side A-CO X4 van l A, X4 och X bar tidigare anglven betydelse, med ett reagens, bestiende av en blandning av aceton och kloroform eller en reaktionsprodukt av aceton och kloroform, for erhillande av en syra med formel I, van i Y betecknar OH och R betecknar CH3, reaktion mellan en hydroxiketon med formeln X A-C // '—OH(VII) X4 yard A, X4 och X bar tddlgare anglven betydelse, och en halogenerat derivat med formeln CH Hal -C-COY 2 vari B och Y her tidlgare angiven betydelse och Hal2 betecknar brom, klor eller jod, fdretridesvis di brom, varvid reaktdonen genomfbres J. en alkohol eller en keton I ng.rvaro av kallumkarbonat eller natriunkarbonat, (g) reaktion mellan en hydroxiketon med formeln VII och en nrening med formeln CH I 3 HO-C-CO-Y2 CH3 van l Y2 bar samma betydelse mom angivlts for Y och fdretrldesvis betecknar hydroxyl, for erhallande av en fbrening med formel I, yard R betecknar metyl, (h) reaktion mellan en lltiumorganlsk fdrening med formeln cH3 Li ux3 X4 FH3 70Y3 A-CO-C-CH \ 0Y3 X4 vilken efter behandling I cur miljd ger en aldehydketon, vilken oxideras medelst kallumpermanganat fOr erhillande av en syra med formel I. van i Y betecknar hydroxyl, (i) reaktion mellan en magneslumorganisk fbrening med formeln X4 Van d X4' X och B bar tddigare angiven betydelse, X betecknar brom eller jod och y3 betecknar alkyl med 1-4 kolatomer, foretradesvis di etyl, och en forening med formeln A-COC1 eller A-OH, van i A bar tidigare anglven betydelse och icke innehiller flagon substituent morn Kr reaktiv mot metallorganlska fdrenlngar, for erhillande av en forening med formeln: X 9H3 A-CO \ 0-0-CH 1 N, 0Y3 x4 vilken behandlas alio= angivits under (h) I det fOregaende fbr er/Allende av en syra med formeln I, vari Y betecknar hydroxyl, (j) reaktion mellan en bromacetal med formeln: CH OY 3 7 3 Br-C-CH I •, 0Y3 yard Y3 bar tddigare angiven betydelse, och en hydroxiketon med formeln VII for erhAllande av en for-ening med formeln : —OH 3 ,,,OY3 R0Y3 van i X4, X och R har tidigare angiven betydelse och Y3 betecknar alkyl med 1-4 kolatomer, fOretrbldesvis dA metyl, och en fdrening med formeln A-CO2Na eller A-CU, marl A har tidigare angiven betydelse och joke innehAller nAgon substituent mom Kr reaktiv not metalorganiska fdreningar, for erallande av en fdrening med formeln: H3 ,,,OY3 O-C-CH OY3 X4 vilken behandlas sAsom angivits under (h) for erhAllande av en syra med formeln I, marl. Y betecknar hydroxyl, och om sA onskas, en sAlunda erhAllen syra dverfores till metallsalt eller ester, eller en erhAllen ester overtures till syra eller en annan ester.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5979/75A GB1539897A (en) | 1975-02-12 | 1975-02-12 | Phenoxypropionic acid derivatives |
GB5063075 | 1975-12-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8005647L true SE8005647L (sv) | 1980-08-11 |
SE447651B SE447651B (sv) | 1986-12-01 |
Family
ID=26240297
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7601370A SE430329B (sv) | 1975-02-12 | 1976-02-09 | Forfarande for framstellning av nya terapeutiskt verksamma foreningar |
SE8005647A SE447651B (sv) | 1975-02-12 | 1980-08-11 | Sett att framstella 2-/4-(p-klorbensoyl)fenoxi/-2-metyl-propionsyra samt dess isopropylester |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7601370A SE430329B (sv) | 1975-02-12 | 1976-02-09 | Forfarande for framstellning av nya terapeutiskt verksamma foreningar |
Country Status (18)
Country | Link |
---|---|
US (1) | US4072705A (sv) |
JP (2) | JPS5195049A (sv) |
AR (2) | AR222773A1 (sv) |
AU (1) | AU512971B2 (sv) |
CA (1) | CA1069523A (sv) |
CH (2) | CH617657A5 (sv) |
DD (2) | DD124115A5 (sv) |
DE (1) | DE2605382C2 (sv) |
DK (1) | DK49676A (sv) |
ES (1) | ES445075A1 (sv) |
FI (1) | FI760328A (sv) |
FR (2) | FR2300552A1 (sv) |
IE (1) | IE43078B1 (sv) |
LU (1) | LU74331A1 (sv) |
MX (1) | MX3485E (sv) |
NL (1) | NL7601461A (sv) |
NO (1) | NO760440L (sv) |
SE (2) | SE430329B (sv) |
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FR2412540A2 (fr) * | 1977-02-14 | 1979-07-20 | Rolland Sa A | Nouveau procede de preparation de derives d'acide methyl-2 phenoxy-2 propionique, nouveaux derives d'acide methyl-2 phenoxy-2 propionique et leur application en therapeutique |
GB1569404A (en) * | 1977-04-22 | 1980-06-11 | Soc D Etudes Prod Chimique | (2-isopropyl-4-(2'-theonyl)-5-methyl) phenoxy acetic acid |
US4172082A (en) * | 1977-05-16 | 1979-10-23 | Riker Laboratories, Inc. | Substituted thiophenes |
FR2408577A1 (fr) * | 1977-11-14 | 1979-06-08 | Devinter Sa | Nouveau procede de synthese d'esters para chlorobenzoyl phenoxy isobutyriques |
FR2419928A1 (fr) * | 1978-03-15 | 1979-10-12 | Metabio Joullie Sa | Nouveaux derives de la n-phenylalanine, leur preparation et leur application comme medicaments |
FR2420522A1 (fr) * | 1978-03-20 | 1979-10-19 | Unicler | Derives de l'acide (m-benzoyl-phenoxy)-2 propionique et leurs applications comme medicaments |
NL7903434A (nl) * | 1978-05-09 | 1979-11-13 | Alfa Farmaceutici Spa | Derivaten van benzoylfenoxyalkaancarbonzuren met anti- lipemische en anticholesterolemische werking, alsmede farmaceutische preparaten die zo'n verbinding bevatten. |
US4220801A (en) * | 1979-07-23 | 1980-09-02 | Abbott Laboratories | Process for making 4-aroyl-substituted phenoxyacetic acids |
CA1149803A (en) * | 1979-10-09 | 1983-07-12 | Carroll W. Ours | HYDROXYAMINOMETHYL DERIVATIVES OF BENZOYL DI-SUBSTITUTED .alpha.-PHENOXY ALKANOYL ESTERS |
US4323691A (en) * | 1979-10-09 | 1982-04-06 | Abbott Laboratories | Hydroxyaminomethyl derivatives of benzoyl di-substituted α-phenoxyalkanoyl esters |
HU190053B (en) * | 1982-12-28 | 1986-08-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for the production of new 1,1-diphenyl-propanol-derivatives, as well as of therapeutic preparations containing them |
JPS617230A (ja) * | 1984-06-20 | 1986-01-13 | Asahi Chem Ind Co Ltd | 4−(パラフルオロベンゾイル)−2,6−ジメチルフエノ−ル及びその製造方法 |
JPS6112643A (ja) * | 1984-06-27 | 1986-01-21 | Asahi Chem Ind Co Ltd | 4−(パラハロゲノベンゾイル)−2,6−ジメチルフエノ−ルのアルカリ金属塩及びその製造方法 |
DE3512179A1 (de) * | 1985-04-03 | 1986-12-04 | Merck Patent Gmbh, 6100 Darmstadt | Fotoinitiatoren fuer die fotopolymerisation in waessrigen systemen |
FR2705343B1 (fr) * | 1993-05-17 | 1995-07-21 | Fournier Ind & Sante | Dérivés de beta,beta-diméthyl-4-pipéridineéthanamine, leur procédé de préparation et leur utilisation en thérapeutique. |
PT1089968E (pt) * | 1998-06-30 | 2005-08-31 | Univ California | Analogos de hormona tiroideia e metodos para a sua preparacao |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
ES2290562T3 (es) * | 2001-01-26 | 2008-02-16 | Schering Corporation | Combinaciones del activador del receptor activado por el proliferador de los peroxisomas (ppar) fenofibrato con el inhibidor de la absorcion de esteroles ezetimiba para indicaciones vasculares. |
DE60221798T2 (de) * | 2001-01-26 | 2008-06-05 | Schering Corp. | Kombinationen von gallensäure sequestriermitteln und hemmern der sterol absorption zur behandlung von kardiovaskulären indikationen |
CZ20032031A3 (cs) * | 2001-01-26 | 2003-12-17 | Schering Corporation | Farmaceutický prostředek |
PL205343B1 (pl) * | 2001-01-26 | 2010-04-30 | Schering Corp | Zastosowanie inhibitora wchłaniania sterolu |
WO2002058734A2 (en) * | 2001-01-26 | 2002-08-01 | Schering Corporation | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
US20020183305A1 (en) * | 2001-01-26 | 2002-12-05 | Schering Corporation | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
DE60216275T2 (de) * | 2001-05-25 | 2007-06-21 | Schering Corp. | Verwendung von mit azetidinon substituierten derivaten bei der behandlung der alzheimer-krankheit |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
EP1427409B1 (en) * | 2001-09-21 | 2008-10-15 | Schering Corporation | Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s) |
EP1429756B1 (en) * | 2001-09-21 | 2006-11-22 | Schering Corporation | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
WO2004043456A1 (en) * | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
US20080051411A1 (en) * | 2002-12-17 | 2008-02-28 | Cink Russell D | Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof |
RU2356549C2 (ru) * | 2002-12-17 | 2009-05-27 | Эббетт ГмбХ унд Ко.КГ | Композиция, включающая фенофибриновую кислоту, ее физиологически приемлемую соль или производное |
US7259186B2 (en) * | 2002-12-17 | 2007-08-21 | Abbott Laboratories | Salts of fenofibric acid and pharmaceutical formulations thereof |
WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
CA2517573C (en) * | 2003-03-07 | 2011-12-06 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
US7208486B2 (en) * | 2003-03-07 | 2007-04-24 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
WO2005046797A2 (en) * | 2003-11-05 | 2005-05-26 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
US20080152714A1 (en) * | 2005-04-08 | 2008-06-26 | Yi Gao | Pharmaceutical Formulations |
CN1966484B (zh) * | 2005-11-14 | 2011-02-02 | 北京美倍他药物研究有限公司 | 新的苯氧基烷酸类衍生物及其医药用途 |
WO2008157537A2 (en) * | 2007-06-19 | 2008-12-24 | Ironwood Pharmaceuticals, Inc | Compositions and methods of use for treating or preventing lipid related disorders |
FR2918366B1 (fr) * | 2007-07-02 | 2009-10-23 | Synkem Soc Par Actions Simplif | Nouveau procede de preparation du fenofibrate |
US20090182053A1 (en) * | 2007-12-19 | 2009-07-16 | Tong Sun | Fenofibric acid amorphous dispersion; method of making; and method of use thereof |
US20090187040A1 (en) * | 2008-01-18 | 2009-07-23 | Tong Sun | Fenofibric acid polymorphs; methods of making; and methods of use thereof |
CA2724873A1 (en) * | 2008-06-06 | 2009-12-10 | Nicox S.A. | Compositions comprising atorvastatin 4-(nitrooxy) butyl ester and a hypolipidemic drug |
CN104628554A (zh) * | 2015-02-09 | 2015-05-20 | 徐州工程学院 | 一种非诺贝特酸晶型及其制备方法 |
CN116082145A (zh) * | 2023-01-19 | 2023-05-09 | 天津科技大学 | 一种具有抗氧化活性的贝特类衍生物、合成方法及其应用 |
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US3332842A (en) * | 1963-08-30 | 1967-07-25 | Ciba Geigy Corp | Ether acids and derivatives thereof |
US3332957A (en) * | 1964-09-02 | 1967-07-25 | Ciba Geigy Corp | Amino esters of substituted phenoxy acetic acids |
GB1121722A (en) * | 1966-03-31 | 1968-07-31 | Ici Ltd | New carboxylic acid derivatives |
DE1668896C3 (de) * | 1968-01-11 | 1974-08-29 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Phenoxyalkancarbonsäuren ihre Salze und Ester und Verfahren zur Herstellung dieser Verbindungen |
DE2003430C3 (de) * | 1969-01-31 | 1978-12-07 | Laboratorien Fournier Gmbh, 6600 Saarbruecken | p-Benzoylphenoxyisobuttersäureester, ihre Herstellung und diese enthaltende Arzneimittel |
US3755603A (en) * | 1970-07-01 | 1973-08-28 | Syntex Corp | Biphenylyloxyacetic acids in pharmaceutical compositions |
GB1422679A (en) * | 1972-11-16 | 1976-01-28 | Funai Pharmaceutical Ind Ltd | Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same |
-
1976
- 1976-01-16 JP JP51003961A patent/JPS5195049A/ja active Pending
- 1976-02-02 CH CH128376A patent/CH617657A5/fr not_active IP Right Cessation
- 1976-02-06 DK DK49676*#A patent/DK49676A/da not_active Application Discontinuation
- 1976-02-09 SE SE7601370A patent/SE430329B/sv not_active IP Right Cessation
- 1976-02-09 US US05/656,711 patent/US4072705A/en not_active Expired - Lifetime
- 1976-02-09 AR AR262192A patent/AR222773A1/es active
- 1976-02-09 IE IE256/76A patent/IE43078B1/en unknown
- 1976-02-11 DE DE2605382A patent/DE2605382C2/de not_active Expired
- 1976-02-11 NO NO760440A patent/NO760440L/no unknown
- 1976-02-11 CA CA245,489A patent/CA1069523A/en not_active Expired
- 1976-02-11 FI FI760328A patent/FI760328A/fi not_active Application Discontinuation
- 1976-02-11 LU LU74331A patent/LU74331A1/xx unknown
- 1976-02-11 ES ES445075A patent/ES445075A1/es not_active Expired
- 1976-02-12 NL NL7601461A patent/NL7601461A/xx not_active Application Discontinuation
- 1976-02-12 DD DD191218A patent/DD124115A5/xx unknown
- 1976-02-12 DD DD76196964A patent/DD143909A5/de unknown
- 1976-02-12 FR FR7603876A patent/FR2300552A1/fr active Granted
- 1976-02-12 JP JP51014389A patent/JPS51131843A/ja active Pending
- 1976-02-12 AU AU11053/76A patent/AU512971B2/en not_active Expired
- 1976-02-12 MX MX276D patent/MX3485E/es unknown
- 1976-12-08 FR FR7637022A patent/FR2342723A1/fr active Granted
-
1977
- 1977-03-16 AR AR266873A patent/AR223305A1/es active
-
1978
- 1978-08-04 CH CH834978A patent/CH620415A5/fr not_active IP Right Cessation
-
1980
- 1980-08-11 SE SE8005647A patent/SE447651B/sv not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FR2300552B1 (sv) | 1981-06-12 |
DE2605382C2 (de) | 1985-10-31 |
AR222773A1 (es) | 1981-06-30 |
IE43078L (en) | 1976-08-12 |
DE2605382A1 (de) | 1976-08-26 |
FR2342723A1 (fr) | 1977-09-30 |
DD143909A5 (de) | 1980-09-17 |
US4072705A (en) | 1978-02-07 |
JPS5195049A (en) | 1976-08-20 |
IE43078B1 (en) | 1980-12-17 |
DK49676A (da) | 1976-08-13 |
CA1069523A (en) | 1980-01-08 |
LU74331A1 (sv) | 1976-08-13 |
FR2342723B1 (sv) | 1981-05-29 |
NO760440L (sv) | 1976-08-13 |
SE7601370L (sv) | 1976-08-13 |
CH617657A5 (sv) | 1980-06-13 |
AU512971B2 (en) | 1980-11-06 |
AR223305A1 (es) | 1981-08-14 |
CH620415A5 (sv) | 1980-11-28 |
SE447651B (sv) | 1986-12-01 |
MX3485E (es) | 1980-12-16 |
AU1105376A (en) | 1977-08-18 |
JPS51131843A (en) | 1976-11-16 |
FI760328A (sv) | 1976-08-13 |
SE430329B (sv) | 1983-11-07 |
FR2300552A1 (fr) | 1976-09-10 |
DD124115A5 (sv) | 1977-02-02 |
ES445075A1 (es) | 1977-08-01 |
NL7601461A (nl) | 1976-08-16 |
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