SE509634C2 - Förfarande för omvandling av 2,3-dihydro-3-hydroxi-2- (4- metoxifenyl)-1,5-bensotiazepin-4(5H)-on med cis-(2R,3R)- konfiguration till en blandning av cis-(2R,3R)- och cis- (2S,3S)-2,3-dihydro-3-hydroxi-2-(4-metoxifenyl)-1,5- bensotiazepin-4(5H)-on - Google Patents

Förfarande för omvandling av 2,3-dihydro-3-hydroxi-2- (4- metoxifenyl)-1,5-bensotiazepin-4(5H)-on med cis-(2R,3R)- konfiguration till en blandning av cis-(2R,3R)- och cis- (2S,3S)-2,3-dihydro-3-hydroxi-2-(4-metoxifenyl)-1,5- bensotiazepin-4(5H)-on

Info

Publication number
SE509634C2
SE509634C2 SE9003860A SE9003860A SE509634C2 SE 509634 C2 SE509634 C2 SE 509634C2 SE 9003860 A SE9003860 A SE 9003860A SE 9003860 A SE9003860 A SE 9003860A SE 509634 C2 SE509634 C2 SE 509634C2
Authority
SE
Sweden
Prior art keywords
cis
methoxyphenyl
compound
dihydro
hydroxy
Prior art date
Application number
SE9003860A
Other languages
English (en)
Swedish (sv)
Other versions
SE9003860D0 (sv
SE9003860L (sv
Inventor
Claudio Giordano
Roberto Casagrande
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of SE9003860D0 publication Critical patent/SE9003860D0/xx
Publication of SE9003860L publication Critical patent/SE9003860L/xx
Publication of SE509634C2 publication Critical patent/SE509634C2/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE9003860A 1989-12-06 1990-12-05 Förfarande för omvandling av 2,3-dihydro-3-hydroxi-2- (4- metoxifenyl)-1,5-bensotiazepin-4(5H)-on med cis-(2R,3R)- konfiguration till en blandning av cis-(2R,3R)- och cis- (2S,3S)-2,3-dihydro-3-hydroxi-2-(4-metoxifenyl)-1,5- bensotiazepin-4(5H)-on SE509634C2 (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02263789A IT1237526B (it) 1989-12-06 1989-12-06 Processo di preparazione di un intermedio per il diltiazem

Publications (3)

Publication Number Publication Date
SE9003860D0 SE9003860D0 (sv) 1990-12-05
SE9003860L SE9003860L (sv) 1991-06-07
SE509634C2 true SE509634C2 (sv) 1999-02-15

Family

ID=11198703

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9003860A SE509634C2 (sv) 1989-12-06 1990-12-05 Förfarande för omvandling av 2,3-dihydro-3-hydroxi-2- (4- metoxifenyl)-1,5-bensotiazepin-4(5H)-on med cis-(2R,3R)- konfiguration till en blandning av cis-(2R,3R)- och cis- (2S,3S)-2,3-dihydro-3-hydroxi-2-(4-metoxifenyl)-1,5- bensotiazepin-4(5H)-on

Country Status (13)

Country Link
US (1) US5102999A (de)
JP (1) JP2987714B2 (de)
AT (1) AT401650B (de)
BE (1) BE1003317A3 (de)
CA (1) CA2030866C (de)
CH (1) CH680443A5 (de)
DE (1) DE4038676C2 (de)
ES (1) ES2023774A6 (de)
FR (1) FR2655340B1 (de)
GB (1) GB2239014B (de)
IT (1) IT1237526B (de)
NL (1) NL194204C (de)
SE (1) SE509634C2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004534A1 (en) * 1993-08-06 1995-02-16 Smithkline Beecham Corporation Endothelin receptor antagonists
WO1995004530A1 (en) * 1993-08-06 1995-02-16 Smithkline Beecham Corporation Endothelin receptor antagonists
IL121525A0 (en) * 1996-08-26 1998-02-08 Tanabe Seiyaku Co Process for preparing optically active benzothiazepine compound and intermediate therefor
IT1295376B1 (it) * 1997-10-22 1999-05-12 Zambon Spa Processo per il riciclo di un sottoprodotto della sintesi del diltiazem
CN100364540C (zh) * 2006-03-14 2008-01-30 北京大学 (2s-顺)-(+)-2,3-二氢-3-羟基-2-(4-甲氧苯基)-1,5-苯并硫氮杂䓬-4(5h)-酮在制备治疗肝炎的药物中的用途
CN100463904C (zh) * 2006-08-15 2009-02-25 宁波工程学院 地尔硫卓中间体的制备方法
CN103755663B (zh) * 2014-01-26 2016-02-24 武汉工程大学 地尔硫卓中间体副产物L-cis-内酰胺的回收工艺
CN110284181A (zh) * 2019-08-07 2019-09-27 山东新华制药股份有限公司 地尔硫卓ab异构体的单晶制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
DE3263466D1 (en) * 1981-02-27 1985-06-20 Tanabe Seiyaku Co Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester
SE449611B (sv) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co Sett att framstella 1,5-bensotiazepinderivat
JPS5920273A (ja) * 1982-07-27 1984-02-01 Tanabe Seiyaku Co Ltd ベンゾチアゼピン誘導体の新規製造法
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
JPS6025982A (ja) * 1983-07-22 1985-02-08 Tanabe Seiyaku Co Ltd ベンゾチアゼピン誘導体の製法
JPS6032779A (ja) * 1983-08-01 1985-02-19 Hamari Yakuhin Kogyo Kk ベンゾチアゼピン誘導体の新規製造法

Also Published As

Publication number Publication date
NL194204C (nl) 2001-09-04
DE4038676A1 (de) 1991-06-13
ATA240890A (de) 1996-03-15
IT1237526B (it) 1993-06-08
CA2030866C (en) 2001-03-13
US5102999A (en) 1992-04-07
FR2655340B1 (fr) 1994-10-14
NL9002529A (nl) 1991-07-01
GB2239014A (en) 1991-06-19
DE4038676C2 (de) 1999-06-02
SE9003860D0 (sv) 1990-12-05
ES2023774A6 (es) 1992-02-01
NL194204B (nl) 2001-05-01
FR2655340A1 (fr) 1991-06-07
IT8922637A1 (it) 1991-06-06
GB2239014B (en) 1993-09-22
BE1003317A3 (fr) 1992-02-25
IT8922637A0 (it) 1989-12-06
SE9003860L (sv) 1991-06-07
GB9025887D0 (en) 1991-01-09
CH680443A5 (de) 1992-08-31
JP2987714B2 (ja) 1999-12-06
JPH03193770A (ja) 1991-08-23
CA2030866A1 (en) 1991-06-07
AT401650B (de) 1996-10-25

Similar Documents

Publication Publication Date Title
HU195182B (en) Process for production of /z/-1-phenil-1-diethil-amino-carbonil-2-amino-methil-cyclopropan hcl
Poindexter et al. The use of 2-oxazolidinones as latent aziridine equivalents. 2. Aminoethylation of aromatic amines, phenols, and thiophenols
SE509634C2 (sv) Förfarande för omvandling av 2,3-dihydro-3-hydroxi-2- (4- metoxifenyl)-1,5-bensotiazepin-4(5H)-on med cis-(2R,3R)- konfiguration till en blandning av cis-(2R,3R)- och cis- (2S,3S)-2,3-dihydro-3-hydroxi-2-(4-metoxifenyl)-1,5- bensotiazepin-4(5H)-on
CA2397270C (en) Method for the preparation of 5-cyanophthalide
FI81339C (fi) Foerfarande foer framstaellning av pyrrolidinoderivat, mellanprodukt och dess framstaellningsfoerfarande.
US4963671A (en) Process for resolving chiral intermediates used in making calcium channel blockers
EP1778620A1 (de) Verfahren zur herstellung einer diastereomer angereicherten verbindung
US6320057B1 (en) Intermediates for the preparation of 2-imidazoline-5-ones
FI84473C (fi) Foerfarande foer framstaellning av oktahydroindolderivat och mellanprodukter av framstaellningen.
US5869694A (en) Process for preparing 4-hydroxy-2-pyrrolidone
US5008434A (en) Process for the preparation of methyl (+)-(2S,3S)-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)-propionates
EP1735297B1 (de) Syntheseverfahren und benzoxathiepinzwischenprodukte
UA125989C2 (uk) Спосіб одержання (1r,2s)-1-(6-бром-2-метоксихінолін-3-іл)-4-диметиламіно-2-(1-нафтил)-1-фенілбутан-2-олу та його фармацевтично прийнятної солі
AU2006201612B2 (en) Method for the preparation of 5-cyanophthalide
JPS63211264A (ja) インドリン類の製造法
JPH07291946A (ja) （ｓ）−３−低級アルキル−２−ピペラジノンの製造方法
ZA200205318B (en) Method for the preparation of 5-cyanophthalide.
IE42935B1 (en) Isoindole derivatives

Legal Events

Date Code Title Description
NUG Patent has lapsed