IT8922637A0 - Processo di preparazione di un intermedio per il diltiazem - Google Patents

Processo di preparazione di un intermedio per il diltiazem

Info

Publication number
IT8922637A0
IT8922637A0 IT22637A IT2263789A IT8922637A0 IT 8922637 A0 IT8922637 A0 IT 8922637A0 IT 22637 A IT22637 A IT 22637A IT 2263789 A IT2263789 A IT 2263789A IT 8922637 A0 IT8922637 A0 IT 8922637A0
Authority
IT
Italy
Prior art keywords
diltiazem
preparation
Prior art date
Application number
IT22637A
Other languages
English (en)
Other versions
IT1237526B (it
IT8922637A1 (it
Inventor
Claudio Giordano
Roberto Casagrande
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of IT8922637A0 publication Critical patent/IT8922637A0/it
Priority to IT02263789A priority Critical patent/IT1237526B/it
Priority to CH3455/90A priority patent/CH680443A5/it
Priority to US07/612,954 priority patent/US5102999A/en
Priority to NL9002529A priority patent/NL194204C/nl
Priority to CA002030866A priority patent/CA2030866C/en
Priority to AT0240890A priority patent/AT401650B/de
Priority to FR909014781A priority patent/FR2655340B1/fr
Priority to JP2333510A priority patent/JP2987714B2/ja
Priority to GB9025887A priority patent/GB2239014B/en
Priority to BE9001134A priority patent/BE1003317A3/fr
Priority to DE4038676A priority patent/DE4038676C2/de
Priority to ES9003121A priority patent/ES2023774A6/es
Priority to SE9003860A priority patent/SE509634C2/sv
Publication of IT8922637A1 publication Critical patent/IT8922637A1/it
Application granted granted Critical
Publication of IT1237526B publication Critical patent/IT1237526B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT02263789A 1989-12-06 1989-12-06 Processo di preparazione di un intermedio per il diltiazem IT1237526B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT02263789A IT1237526B (it) 1989-12-06 1989-12-06 Processo di preparazione di un intermedio per il diltiazem
CH3455/90A CH680443A5 (it) 1989-12-06 1990-10-31
US07/612,954 US5102999A (en) 1989-12-06 1990-11-15 Process for the preparation of an intermediate of diltiazem
NL9002529A NL194204C (nl) 1989-12-06 1990-11-20 Werkwijze voor de bereiding van een tussenproduct van Diltiazem.
CA002030866A CA2030866C (en) 1989-12-06 1990-11-26 Process for the preparation of an intermediate of diltiazem
FR909014781A FR2655340B1 (fr) 1989-12-06 1990-11-27 Procede de preparation de produits intermediaires pour la preparation de diltiazem.
AT0240890A AT401650B (de) 1989-12-06 1990-11-27 Verfahren zur herstellung eines zwischenproduktes von diltiazem
JP2333510A JP2987714B2 (ja) 1989-12-06 1990-11-28 ジルチアゼム中間体の製造法
GB9025887A GB2239014B (en) 1989-12-06 1990-11-28 Racemization of benzothiazepin derivatives
BE9001134A BE1003317A3 (fr) 1989-12-06 1990-11-28 Procede de preparation de produits intermediaires pour la preparation de diltiazem.
DE4038676A DE4038676C2 (de) 1989-12-06 1990-12-04 Verfahren zur Herstellung eines Zwischenprodukts in der Diltiazem-Synthese
ES9003121A ES2023774A6 (es) 1989-12-06 1990-12-05 Procedimiento para la preparacion del intermedio de diltiazem.
SE9003860A SE509634C2 (sv) 1989-12-06 1990-12-05 Förfarande för omvandling av 2,3-dihydro-3-hydroxi-2- (4- metoxifenyl)-1,5-bensotiazepin-4(5H)-on med cis-(2R,3R)- konfiguration till en blandning av cis-(2R,3R)- och cis- (2S,3S)-2,3-dihydro-3-hydroxi-2-(4-metoxifenyl)-1,5- bensotiazepin-4(5H)-on

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02263789A IT1237526B (it) 1989-12-06 1989-12-06 Processo di preparazione di un intermedio per il diltiazem

Publications (3)

Publication Number Publication Date
IT8922637A0 true IT8922637A0 (it) 1989-12-06
IT8922637A1 IT8922637A1 (it) 1991-06-06
IT1237526B IT1237526B (it) 1993-06-08

Family

ID=11198703

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02263789A IT1237526B (it) 1989-12-06 1989-12-06 Processo di preparazione di un intermedio per il diltiazem

Country Status (13)

Country Link
US (1) US5102999A (it)
JP (1) JP2987714B2 (it)
AT (1) AT401650B (it)
BE (1) BE1003317A3 (it)
CA (1) CA2030866C (it)
CH (1) CH680443A5 (it)
DE (1) DE4038676C2 (it)
ES (1) ES2023774A6 (it)
FR (1) FR2655340B1 (it)
GB (1) GB2239014B (it)
IT (1) IT1237526B (it)
NL (1) NL194204C (it)
SE (1) SE509634C2 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004534A1 (en) * 1993-08-06 1995-02-16 Smithkline Beecham Corporation Endothelin receptor antagonists
WO1995004530A1 (en) * 1993-08-06 1995-02-16 Smithkline Beecham Corporation Endothelin receptor antagonists
IL121525A0 (en) * 1996-08-26 1998-02-08 Tanabe Seiyaku Co Process for preparing optically active benzothiazepine compound and intermediate therefor
IT1295376B1 (it) * 1997-10-22 1999-05-12 Zambon Spa Processo per il riciclo di un sottoprodotto della sintesi del diltiazem
CN100364540C (zh) * 2006-03-14 2008-01-30 北京大学 (2s-顺)-(+)-2,3-二氢-3-羟基-2-(4-甲氧苯基)-1,5-苯并硫氮杂䓬-4(5h)-酮在制备治疗肝炎的药物中的用途
CN100463904C (zh) * 2006-08-15 2009-02-25 宁波工程学院 地尔硫卓中间体的制备方法
CN103755663B (zh) * 2014-01-26 2016-02-24 武汉工程大学 地尔硫卓中间体副产物L-cis-内酰胺的回收工艺
CN110284181A (zh) * 2019-08-07 2019-09-27 山东新华制药股份有限公司 地尔硫卓ab异构体的单晶制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
DE3263466D1 (en) * 1981-02-27 1985-06-20 Tanabe Seiyaku Co Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester
SE449611B (sv) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co Sett att framstella 1,5-bensotiazepinderivat
JPS5920273A (ja) * 1982-07-27 1984-02-01 Tanabe Seiyaku Co Ltd ベンゾチアゼピン誘導体の新規製造法
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
JPS6025982A (ja) * 1983-07-22 1985-02-08 Tanabe Seiyaku Co Ltd ベンゾチアゼピン誘導体の製法
JPS6032779A (ja) * 1983-08-01 1985-02-19 Hamari Yakuhin Kogyo Kk ベンゾチアゼピン誘導体の新規製造法

Also Published As

Publication number Publication date
SE509634C2 (sv) 1999-02-15
NL194204C (nl) 2001-09-04
DE4038676A1 (de) 1991-06-13
ATA240890A (de) 1996-03-15
IT1237526B (it) 1993-06-08
CA2030866C (en) 2001-03-13
US5102999A (en) 1992-04-07
FR2655340B1 (fr) 1994-10-14
NL9002529A (nl) 1991-07-01
GB2239014A (en) 1991-06-19
DE4038676C2 (de) 1999-06-02
SE9003860D0 (sv) 1990-12-05
ES2023774A6 (es) 1992-02-01
NL194204B (nl) 2001-05-01
FR2655340A1 (fr) 1991-06-07
IT8922637A1 (it) 1991-06-06
GB2239014B (en) 1993-09-22
BE1003317A3 (fr) 1992-02-25
SE9003860L (sv) 1991-06-07
GB9025887D0 (en) 1991-01-09
CH680443A5 (it) 1992-08-31
JP2987714B2 (ja) 1999-12-06
JPH03193770A (ja) 1991-08-23
CA2030866A1 (en) 1991-06-07
AT401650B (de) 1996-10-25

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971124