EA202090385A1 - Новые промежуточные соединения, используемые для синтеза производных аминопиримидина, способ их получения и способ получения производных аминопиримидина с их использованием - Google Patents
Новые промежуточные соединения, используемые для синтеза производных аминопиримидина, способ их получения и способ получения производных аминопиримидина с их использованиемInfo
- Publication number
- EA202090385A1 EA202090385A1 EA202090385A EA202090385A EA202090385A1 EA 202090385 A1 EA202090385 A1 EA 202090385A1 EA 202090385 A EA202090385 A EA 202090385A EA 202090385 A EA202090385 A EA 202090385A EA 202090385 A1 EA202090385 A1 EA 202090385A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds used
- intermediate compounds
- new intermediate
- synthesis
- aminopyrimidine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Abstract
В настоящем изобретении предложен новый способ получения производного аминопиримидина или его фармацевтически приемлемой соли, имеющих селективную ингибирующую активность в отношении протеинкиназ, особенно в отношении протеинкиназ для мутантных рецепторов эпидермального фактора роста. Кроме того, в настоящем изобретении обеспечены новые промежуточные соединения, используемые в указанном способе, и способы их получения.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170096220 | 2017-07-28 | ||
| PCT/KR2018/008381 WO2019022486A1 (en) | 2017-07-28 | 2018-07-25 | NOVEL INTERMEDIATES USEFUL FOR SYNTHESIZING AMINOPYRIMIDINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES THEREWITH |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA202090385A1 true EA202090385A1 (ru) | 2020-09-09 |
| EA038856B1 EA038856B1 (ru) | 2021-10-28 |
Family
ID=65040817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202090385A EA038856B1 (ru) | 2017-07-28 | 2018-07-25 | Промежуточные соединения, используемые для синтеза производных аминопиримидина, способ их получения и способ получения производных аминопиримидина с их использованием |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10858353B2 (ru) |
| EP (1) | EP3658553B1 (ru) |
| JP (1) | JP7216704B2 (ru) |
| KR (1) | KR20190013554A (ru) |
| CN (1) | CN111032650A (ru) |
| AU (1) | AU2018308039B2 (ru) |
| BR (1) | BR112020001396A2 (ru) |
| CA (1) | CA3069408A1 (ru) |
| CO (1) | CO2020000595A2 (ru) |
| DK (1) | DK3658553T3 (ru) |
| EA (1) | EA038856B1 (ru) |
| ES (1) | ES2923278T3 (ru) |
| HR (1) | HRP20220848T1 (ru) |
| HU (1) | HUE059501T2 (ru) |
| IL (1) | IL271974B (ru) |
| LT (1) | LT3658553T (ru) |
| MA (1) | MA49703A (ru) |
| PH (1) | PH12020500070A1 (ru) |
| PL (1) | PL3658553T3 (ru) |
| PT (1) | PT3658553T (ru) |
| RS (1) | RS63497B1 (ru) |
| SA (1) | SA520411120B1 (ru) |
| SG (1) | SG11201913520YA (ru) |
| SI (1) | SI3658553T1 (ru) |
| UA (1) | UA125664C2 (ru) |
| WO (1) | WO2019022486A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
| WO2020230091A1 (en) | 2019-05-14 | 2020-11-19 | Janssen Biotech, Inc. | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8629132B2 (en) * | 2009-11-13 | 2014-01-14 | Genosco | Kinase inhibitors |
| CN105461695B (zh) * | 2014-09-29 | 2018-03-27 | 齐鲁制药有限公司 | 嘧啶或三嗪衍生物及其制备方法和用途 |
| KR102208775B1 (ko) * | 2014-10-13 | 2021-01-28 | 주식회사유한양행 | Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물 |
| CN104788427B (zh) | 2015-02-05 | 2017-05-31 | 上海泓博智源医药股份有限公司 | 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用 |
| EP3312179B1 (en) * | 2015-04-29 | 2019-07-10 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Fused-ring or tricyclic aryl pyrimidine compound used as kinase inhibitor |
| US10329257B2 (en) * | 2015-08-13 | 2019-06-25 | The Broad Institute, Inc. | Compositions and methods for treating tuberculosis |
| NZ761158A (en) * | 2017-07-28 | 2022-08-26 | Yuhan Corp | Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same |
-
2018
- 2018-07-25 PT PT188381735T patent/PT3658553T/pt unknown
- 2018-07-25 RS RS20220706A patent/RS63497B1/sr unknown
- 2018-07-25 KR KR1020180086377A patent/KR20190013554A/ko active IP Right Grant
- 2018-07-25 HR HRP20220848TT patent/HRP20220848T1/hr unknown
- 2018-07-25 BR BR112020001396-0A patent/BR112020001396A2/pt unknown
- 2018-07-25 DK DK18838173.5T patent/DK3658553T3/da active
- 2018-07-25 CN CN201880049025.7A patent/CN111032650A/zh active Pending
- 2018-07-25 EA EA202090385A patent/EA038856B1/ru unknown
- 2018-07-25 UA UAA202001305A patent/UA125664C2/uk unknown
- 2018-07-25 CA CA3069408A patent/CA3069408A1/en active Pending
- 2018-07-25 US US16/633,695 patent/US10858353B2/en active Active
- 2018-07-25 IL IL271974A patent/IL271974B/en unknown
- 2018-07-25 AU AU2018308039A patent/AU2018308039B2/en active Active
- 2018-07-25 SG SG11201913520YA patent/SG11201913520YA/en unknown
- 2018-07-25 MA MA049703A patent/MA49703A/fr unknown
- 2018-07-25 ES ES18838173T patent/ES2923278T3/es active Active
- 2018-07-25 JP JP2020503944A patent/JP7216704B2/ja active Active
- 2018-07-25 LT LTEPPCT/KR2018/008381T patent/LT3658553T/lt unknown
- 2018-07-25 SI SI201830722T patent/SI3658553T1/sl unknown
- 2018-07-25 WO PCT/KR2018/008381 patent/WO2019022486A1/en active Application Filing
- 2018-07-25 HU HUE18838173A patent/HUE059501T2/hu unknown
- 2018-07-25 PL PL18838173.5T patent/PL3658553T3/pl unknown
- 2018-07-25 EP EP18838173.5A patent/EP3658553B1/en active Active
-
2020
- 2020-01-09 PH PH12020500070A patent/PH12020500070A1/en unknown
- 2020-01-20 CO CONC2020/0000595A patent/CO2020000595A2/es unknown
- 2020-01-22 SA SA520411120A patent/SA520411120B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE059501T2 (hu) | 2022-11-28 |
| PL3658553T3 (pl) | 2022-10-10 |
| SI3658553T1 (sl) | 2022-10-28 |
| MA49703A (fr) | 2021-04-21 |
| EA038856B1 (ru) | 2021-10-28 |
| HRP20220848T1 (hr) | 2022-10-14 |
| US20200207750A1 (en) | 2020-07-02 |
| ES2923278T3 (es) | 2022-09-26 |
| EP3658553A4 (en) | 2021-04-21 |
| US10858353B2 (en) | 2020-12-08 |
| CN111032650A (zh) | 2020-04-17 |
| BR112020001396A2 (pt) | 2020-08-11 |
| SG11201913520YA (en) | 2020-02-27 |
| AU2018308039B2 (en) | 2022-04-14 |
| PH12020500070A1 (en) | 2020-12-07 |
| WO2019022486A1 (en) | 2019-01-31 |
| SA520411120B1 (ar) | 2022-08-25 |
| JP2020528437A (ja) | 2020-09-24 |
| CO2020000595A2 (es) | 2020-05-05 |
| IL271974B (en) | 2022-08-01 |
| LT3658553T (lt) | 2022-09-12 |
| IL271974A (en) | 2020-02-27 |
| RS63497B1 (sr) | 2022-09-30 |
| JP7216704B2 (ja) | 2023-02-01 |
| PT3658553T (pt) | 2022-09-23 |
| EP3658553A1 (en) | 2020-06-03 |
| CA3069408A1 (en) | 2019-01-31 |
| UA125664C2 (uk) | 2022-05-11 |
| DK3658553T3 (da) | 2022-07-25 |
| EP3658553B1 (en) | 2022-06-15 |
| KR20190013554A (ko) | 2019-02-11 |
| AU2018308039A1 (en) | 2020-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA202202097B (en) | Amino pyrimidine ssao inhibitors | |
| EA201991055A1 (ru) | СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛ[1,5-a]ПИРИМИДИНОВ И ИХ СОЛЕЙ | |
| AU2018271990A1 (en) | Covalent inhibitors of KRAS | |
| MX2018000777A (es) | Compuestos de quinazolina sustituido y su uso como inhibidores de proteinas kras, hras y/o nras mutantes g12c. | |
| EA202090383A1 (ru) | Усовершенствованный способ получения производных аминопиримидина | |
| PH12019501688A1 (en) | Pyridine derivative as ask1 inhibitor and preparation method and use thereof | |
| EA201991884A2 (ru) | Ингибиторы g12c kras | |
| EA202090384A1 (ru) | Промежуточные соединения, используемые для синтеза селективного ингибитора протеинкиназы, и способы их получения | |
| WO2017108723A3 (en) | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | |
| CY1124789T1 (el) | Πυριμιδιν-2-υλαμινο-1η-πυραζολια ως αναστολεις lrrk2 για χρηση στη θεραπεια νευροεκφυλιστικων διαταραχων | |
| EA033689B9 (ru) | Ингибиторы g12c kras | |
| PH12020550143A1 (en) | Salts of pyrrolotriazine derivatives useful as tam inhibitors | |
| SG10201902206QA (en) | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof | |
| MX2022004937A (es) | Inhibidores de las cinasas raf. | |
| EP4234547A3 (en) | Pharmaceutical salts of pyrimidine derivatives and method of treating disorders | |
| UY38233A (es) | Agentes inhibidores para la tirosina cinasa de bruton | |
| MX2020010618A (es) | Derivados de pirazolotriazolopiriminina como antagonista del receptor a2a. | |
| MX2021007247A (es) | Derivados de rapamicina. | |
| EP3560931A4 (en) | METHOD FOR PRODUCING A 7H-PYRROLO [2,3-D] PYRIMIDINE DERIVATIVE, AND CO-CRYSTAL OF SAID DERIVATIVE | |
| EA202090385A1 (ru) | Новые промежуточные соединения, используемые для синтеза производных аминопиримидина, способ их получения и способ получения производных аминопиримидина с их использованием | |
| MX2018011592A (es) | Compuesto que tiene actividad inhibitoria de idh mutante, metodo de preparacion y usos del mismo. | |
| EP3802525A4 (en) | Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof | |
| WO2016023028A3 (en) | G protein-coupled receptor kinase 2 inhibitors and methods for use of the same | |
| MX2022005951A (es) | Compuestos de pirrolotriazina que actuan como inhibidor de mnk. | |
| MX2020013352A (es) | Tratamiento para migrañas. |