SG11201913556SA - Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same - Google Patents
Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the sameInfo
- Publication number
- SG11201913556SA SG11201913556SA SG11201913556SA SG11201913556SA SG11201913556SA SG 11201913556S A SG11201913556S A SG 11201913556SA SG 11201913556S A SG11201913556S A SG 11201913556SA SG 11201913556S A SG11201913556S A SG 11201913556SA SG 11201913556S A SG11201913556S A SG 11201913556SA
- Authority
- SG
- Singapore
- Prior art keywords
- synthesis
- preparing
- processes
- same
- protein kinase
- Prior art date
Links
- 102000001253 Protein Kinase Human genes 0.000 title 1
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 108060006633 protein kinase Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170096226 | 2017-07-28 | ||
| PCT/KR2018/008383 WO2019022487A1 (en) | 2017-07-28 | 2018-07-25 | Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201913556SA true SG11201913556SA (en) | 2020-02-27 |
Family
ID=65040643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201913556SA SG11201913556SA (en) | 2017-07-28 | 2018-07-25 | Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US11198684B2 (en) |
| EP (1) | EP3658547B1 (en) |
| JP (1) | JP7189932B2 (en) |
| KR (2) | KR20190013555A (en) |
| CN (1) | CN111295381A (en) |
| AU (1) | AU2018308164B2 (en) |
| BR (1) | BR112020001457A2 (en) |
| CA (1) | CA3070070A1 (en) |
| CO (1) | CO2020000371A2 (en) |
| DK (1) | DK3658547T3 (en) |
| EA (1) | EA038078B1 (en) |
| ES (1) | ES2959967T3 (en) |
| FI (1) | FI3658547T3 (en) |
| HR (1) | HRP20231020T1 (en) |
| HU (1) | HUE063043T2 (en) |
| IL (1) | IL271975B (en) |
| LT (1) | LT3658547T (en) |
| MA (1) | MA49705A (en) |
| NZ (1) | NZ761158A (en) |
| PH (1) | PH12020500093A1 (en) |
| PL (1) | PL3658547T3 (en) |
| PT (1) | PT3658547T (en) |
| RS (1) | RS64545B1 (en) |
| SA (1) | SA520411115B1 (en) |
| SG (1) | SG11201913556SA (en) |
| SI (1) | SI3658547T1 (en) |
| UA (1) | UA125595C2 (en) |
| WO (1) | WO2019022487A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111032650A (en) * | 2017-07-28 | 2020-04-17 | 株式会社柳韩洋行 | Novel intermediate useful for synthesis of aminopyrimidine derivative, method for preparing same, and method for preparing aminopyrimidine derivative using same |
| WO2019022485A1 (en) | 2017-07-28 | 2019-01-31 | Yuhan Corporation | Improved process for preparing aminopyrimidine derivatives |
| US11879013B2 (en) | 2019-05-14 | 2024-01-23 | Janssen Biotech, Inc. | Combination therapies with bispecific anti-EGFR/c-Met antibodies and third generation EGFR tyrosine kinase inhibitors |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011526299A (en) * | 2008-06-27 | 2011-10-06 | アビラ セラピューティクス， インコーポレイテッド | Heteroaryl compounds and their use |
| MX2012005332A (en) | 2009-11-13 | 2012-10-15 | Oscotec Inc | Kinase inhibitors. |
| CN104109161B (en) * | 2011-07-27 | 2016-08-17 | 阿斯利康(瑞典)有限公司 | 2-(2,4,5-substituted aniline) pyrimidine derivatives is used for treating cancer as EGFR modulator |
| US20130165464A1 (en) * | 2011-12-23 | 2013-06-27 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| CN104203943B (en) * | 2012-01-20 | 2017-12-29 | 盖诺斯克公司 | Substituted pyrimidine compound and its purposes as SYK inhibitor |
| EP3144292B1 (en) * | 2014-04-14 | 2020-08-26 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd | 2,3,4,6-tetra-substituted benzene-1,5-diamine derivatives, preparation method therefor and medicinal use thereof |
| CN105461695B (en) * | 2014-09-29 | 2018-03-27 | 齐鲁制药有限公司 | Pyrimidine or pyrrolotriazine derivatives and its production and use |
| CN105524068B (en) | 2014-09-30 | 2017-11-24 | 上海海雁医药科技有限公司 | Azabicyclic derivatives, its preparation method and purposes pharmaceutically |
| EP3604294B1 (en) | 2014-10-13 | 2021-05-05 | Yuhan Corporation | Compounds and compositions for modulating egfr mutant kinase activities |
| CN104788427B (en) | 2015-02-05 | 2017-05-31 | 上海泓博智源医药股份有限公司 | 3 (2 pyrimdinyl-amino) phenylacryloyl amine compounds and its application |
| CN109328059B (en) * | 2016-01-07 | 2021-08-17 | Cs制药技术有限公司 | Selective inhibitors of clinically important mutants of EGFR tyrosine kinase |
| CN106083736A (en) | 2016-06-21 | 2016-11-09 | 郑州泰基鸿诺医药股份有限公司 | A kind of pyrimidines, EGFR inhibitor and application thereof |
-
2018
- 2018-07-25 SI SI201830982T patent/SI3658547T1/en unknown
- 2018-07-25 KR KR1020180086378A patent/KR20190013555A/en active IP Right Grant
- 2018-07-25 JP JP2020504208A patent/JP7189932B2/en active Active
- 2018-07-25 PT PT188387187T patent/PT3658547T/en unknown
- 2018-07-25 NZ NZ761158A patent/NZ761158A/en not_active IP Right Cessation
- 2018-07-25 LT LTEPPCT/KR2018/008383T patent/LT3658547T/en unknown
- 2018-07-25 HU HUE18838718A patent/HUE063043T2/en unknown
- 2018-07-25 PL PL18838718.7T patent/PL3658547T3/en unknown
- 2018-07-25 UA UAA202001302A patent/UA125595C2/en unknown
- 2018-07-25 US US16/633,756 patent/US11198684B2/en active Active
- 2018-07-25 MA MA049705A patent/MA49705A/en unknown
- 2018-07-25 CN CN201880048980.9A patent/CN111295381A/en active Pending
- 2018-07-25 HR HRP20231020TT patent/HRP20231020T1/en unknown
- 2018-07-25 SG SG11201913556SA patent/SG11201913556SA/en unknown
- 2018-07-25 AU AU2018308164A patent/AU2018308164B2/en active Active
- 2018-07-25 DK DK18838718.7T patent/DK3658547T3/en active
- 2018-07-25 ES ES18838718T patent/ES2959967T3/en active Active
- 2018-07-25 WO PCT/KR2018/008383 patent/WO2019022487A1/en active Application Filing
- 2018-07-25 FI FIEP18838718.7T patent/FI3658547T3/en active
- 2018-07-25 IL IL271975A patent/IL271975B/en unknown
- 2018-07-25 CA CA3070070A patent/CA3070070A1/en active Pending
- 2018-07-25 BR BR112020001457-5A patent/BR112020001457A2/en unknown
- 2018-07-25 EA EA202090384A patent/EA038078B1/en unknown
- 2018-07-25 RS RS20230685A patent/RS64545B1/en unknown
- 2018-07-25 EP EP18838718.7A patent/EP3658547B1/en active Active
-
2020
- 2020-01-14 PH PH12020500093A patent/PH12020500093A1/en unknown
- 2020-01-15 CO CONC2020/0000371A patent/CO2020000371A2/en unknown
- 2020-01-22 SA SA520411115A patent/SA520411115B1/en unknown
-
2023
- 2023-09-21 KR KR1020230126377A patent/KR20230137282A/en not_active Application Discontinuation
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