RU2275871C2 - Устройство и способ для прокалывания кожи микровыступами - Google Patents

Устройство и способ для прокалывания кожи микровыступами Download PDF

Info

Publication number
RU2275871C2
RU2275871C2 RU2003110431/14A RU2003110431A RU2275871C2 RU 2275871 C2 RU2275871 C2 RU 2275871C2 RU 2003110431/14 A RU2003110431/14 A RU 2003110431/14A RU 2003110431 A RU2003110431 A RU 2003110431A RU 2275871 C2 RU2275871 C2 RU 2275871C2
Authority
RU
Russia
Prior art keywords
microprotrusion
stratum corneum
applicator
substance
clause
Prior art date
Application number
RU2003110431/14A
Other languages
English (en)
Russian (ru)
Other versions
RU2003110431A (ru
Inventor
Майкл Дж. Н. КОРМИР (US)
Майкл Дж. Н. КОРМИР
Петер Е. ДАДДОНА (US)
Петер Е. ДАДДОНА
Ричард Л. КИНЭН (US)
Ричард Л. КИНЭН
ВейКви ЛИН (US)
ВейКви ЛИН
Джеймс А. МАТРИАНО (US)
Джеймс А. МАТРИАНО
Ахмад П. САМИЕ (US)
Ахмад П. САМИЕ
Джозеф К. ТРОТМЭН (US)
Джозеф К. ТРОТМЭН
Original Assignee
Алза Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22906027&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2275871(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Алза Корпорейшн filed Critical Алза Корпорейшн
Publication of RU2003110431A publication Critical patent/RU2003110431A/ru
Application granted granted Critical
Publication of RU2275871C2 publication Critical patent/RU2275871C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150801—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming
    • A61B5/150824—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism
    • A61B5/15113—Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A61B5/15188—Constructional features of reusable driving devices
    • A61B5/1519—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for propelling the piercing unit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Manufacturing & Machinery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Perforating, Stamping-Out Or Severing By Means Other Than Cutting (AREA)
  • Surgical Instruments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Massaging Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
RU2003110431/14A 2000-10-13 2001-10-12 Устройство и способ для прокалывания кожи микровыступами RU2275871C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24030700P 2000-10-13 2000-10-13
US60/240,307 2000-10-13

Publications (2)

Publication Number Publication Date
RU2003110431A RU2003110431A (ru) 2004-08-27
RU2275871C2 true RU2275871C2 (ru) 2006-05-10

Family

ID=22906027

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003110431/14A RU2275871C2 (ru) 2000-10-13 2001-10-12 Устройство и способ для прокалывания кожи микровыступами

Country Status (22)

Country Link
US (2) US7131960B2 (es)
EP (1) EP1341453B1 (es)
JP (1) JP4659332B2 (es)
KR (1) KR20030068136A (es)
CN (1) CN1250171C (es)
AT (1) ATE428357T1 (es)
AU (2) AU9682801A (es)
BR (1) BR0114629A (es)
CA (1) CA2425315C (es)
CZ (1) CZ20031037A3 (es)
DE (1) DE60138411D1 (es)
ES (1) ES2324461T3 (es)
HU (1) HUP0303558A2 (es)
IL (1) IL155374A0 (es)
MA (1) MA26057A1 (es)
MX (1) MXPA03003299A (es)
NO (1) NO20031681L (es)
NZ (1) NZ525294A (es)
PL (1) PL360998A1 (es)
RU (1) RU2275871C2 (es)
WO (1) WO2002030301A1 (es)
ZA (1) ZA200303633B (es)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2494769C2 (ru) * 2008-11-18 2013-10-10 3М Инновейтив Пропертиз Компани Массив полых микроигл и способ его использования
RU2560646C2 (ru) * 2010-04-28 2015-08-20 Кимберли-Кларк Ворлдвайд, Инк. Изготовленный литьевым прессованием массив микроигл и способ формирования массива микроигл
RU2562885C9 (ru) * 2010-04-28 2016-02-20 Кимберли-Кларк Ворлдвайд, Инк. Медицинское устройство с наноузором с улучшенным взаимодействием с клеткой
RU2585159C2 (ru) * 2010-04-28 2016-05-27 Кимберли-Кларк Ворлдвайд, Инк. Устройство доставки лекарственного средства, применяемого при ревматоидном артрите
RU2585138C2 (ru) * 2010-04-28 2016-05-27 Кимберли-Кларк Ворлдвайд, Инк. Медицинские устройства для доставки кирнк

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR008242A1 (es) * 1996-06-18 1999-12-29 Alza Corp Dispositivo para atravesar el estrato corneo de una superficie corporal
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
AU2001296817B2 (en) * 2000-10-13 2006-05-11 Alza Corporation Microprotrusion member retainer for impact applicator
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
MXPA03003299A (es) * 2000-10-13 2004-12-13 Johnson & Johnson Aparato y metodo para perforacion de la piel con microsalientes.
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
DE60138407D1 (de) 2000-10-26 2009-05-28 Alza Corp Transdermales arzneistoffverabreichungssytem mit beschichteten mikrovorsprüngen
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
MXPA03009603A (es) * 2001-04-20 2004-12-06 Johnson & Johnson Arreglo de microproyeccion que tiene un agente benefico que contiene un recubrimiento.
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
EP1485317A2 (en) * 2001-11-30 2004-12-15 Alza Corporation Methods and apparatuses for forming microprojection arrays
RU2314760C2 (ru) * 2001-12-20 2008-01-20 Алза Корпорейшн Микровыступы, пробивающие кожу, имеющие средство регулирования глубины пробивки
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
ATE336277T1 (de) * 2002-06-28 2006-09-15 Alza Corp Verfahren zur oberflächenbeschichtung von vorrichtungen zur transdermalen verabreichung von arzneien mit beschichteten mikrovorsprüngen
EP1523367A1 (en) * 2002-07-19 2005-04-20 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
AU2003275301A1 (en) * 2002-09-30 2004-04-23 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
AU2003287735A1 (en) * 2002-11-12 2004-06-03 Argose, Inc. Non-invasive measurement of analytes
US20040106163A1 (en) * 2002-11-12 2004-06-03 Workman Jerome James Non-invasive measurement of analytes
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US7226457B2 (en) * 2003-02-19 2007-06-05 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Epidermal sampling apparatus and method
US7087063B2 (en) * 2003-02-19 2006-08-08 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Abrasion device and method
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
KR20060038407A (ko) * 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
AR044985A1 (es) * 2003-07-02 2005-10-12 Alza Corp Metodo y parche de inmunizacion por disposicion de microproyeccion
AR045206A1 (es) * 2003-08-04 2005-10-19 Alza Corp : componente de microproyeccion para insercion dentro de una superficie biologica.
BRPI0415761A (pt) * 2003-10-24 2006-12-19 Alza Corp aparelho e processo para reforçar a distribuição transdérmica de medicamento
CN1897898A (zh) 2003-10-24 2007-01-17 阿尔扎公司 用于增强透皮药物传递的预处理方法和***
AU2004287059A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
US7455654B2 (en) * 2003-10-28 2008-11-25 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
EP1680154B1 (en) * 2003-10-31 2012-01-04 ALZA Corporation Self-actuating applicator for microprojection array
WO2005065241A2 (en) * 2003-12-24 2005-07-21 Argose, Inc. Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors
US20070083151A1 (en) * 2003-12-29 2007-04-12 Carter Chad J Medical devices and kits including same
CN1636505B (zh) * 2004-01-09 2011-11-09 希森美康株式会社 提取器具、提取装置和血糖值测量装置
EP2929909B1 (en) 2004-03-08 2018-08-15 Ichor Medical Systems Inc. Improved apparatus for electrically mediated delivery of therapeutic agents
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
US20050271684A1 (en) * 2004-04-13 2005-12-08 Trautman Joseph C Apparatus and method for transdermal delivery of multiple vaccines
MXPA06013168A (es) 2004-05-13 2007-05-15 Johnson & Johnson Aparato y metodo para el suministro transdermico de agentes de la hormona paratiroidea.
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
CN101014381A (zh) * 2004-09-08 2007-08-08 阿尔扎公司 具有改善的皮肤粘附力和顺应性的微突物阵列
AU2005306429B2 (en) 2004-11-18 2011-04-14 3M Innovative Properties Company Microneedle array applicator and retainer
MX2007005813A (es) 2004-11-18 2007-07-18 3M Innovative Properties Co Aplicador con arreglo de microagujas de perfil bajo.
WO2006089056A2 (en) * 2005-02-16 2006-08-24 Alza Corporation Apparatus and method for transdermal delivery of erythropoetin-based agents
WO2006105146A2 (en) 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
EP1871459B1 (en) 2005-04-07 2019-06-19 3M Innovative Properties Company System for tool feedback sensing
EP1885405A1 (en) * 2005-06-02 2008-02-13 Alza Corporation, Inc. Method for terminal sterilization of transdermal delivery devices
EP1904158B1 (en) * 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
AU2006261898B2 (en) * 2005-06-27 2011-11-03 3M Innovative Properties Company Microneedle array applicator device
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
AU2006291157A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Coatable transdermal delivery microprojection assembly
EP1957145A4 (en) * 2005-11-30 2011-03-23 3M Innovative Properties Co MICRONADEL ASSEMBLIES AND APPLICATION METHOD
JP4963849B2 (ja) 2006-03-13 2012-06-27 シスメックス株式会社 微細孔形成システム
CN101466393A (zh) * 2006-03-15 2009-06-24 阿尔扎公司 用于经皮递送甲状旁腺激素药剂以治疗骨质减少的方法
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007127815A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
US20070293816A1 (en) * 2006-04-25 2007-12-20 Alza Corporation Microprojection Array Application with Grouped Microprojections for High Drug Loading
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
CA2676221C (en) 2007-01-22 2016-12-20 Corium International, Inc. Applicators for microneedles
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
WO2008130587A2 (en) 2007-04-16 2008-10-30 Corium International, Inc. Solvent-cast microneedle arrays containing active
US20090247984A1 (en) * 2007-10-24 2009-10-01 Masimo Laboratories, Inc. Use of microneedles for small molecule metabolite reporter delivery
JP5508272B2 (ja) * 2007-10-29 2014-05-28 トランスファーマ メディカル リミテッド 垂直的なパッチ乾燥
WO2009129349A2 (en) * 2008-04-16 2009-10-22 Kim Stanley I Single-use disposable lancing apparatus and methods
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
CN102405015B (zh) 2009-03-02 2017-01-18 第七感生物***有限公司 用于分析可提取介质的装置和方法
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
CN102497909B (zh) 2009-07-31 2014-10-29 3M创新有限公司 中空微针阵列
US8409147B2 (en) * 2009-08-22 2013-04-02 Joseph Wayne Kraft Rapid local anesthesia linear injection device
US8088108B2 (en) * 2009-08-22 2012-01-03 Joseph Wayne Kraft Rapid local anesthesia injection cone
WO2011105496A1 (ja) * 2010-02-24 2011-09-01 久光製薬株式会社 マイクロニードルデバイス
GB201007207D0 (en) 2010-04-29 2010-06-16 Univ Cork Method
AU2011248108B2 (en) * 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
EP2566568B1 (en) 2010-05-04 2019-04-10 Corium International, Inc. Applicators for microneedles
EP2578265B1 (en) 2010-05-28 2019-04-03 Hisamitsu Pharmaceutical Co., Inc. Array with fine protrusions
WO2011148994A1 (ja) 2010-05-28 2011-12-01 久光製薬株式会社 微小突起付きアレイを有するデバイス
JP5562138B2 (ja) * 2010-06-24 2014-07-30 シスメックス株式会社 微細孔形成装置
EP2399635A1 (en) 2010-06-28 2011-12-28 Sanofi-Aventis Deutschland GmbH Auto-injector
US8257379B2 (en) * 2010-07-29 2012-09-04 Kyphon Sarl Tissue structure perforation system and method
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
JP5885667B2 (ja) * 2010-10-07 2016-03-15 久光製薬株式会社 アプリケータ
DE202010013095U1 (de) 2010-12-10 2011-02-17 Mt Derm Gmbh Vorrichtung zum wiederholten Aufstechen von Haut und Stechmodul
EP2489387A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2489385A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2489382A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2489380A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Injection device
EP2489390A1 (en) * 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Detent mechanism
EP2489389A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Detent mechanism
EP2489388A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2489386A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2489381A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Auto-injector
EP3970723A1 (en) 2011-02-18 2022-03-23 Asana BioSciences, LLC Aminoindane compounds for use in treating urological pain
EP2489384A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Auto-injector
KR20120119250A (ko) * 2011-04-21 2012-10-31 (주)마이티시스템 단턱이 형성된 미세바늘
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
KR102237667B1 (ko) * 2011-04-29 2021-04-12 세븐쓰 센스 바이오시스템즈, 인크. 유체들의 전달 및/또는 수용
EP3236259A1 (en) 2011-04-29 2017-10-25 Seventh Sense Biosystems, Inc. Plasma or serum production and removal of fluids under reduced pressure
US9498611B2 (en) 2011-10-06 2016-11-22 Hisamitsu Pharmaceutical Co., Inc. Applicator
IN2014CN02643A (es) 2011-10-12 2015-08-07 3M Innovative Properties Co
US8685418B2 (en) 2011-10-24 2014-04-01 Endo Pharmaceuticals Inc. Cyclohexylamines
USD733290S1 (en) 2012-01-27 2015-06-30 3M Innovative Properties Company Microneedle applicator
US20150057604A1 (en) 2012-04-05 2015-02-26 Hisamitsu Pharmaceutical Co., Inc. Puncture Device and Method for Manufacturing Same
EP2841147A4 (en) * 2012-05-01 2016-04-13 Univ Pittsburgh MICRO-NEEDLES NETWORKS WITH CHARGED END FOR TRANSDERMAL INSERTION
JP6009302B2 (ja) * 2012-09-27 2016-10-19 シスメックス株式会社 微細孔形成装置、微細針チップおよびチップホルダ
CN105073102B (zh) 2012-10-01 2018-06-19 香港科技大学 透皮贴装置
JP6158838B2 (ja) 2012-12-21 2017-07-05 久光製薬株式会社 アプリケータ
MX2015008157A (es) 2012-12-21 2016-02-22 Corium Int Inc Microarreglo para la entrega de agente terapeutico y metodos de uso.
EP3932463A1 (en) * 2013-01-08 2022-01-05 Kindeva Drug Delivery L.P. Applicator for applying a microneedle device to skin
BR122020006959B1 (pt) 2013-03-12 2022-04-26 Corium, Inc Aplicador de microprojeções
RU2711567C2 (ru) 2013-03-15 2020-01-17 Кориум, ИНК. Микрочип для доставки лекарственного средства и способы его использования
CA2903583C (en) 2013-03-15 2021-12-28 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US20150038897A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-Profile Microneedle Patch Applicator
US10232158B2 (en) 2013-09-18 2019-03-19 Cosmed Pharmaceutical Co., Ltd. Microneedle patch application device and patch holder
JP6215343B2 (ja) 2013-11-05 2017-10-18 久光製薬株式会社 アプリケータ
EP3083619B1 (en) 2013-12-16 2021-11-03 Asana BioSciences, LLC P2x3 and/or p2x2/3 compounds and methods
CN103654969B (zh) * 2013-12-24 2015-12-30 湖州美奇医疗器械有限公司 一种医疗助针器
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
US10137289B2 (en) * 2014-12-20 2018-11-27 Esthetic Education LLC Microneedle cartridge and nosecone assembly
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
MA41818A (fr) 2015-03-27 2018-01-30 Leo Pharma As Timbre à micro-aiguilles pour administration d'un principe actif à la peau
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP2017023404A (ja) 2015-07-22 2017-02-02 日本写真印刷株式会社 マイクロニードルパッチ用インパクト付加型アプリケータ及び先端部材
JP6676644B2 (ja) 2015-09-02 2020-04-08 久光製薬株式会社 アプリケータ
EP3416618A1 (en) 2016-02-19 2018-12-26 ZP Opco, Inc. Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
EP3431133B1 (en) 2016-03-16 2022-04-20 Cosmed Pharmaceutical Co., Ltd. Microneedle patch case
WO2017172838A1 (en) 2016-03-28 2017-10-05 Ichor Medical Systems, Inc. Method and apparatus for delivery of therapeutic agents
CA3037748A1 (en) 2016-09-30 2018-04-05 Asana Biosciences, Llc P2x3 and/or p2x2/3 compounds and methods
JP6931217B2 (ja) 2017-03-28 2021-09-01 コスメディ製薬株式会社 水溶性シート状製剤のアプリケータ
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
KR102340393B1 (ko) 2017-08-23 2021-12-17 조사노 파마 코포레이션 편두통 및 군발성 두통의 치료를 위한 졸미트립탄의 치료적 농도를 신속하게 달성하는 방법
IL273926B1 (en) 2017-10-17 2024-02-01 3M Innovative Properties Company Conductor for applying an array of micro-needles to the skin
AU2019211652A1 (en) 2018-01-24 2020-07-30 Cosmed Pharmaceutical Co., Ltd. Tight-binding device for micro-needle
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
DE102019200563A1 (de) * 2019-01-17 2020-07-23 Lts Lohmann Therapie-Systeme Ag Applikator
JP7491551B2 (ja) 2019-04-25 2024-05-28 コスメディ製薬株式会社 水溶性シート状製剤のアプリケータ２

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) 1964-09-08 Means for vaccinating
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US6048337A (en) 1992-01-07 2000-04-11 Principal Ab Transdermal perfusion of fluids
CN1098712C (zh) 1994-08-18 2003-01-15 Nmt集团公开有限公司 针缩回机构
AU4256496A (en) * 1994-12-09 1996-06-26 Novartis Ag Transdermal system
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5613978A (en) 1996-06-04 1997-03-25 Palco Laboratories Adjustable tip for lancet device
AR008242A1 (es) * 1996-06-18 1999-12-29 Alza Corp Dispositivo para atravesar el estrato corneo de una superficie corporal
DK0921840T3 (da) 1996-07-03 2003-09-22 Altea Therapeutics Corp Multipel mekanisk mikroperforering af hud eller slimhinde
EP0934093B1 (en) 1996-09-17 2003-01-15 Deka Products Limited Partnership System for delivery of drugs by transport
WO1998028037A1 (en) * 1996-12-20 1998-07-02 Alza Corporation Device and method for enhancing transdermal agent flux
DE19654391A1 (de) 1996-12-27 1998-07-02 Basf Ag Katalysator zur selektiven Herstellung von Propylen aus Propan
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
CN1161164C (zh) * 1997-12-11 2004-08-11 阿尔扎有限公司 用于通过体表导入或提取质剂的装置
CN1206004C (zh) * 1997-12-11 2005-06-15 阿尔扎有限公司 增强透皮物剂流量的装置
ATE302041T1 (de) 1997-12-11 2005-09-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
JP2002517300A (ja) 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
GB9817662D0 (en) * 1998-08-13 1998-10-07 Crocker Peter J Substance delivery
EP2286868A3 (en) * 1999-06-08 2012-05-16 Altea Therapeutics Corporation Apparatus for microporation of biological membranes using thin film tissue interface devices, and method for manufacturing
US6364889B1 (en) * 1999-11-17 2002-04-02 Bayer Corporation Electronic lancing device
EP1239775B1 (en) * 1999-12-16 2005-03-16 ALZA Corporation Device for enhancing transdermal flux of sampled agents
MXPA03003299A (es) * 2000-10-13 2004-12-13 Johnson & Johnson Aparato y metodo para perforacion de la piel con microsalientes.
AU2001296817B2 (en) * 2000-10-13 2006-05-11 Alza Corporation Microprotrusion member retainer for impact applicator
KR100818545B1 (ko) * 2000-10-13 2008-04-01 알자 코포레이션 마이크로블레이드 어레이 충격 어플리케이터
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
DE60138407D1 (de) * 2000-10-26 2009-05-28 Alza Corp Transdermales arzneistoffverabreichungssytem mit beschichteten mikrovorsprüngen
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
MXPA03009603A (es) * 2001-04-20 2004-12-06 Johnson & Johnson Arreglo de microproyeccion que tiene un agente benefico que contiene un recubrimiento.
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
EP1485317A2 (en) * 2001-11-30 2004-12-15 Alza Corporation Methods and apparatuses for forming microprojection arrays
RU2314760C2 (ru) * 2001-12-20 2008-01-20 Алза Корпорейшн Микровыступы, пробивающие кожу, имеющие средство регулирования глубины пробивки
ATE336277T1 (de) * 2002-06-28 2006-09-15 Alza Corp Verfahren zur oberflächenbeschichtung von vorrichtungen zur transdermalen verabreichung von arzneien mit beschichteten mikrovorsprüngen
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
KR20060038407A (ko) * 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
AU2004287059A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
EP1680154B1 (en) * 2003-10-31 2012-01-04 ALZA Corporation Self-actuating applicator for microprojection array
EP1682012A4 (en) * 2003-11-13 2008-09-24 Alza Corp COMPOSITION AND APPARATUS FOR TRANSDERMAL DELIVERY
MXPA06013168A (es) * 2004-05-13 2007-05-15 Johnson & Johnson Aparato y metodo para el suministro transdermico de agentes de la hormona paratiroidea.

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2494769C2 (ru) * 2008-11-18 2013-10-10 3М Инновейтив Пропертиз Компани Массив полых микроигл и способ его использования
RU2560646C2 (ru) * 2010-04-28 2015-08-20 Кимберли-Кларк Ворлдвайд, Инк. Изготовленный литьевым прессованием массив микроигл и способ формирования массива микроигл
RU2562885C2 (ru) * 2010-04-28 2015-09-10 Кимберли-Кларк Ворлдвайд, Инк. Медицинское устройство с наноузором с улучшенным взаимодействием с клеткой
RU2562885C9 (ru) * 2010-04-28 2016-02-20 Кимберли-Кларк Ворлдвайд, Инк. Медицинское устройство с наноузором с улучшенным взаимодействием с клеткой
RU2560646C9 (ru) * 2010-04-28 2016-02-20 Кимберли-Кларк Ворлдвайд, Инк. Изготовленный литьевым прессованием массив микроигл и способ формирования массива микроигл
RU2585159C2 (ru) * 2010-04-28 2016-05-27 Кимберли-Кларк Ворлдвайд, Инк. Устройство доставки лекарственного средства, применяемого при ревматоидном артрите
RU2585138C2 (ru) * 2010-04-28 2016-05-27 Кимберли-Кларк Ворлдвайд, Инк. Медицинские устройства для доставки кирнк

Also Published As

Publication number Publication date
HUP0303558A2 (en) 2004-01-28
CN1250171C (zh) 2006-04-12
IL155374A0 (en) 2003-11-23
US7131960B2 (en) 2006-11-07
AU9682801A (en) 2002-04-22
DE60138411D1 (de) 2009-05-28
WO2002030301A1 (en) 2002-04-18
KR20030068136A (ko) 2003-08-19
CA2425315A1 (en) 2002-04-18
JP2004510535A (ja) 2004-04-08
ES2324461T3 (es) 2009-08-07
NZ525294A (en) 2005-02-25
BR0114629A (pt) 2004-01-20
EP1341453A1 (en) 2003-09-10
US20020123675A1 (en) 2002-09-05
ZA200303633B (en) 2004-05-12
US7798987B2 (en) 2010-09-21
EP1341453B1 (en) 2009-04-15
CN1479590A (zh) 2004-03-03
AU2001296828B2 (en) 2005-11-24
CA2425315C (en) 2010-01-12
NO20031681L (no) 2003-06-13
PL360998A1 (en) 2004-09-20
US20050234401A1 (en) 2005-10-20
MXPA03003299A (es) 2004-12-13
ATE428357T1 (de) 2009-05-15
CZ20031037A3 (cs) 2003-10-15
MA26057A1 (fr) 2004-04-01
NO20031681D0 (no) 2003-04-11
JP4659332B2 (ja) 2011-03-30

Similar Documents

Publication Publication Date Title
RU2275871C2 (ru) Устройство и способ для прокалывания кожи микровыступами
RU2277390C2 (ru) Аппликатор для силового воздействия комплектом микроножей
US7419481B2 (en) Apparatus and method for piercing skin with microprotrusions
JP4104975B2 (ja) 衝撃適用装置用の微小突起部材保持器
AU2001296828A1 (en) Apparatus and method for piercing skin with microprotrusions
AU2004287414A1 (en) Self-actuating applicator for microprojection array
MXPA06004903A (es) Aplicador autoactivado para un arreglo de microproyeccion

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20081013