RU2012140148A - (2s,3r)-n-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамид, новые солевые формы и способы их применения - Google Patents
(2s,3r)-n-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамид, новые солевые формы и способы их применения Download PDFInfo
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Abstract
1. (2S,3R)-N-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамид или его фармацевтически приемлемая соль, по существу свободная от (2S,3S)-N-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамида или его фармацевтически приемлемой соли, (2R,3S)-N-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамида или его фармацевтически приемлемой соли или (2R,3R)-N-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамида или его фармацевтически приемлемой соли.2. Способ лечения или предупреждения нарушения центральной нервной системы, воспаления, боли или неоваскуляризации, включающий введение соединения по п.1.3. Способ по п.2, где нарушение центральной нервной системы выбирают из слабого когнитивного ухудшения, связанного с возрастом ухудшения памяти, предстарческого слабоумия, раннего начала болезни Альцгеймера, старческого слабоумия, слабоумия по типу Альцгеймера, болезни Альцгеймера, деменции с тельцами Леви, слабоумия в результате микроинфаркта, связанного со СПИД слабоумия, ВИЧ-слабоумия, множественных церебральных инфарктов, паркинсонизма, болезни Паркинсона, болезни Пика, прогрессирующего супрануклеарного паралича, хореи Хантингтона, поздней дискинезии, гиперкинезии, мании, нарушения, связанного с дефицитом внимания, гиперактивности, связанной с дефицитом внимания, тревоги, депрессии, дислексии, шизофрении, когнитивной дисфункции при шизофрении, депрессии, обсессивно-компульсивных нарушений или синдрома Туретта.4. Способ по п.2, где нарушение центральной нервной системы выбирают из болезни Альцгеймера, мании, нарушения, связанного с дефицитом внимания, нарушения,
Claims (7)
1. (2S,3R)-N-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамид или его фармацевтически приемлемая соль, по существу свободная от (2S,3S)-N-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамида или его фармацевтически приемлемой соли, (2R,3S)-N-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамида или его фармацевтически приемлемой соли или (2R,3R)-N-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамида или его фармацевтически приемлемой соли.
2. Способ лечения или предупреждения нарушения центральной нервной системы, воспаления, боли или неоваскуляризации, включающий введение соединения по п.1.
3. Способ по п.2, где нарушение центральной нервной системы выбирают из слабого когнитивного ухудшения, связанного с возрастом ухудшения памяти, предстарческого слабоумия, раннего начала болезни Альцгеймера, старческого слабоумия, слабоумия по типу Альцгеймера, болезни Альцгеймера, деменции с тельцами Леви, слабоумия в результате микроинфаркта, связанного со СПИД слабоумия, ВИЧ-слабоумия, множественных церебральных инфарктов, паркинсонизма, болезни Паркинсона, болезни Пика, прогрессирующего супрануклеарного паралича, хореи Хантингтона, поздней дискинезии, гиперкинезии, мании, нарушения, связанного с дефицитом внимания, гиперактивности, связанной с дефицитом внимания, тревоги, депрессии, дислексии, шизофрении, когнитивной дисфункции при шизофрении, депрессии, обсессивно-компульсивных нарушений или синдрома Туретта.
4. Способ по п.2, где нарушение центральной нервной системы выбирают из болезни Альцгеймера, мании, нарушения, связанного с дефицитом внимания, нарушения, связанного с дефицитом внимания, вызванного гиперактивностью, тревоги, дислексии, шизофрении, когнитивной дисфункции при шизофрении, депрессии, обсессивно-компульсивных нарушений или синдрома Туретта.
5. Способ по п.2, где нарушение центральной нервной системы выбирают из шизофрении или когнитивной дисфункции при шизофрении.
6. Способ по п.2, где нарушение центральной нервной системы выбирают из нарушения, связанного с дефицитом внимания, или нарушения, связанного с дефицитом внимания, вызванного гиперактивностью.
7. Фармацевтическая композиция, включающая соединение по п.1 и один или несколько фармацевтически приемлемых растворителя, эксципиента или носителя.
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RU2012140182/15A RU2012140182A (ru) | 2007-08-02 | 2012-09-19 | (2s,3r)-n-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамид, новые солевые формы и способы их применения |
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US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
SA08290475B1 (ar) * | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
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