SE9600683D0 - Azabicyclic esters of carbamic acids useful in therapy - Google Patents

Azabicyclic esters of carbamic acids useful in therapy

Info

Publication number
SE9600683D0
SE9600683D0 SE9600683A SE9600683A SE9600683D0 SE 9600683 D0 SE9600683 D0 SE 9600683D0 SE 9600683 A SE9600683 A SE 9600683A SE 9600683 A SE9600683 A SE 9600683A SE 9600683 D0 SE9600683 D0 SE 9600683D0
Authority
SE
Sweden
Prior art keywords
alkyl
halogen
hydrogen
therapy
och3
Prior art date
Application number
SE9600683A
Other languages
English (en)
Inventor
John Macor
Edwin Wu
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9600683A priority Critical patent/SE9600683D0/sv
Publication of SE9600683D0 publication Critical patent/SE9600683D0/sv
Priority to ZA9701082A priority patent/ZA971082B/xx
Priority to ARP970100618A priority patent/AR005876A1/es
Priority to IDP970487A priority patent/ID15969A/id
Priority to AT97905544T priority patent/ATE219081T1/de
Priority to IL12562097A priority patent/IL125620A/en
Priority to CZ19982659A priority patent/CZ289110B6/cs
Priority to JP9530075A priority patent/JP2000505452A/ja
Priority to NZ331145A priority patent/NZ331145A/en
Priority to EE9800250A priority patent/EE9800250A/xx
Priority to TR1998/01642T priority patent/TR199801642T2/xx
Priority to PCT/SE1997/000294 priority patent/WO1997030998A1/en
Priority to SK1027-98A priority patent/SK102798A3/sk
Priority to CN97192461A priority patent/CN1063749C/zh
Priority to RU98117804A priority patent/RU2172739C2/ru
Priority to HU9901273A priority patent/HUP9901273A3/hu
Priority to DE69713295T priority patent/DE69713295T2/de
Priority to PL97328614A priority patent/PL328614A1/xx
Priority to US08/836,143 priority patent/US5998429A/en
Priority to AU22387/97A priority patent/AU706944B2/en
Priority to KR1019980706579A priority patent/KR19990087184A/ko
Priority to EP97905544A priority patent/EP0885221B1/en
Priority to BR9707616A priority patent/BR9707616A/pt
Priority to CA002246051A priority patent/CA2246051A1/en
Priority to NO983711A priority patent/NO983711L/no
Priority to IS4830A priority patent/IS4830A/is
Priority to US09/276,689 priority patent/US6054464A/en
Priority to HK99102514A priority patent/HK1017357A1/xx
Priority to IL13758500A priority patent/IL137585A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
SE9600683A 1996-02-23 1996-02-23 Azabicyclic esters of carbamic acids useful in therapy SE9600683D0 (sv)

Priority Applications (29)

Application Number Priority Date Filing Date Title
SE9600683A SE9600683D0 (sv) 1996-02-23 1996-02-23 Azabicyclic esters of carbamic acids useful in therapy
ZA9701082A ZA971082B (en) 1996-02-23 1997-02-10 Azabicyclic esters of carbamic acids useful in therapy.
ARP970100618A AR005876A1 (es) 1996-02-23 1997-02-17 Esteres azabiciclicos de acidos carbamicos utiles en terapia, composicion farmaceutica que incluye a dichos esteres, uso de dichos esteres, metodos parael tratamiento o profilaxis de varios desordenes, enfermedades y adicciones, procedimiento para la preparacion de dichos esteres, intermediarios utilizados
IDP970487A ID15969A (id) 1996-02-23 1997-02-20 Ester azabisiklik asam karbamat yang berguna dalam terapi.
CA002246051A CA2246051A1 (en) 1996-02-23 1997-02-21 Azabicyclic esters of carbamic acids useful in therapy
SK1027-98A SK102798A3 (en) 1996-02-23 1997-02-21 Azabicyclic esters of carbamic acids useful in therapy
PL97328614A PL328614A1 (en) 1996-02-23 1997-02-21 Azabicyclic carbaminic esters useful in therapy
CZ19982659A CZ289110B6 (cs) 1996-02-23 1997-02-21 Azabicyklické estery pro léčení poruch psychotických nebo naruąení intelektu
JP9530075A JP2000505452A (ja) 1996-02-23 1997-02-21 治療に有用なカルバミン酸のアザビシクロエステル
NZ331145A NZ331145A (en) 1996-02-23 1997-02-21 Azabicyclic esters of carbamic acids useful in treating disorders involving reduced cholinergic function
EE9800250A EE9800250A (et) 1996-02-23 1997-02-21 Teraapias kasutatavad karbaamhapete asabitsüklilised estrid
TR1998/01642T TR199801642T2 (xx) 1996-02-23 1997-02-21 Tedavide faydal� olan karbamik asitlerin azabisiklik esterleri.
PCT/SE1997/000294 WO1997030998A1 (en) 1996-02-23 1997-02-21 Azabicyclic esters of carbamic acids useful in therapy
AT97905544T ATE219081T1 (de) 1996-02-23 1997-02-21 Azabicyclishe carbaniumsaureester zur therapeutsichen verwendung
CN97192461A CN1063749C (zh) 1996-02-23 1997-02-21 用于治疗的氨基甲酸的氮杂双环酯
RU98117804A RU2172739C2 (ru) 1996-02-23 1997-02-21 Азабициклические сложные эфиры карбаминовых кислот, способы их получения, фармацевтическая композиция и промежуточные соединения
HU9901273A HUP9901273A3 (en) 1996-02-23 1997-02-21 Azabicyclic esters of carbamic acids useful in therapy
DE69713295T DE69713295T2 (de) 1996-02-23 1997-02-21 Azabicyclishe carbaniumsaureester zur therapeutsichen verwendung
IL12562097A IL125620A (en) 1996-02-23 1997-02-21 Azabicyclic esters of cereal phenylic and pyridylic acids, their preparations and medicinal preparations containing them
US08/836,143 US5998429A (en) 1996-02-23 1997-02-21 Azabicyclic esters of carbamic acids useful in therapy
AU22387/97A AU706944B2 (en) 1996-02-23 1997-02-21 Azabicyclic esters of carbamic acids useful in therapy
KR1019980706579A KR19990087184A (ko) 1996-02-23 1997-02-21 치료에 유용한 카르밤산의 아자비시클릭 에스테르
EP97905544A EP0885221B1 (en) 1996-02-23 1997-02-21 Azabicyclic esters of carbamic acids useful in therapy
BR9707616A BR9707616A (pt) 1996-02-23 1997-02-21 Composto composiç o farmacéutica utilização de um composto e processo para a preparação de um composto para o tratamento ou profilaxia de distúrbios de deficiéncia intelectual ou profilaxia da doença de parkinson doença de huntington síndrome de tourette esclerose amiotrófica lateral ou distúrbios neurodegenerativos
NO983711A NO983711L (no) 1996-02-23 1998-08-13 Azabicykliske estere av karbaminsyrer som er nyttige i terapi
IS4830A IS4830A (is) 1996-02-23 1998-08-20 Asabísýklískir esterar af karbamiksýrum sem eru gagnlegir við læknismeðferð
US09/276,689 US6054464A (en) 1996-02-23 1999-03-26 Azabicyclic esters of carbamic acids useful in therapy
HK99102514A HK1017357A1 (en) 1996-02-23 1999-06-09 Azabicyclic esters of carbamic acids useful in therapy
IL13758500A IL137585A0 (en) 1996-02-23 2000-07-30 Azabicyclic esters of phenyl and pyridyl carbamic adics, their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9600683A SE9600683D0 (sv) 1996-02-23 1996-02-23 Azabicyclic esters of carbamic acids useful in therapy

Publications (1)

Publication Number Publication Date
SE9600683D0 true SE9600683D0 (sv) 1996-02-23

Family

ID=20401517

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9600683A SE9600683D0 (sv) 1996-02-23 1996-02-23 Azabicyclic esters of carbamic acids useful in therapy

Country Status (27)

Country Link
US (2) US5998429A (sv)
EP (1) EP0885221B1 (sv)
JP (1) JP2000505452A (sv)
KR (1) KR19990087184A (sv)
CN (1) CN1063749C (sv)
AR (1) AR005876A1 (sv)
AT (1) ATE219081T1 (sv)
AU (1) AU706944B2 (sv)
BR (1) BR9707616A (sv)
CA (1) CA2246051A1 (sv)
CZ (1) CZ289110B6 (sv)
DE (1) DE69713295T2 (sv)
EE (1) EE9800250A (sv)
HK (1) HK1017357A1 (sv)
HU (1) HUP9901273A3 (sv)
ID (1) ID15969A (sv)
IL (2) IL125620A (sv)
IS (1) IS4830A (sv)
NO (1) NO983711L (sv)
NZ (1) NZ331145A (sv)
PL (1) PL328614A1 (sv)
RU (1) RU2172739C2 (sv)
SE (1) SE9600683D0 (sv)
SK (1) SK102798A3 (sv)
TR (1) TR199801642T2 (sv)
WO (1) WO1997030998A1 (sv)
ZA (1) ZA971082B (sv)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977144A (en) * 1992-08-31 1999-11-02 University Of Florida Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines
US7214686B2 (en) 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
US6277870B1 (en) 1998-05-04 2001-08-21 Astra Ab Use
FR2804430B1 (fr) * 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
GB0010955D0 (en) 2000-05-05 2000-06-28 Novartis Ag Organic compounds
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US6486172B2 (en) 2000-08-18 2002-11-26 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492386B2 (en) * 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2001282874A1 (en) * 2000-08-18 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
EP1311505A2 (en) * 2000-08-21 2003-05-21 PHARMACIA & UPJOHN COMPANY Quinuclidine-substituted heteroaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands )
WO2002015662A2 (en) * 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
WO2002017358A2 (en) * 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
AR036041A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
WO2003018586A1 (en) * 2001-08-24 2003-03-06 Pharmacia & Upjohn Company Substituted-aryl 7-aza[2.2.1]bicycloheptanes for the treatment of disease
BR0212101A (pt) 2001-08-24 2004-08-24 Pharmacia & Up John Company 7-aza [2.2.1] biciclo-heptanos substituìdos com heteroarila para o tratamento de doenças
BR0212477A (pt) * 2001-09-12 2004-08-24 Upjohn Co 7-aza[2.2.1] bicicloheptanos substituìdos para o tratamento de doenças
CA2462453C (en) * 2001-10-02 2009-07-28 Pharmacia & Upjohn Company Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
MXPA04004464A (es) 2001-11-08 2004-08-11 Upjohn Co Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades.
CA2466344A1 (en) 2001-11-09 2003-05-22 Pharmacia & Upjohn Company Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands
US7067261B2 (en) 2001-12-14 2006-06-27 Targacept, Inc. Methods and compositions for treatment of central nervous system disorders
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
WO2003070728A2 (en) 2002-02-15 2003-08-28 Pharmacia & Upjohn Company Azabicyclo-substituted benzoylamides and thioamides for treatment of cns-related disorders
US6894042B2 (en) * 2002-02-19 2005-05-17 Pharmacia & Upjohn Company Azabicyclic compounds for the treatment of disease
CA2476681A1 (en) * 2002-02-19 2003-08-28 Bruce N. Rogers Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
EP1478646A1 (en) * 2002-02-20 2004-11-24 PHARMACIA & UPJOHN COMPANY Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
DE10211415A1 (de) * 2002-03-15 2003-09-25 Bayer Ag Bicyclische N-Biarylamide
DE10211416A1 (de) * 2002-03-15 2003-09-25 Bayer Ag Essig- und Propionsäureamide
US7176198B2 (en) 2002-08-01 2007-02-13 Pfizer Inc. 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
EP1531820A1 (en) 2002-08-30 2005-05-25 Memory Pharmaceuticals Corporation Anabaseine derivatives useful in the treatment of neurodegenerative diseases
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
EP1543000B1 (en) 2002-09-25 2013-03-06 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
CA2503786A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Compounds having both alpha7 nicotinic agonist activity and 5ht, antagonist activity for treatment of cns diseases
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
AU2003298939B2 (en) * 2002-12-06 2007-03-15 The Feinstein Institute For Medical Research Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists
MXPA05010496A (es) * 2003-03-28 2005-11-16 Pharmacia & Upjohn Co Llc Moduladores alostericos positivos del receptor de acetilcolina nicotinico.
GB0310867D0 (en) 2003-05-12 2003-06-18 Novartis Ag Organic compounds
DE10334724A1 (de) * 2003-07-30 2005-02-24 Bayer Healthcare Ag N-Biarylamide
ATE451368T1 (de) 2003-10-15 2009-12-15 Targacept Inc Azabicyclische verbindungen zur linderung von schmerzen und zur behandlung von erkrankungen des zentralen nervensystems
CA2550689A1 (en) 2003-12-22 2005-07-14 Memory Pharmaceuticals Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
US20050137217A1 (en) * 2003-12-22 2005-06-23 Jianguo Ji Spirocyclic quinuclidinic ether derivatives
JP4995075B2 (ja) 2004-03-25 2012-08-08 メモリー・ファーマシューティカルズ・コーポレイション インダゾール、ベンゾチアゾール、ベンゾイソチアゾール、ベンズイソキサゾール、ならびにそれらの調製および使用
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
ATE487716T1 (de) 2004-04-22 2010-11-15 Memory Pharm Corp Indole, 1h-indazole, 1,2-benzisoxazole, 1,2- benzoisothiazole, deren herstellung und verwendungen
BRPI0510212A (pt) 2004-05-07 2007-10-16 Memory Pharm Corp 1h-indazóis, benzotiazóis, 1,2 - benzoisoxazóis, 1,2-benzoisotiazóis, e cromonas e a preparação e usos dos mesmos
AR049401A1 (es) 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0424564D0 (en) * 2004-11-05 2004-12-08 Novartis Ag Organic compounds
WO2006069097A2 (en) 2004-12-22 2006-06-29 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
US11207518B2 (en) 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
JP2008525102A (ja) 2004-12-27 2008-07-17 ノース ショア−ロング アイランド ジューウィッシュ リサーチ インスティテュート 電気的な迷走神経刺激による炎症性障害の処置
NZ565628A (en) 2005-08-22 2011-03-31 Targacept Inc Heteroaryl-substituted diazatricycloalkanes, methods for its preparation and use thereof
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
TWI454262B (zh) * 2006-11-02 2014-10-01 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
CL2008000119A1 (es) 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
WO2008096870A1 (ja) * 2007-02-09 2008-08-14 Astellas Pharma Inc. アザ架橋環化合物
TW200911808A (en) * 2007-07-23 2009-03-16 Astrazeneca Ab Novel compounds
SA08290475B1 (ar) 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
US8391970B2 (en) 2007-08-27 2013-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
DK2217597T3 (da) 2007-10-01 2011-06-20 Comentis Inc Quinuclidin-4-ylmethyl-1h-indol-3-carboxylatderivater som alpha-7-nicotin-acetylcholin-receptor-ligander til behandling af Alzheimers sygdom
DK2254598T3 (da) 2008-02-13 2013-07-29 Targacept Inc Kombination af alfa 7-nikotinagonister og antipsykotika
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
WO2009146030A1 (en) 2008-03-31 2009-12-03 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of t-cell activity
EA201001889A1 (ru) 2008-06-20 2011-08-30 Астразенека Аб Производные дибензотиазепина и их применение
WO2010059617A2 (en) 2008-11-18 2010-05-27 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
AR075183A1 (es) * 2009-01-28 2011-03-16 Astrazeneca Ab Compuestos de 2-aza-biciclo (2,2,1) heptano y sus usos
US8886339B2 (en) 2009-06-09 2014-11-11 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8996116B2 (en) 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
FR2948368B1 (fr) * 2009-07-21 2011-07-22 Servier Lab Nouveaux composes piperidiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US11051744B2 (en) 2009-11-17 2021-07-06 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
AU2010336337B2 (en) 2009-12-23 2016-02-04 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
WO2011146511A1 (en) 2010-05-17 2011-11-24 Envivo Pharmaceuticals, Inc. A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
BR112013003847A8 (pt) 2010-08-19 2017-12-26 Buck Institute For Age Res métodos de tratar a deterioração cognitiva moderada (mci) e os distúrbios relacionados
EP2707094B1 (en) 2011-05-09 2016-02-03 Setpoint Medical Corporation Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
GB201111705D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Compounds and their use
GB201111704D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Novel compounds
JO3115B1 (ar) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
AU2013259871A1 (en) 2012-05-08 2014-11-20 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
GB201209587D0 (en) 2012-05-30 2012-07-11 Takeda Pharmaceutical Therapeutic compounds
MA37975B2 (fr) * 2012-09-11 2021-03-31 Genzyme Corp Inhibiteurs de synthase de glucosylcéramide
WO2014122474A1 (en) 2013-02-07 2014-08-14 Takeda Pharmaceutical Company Limited Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists
CN105189491B (zh) * 2013-03-15 2018-07-06 建新公司 制备葡萄糖基神经酰胺合酶抑制剂的方法
EP3010900B1 (en) 2013-06-21 2018-01-03 Takeda Pharmaceutical Company Limited 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors
GB201314286D0 (en) 2013-08-08 2013-09-25 Takeda Pharmaceutical Therapeutic Compounds
GB201318222D0 (en) 2013-10-15 2013-11-27 Takeda Pharmaceutical Novel compounds
GB201320905D0 (en) 2013-11-27 2014-01-08 Takeda Pharmaceutical Therapeutic compounds
TW201613864A (en) 2014-02-20 2016-04-16 Takeda Pharmaceutical Novel compounds
EP3166940A4 (en) 2014-07-11 2018-04-25 Alpharmagen, LLC Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
WO2016126807A1 (en) 2015-02-03 2016-08-11 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US9724340B2 (en) 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
EP3405255A4 (en) 2016-01-20 2019-10-16 Setpoint Medical Corporation IMPLANTABLE MICROSTIMULATORS AND INDUCTION RECHARGE SYSTEMS
US10695569B2 (en) 2016-01-20 2020-06-30 Setpoint Medical Corporation Control of vagal stimulation
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
GB201616839D0 (en) 2016-10-04 2016-11-16 Takeda Pharmaceutical Company Limited Therapeutic compounds
GB201619514D0 (en) 2016-11-18 2017-01-04 Takeda Pharmaceuticals Co Novel compounds
DE102017210141A1 (de) 2017-06-16 2018-12-20 Henkel Ag & Co. Kgaa Portion zur Bereitstellung tensidhaltiger Flotten
US11173307B2 (en) 2017-08-14 2021-11-16 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
US11660443B2 (en) 2018-04-20 2023-05-30 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
EP4041734B1 (en) * 2019-11-15 2024-04-24 Yuhan Corporation Derivatives having 1,2,3,4-tetrahydronaphthalene moiety or pharmaceutically acceptable salt thereof and pharmaceutical compositions comprising the same
JP2023503830A (ja) * 2019-11-15 2023-02-01 ユーハン・コーポレイション ２，３－ジヒドロ－１ｈ－インデン基もしくは２，３－ジヒドロベンゾフラン基を有する新規な誘導体またはその薬学的に許容可能な塩及びこれらを含む医薬組成物
JP2021138648A (ja) 2020-03-04 2021-09-16 武田薬品工業株式会社 経口固形製剤
JP2023526080A (ja) 2020-05-21 2023-06-20 ザ・フェインステイン・インスティチュート・フォー・メディカル・リサーチ 迷走神経刺激のためのシステムおよび方法
AU2021311131A1 (en) 2020-07-24 2023-03-23 Genzyme Corporation Pharmaceutical compositions comprising venglustat
BR112023022015A2 (pt) * 2021-05-11 2023-12-26 Green Cross Corp Novos compostos que têm atividade inibidora contra glucosilceramida sintase ou sal farmaceuticamente aceitável da mesma, processos para preparar os mesmos e respectivas composições farmacêuticas

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE8817121U1 (sv) * 1988-11-22 1993-02-04 Boehringer Ingelheim Kg, 6507 Ingelheim, De
JP3169188B2 (ja) * 1991-01-31 2001-05-21 杏林製薬株式会社 カルバミン酸誘導体及びその製造方法
US5468875A (en) * 1994-12-22 1995-11-21 American Home Products Corporation 1-azabicycloheptane derivatives

Also Published As

Publication number Publication date
BR9707616A (pt) 1999-07-27
PL328614A1 (en) 1999-02-01
CA2246051A1 (en) 1997-08-28
RU2172739C2 (ru) 2001-08-27
AR005876A1 (es) 1999-07-21
IL137585A0 (en) 2001-07-24
US5998429A (en) 1999-12-07
HK1017357A1 (en) 1999-11-19
ID15969A (id) 1997-08-21
NO983711D0 (no) 1998-08-13
CZ289110B6 (cs) 2001-11-14
IS4830A (is) 1998-08-20
AU706944B2 (en) 1999-07-01
JP2000505452A (ja) 2000-05-09
NZ331145A (en) 2000-02-28
EP0885221B1 (en) 2002-06-12
IL125620A0 (en) 1999-04-11
CN1211983A (zh) 1999-03-24
DE69713295T2 (de) 2003-01-09
EE9800250A (et) 1999-02-15
TR199801642T2 (xx) 1998-11-23
AU2238797A (en) 1997-09-10
ATE219081T1 (de) 2002-06-15
IL125620A (en) 2001-09-13
EP0885221A1 (en) 1998-12-23
KR19990087184A (ko) 1999-12-15
DE69713295D1 (de) 2002-07-18
HUP9901273A3 (en) 2000-06-28
HUP9901273A2 (hu) 1999-07-28
ZA971082B (en) 1997-08-25
WO1997030998A1 (en) 1997-08-28
CZ265998A3 (cs) 2000-02-16
CN1063749C (zh) 2001-03-28
NO983711L (no) 1998-08-13
SK102798A3 (en) 1999-01-11
US6054464A (en) 2000-04-25

Similar Documents

Publication Publication Date Title
SE9600683D0 (sv) Azabicyclic esters of carbamic acids useful in therapy
ATE63742T1 (de) Chinazolinon-derivate.
ATE399753T1 (de) Amide als pyruvatdehydrogenaseinhibitoren
TW370529B (en) Pyrazolopyrimidines
EA200500018A1 (ru) Бензконденсированные гетероариламидные производные тиенопиридинов, применяемые в качестве терапевтических агентов, фармацевтические композиции, включающие их, и способы их применения
EP1689387A4 (en) MEK BICYCLIC INHIBITORS AND METHODS OF MAKING SAME
SE9701144D0 (sv) Novel compounds, their use and preparation
MXPA05007496A (es) Tienopirimidindionas y su uso en la modulacion de enfermedades autoinmunes.
HUP0001760A2 (hu) Aril-acil-piridazin-származékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és a vegyületek alkalmazása gyógyszerkészítmények előállítására
HUP0100488A2 (hu) Tieno-pirimidinek, eljárás az előállításukra és a vegyületeket tartalmazó gyógyászati készítmények
AP1564A (en) Piperazinyl sulfonic acid derivatives, their pharmaceutical compositions and methods of use.
NO852026L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive bis -(4-aminofenyl)-sulfoner.
ES8606337A1 (es) Un procedimiento para preparar nuevas benzamidas con actividada antagonista de 5-ht.
HUP0001093A2 (hu) 5-HT2A-antagonista oxazolidinon-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
ES472290A1 (es) Un procedimiento para preparar un compuesto de benceno di- sustituido en orto
NO160783C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive substituerte beta-karbolinderivater.
ES2000524A6 (es) Procedimiento para la preparacion de nuevas benzamidas y benzoatos sustituidos.
HUP0000233A2 (hu) Pirazolinon-származékok alkalmazása potenciazavarok kezelésére szolgáló gyógyszerkészítmények előállítására
HUP0203364A2 (hu) Eljárás 3-helyettesített-4-arilkinolin-2-on származékok előállítására
EA200500738A1 (ru) КРИСТАЛЛИЧЕСКИЕ ФУМАРАТНЫЕ СОЛИ 1-АЗАБИЦИКЛО [2.2.2]ОКТЗАМЕЩЕННОГО ФУРО [2,3-c] ПИРИДИНИЛКАРБОКСАМИДА И ИХ КОМПОЗИЦИИ И ПОЛУЧЕНИЕ
PT1430034E (pt) Derivados de alquilaminopiridazinona substituida processo para sua preparacao e composicoes farmaceuticas que os contem
HUP0002826A2 (hu) 6-Azauracil-származékok, eljárás előállításukra, alkalmazásuk gyulladások elleni gyógyszer előállítására és az ilyen kompozíciók
HUP0302645A2 (hu) Pirazolo[4,3-d]pirimidin-származékok alkalmazása gyógyszerkészítmények előállítására
HUP9800889A1 (hu) Új naftil-piperazin-származékok
ATE41770T1 (de) Derivate von n-(2-pyrrolidinylmethyl)benzamid, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zubereitung.