SG165417A1 - Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof - Google Patents
Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereofInfo
- Publication number
- SG165417A1 SG165417A1 SG201006955-7A SG2010069557A SG165417A1 SG 165417 A1 SG165417 A1 SG 165417A1 SG 2010069557 A SG2010069557 A SG 2010069557A SG 165417 A1 SG165417 A1 SG 165417A1
- Authority
- SG
- Singapore
- Prior art keywords
- indazoles
- benzothiazoles
- receptors
- nach
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the a7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71955205P | 2005-09-23 | 2005-09-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG165417A1 true SG165417A1 (en) | 2010-10-28 |
Family
ID=37715973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG201006955-7A SG165417A1 (en) | 2005-09-23 | 2006-09-22 | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1940833A1 (en) |
JP (1) | JP2009509964A (en) |
KR (1) | KR20080048550A (en) |
CN (1) | CN101312968A (en) |
AU (1) | AU2006295397A1 (en) |
BR (1) | BRPI0617534A2 (en) |
CA (1) | CA2622677A1 (en) |
IL (1) | IL190358A0 (en) |
RU (1) | RU2450003C2 (en) |
SG (1) | SG165417A1 (en) |
WO (1) | WO2007038367A1 (en) |
ZA (1) | ZA200802342B (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10164139A1 (en) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-heteroaryl carboxamides |
AU2007229492B2 (en) | 2006-03-28 | 2011-11-03 | High Point Pharmaceuticals, Llc | Benzothiazoles having histamine H3 receptor activity |
SA08290475B1 (en) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2S,3R)-N-(2-((3-Pyridinyl)Methyl)-1-Azabicyclo[2.2.2]Oct-3-yl)Benzofuran-2-Carboxamide, Novel Salt forms, and Methods of Use Thereof |
JP5544296B2 (en) * | 2007-11-16 | 2014-07-09 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Carboxamide, sulfonamide, and amine compounds for metabolic disorders |
MX2010008778A (en) * | 2008-02-15 | 2010-08-30 | Hoffmann La Roche | 3-alkyl-piperazine derivatives and uses thereof. |
KR101338726B1 (en) * | 2008-10-13 | 2013-12-06 | 에프. 호프만-라 로슈 아게 | Diazonium-free method to make an indazole intermediate in the synthesis of bicyclic 5-(trifluormethoxy)-1h-3-indazolecarboxylic acid amides |
HUE037938T2 (en) | 2008-11-19 | 2018-09-28 | Forum Pharmaceuticals Inc | Treatment of negative symptoms of schizophrenia with (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
JO3250B1 (en) | 2009-09-22 | 2018-09-16 | Novartis Ag | Use of nicotinic acetylcholine receptor alpha 7 activators |
US20110172428A1 (en) | 2010-01-12 | 2011-07-14 | Shan-Ming Kuang | Methods for the preparation of indazole-3-carboxylic acid and n-(s)-1-azabicyclo[2.2.2]oct-3-yl-1h-indazole-3-carboxamide hydrochloride salt |
CN103025744A (en) * | 2010-04-30 | 2013-04-03 | 百时美施贵宝公司 | Aza-bicyclic amine n-oxide compounds as alpha-7 nicotinic acetylcholine receptor ligand pro-drugs |
PT3029039T (en) | 2010-05-17 | 2017-11-28 | Forum Pharmaceuticals Inc | Pharmaceutical formulations comprising crystalline forms of (r)-7-chloro-n-(quinuclidin-3-yl)benzo(b)thiophene-2-carboxamide hydrochloride monohydrate |
US8242276B2 (en) | 2010-06-30 | 2012-08-14 | Hoffmann-La Roche Inc. | Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt |
RU2013108223A (en) | 2010-07-26 | 2014-09-10 | Энвиво Фармасьютикалз, Инк. | TREATMENT OF COGNITIVE DISTURBANCES BY SPECIFIC ALPHA-7 NICOTIN ACID RECEPTOR AGONISTS COMBINED WITH ACETYLCHOLINESTERASE INHIBITORS |
AR086791A1 (en) * | 2011-07-01 | 2014-01-22 | Lundbeck & Co As H | POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETILCOLINE RECEIVER |
CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
JOP20130213B1 (en) | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | 5-ht3 receptor antagonists |
MA37975B2 (en) * | 2012-09-11 | 2021-03-31 | Genzyme Corp | Glucosylceramide synthase inhibitors |
JP6249952B2 (en) * | 2012-10-16 | 2017-12-20 | 武田薬品工業株式会社 | Heterocyclic compounds |
EP3010889B1 (en) | 2013-06-20 | 2018-10-03 | Bayer CropScience Aktiengesellschaft | Arylsulfide and arylsulfoxide derivatives as acaricides and insecticides |
JP6449880B2 (en) * | 2013-08-08 | 2019-01-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | New pyrazinamide compounds |
US9745271B2 (en) | 2014-03-20 | 2017-08-29 | Samumed, Llc | 5-substituted indazole-3-carboxamides and preparation and use thereof |
KR101532211B1 (en) * | 2014-04-30 | 2015-06-30 | 세종대학교산학협력단 | Pharmaceutical composition and method for treating stoke based on the inhibition of AMPK |
WO2016053947A1 (en) | 2014-09-29 | 2016-04-07 | Takeda Pharmaceutical Company Limited | Crystalline form of 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1h-indole-3-carboxamide |
RU2017145964A (en) * | 2015-06-10 | 2019-07-10 | Аксовант Сайенсиз Гмбх | Aminobenzisoxazole compounds as α7-nicotinic acetylcholine receptor agonists |
JP2018523707A (en) * | 2015-08-12 | 2018-08-23 | アクソバント サイエンシズ ゲーエムベーハー | Geminal-substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors |
EP3362455A1 (en) * | 2015-10-16 | 2018-08-22 | AbbVie Inc. | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
EP3606921B1 (en) | 2017-04-06 | 2022-06-01 | Inventiva | New compounds inhibitors of the yap/taz-tead interaction and their use in the treatment of malignant mesothelioma. |
EP3632908A1 (en) | 2018-10-02 | 2020-04-08 | Inventiva | Inhibitors of the yap/taz-tead interaction and their use in the treatment of cancer |
IL300090A (en) | 2020-07-24 | 2023-03-01 | Genzyme Corp | Pharmaceutical compositions comprising venglustat |
US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA93737B (en) * | 1992-02-04 | 1993-09-06 | Eisai Co Ltd | Aminobenzoic acid derivatives. |
AR036041A1 (en) * | 2001-06-12 | 2004-08-04 | Upjohn Co | HETEROCICLIC AROMATIC COMPOUNDS REPLACED WITH QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
AR036040A1 (en) * | 2001-06-12 | 2004-08-04 | Upjohn Co | MULTICICLIC HETEROARYL COMPOUNDS REPLACED WITH QUINUCLIDINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
DE10162375A1 (en) * | 2001-12-19 | 2003-07-10 | Bayer Ag | Bicyclic N-aryl amides |
NZ538058A (en) * | 2002-08-14 | 2006-11-30 | Neurosearch As | Quinuclidine derivatives and their use for treating disorders related to CNS and PNS |
SK288115B6 (en) * | 2002-09-25 | 2013-09-03 | Memory Pharmaceuticals Corporation | Indazoles, pharmaceutical compositions comprising them and their use |
AU2004206107A1 (en) * | 2003-01-22 | 2004-08-05 | Pharmacia & Upjohn Company Llc | Treatment of diseases with alpha-7 nach receptor full agonists |
DK1697378T3 (en) * | 2003-12-22 | 2008-03-17 | Memory Pharm Corp | Indoles, 1H-indazoles, 1,2-benzisoxazoles and 1,2-benzisothiazoles and their preparation and uses |
-
2006
- 2006-09-22 CA CA002622677A patent/CA2622677A1/en not_active Abandoned
- 2006-09-22 KR KR1020087009574A patent/KR20080048550A/en not_active Application Discontinuation
- 2006-09-22 CN CNA2006800439794A patent/CN101312968A/en active Pending
- 2006-09-22 AU AU2006295397A patent/AU2006295397A1/en not_active Abandoned
- 2006-09-22 JP JP2008532459A patent/JP2009509964A/en active Pending
- 2006-09-22 RU RU2008115268/04A patent/RU2450003C2/en not_active IP Right Cessation
- 2006-09-22 WO PCT/US2006/037142 patent/WO2007038367A1/en active Application Filing
- 2006-09-22 SG SG201006955-7A patent/SG165417A1/en unknown
- 2006-09-22 BR BRPI0617534-1A patent/BRPI0617534A2/en not_active IP Right Cessation
- 2006-09-22 EP EP06815264A patent/EP1940833A1/en not_active Withdrawn
-
2008
- 2008-03-12 ZA ZA200802342A patent/ZA200802342B/en unknown
- 2008-03-20 IL IL190358A patent/IL190358A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2006295397A1 (en) | 2007-04-05 |
ZA200802342B (en) | 2009-03-25 |
JP2009509964A (en) | 2009-03-12 |
KR20080048550A (en) | 2008-06-02 |
WO2007038367A1 (en) | 2007-04-05 |
BRPI0617534A2 (en) | 2011-07-26 |
RU2450003C2 (en) | 2012-05-10 |
IL190358A0 (en) | 2009-09-22 |
CN101312968A (en) | 2008-11-26 |
CA2622677A1 (en) | 2007-04-05 |
RU2008115268A (en) | 2009-10-27 |
EP1940833A1 (en) | 2008-07-09 |
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