AU2001284645A1 - Quinuclidine-substituted aryl compounds for treatment of disease - Google Patents

Quinuclidine-substituted aryl compounds for treatment of disease

Info

Publication number
AU2001284645A1
AU2001284645A1 AU2001284645A AU8464501A AU2001284645A1 AU 2001284645 A1 AU2001284645 A1 AU 2001284645A1 AU 2001284645 A AU2001284645 A AU 2001284645A AU 8464501 A AU8464501 A AU 8464501A AU 2001284645 A1 AU2001284645 A1 AU 2001284645A1
Authority
AU
Australia
Prior art keywords
quinuclidine
disease
treatment
substituted aryl
aryl compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284645A
Inventor
Vincent E. Groppi Jr.
Jason K. Myers
David W. Piotrowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of AU2001284645A1 publication Critical patent/AU2001284645A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
AU2001284645A 2000-08-18 2001-08-17 Quinuclidine-substituted aryl compounds for treatment of disease Abandoned AU2001284645A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US22616400P 2000-08-18 2000-08-18
US60226164 2000-08-18
US28495601P 2001-04-19 2001-04-19
US28496801P 2001-04-19 2001-04-19
US28497101P 2001-04-19 2001-04-19
US60284968 2001-04-19
US60284956 2001-04-19
US60284971 2001-04-19
PCT/US2001/021136 WO2002016356A2 (en) 2000-08-18 2001-08-17 Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)

Publications (1)

Publication Number Publication Date
AU2001284645A1 true AU2001284645A1 (en) 2002-03-04

Family

ID=27499421

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284645A Abandoned AU2001284645A1 (en) 2000-08-18 2001-08-17 Quinuclidine-substituted aryl compounds for treatment of disease

Country Status (3)

Country Link
US (1) US6492386B2 (en)
AU (1) AU2001284645A1 (en)
WO (1) WO2002016356A2 (en)

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US7214686B2 (en) 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
SE0000540D0 (en) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
AU2002339810A1 (en) * 2001-10-16 2003-04-28 Astrazeneca Ab Azabicyclic compounds for the treatment of fibromyalgia syndrome
CA2470567A1 (en) 2001-12-14 2003-06-26 Targacept, Inc. Methods and compositions for treatment of central nervous system disorders
DE10164139A1 (en) 2001-12-27 2003-07-10 Bayer Ag 2-heteroaryl carboxamides
DE60306896T2 (en) * 2002-02-21 2007-02-15 Aprea Ab USE OF LOW-MOLECULAR COMPOUNDS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF P53-MEDIATED DISEASES
AU2003269413A1 (en) * 2002-11-01 2004-05-25 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
ES2293086T3 (en) * 2002-12-06 2008-03-16 The Feinstein Institute For Medical Research INFLAMMATION INHIBITION USING COLINERGIC AGONISTS FROM UNION TO ALFA RECEIVER 7.
WO2005000305A1 (en) * 2003-06-20 2005-01-06 Eli Lilly And Company 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
DE602004024565D1 (en) 2003-10-15 2010-01-21 Targacept Inc AZABICYCLIC COMPOUNDS FOR AFFILIATING PAIN AND TREATING DISEASES OF THE CENTRAL NERVOUS SYSTEM
US7514450B2 (en) * 2004-05-19 2009-04-07 Neurosearch A/S Azabicyclic aryl derivatives
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
EP1917265B1 (en) 2005-08-22 2010-09-29 Targacept, Inc. HETEROARYL-SUBSTiTUTED DIAZATRICYCLOALKANES, METHODS FOR ITS PREPARATION AND USE THEREOF
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
SA08290475B1 (en) 2007-08-02 2013-06-22 Targacept Inc (2S,3R)-N-(2-((3-Pyridinyl)Methyl)-1-Azabicyclo[2.2.2]Oct-3-yl)Benzofuran-2-Carboxamide, Novel Salt forms, and Methods of Use Thereof
ATE503754T1 (en) 2007-10-01 2011-04-15 Comentis Inc 1H-INDOLE-3-CARBONIC ACID-QUINUCLIDINE-4-YLMETHYL ESTER DERIVATIVES AS LIGANDS FOR THE NICOTINIC ALPHA-7-ACETYLCHOLINE RECEPTOR FOR THE TREATMENT OF ALZHEIMER'S DISEASE
ES2430622T3 (en) 2008-02-13 2013-11-21 Targacept, Inc. Combination of alpha 7 nicotinic and antipsychotic agonists
US20090318520A1 (en) * 2008-06-20 2009-12-24 Afecta Pharmaceuticals Drive Use of isoindoles for the treatment of neurobehavioral disorders
DK2355822T3 (en) 2008-11-19 2013-01-28 Envivo Pharmaceuticals Inc treatment of cognitive disorders with (R) -7-chloro-N- (quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
JP5808319B2 (en) * 2009-05-11 2015-11-10 フォルム ファーマシューティカルズ、インコーポレイテッド Treatment of cognitive impairment using specific α7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors
RU2577334C2 (en) 2010-05-17 2016-03-20 Энвиво Фармасьютикалз, Инк. CRYSTALLINE FORM OF (R)-7-CHLORO-N-(QUINUCLIDIN-3-YL)BENZO[b]THIOPHENE-2-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE
CN103183625B (en) * 2011-12-28 2015-07-08 四川大学 Anti-HIV compound and preparation method and application thereof
AU2013259871A1 (en) 2012-05-08 2014-11-20 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
JOP20130273B1 (en) 2012-09-11 2021-08-17 Genzyme Corp Glucosylceramide synthase inhibitors
EP3166940A4 (en) 2014-07-11 2018-04-25 Alpharmagen, LLC Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity
US9724340B2 (en) 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods
JP2023534322A (en) 2020-07-24 2023-08-09 ジェンザイム・コーポレーション Pharmaceutical composition containing benglustat

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US5237066A (en) * 1987-02-04 1993-08-17 Delande S.A. Enantiomers of absolute configuration S of amide derivatives of 3-aminoquinuclidine, the process for preparing them and their application in therapy
US4863919A (en) * 1988-02-01 1989-09-05 A. H. Robins Company, Incorporated Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes
EP0353371A1 (en) * 1988-08-04 1990-02-07 Synthelabo Memory enhancing-R-N-(1-azabicyclo[2.2.2] oct-3-yl) benzamides and thiobenzamides
GB9027487D0 (en) * 1990-12-19 1991-02-06 Beecham Group Plc Pharmaceuticals
US5741819A (en) * 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
SE9600683D0 (en) * 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
SE9903760D0 (en) * 1999-10-18 1999-10-18 Astra Ab New compounds
SE9904176D0 (en) * 1999-11-18 1999-11-18 Astra Ab New use
SE0000540D0 (en) * 2000-02-18 2000-02-18 Astrazeneca Ab New compounds

Also Published As

Publication number Publication date
WO2002016356A2 (en) 2002-02-28
WO2002016356A3 (en) 2002-05-16
US20020052389A1 (en) 2002-05-02
US6492386B2 (en) 2002-12-10

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