RU2005134394A - Лечение аутоиммунных заболеваний у пациента с неадекватным ответом на ингибитор tnf-альфа - Google Patents
Лечение аутоиммунных заболеваний у пациента с неадекватным ответом на ингибитор tnf-альфа Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Claims (13)
1. Способ лечения аутоиммунного заболевания у млекопитающего с неадекватным ответом на ингибитор TNFα, заключающийся во введении такому млекопитающему терапевтически эффективного количества антагониста, который связывается с поверхностным маркером В-клеток.
2. Способ по п.1, в котором поверхностный маркер В-клеток выбран из группы, включающей: CD10, CD19, CD20, CD21, CD22, CD23, CD24, CD37, CD40, CD53, CD72, CD73, CD74, CDw75, CDw76, CD77, CDw78, CD79a, CD80, CD81, CD82, CD83, CDw84, CD85 и CD86.
3. Способ по п.1, в котором антагонистом является антитело.
4. Способ по п.3, в котором антитело связывает CD20.
5. Способ по п.1, в котором аутоиммунное заболевание выбрано из группы, включающей артрит, ревматоидный артрит, ювенильный ревматоидный артрит, остеоартрит, псориатический артрит, псориаз, дерматит, полимиозит/дерматомиозит, токсический эпидермальный некролиз, системная склеродермия и склероз, иммунные ответы, связанные с воспалительными заболеваниями кишечника, болезнь Крона, язвенный колит, респираторный дистресс-синдром, респираторный дистресс-синдром взрослых (ARDS), менингит, энцефалит, увеит, колит, гломерулонефрит, аллергические состояния, экзема, астма, состояния, сопровождающиеся Т-клеточной инфильтрацией и хроническим воспалительным ответом, атеросклероз, аутоиммунный миокардит, нарушение адгезии лейкоцитов, системная красная волчанка (SLE), ювенильный диабет, рассеянный склероз, аллергический энцефаломиелит, иммунные ответы, связанные с реакцией гиперчувствительности немедленного и замедленного типов, опосредованной цитокинами и Т-лимфоцитами, туберкулез, саркоидоз, гарнулематоз, включая гранулематоз Вегенера, агранулоцитоз, васкулит (включая ANCA), апластическая анемия, анемия Дайемонда-Блекфэна, иммунная гемолитическая анемия, включая аутоиммунную гемолитическую анемию (AIHA), пернициозная анемия, истинная эритроцитарная аплазия (PRCA), недостаточность фактора VIII, гемофилия А, аутоиммунная нейтропения, панцитопения, лейкопения, заболевания, ассоциированные с диапедезом лейкоцитов, воспалительные заболевания центральной нервной системы (CNS), синдром множественного поражения органов, миастения гравис, заболевания, опосредованные комплексом антиген-антитело, заболевания, связанные с образованием антигломерулярных антител в базальной мембране, антифосфолипидный синдром, аллергический нейрит, болезнь Бехчета, синдром Кастельмана, синдром Гудпасчера, миастенический синдром Ламберта-Итона, Синдром Рейно, синдром Шегрена, синдром Стивенса-Джонсона, реакция отторжения трансплантата, реакция "трансплантат против хозяина" (GVHD), пузырчатка буллезная, пузырчатка, аутоиммунные полиэндокринопатии, синдром Рейтера, синдром "деревянного человека", гигантоклеточный артериит, иммунокомплексный нефрит, IgA нефропатия, IgM полинейропатии или опосредованные IgM нейропатии, идиопатическая тромбоцитопеническая пурпура (ITP), тромботическая тромбоцитопеническая пурпура (ТТР), аутоиммунная тромбоцитопения, аутоиммунные заболевания яичек и яичников, включая аутоиммунный орхит и оофорит, первичный гипотиреоидизм, аутоиммунные эндокринные заболевания, включая аутоиммунный тиреоидит, хронический тиреоидит (тиреоидит Хашимото), подострый тиреоидит, идиопатический гипотиреоидизм, болезнь Аддисона, болезнь Грейвса, аутоиммунный полигландулярный синдром (или синдромы полигландулярной эндокринопатии), диабет I типа, также называемый инсулинзависимым сахарным диабетом (IDDM) и синдром Шихана; аутоиммунный гепатит, лимфоидный интерстициальный пневмонит (HIV), облитерирующий бронхиолит (нетрансплантационный) в противоположность NSIP, синдром Гиейна-Барре, васкулиты крупных сосудов (включая ревматическую полимиалгию и гигантоклеточный артериит (болезнь Такаясу), васкулиты сосудов среднего диаметра (включая болезнь Кавасаки и узелковый полиартериит), анкилозирующий спондилит, болезнь Бергера (IgA нефропатия), быстро прогрессирущий гломерулонефрит, первичный билиарный цирроз, целиакия (глютеновая энтеропатия), криоглобулинемия, боковой амиотрофический склероз (ALS), ишемическая болезнь сердца.
6. Способ по п.1, в котором млекопитающим является человек.
7. Способ по п.3, в котором антитело не конъюгировано с цитотоксическим агентом.
8. Способ по п.4, в котором антителом является ритуксимаб.
9. Способ по п.4, в котором антителом является гумманизированным атителом 2Н7 v16, содержащим вариабельные домены, представленные SEQ ID Nos. 1 и 2.
10. Способ по п.3, в котором антитело конъюгировано с цитотоксическим агентом.
11. Способ по п.1, который, по существу, заключается во введении млекопитающему антагониста.
12. Способ лечения ревматоидного артрита у млекопитающего с неадекватным ответом на ингибитор TNFα, заключающийся во введении такому млекопитающему терапевтически эффективного количества антитела, которое связывается с CD20.
13. Способ снижения риска негативных побочных эффектов, таких как инфекция, сердечная недостаточность и демиелинизация, заключающийся во введении млекопитающему, страдающему аутоиммунным заболеванием, терапевтически эффективного количества антагониста, который связывается с поверхностным маркером В-клеток.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46148103P | 2003-04-09 | 2003-04-09 | |
| US60/461,481 | 2003-04-09 | ||
| PCT/US2004/010509 WO2004091657A2 (en) | 2003-04-09 | 2004-04-06 | Therapy of autoimmune disease in a patient with an inadequate response to a tnf-alpha inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008140661/15A Division RU2489166C2 (ru) | 2006-04-09 | 2008-10-14 | Применение антитела для лечения аутоиммунных заболеваний у пациента с неадекватным ответом на ингибитор tnf-альфа |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2005134394A true RU2005134394A (ru) | 2006-05-27 |
| RU2358762C2 RU2358762C2 (ru) | 2009-06-20 |
| RU2358762C9 RU2358762C9 (ru) | 2016-10-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005134394/14A RU2358762C9 (ru) | 2003-04-09 | 2004-04-06 | Лечение аутоиммунных заболеваний у пациента с неадекватным ответом на ингибитор tnf-альфа |
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| Country | Link |
|---|---|
| US (4) | US20040202658A1 (ru) |
| EP (2) | EP2062916A3 (ru) |
| JP (3) | JP2006522811A (ru) |
| KR (2) | KR20110044809A (ru) |
| CN (2) | CN101371924A (ru) |
| AT (1) | ATE425766T1 (ru) |
| AU (1) | AU2004229376B2 (ru) |
| BR (1) | BRPI0409534A (ru) |
| CA (1) | CA2519870A1 (ru) |
| CR (1) | CR8033A (ru) |
| CY (1) | CY1109127T1 (ru) |
| DE (1) | DE602004020061D1 (ru) |
| DK (1) | DK1613350T3 (ru) |
| EC (1) | ECSP056082A (ru) |
| ES (1) | ES2322267T3 (ru) |
| HK (1) | HK1086480A1 (ru) |
| HR (2) | HRP20050940A2 (ru) |
| IL (2) | IL171038A (ru) |
| MA (1) | MA27838A1 (ru) |
| ME (1) | ME00426B (ru) |
| MX (1) | MXPA05010778A (ru) |
| NO (1) | NO20055253L (ru) |
| NZ (2) | NZ587776A (ru) |
| PL (1) | PL1613350T3 (ru) |
| PT (1) | PT1613350E (ru) |
| RS (1) | RS51686B (ru) |
| RU (1) | RU2358762C9 (ru) |
| SI (1) | SI1613350T1 (ru) |
| TN (1) | TNSN05234A1 (ru) |
| UA (2) | UA91961C2 (ru) |
| WO (1) | WO2004091657A2 (ru) |
| ZA (1) | ZA200507805B (ru) |
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