RS20050106A - Combination therapy for hyperproliferative diseases - Google Patents
Combination therapy for hyperproliferative diseasesInfo
- Publication number
- RS20050106A RS20050106A YUP-2005/0106A YUP20050106A RS20050106A RS 20050106 A RS20050106 A RS 20050106A YU P20050106 A YUP20050106 A YU P20050106A RS 20050106 A RS20050106 A RS 20050106A
- Authority
- RS
- Serbia
- Prior art keywords
- hyperproliferative diseases
- relates
- group
- present
- anthracycline
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Ovaj pronalazak se odnosi na postupak za lečenje hiperproliferativnih bolesti. Još preciznije, ovaj pronalazak se odnosi na postupak za lečenje hiperproliferativnih bolesti, kao što je kancer, koji uključuje fazu primene na sisaru kome je takav tretman potreban, ili istovremene ili jedne za drugom, (i) terapeutski efektivne količine derivata taksana, platina-koordinisanog kompleksa izabranog od grupe koja sadrži karboplatin, tetraplatin i topotekan, analoga nukleozida izabranog iz grupe koja sadrži gemcitabin hidrohlorid i 5-UF, nekog antraciklina, topoizomeraze izabrane iz grupe koja sadrži etopozid, tenipozid, amsakrin, topotekan i Camptosar®, inhibitora armataze; i (ii) nekog derivata izotiazola. Kombinacije ovog pronalaska mogu opciono da obuhvate neko anti-hipertenzivno sredstvo. Ovaj pronalazak se takođe odnosi na farmaceutske kompozicije koje su korisne u tretmanu hiperproliferativnih bolesti kod sisara, a koje sadrže ove kombinacije. Ovaj pronalazak se takođe odnosi na kitove koji imaju prvi deo sa jedinjenjem formule 1 i drugi deo koji sadrži derivat taksana, platina koordinisani kompleks, analog nukleozida, neki antraciklin, inhibitor topoizomeraze ili inhibitor aromataze i treći deo koji sadrži neko anti-hipertenzivno sredstvo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40446102P | 2002-08-19 | 2002-08-19 | |
PCT/IB2003/003550 WO2004017964A1 (en) | 2002-08-19 | 2003-08-07 | Combination therapy for hyperproliferative diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
RS20050106A true RS20050106A (en) | 2007-11-15 |
Family
ID=31946725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-2005/0106A RS20050106A (en) | 2002-08-19 | 2003-08-07 | Combination therapy for hyperproliferative diseases |
Country Status (33)
Country | Link |
---|---|
US (1) | US20070197517A1 (sr) |
EP (1) | EP1545519B1 (sr) |
JP (1) | JP3835763B2 (sr) |
KR (1) | KR100668539B1 (sr) |
CN (1) | CN1681495B (sr) |
AP (1) | AP2005003232A0 (sr) |
AR (1) | AR040995A1 (sr) |
AT (1) | ATE502635T1 (sr) |
AU (1) | AU2003250483A1 (sr) |
BR (1) | BR0313593A (sr) |
CA (1) | CA2495962A1 (sr) |
CR (1) | CR7693A (sr) |
DE (1) | DE60336485D1 (sr) |
EA (1) | EA200500234A1 (sr) |
EC (1) | ECSP055618A (sr) |
ES (1) | ES2362998T3 (sr) |
GE (1) | GEP20074134B (sr) |
GT (1) | GT200300177A (sr) |
HK (1) | HK1079106A1 (sr) |
HR (1) | HRP20050163A2 (sr) |
IL (1) | IL166545A0 (sr) |
IS (1) | IS7670A (sr) |
MA (1) | MA27385A1 (sr) |
MX (1) | MXPA05001958A (sr) |
NO (1) | NO20050621L (sr) |
OA (1) | OA12905A (sr) |
PA (1) | PA8580201A1 (sr) |
PE (1) | PE20040993A1 (sr) |
PL (1) | PL375713A1 (sr) |
RS (1) | RS20050106A (sr) |
TN (1) | TNSN05051A1 (sr) |
TW (1) | TW200403057A (sr) |
WO (1) | WO2004017964A1 (sr) |
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US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
US5440056A (en) | 1992-04-17 | 1995-08-08 | Abbott Laboratories | 9-deoxotaxane compounds |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
EP1140182A2 (en) * | 1998-12-23 | 2001-10-10 | G.D. Searle & Co. | Use of a matrix metalloproteinase inhibitor together with an antineoplastic agent, optionally also together with radiation, in the treatment of neoplasia |
JP2004505057A (ja) * | 2000-07-27 | 2004-02-19 | ニュクリスト ファーマシューティカルズ コーポレーション | 過剰増殖性の皮膚障害および皮膚疾患の処置 |
KR20030059275A (ko) * | 2000-11-28 | 2003-07-07 | 화이자 프로덕츠 인크. | 이소티아졸-4-카복사미드의 염 및 과증식-억제제로서의그의 용도 |
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2003
- 2003-08-07 AT AT03792573T patent/ATE502635T1/de active
- 2003-08-07 EP EP03792573A patent/EP1545519B1/en not_active Expired - Lifetime
- 2003-08-07 CA CA002495962A patent/CA2495962A1/en not_active Abandoned
- 2003-08-07 JP JP2004530452A patent/JP3835763B2/ja not_active Expired - Fee Related
- 2003-08-07 DE DE60336485T patent/DE60336485D1/de not_active Expired - Lifetime
- 2003-08-07 AU AU2003250483A patent/AU2003250483A1/en not_active Abandoned
- 2003-08-07 OA OA1200500044A patent/OA12905A/en unknown
- 2003-08-07 AP AP2005003232A patent/AP2005003232A0/xx unknown
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- 2003-08-07 ES ES03792573T patent/ES2362998T3/es not_active Expired - Lifetime
- 2003-08-07 MX MXPA05001958A patent/MXPA05001958A/es active IP Right Grant
- 2003-08-07 PL PL03375713A patent/PL375713A1/xx not_active Application Discontinuation
- 2003-08-07 CN CN038221616A patent/CN1681495B/zh not_active Expired - Fee Related
- 2003-08-07 RS YUP-2005/0106A patent/RS20050106A/sr unknown
- 2003-08-07 KR KR1020057002757A patent/KR100668539B1/ko not_active IP Right Cessation
- 2003-08-07 WO PCT/IB2003/003550 patent/WO2004017964A1/en active Application Filing
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- 2003-08-19 US US10/643,546 patent/US20070197517A1/en not_active Abandoned
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2005
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