PT1474395E - Derivados de nicotinamida úteis como inibidores de p38 - Google Patents

Derivados de nicotinamida úteis como inibidores de p38 Download PDF

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Publication number
PT1474395E
PT1474395E PT03704769T PT03704769T PT1474395E PT 1474395 E PT1474395 E PT 1474395E PT 03704769 T PT03704769 T PT 03704769T PT 03704769 T PT03704769 T PT 03704769T PT 1474395 E PT1474395 E PT 1474395E
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PT
Portugal
Prior art keywords
inhibitors
useful
nicotinamide derivates
derivates useful
nicotinamide
Prior art date
Application number
PT03704769T
Other languages
English (en)
Inventor
Nicola Mary Aston
Paul Bamborough
Ann Louise Walker
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0203301.7A external-priority patent/GB0203301D0/en
Priority claimed from GB0225385A external-priority patent/GB0225385D0/en
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PT1474395E publication Critical patent/PT1474395E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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PT03704769T 2002-02-12 2003-02-10 Derivados de nicotinamida úteis como inibidores de p38 PT1474395E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0203301.7A GB0203301D0 (en) 2002-02-12 2002-02-12 Novel compounds
GB0225385A GB0225385D0 (en) 2002-10-31 2002-10-31 Novel compounds

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PT1474395E true PT1474395E (pt) 2008-01-02

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PT07117575T PT1864975E (pt) 2002-02-12 2003-02-10 Derivados de nicotinamida úteis como inibidores de p38
PT03704769T PT1474395E (pt) 2002-02-12 2003-02-10 Derivados de nicotinamida úteis como inibidores de p38

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EP (3) EP2258687B1 (pt)
JP (2) JP4472349B2 (pt)
KR (1) KR101058292B1 (pt)
CN (1) CN100369898C (pt)
AT (2) ATE375980T1 (pt)
AU (1) AU2003207298B2 (pt)
BR (1) BRPI0307351B8 (pt)
CA (1) CA2474192C (pt)
CO (1) CO5611147A2 (pt)
CY (2) CY1107117T1 (pt)
DE (2) DE60316913T2 (pt)
DK (2) DK1474395T3 (pt)
ES (2) ES2400486T3 (pt)
HK (2) HK1070896A1 (pt)
IL (1) IL163090A (pt)
IS (1) IS2520B (pt)
MX (1) MXPA04007838A (pt)
NO (1) NO327418B1 (pt)
NZ (1) NZ533865A (pt)
PL (1) PL212910B1 (pt)
PT (2) PT1864975E (pt)
RU (1) RU2309951C2 (pt)
SI (2) SI1474395T1 (pt)
WO (1) WO2003068747A1 (pt)
ZA (1) ZA200405602B (pt)

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