EA200900706A1 - Арилвинилазациклоалкановые соединения и способы их получения и применения - Google Patents
Арилвинилазациклоалкановые соединения и способы их получения и примененияInfo
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- EA200900706A1 EA200900706A1 EA200900706A EA200900706A EA200900706A1 EA 200900706 A1 EA200900706 A1 EA 200900706A1 EA 200900706 A EA200900706 A EA 200900706A EA 200900706 A EA200900706 A EA 200900706A EA 200900706 A1 EA200900706 A1 EA 200900706A1
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
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Abstract
Описываются новые винилазациклоалкановые соединения формулы (I). Соединения представляют лиганды различных nAChR. Соединения и их фармацевтически приемлемые соли могут применяться для приготовления фармацевтических композиций и/или медикаментов, предназначенных для профилактики или лечения расстройств, связанных с дисфункцией nAChR, в частности, в центральной нервной системе или желудочно-кишечной системе. Примеры типов расстройств, которые могут лечиться, включают нейродегенеративные расстройства, включая расстройства центральной нервной системы, такие как болезнь Альцгеймера, когнитивные расстройства, двигательные расстройства, такие как болезнь Паркинсона, лекарственная зависимость, нарушения поведения, и воспалительные расстройства в желудочно-кишечной системе. Соединения также могут служить в качестве анальгетиков при лечении острой, хронической или рецидивной боли.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/379,868 US7098331B2 (en) | 2003-03-05 | 2003-03-05 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200900706A1 true EA200900706A1 (ru) | 2009-10-30 |
EA019240B1 EA019240B1 (ru) | 2014-02-28 |
Family
ID=32926772
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200501425A EA010870B1 (ru) | 2003-03-05 | 2004-03-04 | Арилвинилазациклоалкановые соединения и способы их получения и применения |
EA200801764A EA014714B1 (ru) | 2003-03-05 | 2004-03-04 | Арилвинилазациклоалкановое соединение, фармацевтическая композиция на его основе и способы его применения |
EA200900706A EA019240B1 (ru) | 2003-03-05 | 2004-03-04 | Арилвинилазациклоалкановые соединения и способы их получения и применения |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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EA200501425A EA010870B1 (ru) | 2003-03-05 | 2004-03-04 | Арилвинилазациклоалкановые соединения и способы их получения и применения |
EA200801764A EA014714B1 (ru) | 2003-03-05 | 2004-03-04 | Арилвинилазациклоалкановое соединение, фармацевтическая композиция на его основе и способы его применения |
Country Status (32)
Country | Link |
---|---|
US (8) | US7098331B2 (ru) |
EP (3) | EP2085395B1 (ru) |
JP (3) | JP4663627B2 (ru) |
KR (4) | KR100953150B1 (ru) |
CN (3) | CN100526308C (ru) |
AR (3) | AR043469A1 (ru) |
AT (3) | ATE394394T1 (ru) |
AU (3) | AU2004217903B2 (ru) |
BR (1) | BRPI0409576A (ru) |
CA (1) | CA2516514C (ru) |
CL (1) | CL2004000452A1 (ru) |
CY (2) | CY1110391T1 (ru) |
DE (2) | DE602004031165D1 (ru) |
DK (2) | DK1601670T3 (ru) |
EA (3) | EA010870B1 (ru) |
ES (3) | ES2309507T3 (ru) |
GT (1) | GT200400033A (ru) |
HK (3) | HK1084949A1 (ru) |
IL (3) | IL170155A (ru) |
JO (1) | JO2488B1 (ru) |
MX (1) | MXPA05009386A (ru) |
NO (3) | NO331920B1 (ru) |
NZ (1) | NZ541795A (ru) |
PA (1) | PA8597201A1 (ru) |
PE (1) | PE20040930A1 (ru) |
PL (5) | PL394600A1 (ru) |
PT (2) | PT2085395E (ru) |
SI (2) | SI1601670T1 (ru) |
TW (3) | TW200927746A (ru) |
UY (1) | UY28218A1 (ru) |
WO (1) | WO2004078752A1 (ru) |
ZA (1) | ZA200506790B (ru) |
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US7098331B2 (en) * | 2003-03-05 | 2006-08-29 | Targacept, Inc. | Arylvinylazacycloalkane compounds and methods of preparation and use thereof |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |