PH24804A - Expression,processing and secretion of heterologous proteins by yeast - Google Patents

Expression,processing and secretion of heterologous proteins by yeast

Info

Publication number
PH24804A
PH24804A PH28614A PH28614A PH24804A PH 24804 A PH24804 A PH 24804A PH 28614 A PH28614 A PH 28614A PH 28614 A PH28614 A PH 28614A PH 24804 A PH24804 A PH 24804A
Authority
PH
Philippines
Prior art keywords
secretion
yeast
expression
processing
heterologous proteins
Prior art date
Application number
PH28614A
Other languages
English (en)
Inventor
Ronald Arthur Hitzman
David Wai-Hung Leung
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26998782&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH24804(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PH24804A publication Critical patent/PH24804A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/12Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/14Lymphokine; related peptides
    • Y10S930/142Interferon
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/30Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Treatment And Processing Of Natural Fur Or Leather (AREA)
  • Lubricants (AREA)
PH28614A 1982-03-08 1983-03-08 Expression,processing and secretion of heterologous proteins by yeast PH24804A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35529782A 1982-03-08 1982-03-08
US06/438,236 US4775622A (en) 1982-03-08 1982-11-01 Expression, processing and secretion of heterologous protein by yeast

Publications (1)

Publication Number Publication Date
PH24804A true PH24804A (en) 1990-10-30

Family

ID=26998782

Family Applications (1)

Application Number Title Priority Date Filing Date
PH28614A PH24804A (en) 1982-03-08 1983-03-08 Expression,processing and secretion of heterologous proteins by yeast

Country Status (28)

Country Link
US (1) US4775622A (fr)
EP (1) EP0088632B1 (fr)
JP (2) JPH0829111B2 (fr)
AU (1) AU574323B2 (fr)
BG (1) BG46159A3 (fr)
BR (1) BR8301150A (fr)
CZ (1) CZ282905B6 (fr)
DD (1) DD207220A5 (fr)
DE (2) DE3308215C2 (fr)
DK (1) DK163932C (fr)
DZ (1) DZ513A1 (fr)
ES (1) ES8500324A1 (fr)
FI (1) FI830774L (fr)
FR (1) FR2523152B1 (fr)
GB (1) GB2116567B (fr)
GR (1) GR78506B (fr)
IE (1) IE55743B1 (fr)
IL (1) IL68058A (fr)
MX (1) MX163813B (fr)
NO (1) NO830780L (fr)
NZ (1) NZ203494A (fr)
OA (1) OA07338A (fr)
PH (1) PH24804A (fr)
PL (1) PL153724B1 (fr)
PT (1) PT76360B (fr)
RO (1) RO88582A (fr)
YU (1) YU46723B (fr)
ZW (1) ZW6283A1 (fr)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196194A (en) * 1979-05-24 1993-03-23 The Regents Of The University Of California Vaccines containing Hepatitis B S-protein
EP0038765B1 (fr) * 1980-04-22 1987-09-02 Institut Pasteur Vaccin contre l'hépatite virale B, procédé et cellules eucaryotes transformées pour la production de ce vaccin
US4769238A (en) 1981-08-04 1988-09-06 The Regents Of The University Of California Synthesis of human virus antigens by yeast
JPS58146281A (ja) * 1981-10-19 1983-08-31 Suntory Ltd 酵母細胞の形質転換法
US4943529A (en) * 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
US5618697A (en) * 1982-12-10 1997-04-08 Novo Nordisk A/S Process for preparing a desired protein
DE3382547D1 (de) * 1983-01-12 1992-05-27 Chiron Corp Sekretorische expression in eukaryoten.
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
US7198919B1 (en) 1983-04-25 2007-04-03 Genentech, Inc. Use of alpha factor sequences in yeast expression systems
US4859600A (en) * 1983-04-25 1989-08-22 Genentech, Inc. Recombinant procaryotic cell containing correctly processed human growth hormone
NZ207925A (en) * 1983-04-25 1988-05-30 Genentech Inc Yeast expression vehicle consisting of a yeast promoter and signal peptide encoding region linked to a heterologus peptide coding region; expression and culture
US4870008A (en) * 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
EP0143081B1 (fr) * 1983-11-21 1989-08-23 Ciba-Geigy Ag Synthèse d'activateur du plasminogene tissulaire(TPA) par levure
PH23920A (en) * 1983-12-20 1990-01-23 Cetus Corp Glucoamylase cdna
FI841500A0 (fi) * 1984-04-13 1984-04-13 Valtion Teknillinen Foerfarande foer uppbygnande av cellulolytiska jaeststammar.
US7273695B1 (en) 1984-10-31 2007-09-25 Novartis Vaccines And Diagnostics, Inc. HIV immunoassays using synthetic envelope polypeptides
US7393949B1 (en) 1987-12-24 2008-07-01 Novartis Vaccines And Diagnostics, Inc. Human immunodeficiency virus (HIV) nucleotide sequences
CA1341482C (fr) 1984-10-31 2005-05-10 Paul A. Luciw Procede de preparation de fragments de retrovirus du groupe du sida
US7285271B1 (en) 1984-10-31 2007-10-23 Novartis Vaccines And Diagnostics, Inc. Antigenic composition comprising an HIV gag or env polypeptide
ATE88754T1 (de) * 1984-12-06 1993-05-15 Fina Research Transformierte hefen die lysozym produzieren, fuer diese transformation zu verwendende plasmide und deren verwendung.
US4902620A (en) * 1985-04-25 1990-02-20 Eli Lilly And Company Novel DNA for expression of delta-aminolevulinic acid synthetase and related method
EP0226639B1 (fr) * 1985-05-29 1990-11-14 The Green Cross Corporation Procede de preparation d'une proteine heterogene
US5164485A (en) * 1985-08-20 1992-11-17 Takeda Chemical Industries, Ltd. Modified hepatitis B virus surface antigen P31 and production thereof
JPS62175183A (ja) * 1985-08-29 1987-07-31 ジエネンコ− インコ−ポレ−テツド 繊維状菌類中に発現する異種ポリペプチドとその製造方法及びその製造のためのベクタ−
DE3650202T3 (de) * 1985-08-29 2004-06-03 Genencor International, Inc., South San Francisco Expression von heterologen Polypeptiden in filamentösen Pilzen, Verfahren zu deren Herstellung und Vektoren zu deren Herstellung.
US4937189A (en) * 1985-10-18 1990-06-26 Pfizer Inc. Expression and secretion of heterologous proteins by Yarrowia lipolytica transformants
CA1295567C (fr) * 1988-07-25 1992-02-11 Lawrence T. Malek Systeme d'expression pour la secretion du facteur stimulateur de colonies de granulocytes et de macrophages (gm-csf), ainsi que d'autres proteines heterologues, humains et bioactifs, a partir de streptomyces
GB8530631D0 (en) 1985-12-12 1986-01-22 Ciba Geigy Ag Thrombin inhibitors
US5024941A (en) * 1985-12-18 1991-06-18 Biotechnica International, Inc. Expression and secretion vector for yeast containing a glucoamylase signal sequence
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
US5766912A (en) * 1986-03-17 1998-06-16 Novo Nordisk A/S Humicola lipase produced in aspergillus
US5536661A (en) * 1987-03-10 1996-07-16 Novo Nordisk A/S Process for the production of protein products in aspergillus
FR2599753B1 (fr) * 1986-06-05 1989-12-08 Sanofi Sa Sequence d'adn composite et son application pour la production de l'hormone de croissance
GB8615701D0 (en) * 1986-06-27 1986-08-06 Delta Biotechnology Ltd Stable gene integration vector
JPH0616716B2 (ja) * 1986-10-14 1994-03-09 塩野義製薬株式会社 酵母におけるヒトpstiの製造法
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
US5610034A (en) * 1987-04-29 1997-03-11 Alko Group Ltd. Immunoglobulin production by trichoderma
JP2791418B2 (ja) * 1987-12-02 1998-08-27 株式会社ミドリ十字 異種蛋白質の製造方法、組換えdna、形質転換体
CA1340772C (fr) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression et secretion de proteines heterologues dans une levure au moyen de sequences leader tronquees du facteur alpha
JPH01240191A (ja) * 1988-02-16 1989-09-25 Green Cross Corp:The 酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現
US5149544A (en) * 1989-11-13 1992-09-22 Research Corporation Technologies, Inc. Method of inhibiting progenitor cell proliferation
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
CA2092717C (fr) * 1990-09-13 2001-06-12 Klim King Expression de recepteurs apparies de la proteine g chez la levure
AU8740491A (en) * 1990-09-28 1992-04-28 Protein Engineering Corporation Proteinaceous anti-dental plaque agents
US5932483A (en) * 1990-10-16 1999-08-03 Northwestern University Synthetic peptide and its uses
US5364930A (en) * 1990-10-16 1994-11-15 Northwestern University Synthetic C1q peptide fragments
ATE254179T1 (de) * 1990-11-29 2003-11-15 Agronomique Inst Nat Rech Neue type-i-interferon varianten, ihre verfahren zur herstellung, und ihre verwendungen
FR2669931B1 (fr) * 1990-11-29 1995-03-31 Transgene Nouveaux variants derives des interferons-alpha et leur procede de production.
CA2058820C (fr) * 1991-04-25 2003-07-15 Kotikanyad Sreekrishna Cassettes d'expression et vecteurs pour la secretion de serum albumine humaine dans des cellules pichia pastoris
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5538863A (en) * 1993-07-01 1996-07-23 Immunex Corporation Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
JP3763924B2 (ja) * 1997-03-17 2006-04-05 フクダ電子株式会社 超音波診断装置
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
AU7466998A (en) 1997-04-14 1998-11-11 Byron E. Anderson Method and material for inhibiting complement
FR2768743B1 (fr) * 1997-09-23 2001-09-14 Bio Merieux Procede de lyse de micro-organisme
GB2338236B (en) 1998-06-13 2003-04-09 Aea Technology Plc Microbiological cell processing
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
US6890730B1 (en) 1999-12-10 2005-05-10 The Salk Institute Sequence and method for increasing protein expression in cellular expression systems
US20030171267A1 (en) 2000-04-12 2003-09-11 Rosen Craig A. Albumin fusion proteins
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
US6358733B1 (en) 2000-05-19 2002-03-19 Apolife, Inc. Expression of heterologous multi-domain proteins in yeast
US7863020B2 (en) * 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
ES2252261T3 (es) * 2000-06-28 2006-05-16 Glycofi, Inc. Metodos para producir glicoproteinas modificadas.
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
US7625756B2 (en) * 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
WO2002039951A2 (fr) * 2000-11-15 2002-05-23 Globe Immune, Inc. Vaccins a base de cellules dendritiques et de levure, et leurs utilisations
US7507413B2 (en) * 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
EP1997829A1 (fr) 2001-12-21 2008-12-03 Human Genome Sciences, Inc. Protéines de fusion d'albumine
AU2002364587A1 (en) 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
ES2343518T3 (es) * 2002-09-09 2010-08-03 Hanall Biopharma Co., Ltd. Polipeptidos interferon alfa modificados resistentes a proteasas.
KR101164509B1 (ko) 2002-12-16 2012-07-10 글로브이뮨 면역 요법으로서의 효모계 백신
US8343502B2 (en) * 2002-12-16 2013-01-01 Globeimmune, Inc. Yeast-based vaccines as immunotherapy
US7439042B2 (en) * 2002-12-16 2008-10-21 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis C infection
EP1594530A4 (fr) 2003-01-22 2006-10-11 Human Genome Sciences Inc Proteines hybrides d'albumine
US7332299B2 (en) * 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
WO2005014825A2 (fr) * 2003-08-08 2005-02-17 Arriva Pharmaceuticals, Inc. Procede de production de proteines dans une levure
PT1678314E (pt) 2003-10-22 2012-11-27 Keck Graduate Inst Métodos de síntese de polipéptidos heteromultiméricos em levedura utilizando uma estratégia de conjugação haplóide
WO2005048985A2 (fr) * 2003-11-14 2005-06-02 Baxter International Inc. Compositions d'alpha 1-antitrypsine et procedes de traitement mettant en oeuvre de telles compositions
JP2008500275A (ja) * 2003-12-31 2008-01-10 セントカー・インコーポレーテツド N末端の遊離チオールを有する新規な組み換えタンパク質
CA2559379A1 (fr) 2004-01-20 2005-07-28 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Procede de production d'albumine serique humaine par chauffage en presence de cation divalent
JP2008516610A (ja) * 2004-10-18 2008-05-22 グローブイミューン,インコーポレイテッド 酵母を用いた慢性c型肝炎感染の治療
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US20070105768A1 (en) * 2004-11-10 2007-05-10 Rajiv Nayar Dry recombinant human alpha 1-antitrypsin formulation
US20100034840A1 (en) * 2005-07-11 2010-02-11 David Apelian Compositions and methods for eliciting an immune response to escape mutants of targeted therapies
US20070172503A1 (en) * 2005-12-13 2007-07-26 Mycologics,Inc. Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines
US7745128B2 (en) * 2006-03-27 2010-06-29 Globeimmune, Inc. Ras mutation and compositions and methods related thereto
JP2008174489A (ja) * 2007-01-18 2008-07-31 Nitto Denko Corp 微生物とペプチド性薬物を含む新規製剤
JP5570819B2 (ja) 2007-02-02 2014-08-13 グローブイミューン,インコーポレイテッド 酵母を含む組成物および酵母を増殖させる方法
CA2681246A1 (fr) * 2007-03-19 2008-09-25 Globeimmune, Inc. Compositions et procedes pour l'ablation ciblee de la metasynthese de therapies ciblees pour le cancer
WO2010033841A1 (fr) 2008-09-19 2010-03-25 Globeimmune, Inc. Immunothérapie pour infection chronique par le virus de l'hépatite c
EP3320915A1 (fr) 2009-04-17 2018-05-16 Globeimmune, Inc. Compositions d'immunothérapie de combinaison contre le cancer et méthoprocédés
AU2010291985B2 (en) 2009-09-14 2016-05-05 The Regents Of The University Of Colorado Modulation of yeast-based immunotherapy products and responses
ES2696551T3 (es) 2010-12-17 2019-01-16 Globeimmune Inc Composiciones y métodos para el tratamiento o la prevención de la infección por adenovirus-36 humano
ES2643389T3 (es) 2011-02-12 2017-11-22 Globeimmune, Inc. Producto terapéutico basado en levadura para infección por hepatitis B crónica
EP3238731B1 (fr) 2011-03-17 2021-02-17 Globeimmune, Inc. Compositions immunothérapeutiques de la protéine brachyury au moyen de levures
WO2012174220A1 (fr) 2011-06-14 2012-12-20 Globeimmune, Inc. Compositions à base de levure, et procédés de traitement ou de prévention d'une infection par le virus delta de l'hépatite
BR112014003477B1 (pt) 2011-08-17 2021-11-03 Globeimmune, Inc. Composição imunoterapêutica de muc1 de levedura
US9653272B2 (en) 2012-06-26 2017-05-16 Biodesix, Inc. Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
LT2872644T (lt) 2012-07-12 2017-10-10 Uab Baltymas Natyvių rekombinantinių sekretuojamų žmogaus endoplazminio tinklo šaperonų gamyba, panaudojant jų natyvias signalines sekas, mielių raiškos sistemose
RU2679806C2 (ru) 2013-03-19 2019-02-13 Дзе Юнайтед Стейтс Оф Эмерика, Эз Репрезентед Бай Дзе Секретэри, Дипартмент Оф Хелт Энд Хьюман Сервисиз Дрожжевая иммунотерапия хордомы
WO2014160747A2 (fr) 2013-03-26 2014-10-02 Globeimmune, Inc. Compositions et méthodes de traitement ou de prévention d'une infection par le virus de l'immunodéficience humaine
TWI654200B (zh) 2013-08-30 2019-03-21 環球免疫公司 治療或預防結核病的組合物及方法
US11066455B2 (en) * 2014-02-24 2021-07-20 The Johns Hopkins University Tmem100 peptides and variants thereof and their use in treating or preventing diseases or conditions
US10799567B2 (en) 2014-04-11 2020-10-13 Globeimmune, Inc. Yeast-based immunotherapy and type I interferon sensitivity
US11065313B2 (en) 2015-08-03 2021-07-20 Globeimmune, Inc. Modified yeast-brachyury immunotherapeutic compositions
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
CN113549639B (zh) * 2021-07-21 2022-07-29 云南中烟工业有限责任公司 一种降低烟叶总蛋白及烟气苯酚含量的调控基因

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2441659A1 (fr) * 1978-11-14 1980-06-13 Anvar Nouveaux plasmides hybrides et microorganismes les contenant
US4503035B1 (en) 1978-11-24 1996-03-19 Hoffmann La Roche Protein purification process and product
ZA802992B (en) * 1979-06-01 1981-10-28 Univ California Human pre-growth hormone
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
JPS5630925A (en) * 1979-08-21 1981-03-28 Sumitomo Chem Co Ltd Purification of human growth hormone
US4443539A (en) * 1980-02-05 1984-04-17 The Upjohn Company Process for preparing bovine growth hormone
GB2068969B (en) * 1980-02-05 1983-07-27 Upjohn Co Gene expression
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
GB2079288B (en) * 1980-05-12 1984-05-16 Biogen Nv Dna sequences recombinat dna molecules and processes for producing polypeptides with the specificity of foot and mouth disease viral antigens
CH657141A5 (de) * 1980-07-01 1986-08-15 Hoffmann La Roche Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen.
NZ198445A (en) * 1980-09-25 1984-05-31 Genentech Inc Production of human fibroblast interferon by recombinant dna technology
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
US4456748A (en) * 1981-02-23 1984-06-26 Genentech, Inc. Hybrid human leukocyte interferons
US4414150A (en) * 1980-11-10 1983-11-08 Genentech, Inc. Hybrid human leukocyte interferons
US4666847A (en) * 1981-01-16 1987-05-19 Collaborative Research, Inc. Recombinant DNA means and method
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58996A (ja) * 1981-06-01 1983-01-06 ザ・ボ−ド・オブ・トラステイ−ズ・ミシガンステ−トユニバ−シテイ− 細菌中での牛成長ホルモン遺伝子のクロ−ン化
IE53517B1 (en) * 1981-06-17 1988-12-07 Celltech Ltd Process for the production of a polypeptide
US4615974A (en) * 1981-08-25 1986-10-07 Celltech Limited Yeast expression vectors
NZ201705A (en) * 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4546082A (en) * 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins

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BR8301150A (pt) 1983-11-22
ES520416A0 (es) 1984-11-01
IL68058A0 (en) 1983-06-15
PL153724B1 (en) 1991-05-31
JPS58174396A (ja) 1983-10-13
DZ513A1 (fr) 2004-09-13
DK163932B (da) 1992-04-21
GB2116567B (en) 1986-01-02
PT76360A (en) 1983-04-01
GB8306285D0 (en) 1983-04-13
GR78506B (fr) 1984-09-27
PT76360B (en) 1986-02-12
IE830498L (en) 1983-09-08
JPH0829111B2 (ja) 1996-03-27
OA07338A (fr) 1984-08-31
FR2523152B1 (fr) 1985-08-23
FR2523152A1 (fr) 1983-09-16
NZ203494A (en) 1986-06-11
DK163932C (da) 1996-12-23
CZ160883A3 (en) 1997-07-16
NO830780L (no) 1983-09-09
FI830774A0 (fi) 1983-03-08
YU55683A (en) 1989-08-31
YU46723B (sh) 1994-04-05
IL68058A (en) 1989-12-15
EP0088632A2 (fr) 1983-09-14
GB2116567A (en) 1983-09-28
AU574323B2 (en) 1988-07-07
DK111283D0 (da) 1983-03-07
IE55743B1 (en) 1991-01-02
BG46159A3 (en) 1989-10-16
PL240927A1 (en) 1983-11-07
ES8500324A1 (es) 1984-11-01
DE3308215A1 (de) 1983-11-17
ZW6283A1 (en) 1983-06-01
EP0088632B1 (fr) 1993-06-16
DE3382694D1 (de) 1993-07-22
DE3382694T2 (de) 1993-09-23
US4775622A (en) 1988-10-04
DD207220A5 (de) 1984-02-22
DE3308215C2 (de) 1994-01-27
JPH06181779A (ja) 1994-07-05
FI830774L (fi) 1983-09-09
MX163813B (es) 1992-06-22
AU1215283A (en) 1983-09-15
CZ282905B6 (cs) 1997-11-12
RO88582A (fr) 1986-02-28
DK111283A (da) 1983-10-28
EP0088632A3 (en) 1984-06-20

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