DK55685A - Enzym eller enzymkompleks med proteolytisk aktivitet - Google Patents

Enzym eller enzymkompleks med proteolytisk aktivitet Download PDF

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Publication number
DK55685A
DK55685A DK055685A DK55685A DK55685A DK 55685 A DK55685 A DK 55685A DK 055685 A DK055685 A DK 055685A DK 55685 A DK55685 A DK 55685A DK 55685 A DK55685 A DK 55685A
Authority
DK
Denmark
Prior art keywords
enzym
complex
proteolytic activity
proteolytic
activity
Prior art date
Application number
DK055685A
Other languages
English (en)
Other versions
DK55685D0 (da
Inventor
Henrik Dalboege Andersen
John Pedersen
Thorkild Christensen
Joerli Winnie Hansen
Original Assignee
Nordisk Gentofte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8094869&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK55685(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of DK55685D0 publication Critical patent/DK55685D0/da
Priority to DK055685A priority Critical patent/DK55685A/da
Application filed by Nordisk Gentofte filed Critical Nordisk Gentofte
Priority to AU55145/86A priority patent/AU590258B2/en
Priority to PCT/DK1986/000014 priority patent/WO1986004609A1/en
Priority to AT86901361T priority patent/ATE52807T1/de
Priority to DE8686901361T priority patent/DE3671245D1/de
Priority to JP61501206A priority patent/JPH0665318B2/ja
Priority to EP86901361A priority patent/EP0217814B2/en
Publication of DK55685A publication Critical patent/DK55685A/da
Priority to DK2192A priority patent/DK2192A/da
Priority to US08/372,692 priority patent/US5618697A/en
Priority to US08/402,455 priority patent/US5691169A/en
Priority to US08/402,286 priority patent/US5633352A/en
Priority to US08/450,837 priority patent/US5679552A/en
Priority to US08/450,094 priority patent/US5635604A/en
Priority to US08/953,217 priority patent/US20010018199A1/en
Priority to US10/689,445 priority patent/US20040235090A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DK055685A 1982-12-10 1985-02-07 Enzym eller enzymkompleks med proteolytisk aktivitet DK55685A (da)

Priority Applications (15)

Application Number Priority Date Filing Date Title
DK055685A DK55685A (da) 1985-02-07 1985-02-07 Enzym eller enzymkompleks med proteolytisk aktivitet
AU55145/86A AU590258B2 (en) 1985-02-07 1986-02-06 A process for producing human growth hormone
PCT/DK1986/000014 WO1986004609A1 (en) 1985-02-07 1986-02-06 A process for producing human growth hormone
AT86901361T ATE52807T1 (de) 1985-02-07 1986-02-06 Herstellungsverfahren fuer menschliches wachstumhormon.
DE8686901361T DE3671245D1 (de) 1985-02-07 1986-02-06 Herstellungsverfahren fuer menschliches wachstumhormon.
JP61501206A JPH0665318B2 (ja) 1985-02-07 1986-02-06 ヒト成長ホルモンの製造方法
EP86901361A EP0217814B2 (en) 1985-02-07 1986-02-06 A process for producing human growth hormone
DK2192A DK2192A (da) 1985-02-07 1992-01-08 Enzymatisk fremgangsmaade til fremstilling af humant vaeksthormon
US08/372,692 US5618697A (en) 1982-12-10 1995-01-13 Process for preparing a desired protein
US08/402,286 US5633352A (en) 1982-12-10 1995-03-10 Biosynthetic human growth hormone
US08/402,455 US5691169A (en) 1982-12-10 1995-03-10 Process for preparing a desired protein
US08/450,837 US5679552A (en) 1982-12-10 1995-05-25 Process for preparing a desired protein
US08/450,094 US5635604A (en) 1982-12-10 1995-05-25 Amino-terminally extended human growth hormone (HGH)
US08/953,217 US20010018199A1 (en) 1985-02-07 1997-10-17 Process for preparing a desired protein
US10/689,445 US20040235090A1 (en) 1983-12-09 2003-10-20 Process for preparing a desired protein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK055685A DK55685A (da) 1985-02-07 1985-02-07 Enzym eller enzymkompleks med proteolytisk aktivitet

Publications (2)

Publication Number Publication Date
DK55685D0 DK55685D0 (da) 1985-02-07
DK55685A true DK55685A (da) 1986-08-08

Family

ID=8094869

Family Applications (1)

Application Number Title Priority Date Filing Date
DK055685A DK55685A (da) 1982-12-10 1985-02-07 Enzym eller enzymkompleks med proteolytisk aktivitet

Country Status (7)

Country Link
US (2) US20010018199A1 (da)
EP (1) EP0217814B2 (da)
JP (1) JPH0665318B2 (da)
AU (1) AU590258B2 (da)
DE (1) DE3671245D1 (da)
DK (1) DK55685A (da)
WO (1) WO1986004609A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3586773T2 (de) * 1984-08-16 1993-03-18 Bio Technology General Corp Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.
IT1228925B (it) * 1987-08-07 1991-07-10 Eniricerche Spa Procedimento per la preparazione dell'ormone della crescita umano
IT1223577B (it) * 1987-12-22 1990-09-19 Eniricerche Spa Procedimento migliorato per la preparazione dell'ormone della crescita umano naturale in forma pura
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
DE4105480A1 (de) * 1991-02-21 1992-08-27 Boehringer Mannheim Gmbh Verbesserte aktivierung von rekombinanten proteinen
TW257792B (da) * 1992-10-01 1995-09-21 Lilly Co Eli
KR970010135B1 (ko) * 1993-06-17 1997-06-21 주식회사 엘지화학 신규 아미노펩티다제
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
US5783413A (en) * 1994-05-09 1998-07-21 Unizyme Laboratories A/S Enzymatic process for producing a desired protein from an amino terminal extended protein
US5840517A (en) * 1995-04-26 1998-11-24 Eli Lilly And Company Process for preparing obesity protein analogs
US5614379A (en) * 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
US7714020B2 (en) 2001-05-24 2010-05-11 Neuren Pharmaceuticals Limited Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate
JP2004536069A (ja) 2001-05-24 2004-12-02 ニューロンズ・リミテッド Ｇｐｅ類縁体及びペプチドミメティック
US7605177B2 (en) * 2001-05-24 2009-10-20 Neuren Pharmaceuticals Limited Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60184A (en) * 1979-05-31 1984-05-31 Schering Ag Process for the specific cleavage of protein sequences from proteins
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4769326A (en) * 1980-02-29 1988-09-06 The Regents Of The University Of California Expression linkers
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
US4745069A (en) * 1982-05-25 1988-05-17 Eli Lilly And Company Cloning vectors for expression of exogenous protein
JPS60500043A (ja) * 1982-12-10 1985-01-17 ノルデイスク・インスリンラボラトリウム 原核細胞又は真核細胞中で合成される融合蛋白質から成熟蛋白質を作る方法
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
DE3586773T2 (de) * 1984-08-16 1993-03-18 Bio Technology General Corp Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase

Also Published As

Publication number Publication date
EP0217814B2 (en) 1994-12-21
AU5514586A (en) 1986-08-26
US20010018199A1 (en) 2001-08-30
AU590258B2 (en) 1989-11-02
WO1986004609A1 (en) 1986-08-14
EP0217814A1 (en) 1987-04-15
EP0217814B1 (en) 1990-05-16
DK55685D0 (da) 1985-02-07
DE3671245D1 (de) 1990-06-21
JPH0665318B2 (ja) 1994-08-24
US20040235090A1 (en) 2004-11-25
JPS62501609A (ja) 1987-07-02

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