CL2020001576A1 - Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5. - Google Patents

Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5.

Info

Publication number
CL2020001576A1
CL2020001576A1 CL2020001576A CL2020001576A CL2020001576A1 CL 2020001576 A1 CL2020001576 A1 CL 2020001576A1 CL 2020001576 A CL2020001576 A CL 2020001576A CL 2020001576 A CL2020001576 A CL 2020001576A CL 2020001576 A1 CL2020001576 A1 CL 2020001576A1
Authority
CL
Chile
Prior art keywords
bicyclic heterocyclic
substituted bicyclic
prmt5 inhibitors
heterocyclic components
prmt5
Prior art date
Application number
CL2020001576A
Other languages
English (en)
Inventor
Prathap Sreedharan Nair
Ganesh Bhausaheb Gudade
Sachin Sethi
Dipak Raychand Lagad
Chetan Sanjay Pawar
Mahadeo Bhaskar Tryambake
Chaitanya Prabhakar Kulkarni
Anil Kashiram Hajare
Balasaheb Arjun Gore
Milind Dattatraya Sindkhedkar
Venkata P Palle
Rajender Kumar Kamboj
Sanjeev Anant Kulkarni
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of CL2020001576A1 publication Critical patent/CL2020001576A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a compuestos heterocíclicos bicíclicos sustituidos de fórmula (I), a sales farmacéuticamente aceptables de los mismos y a composiciones farmacéuticas para tratar enfermedades, trastornos o afecciones asociados con la sobreexpresión de la enzima PRMT5. La invención también se refiere a métodos para tratar enfermedades, trastornos o afecciones asociados con la sobreexpresión de la enzima PRMT5.
CL2020001576A 2017-12-13 2020-06-11 Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5. CL2020001576A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201721044886 2017-12-13
IN201821024634 2018-07-02
IN201821040029 2018-10-23

Publications (1)

Publication Number Publication Date
CL2020001576A1 true CL2020001576A1 (es) 2020-11-06

Family

ID=65036860

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020001576A CL2020001576A1 (es) 2017-12-13 2020-06-11 Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5.

Country Status (28)

Country Link
US (2) US11459330B2 (es)
EP (1) EP3724190B1 (es)
JP (1) JP7282778B2 (es)
KR (1) KR20200098598A (es)
CN (1) CN111712498B (es)
AU (1) AU2018385664B2 (es)
BR (1) BR112020011746A2 (es)
CA (1) CA3085259A1 (es)
CL (1) CL2020001576A1 (es)
CR (1) CR20200263A (es)
CU (1) CU24621B1 (es)
DK (1) DK3724190T3 (es)
ES (1) ES2927860T3 (es)
GE (1) GEP20227359B (es)
HR (1) HRP20221207T1 (es)
HU (1) HUE059945T2 (es)
IL (1) IL274936B2 (es)
LT (1) LT3724190T (es)
MX (1) MX2020006181A (es)
PE (1) PE20211444A1 (es)
PH (1) PH12020550881A1 (es)
PL (1) PL3724190T3 (es)
PT (1) PT3724190T (es)
RS (1) RS63623B1 (es)
SG (1) SG11202004934QA (es)
UA (1) UA126349C2 (es)
WO (1) WO2019116302A1 (es)
ZA (1) ZA202003528B (es)

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CR20230402A (es) 2021-01-19 2023-11-21 Lupin Ltd Combinaciones farmacéuticas de inhibidores de sos1 para tratar o prevenir cancer
CN113234079B (zh) * 2021-04-30 2022-02-01 上海湃隆生物科技有限公司 用作prmt5抑制剂的核苷类似物

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EP3724190A1 (en) 2020-10-21
SG11202004934QA (en) 2020-07-29
EP3724190B1 (en) 2022-07-06
IL274936B2 (en) 2023-09-01
DK3724190T3 (da) 2022-10-10
IL274936B1 (en) 2023-05-01
AU2018385664B2 (en) 2022-06-02
US20210163486A1 (en) 2021-06-03
CN111712498B (zh) 2023-09-29
ES2927860T3 (es) 2022-11-11
ZA202003528B (en) 2022-05-25
CU24621B1 (es) 2022-09-08
MX2020006181A (es) 2020-09-03
CU20200051A7 (es) 2021-03-11
AU2018385664A1 (en) 2020-07-02
RS63623B1 (sr) 2022-10-31
CA3085259A1 (en) 2019-06-20
CN111712498A (zh) 2020-09-25
PT3724190T (pt) 2022-10-03
WO2019116302A1 (en) 2019-06-20
IL274936A (en) 2020-07-30
HUE059945T2 (hu) 2023-01-28
UA126349C2 (uk) 2022-09-21
US20220267339A1 (en) 2022-08-25
CR20200263A (es) 2020-07-26
US11952380B2 (en) 2024-04-09
GEP20227359B (en) 2022-03-10
HRP20221207T1 (hr) 2022-12-09
BR112020011746A2 (pt) 2020-11-17
JP7282778B2 (ja) 2023-05-29
LT3724190T (lt) 2022-10-10
US11459330B2 (en) 2022-10-04
KR20200098598A (ko) 2020-08-20
JP2021506793A (ja) 2021-02-22
PH12020550881A1 (en) 2021-04-05
PE20211444A1 (es) 2021-08-05
PL3724190T3 (pl) 2022-10-31

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