PE20081849A1 - Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr - Google Patents
Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcrInfo
- Publication number
- PE20081849A1 PE20081849A1 PE2008000085A PE2008000085A PE20081849A1 PE 20081849 A1 PE20081849 A1 PE 20081849A1 PE 2008000085 A PE2008000085 A PE 2008000085A PE 2008000085 A PE2008000085 A PE 2008000085A PE 20081849 A1 PE20081849 A1 PE 20081849A1
- Authority
- PE
- Peru
- Prior art keywords
- piperidin
- propoxy
- benzamide derivatives
- hydroxy
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIPERIDIN-4-IL-PROPOXI-BENZAMIDA DE FORMULA (I), EN DONDE UNO DE X O Y ES O Y EL OTRO ES N; R1 ES -CONHR5; R2 ES H, HALO O METILO; R3 ES H O METILO; R4 ES ALQUILO (C2-C5) Y R5 ES H, ALQUILO(C1-C3) O ALQUILO(C2-C3) SUSTITUIDO CON HIDROXI. SON SELECCIONADOS: 2-FLUORO-N-((R-2-HIDROXI-1-METILETIL)-4-{3-[1-(3-ISOPROPIL-[1,2,4]-OXADIAZOL-5-IL)PIPERIDIN-4-IL]PROPOXI}BENZAMIDA, N-((R-2-HIDROXI-1-METILETIL)-4-{3-[1-(3-ISOPROPIL-[1,2,4]OXADIAZOL-5-IL)PIPERIDIN-4-IL]PROPOXI}-2-METILBENZAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR ACOPLADO A LA PROTEINA G (GPCR) Y SON UTILES EN EL TRATAMIENTO DE LA OBESIDAD, COMO REGULADORES DE LA SACIEDAD, DEL SINDROME METABOLICO Y LA DIABETES
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0700124A GB0700124D0 (en) | 2007-01-04 | 2007-01-04 | GPCR agonists |
GB0708740A GB0708740D0 (en) | 2007-05-08 | 2007-05-08 | Gpcr agonists |
GB0719762A GB0719762D0 (en) | 2007-10-10 | 2007-10-10 | GPCR agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081849A1 true PE20081849A1 (es) | 2009-01-26 |
Family
ID=39203222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000085A PE20081849A1 (es) | 2007-01-04 | 2008-01-03 | Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr |
Country Status (28)
Country | Link |
---|---|
US (1) | US20100022591A1 (es) |
EP (2) | EP2114931B1 (es) |
JP (1) | JP2010514829A (es) |
KR (1) | KR20090104092A (es) |
CN (1) | CN101627036A (es) |
AR (1) | AR064736A1 (es) |
AT (1) | ATE531710T1 (es) |
AU (1) | AU2008203673A1 (es) |
BR (1) | BRPI0806468A2 (es) |
CA (1) | CA2674093A1 (es) |
CL (1) | CL2008000017A1 (es) |
DK (1) | DK2114931T3 (es) |
EA (1) | EA015805B9 (es) |
ES (1) | ES2376015T3 (es) |
HK (1) | HK1135704A1 (es) |
HR (1) | HRP20110964T1 (es) |
IL (1) | IL199680A0 (es) |
MA (1) | MA31084B1 (es) |
MX (1) | MX2009007180A (es) |
NZ (1) | NZ578144A (es) |
PE (1) | PE20081849A1 (es) |
PL (1) | PL2114931T3 (es) |
PT (1) | PT2114931E (es) |
RS (1) | RS52168B (es) |
SA (1) | SA08280756B1 (es) |
SI (1) | SI2114931T1 (es) |
TW (1) | TWI380818B (es) |
WO (1) | WO2008081205A1 (es) |
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US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
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DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
WO2007128721A1 (de) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim Internationalgmbh | Polymorphe |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
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CL2008000018A1 (es) * | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
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US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
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-
2008
- 2008-01-03 CL CL200800017A patent/CL2008000017A1/es unknown
- 2008-01-03 AR ARP080100018A patent/AR064736A1/es not_active Application Discontinuation
- 2008-01-03 PE PE2008000085A patent/PE20081849A1/es not_active Application Discontinuation
- 2008-01-04 ES ES08700184T patent/ES2376015T3/es active Active
- 2008-01-04 RS RS20120031A patent/RS52168B/en unknown
- 2008-01-04 MX MX2009007180A patent/MX2009007180A/es active IP Right Grant
- 2008-01-04 EP EP08700184A patent/EP2114931B1/en active Active
- 2008-01-04 JP JP2009544448A patent/JP2010514829A/ja active Pending
- 2008-01-04 CN CN200880007091A patent/CN101627036A/zh active Pending
- 2008-01-04 DK DK08700184.8T patent/DK2114931T3/da active
- 2008-01-04 AU AU2008203673A patent/AU2008203673A1/en not_active Abandoned
- 2008-01-04 WO PCT/GB2008/050011 patent/WO2008081205A1/en active Application Filing
- 2008-01-04 TW TW097100419A patent/TWI380818B/zh not_active IP Right Cessation
- 2008-01-04 EA EA200900796A patent/EA015805B9/ru not_active IP Right Cessation
- 2008-01-04 EP EP11172885A patent/EP2383270A1/en not_active Withdrawn
- 2008-01-04 NZ NZ578144A patent/NZ578144A/en not_active IP Right Cessation
- 2008-01-04 AT AT08700184T patent/ATE531710T1/de active
- 2008-01-04 KR KR1020097016214A patent/KR20090104092A/ko not_active Application Discontinuation
- 2008-01-04 CA CA002674093A patent/CA2674093A1/en not_active Abandoned
- 2008-01-04 PL PL08700184T patent/PL2114931T3/pl unknown
- 2008-01-04 BR BRPI0806468-7A patent/BRPI0806468A2/pt not_active IP Right Cessation
- 2008-01-04 SI SI200830517T patent/SI2114931T1/sl unknown
- 2008-01-04 PT PT08700184T patent/PT2114931E/pt unknown
- 2008-01-04 US US12/522,018 patent/US20100022591A1/en not_active Abandoned
- 2008-01-05 SA SA8280756A patent/SA08280756B1/ar unknown
-
2009
- 2009-07-02 IL IL199680A patent/IL199680A0/en unknown
- 2009-07-03 MA MA32072A patent/MA31084B1/fr unknown
-
2010
- 2010-04-16 HK HK10103732.5A patent/HK1135704A1/xx not_active IP Right Cessation
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2011
- 2011-12-21 HR HR20110964T patent/HRP20110964T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
CL2008000017A1 (es) | 2008-08-01 |
EA015805B9 (ru) | 2012-03-30 |
SA08280756B1 (ar) | 2011-01-24 |
KR20090104092A (ko) | 2009-10-05 |
HRP20110964T1 (hr) | 2012-01-31 |
SI2114931T1 (sl) | 2012-02-29 |
PT2114931E (pt) | 2012-01-12 |
RS52168B (en) | 2012-08-31 |
ES2376015T3 (es) | 2012-03-08 |
CA2674093A1 (en) | 2008-07-10 |
EA200900796A1 (ru) | 2010-02-26 |
EP2383270A1 (en) | 2011-11-02 |
JP2010514829A (ja) | 2010-05-06 |
BRPI0806468A2 (pt) | 2011-09-27 |
IL199680A0 (en) | 2010-04-15 |
EP2114931B1 (en) | 2011-11-02 |
MA31084B1 (fr) | 2010-01-04 |
CN101627036A (zh) | 2010-01-13 |
TW200835489A (en) | 2008-09-01 |
DK2114931T3 (da) | 2012-02-13 |
AR064736A1 (es) | 2009-04-22 |
EP2114931A1 (en) | 2009-11-11 |
TWI380818B (zh) | 2013-01-01 |
NZ578144A (en) | 2011-03-31 |
ATE531710T1 (de) | 2011-11-15 |
HK1135704A1 (en) | 2010-06-11 |
MX2009007180A (es) | 2009-07-15 |
US20100022591A1 (en) | 2010-01-28 |
WO2008081205A1 (en) | 2008-07-10 |
EA015805B1 (ru) | 2011-12-30 |
PL2114931T3 (pl) | 2012-03-30 |
AU2008203673A1 (en) | 2008-07-10 |
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