PE20120218A1 - Compuestos para el tratamiento de trastornos metabolicos - Google Patents
Compuestos para el tratamiento de trastornos metabolicosInfo
- Publication number
- PE20120218A1 PE20120218A1 PE2011001638A PE2011001638A PE20120218A1 PE 20120218 A1 PE20120218 A1 PE 20120218A1 PE 2011001638 A PE2011001638 A PE 2011001638A PE 2011001638 A PE2011001638 A PE 2011001638A PE 20120218 A1 PE20120218 A1 PE 20120218A1
- Authority
- PE
- Peru
- Prior art keywords
- piperidin
- alkyl
- compounds
- halo
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE Z ES C(O)OR4, HETEROARILO, ENTRE OTROS, EN DONDE R4 ES ALQUILO(C2-C6) O CICLOALQUILO(C3-C6); X ES O, NR7 O CR6R66, EN DONDE R6 Y R66 SON CADA UNO H, F O ALQUILO(C1-C4); R7 ES H O ALQUILO(C1-C4); Y ES ALQUILENO(C2-C4) OPCIONALMENTE SUSTITUIDO CON F O METILO; A ES FENILO O UN ANILLO HETEROAROMATICO DE 6 MIEMBROS QUE CONTIENE 1 A 2 ATOMOS DE N; R1 ES H, HALO, CN, ALQUILO(C1-C4) O HALOALQUILO(C1-C4); R2 ES FENILO SUSTITUIDO OPCIONALMENTE CON HALO, PIRIDILO SUSTITUIDO OPCIONALMENTE CON HALO O METILO, ENTRE OTROS; p ES 1 O 2; q ES 1 O 2. SON COMPUESTOS PREFERIDOS: 1-[(3S,4S)-4-AMINO-1-(5-{(R)-3-[1-(5-CLOROPIRIMIDIN-2-IL)PIPERIDIN-4-IL]BUTOXI}PIRIMIDIN-2-IL)PIRROLIDIN-3-IL]PIPERIDIN-2-ONA, 1-[(3S,4S)-4-AMINO-1-(6-{(R)-3-[1-(3-ISOPROPIL-[1,2,4]OXADIAZOL-5-IL)PIPERIDIN-4-IL]BUTOXI}PIRIMIDIN-4-IL)PIRROLIDIN-3-IL]PIPERIDIN-2-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR ACOPLADO A PROTEINA G 119 (GPR119) SIENDO UTILES EN EL TRATAMIENTO DE DIABETES TIPO II, OBESIDAD, SINDROME METABOLICO, HIPERLIPIDEMIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0904285.4A GB0904285D0 (en) | 2009-03-12 | 2009-03-12 | Compounds for the treatment of metabolic disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120218A1 true PE20120218A1 (es) | 2012-03-19 |
Family
ID=40600947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001638A PE20120218A1 (es) | 2009-03-12 | 2010-03-12 | Compuestos para el tratamiento de trastornos metabolicos |
Country Status (18)
Country | Link |
---|---|
US (1) | US20120059014A1 (es) |
EP (1) | EP2406251A1 (es) |
JP (1) | JP2012520283A (es) |
KR (1) | KR20110133045A (es) |
CN (1) | CN102395578A (es) |
AU (1) | AU2010222672A1 (es) |
BR (1) | BRPI1009783A2 (es) |
CA (1) | CA2754791A1 (es) |
CL (1) | CL2011002182A1 (es) |
EA (1) | EA201190207A1 (es) |
GB (1) | GB0904285D0 (es) |
IL (1) | IL215050A0 (es) |
MA (1) | MA33241B1 (es) |
MX (1) | MX2011009493A (es) |
PE (1) | PE20120218A1 (es) |
SG (1) | SG174363A1 (es) |
WO (1) | WO2010103334A1 (es) |
ZA (1) | ZA201107449B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007007751A1 (de) * | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
DE102007035333A1 (de) * | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
TW201111361A (en) | 2009-06-24 | 2011-04-01 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
JP2012530758A (ja) | 2009-06-24 | 2012-12-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物、医薬組成物及びそれに関する方法 |
EP2547339A1 (en) | 2010-03-18 | 2013-01-23 | Boehringer Ingelheim International GmbH | Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions |
GB201006167D0 (en) * | 2010-04-14 | 2010-05-26 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
AR083904A1 (es) | 2010-11-18 | 2013-04-10 | Prosidion Ltd | Derivados de 1,4-pirrolidinas disustituidos y 3-il-aminas y sus usos en el tratamiento de desordenes metabolicos |
GB201114389D0 (en) | 2011-08-22 | 2011-10-05 | Prosidion Ltd | Novel compounds |
RU2606131C2 (ru) | 2011-05-13 | 2017-01-10 | Эррэй Биофарма Инк. | СОЕДИНЕНИЯ ПИРРОЛИДИНИЛМОЧЕВИНЫ И ПИРРОЛИДИНИЛТИОМОЧЕВИНЫ КАК ИНГИБИТОРЫ КИНАЗЫ TrkA |
EP2718279B1 (en) | 2011-06-09 | 2016-08-10 | Rhizen Pharmaceuticals SA | Novel compounds as modulators of gpr-119 |
GB2497351A (en) * | 2011-12-09 | 2013-06-12 | Prosidion Ltd | Compounds useful as GPR119 agonists |
EP2872127A1 (en) | 2012-07-11 | 2015-05-20 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
WO2016131198A1 (en) * | 2015-02-18 | 2016-08-25 | Eli Lilly And Company | Pyrazole compounds |
IL261606B (en) * | 2016-03-16 | 2022-09-01 | Kura Oncology Inc | Inhibitors of converted menin-mll and methods of use |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6100042A (en) | 1993-03-31 | 2000-08-08 | Cadus Pharmaceutical Corporation | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor |
GB9719496D0 (en) | 1997-09-13 | 1997-11-19 | Glaxo Group Ltd | G protien chimeras |
EP1112359A2 (en) | 1998-09-01 | 2001-07-04 | BASF Aktiengesellschaft | Enhanced functional expression of g protein-coupled receptors |
US6221660B1 (en) | 1999-02-22 | 2001-04-24 | Synaptic Pharmaceutical Corporation | DNA encoding SNORF25 receptor |
WO2005061489A1 (en) | 2003-12-24 | 2005-07-07 | Prosidion Limited | Heterocyclic derivatives as gpcr receptor agonists |
BRPI0516407A (pt) | 2004-12-24 | 2008-09-02 | Prosidion Ltd | agonistas de receptor acoplado à proteìna g (gpr116) e uso destes para o tratamento de obesidade e diabetes |
US8193359B2 (en) | 2004-12-24 | 2012-06-05 | Prosidion Limited | G-protein coupled receptor agonists |
GB0428514D0 (en) | 2004-12-31 | 2005-02-09 | Prosidion Ltd | Compounds |
WO2007003960A1 (en) | 2005-06-30 | 2007-01-11 | Prosidion Limited | Gpcr agonists |
US20090203676A1 (en) | 2005-06-30 | 2009-08-13 | Oscar Barba | G-protein Coupled Receptor Agonists |
WO2007003961A2 (en) | 2005-06-30 | 2007-01-11 | Prosidion Limited | Gpcr agonists |
US20100063081A1 (en) | 2005-06-30 | 2010-03-11 | Stuart Edward Bradly | CPCR Agonists |
WO2007116229A1 (en) | 2006-04-06 | 2007-10-18 | Prosidion Limited | Heterocyclic gpcr agonists |
GB0607196D0 (en) | 2006-04-11 | 2006-05-17 | Prosidion Ltd | G-protein coupled receptor agonists |
GB0610746D0 (en) | 2006-06-01 | 2006-07-12 | Prosidion Ltd | Method of treatment |
WO2007148185A2 (en) | 2006-06-21 | 2007-12-27 | Pfizer Products Inc. | Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors |
EP2094683B1 (en) | 2006-12-06 | 2011-10-12 | GlaxoSmithKline LLC | Bicyclic compounds and use as antidiabetics |
PE20081659A1 (es) | 2007-01-04 | 2008-10-24 | Prosidion Ltd | Agonistas de gpcr |
GB0700122D0 (en) | 2007-01-04 | 2007-02-14 | Prosidion Ltd | GPCR agonists |
EP2114936A1 (en) | 2007-01-04 | 2009-11-11 | Prosidion Limited | Piperidine gpcr agonists |
PE20081849A1 (es) | 2007-01-04 | 2009-01-26 | Prosidion Ltd | Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr |
JP2010514828A (ja) | 2007-01-04 | 2010-05-06 | プロシディオン・リミテッド | ピペリジンgpcrアゴニスト |
US20080186971A1 (en) | 2007-02-02 | 2008-08-07 | Tarari, Inc. | Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic |
AU2008279447A1 (en) | 2007-07-19 | 2009-01-29 | Metabolex, Inc. | N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders |
US20100286112A1 (en) | 2007-09-10 | 2010-11-11 | Oscar Barba | Compounds for the treatment of metabolic disorders |
GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
CN101827958A (zh) | 2007-10-18 | 2010-09-08 | 日矿金属株式会社 | 金属包覆的聚酰亚胺复合体、该复合体的制造方法以及电子电路板的制造方法 |
CN101621337B (zh) | 2008-06-30 | 2013-08-07 | 华为技术有限公司 | 一种时延调节装置与方法 |
US20110269734A1 (en) | 2008-07-10 | 2011-11-03 | Prosidion Limited | Piperidinyl gpcr agonists |
US20110230507A1 (en) | 2008-07-10 | 2011-09-22 | Prosidion Limited | Piperidine GPCR Agonists |
GB0812641D0 (en) | 2008-07-10 | 2008-08-20 | Prosidion Ltd | Compounds |
GB0812648D0 (en) | 2008-07-10 | 2008-08-20 | Prosidion Ltd | Compounds |
-
2009
- 2009-03-12 GB GBGB0904285.4A patent/GB0904285D0/en not_active Ceased
-
2010
- 2010-03-12 CA CA2754791A patent/CA2754791A1/en not_active Abandoned
- 2010-03-12 CN CN2010800171471A patent/CN102395578A/zh active Pending
- 2010-03-12 US US13/255,531 patent/US20120059014A1/en not_active Abandoned
- 2010-03-12 KR KR1020117024019A patent/KR20110133045A/ko not_active Application Discontinuation
- 2010-03-12 PE PE2011001638A patent/PE20120218A1/es not_active Application Discontinuation
- 2010-03-12 MA MA34245A patent/MA33241B1/fr unknown
- 2010-03-12 EA EA201190207A patent/EA201190207A1/ru unknown
- 2010-03-12 MX MX2011009493A patent/MX2011009493A/es unknown
- 2010-03-12 JP JP2011553533A patent/JP2012520283A/ja active Pending
- 2010-03-12 BR BRPI1009783A patent/BRPI1009783A2/pt not_active Application Discontinuation
- 2010-03-12 AU AU2010222672A patent/AU2010222672A1/en not_active Abandoned
- 2010-03-12 EP EP10709053A patent/EP2406251A1/en not_active Withdrawn
- 2010-03-12 SG SG2011065802A patent/SG174363A1/en unknown
- 2010-03-12 WO PCT/GB2010/050441 patent/WO2010103334A1/en active Application Filing
-
2011
- 2011-09-05 CL CL2011002182A patent/CL2011002182A1/es unknown
- 2011-09-08 IL IL215050A patent/IL215050A0/en unknown
- 2011-10-11 ZA ZA2011/07449A patent/ZA201107449B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CL2011002182A1 (es) | 2012-03-30 |
GB0904285D0 (en) | 2009-04-22 |
SG174363A1 (en) | 2011-10-28 |
JP2012520283A (ja) | 2012-09-06 |
CN102395578A (zh) | 2012-03-28 |
MX2011009493A (es) | 2011-10-11 |
MA33241B1 (fr) | 2012-05-02 |
BRPI1009783A2 (pt) | 2016-03-08 |
EP2406251A1 (en) | 2012-01-18 |
US20120059014A1 (en) | 2012-03-08 |
AU2010222672A1 (en) | 2011-11-03 |
WO2010103334A1 (en) | 2010-09-16 |
EA201190207A1 (ru) | 2012-04-30 |
CA2754791A1 (en) | 2010-09-16 |
IL215050A0 (en) | 2011-11-30 |
KR20110133045A (ko) | 2011-12-09 |
ZA201107449B (en) | 2012-06-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |