CN102219859B - 拮抗血管新生诱导因子的融合蛋白及其用途 - Google Patents
拮抗血管新生诱导因子的融合蛋白及其用途 Download PDFInfo
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Abstract
Description
融合蛋白 | 氨基酸序列 | 核苷酸序列 |
2# | SEQ ID NO:9 | SEQ ID NO:26 |
4# | SEQ ID NO:10 | SEQ ID NO:27 |
7# | SEQ ID NO:11 | SEQ ID NO:28 |
9# | SEQ ID NO:12 | SEQ ID NO:29 |
10# | SEQ ID NO:13 | SEQ ID NO:30 |
11# | SEQ ID NO:14 | SEQ ID NO:31 |
12# | SEQ ID NO:15 | SEQ ID NO:32 |
14# | SEQ ID NO:16 | SEQ ID NO:33 |
15# | SEQ ID NO:17 | SEQ ID NO:34 |
16# | SEQ ID NO:18 | SEQ ID NO:35 |
20# | SEQ ID NO:19 | SEQ ID NO:36 |
21# | SEQ ID NO:20 | SEQ ID NO:37 |
24# | SEQ ID NO:21 | SEQ ID NO:38 |
25# | SEQ ID NO:22 | SEQ ID NO:39 |
26# | SEQ ID NO:71 | SEQ ID NO:72 |
27# | SEQ ID NO:23 | SEQ ID NO:40 |
28# | SEQ ID NO:24 | SEQ ID NO:41 |
Claims (34)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110131029A CN102219859B (zh) | 2011-05-20 | 2011-05-20 | 拮抗血管新生诱导因子的融合蛋白及其用途 |
AU2012261410A AU2012261410B2 (en) | 2011-05-20 | 2012-05-18 | Fusion protein for antagonizing angiogenesis inducible factors and uses thereof |
JP2014505501A JP2014513940A (ja) | 2011-05-20 | 2012-05-18 | 血管新生誘導因子に拮抗する融合蛋白質およびその使用 |
RU2013140472/10A RU2560589C2 (ru) | 2011-05-20 | 2012-05-18 | Слитный белок антиангиогенного индуцирующего фактора и его применение |
PCT/CN2012/075700 WO2012159548A1 (zh) | 2011-05-20 | 2012-05-18 | 拮抗血管新生诱导因子的融合蛋白及其用途 |
EP12789790.8A EP2711377B1 (en) | 2011-05-20 | 2012-05-18 | Fusion protein for antagonizing angiogenesis inducible factors and uses thereof |
KR1020167001260A KR101682496B1 (ko) | 2011-05-20 | 2012-05-18 | 혈관형성 유도인자를 길항하는 융합단백질 및 그 용도 |
BR112013022279-4A BR112013022279B1 (pt) | 2011-05-20 | 2012-05-18 | Proteína de fusão para antagonizar fatores induzíveis de angionêse e utilizações da mesma |
KR1020137023243A KR20130125809A (ko) | 2011-05-20 | 2012-05-18 | 혈관형성 유도인자를 길항하는 융합단백질 및 그 용도 |
CA2831161A CA2831161C (en) | 2011-05-20 | 2012-05-18 | Fusion protein for antagonizing angiogenesis inducible factors and uses thereof |
US13/842,667 US9522949B2 (en) | 2011-05-20 | 2013-03-15 | Fusion protein for antagonizing angiogenesis inducible factors and uses thereof |
JP2016038503A JP6328164B2 (ja) | 2011-05-20 | 2016-03-01 | 血管新生誘導因子に拮抗する融合蛋白質およびその使用 |
Applications Claiming Priority (1)
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---|---|---|---|
CN201110131029A CN102219859B (zh) | 2011-05-20 | 2011-05-20 | 拮抗血管新生诱导因子的融合蛋白及其用途 |
Publications (2)
Publication Number | Publication Date |
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CN102219859A CN102219859A (zh) | 2011-10-19 |
CN102219859B true CN102219859B (zh) | 2012-09-12 |
Family
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Family Applications (1)
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CN201110131029A Active CN102219859B (zh) | 2011-05-20 | 2011-05-20 | 拮抗血管新生诱导因子的融合蛋白及其用途 |
Country Status (10)
Country | Link |
---|---|
US (1) | US9522949B2 (zh) |
EP (1) | EP2711377B1 (zh) |
JP (2) | JP2014513940A (zh) |
KR (2) | KR20130125809A (zh) |
CN (1) | CN102219859B (zh) |
AU (1) | AU2012261410B2 (zh) |
BR (1) | BR112013022279B1 (zh) |
CA (1) | CA2831161C (zh) |
RU (1) | RU2560589C2 (zh) |
WO (1) | WO2012159548A1 (zh) |
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CN102219859B (zh) * | 2011-05-20 | 2012-09-12 | 烟台荣昌生物工程有限公司 | 拮抗血管新生诱导因子的融合蛋白及其用途 |
CN102219860B (zh) * | 2011-05-20 | 2012-09-12 | 烟台荣昌生物工程有限公司 | FGFR-Fc融合蛋白及其用途 |
CA2857168C (en) * | 2011-12-01 | 2020-10-27 | Protevobio, Inc. | Protein inhibitors to complement and vegf pathways and methods of use thereof |
HUE060464T2 (hu) * | 2013-03-13 | 2023-03-28 | Genzyme Corp | PDGF- és VEGF-kötõrészeket tartalmazó fúziós fehérjék és eljárások azok alkalmazására |
US9957313B2 (en) | 2013-03-15 | 2018-05-01 | Remegen, Ltd. | FGFR-FC fusion proteins and the use thereof |
CN105026433B (zh) * | 2014-01-24 | 2018-10-19 | 上海恒瑞医药有限公司 | VEGF与PDGFRβ双特异性融合蛋白及其用途 |
CN105983093A (zh) * | 2015-02-11 | 2016-10-05 | 烟台荣昌生物工程有限公司 | 血管新生因子融合蛋白在制备用于治疗与血管新生相关的眼部疾病药物中的应用 |
CN106084062B (zh) * | 2015-04-28 | 2021-04-02 | 荣昌生物制药(烟台)有限公司 | 桥连的双特异性融合蛋白 |
CA3005391A1 (en) * | 2015-11-19 | 2017-05-26 | Zhuhai Tairuishang Biopharm Ltd. | Methods and compositions for binding vegf |
WO2018145048A1 (en) * | 2017-02-06 | 2018-08-09 | Academia Sinica | Recombinant proteins and uses thereof |
BR112020012336A2 (pt) * | 2017-12-19 | 2021-03-30 | Akouos, Inc. | Administração de anticorpos terapêuticos mediada por aav para o ouvido interno |
BR112021003275A2 (pt) | 2018-12-07 | 2021-06-22 | Remegen Co., Ltd. | inibidor de angiogênese bifuncional e uso do mesmo |
CN112206309A (zh) * | 2019-07-11 | 2021-01-12 | 滨州医学院 | 双靶点血管抑制剂在制备预防或治疗纤维化药物中的用途 |
CN110423281B (zh) * | 2019-07-31 | 2021-04-30 | 成都金唯科生物科技有限公司 | 用于治疗老年性黄斑变性的融合蛋白、病毒载体和药物 |
CN110627905B (zh) * | 2019-09-18 | 2021-04-27 | 中国医学科学院肿瘤医院 | 靶向vegf与egfr的双功能融合蛋白及其应用 |
CN113046390B (zh) * | 2020-03-09 | 2024-01-09 | 百奥赛图江苏基因生物技术有限公司 | Csf1r基因人源化的非人动物及其构建方法和应用 |
CN115850441B (zh) * | 2022-11-22 | 2023-10-24 | 无锡市人民医院 | 一种特异性靶向降解egfr及其突变体的重组蛋白、制备方法及其应用 |
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2012
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- 2012-05-18 JP JP2014505501A patent/JP2014513940A/ja active Pending
- 2012-05-18 KR KR1020137023243A patent/KR20130125809A/ko active Application Filing
- 2012-05-18 EP EP12789790.8A patent/EP2711377B1/en active Active
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CN101679988A (zh) * | 2007-02-27 | 2010-03-24 | 金克赛尔森株式会社 | 结合生长因子的融合蛋白 |
Also Published As
Publication number | Publication date |
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RU2013140472A (ru) | 2015-03-10 |
CA2831161A1 (en) | 2012-11-29 |
EP2711377A4 (en) | 2014-12-31 |
RU2560589C2 (ru) | 2015-08-20 |
EP2711377A1 (en) | 2014-03-26 |
JP6328164B2 (ja) | 2018-05-23 |
CN102219859A (zh) | 2011-10-19 |
WO2012159548A1 (zh) | 2012-11-29 |
US9522949B2 (en) | 2016-12-20 |
AU2012261410B2 (en) | 2016-03-03 |
BR112013022279A2 (pt) | 2016-12-06 |
AU2012261410A1 (en) | 2013-10-17 |
JP2016106128A (ja) | 2016-06-16 |
JP2014513940A (ja) | 2014-06-19 |
CA2831161C (en) | 2017-09-12 |
KR20160011240A (ko) | 2016-01-29 |
BR112013022279B1 (pt) | 2020-12-15 |
KR20130125809A (ko) | 2013-11-19 |
EP2711377B1 (en) | 2017-10-18 |
US20130190235A1 (en) | 2013-07-25 |
KR101682496B1 (ko) | 2016-12-12 |
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