UA117807C2 - ІМУНОКОН'ЮГАТ, ЩО МІСТИТЬ РЕКОМБІНАНТНЕ АНТИТІЛО ДО РЕЦЕПТОРА ЕПІДЕРМАЛЬНОГО ФАКТОРА РОСТУ ЛЮДИНИ (hEGFR), ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЯКА ЙОГО МІСТИТЬ - Google Patents
ІМУНОКОН'ЮГАТ, ЩО МІСТИТЬ РЕКОМБІНАНТНЕ АНТИТІЛО ДО РЕЦЕПТОРА ЕПІДЕРМАЛЬНОГО ФАКТОРА РОСТУ ЛЮДИНИ (hEGFR), ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЯКА ЙОГО МІСТИТЬInfo
- Publication number
- UA117807C2 UA117807C2 UAA201407733A UAA201407733A UA117807C2 UA 117807 C2 UA117807 C2 UA 117807C2 UA A201407733 A UAA201407733 A UA A201407733A UA A201407733 A UAA201407733 A UA A201407733A UA 117807 C2 UA117807 C2 UA 117807C2
- Authority
- UA
- Ukraine
- Prior art keywords
- hegfr
- growth factor
- factor receptor
- epidermal growth
- pharmacostatic
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 3
- 102000001301 EGF receptor Human genes 0.000 title 1
- 108060006698 EGF receptor Proteins 0.000 title 1
- 238000009264 composting Methods 0.000 title 1
- 101000851181 Homo sapiens Epidermal growth factor receptor Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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- C—CHEMISTRY; METALLURGY
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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Abstract
Винахід стосується імунокон’югата, що містить рекомбінантне антитіло до рецептора епідермального фактора росту людини (hEGFR), яке ковалентно приєднане до цитотоксичного агента, де антитіло являє собою антитіло IgGl, що проявляє одну афінність зв'язування з hEGFR. Винахід також стосується фармацевтичної композиції, яка містить ефективну кількість імунокон'югата, та cпособу лікування раку.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/388,504 US20100056762A1 (en) | 2001-05-11 | 2009-02-18 | Specific binding proteins and uses thereof |
UAA201111099A UA106607C2 (uk) | 2009-02-18 | 2010-02-17 | Білки специфічного зв'язування і їх застосування |
Publications (1)
Publication Number | Publication Date |
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UA117807C2 true UA117807C2 (uk) | 2018-10-10 |
Family
ID=42077108
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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UAA201407733A UA117807C2 (uk) | 2009-02-18 | 2010-02-17 | ІМУНОКОН'ЮГАТ, ЩО МІСТИТЬ РЕКОМБІНАНТНЕ АНТИТІЛО ДО РЕЦЕПТОРА ЕПІДЕРМАЛЬНОГО ФАКТОРА РОСТУ ЛЮДИНИ (hEGFR), ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЯКА ЙОГО МІСТИТЬ |
UAA201111099A UA106607C2 (uk) | 2009-02-18 | 2010-02-17 | Білки специфічного зв'язування і їх застосування |
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UAA201111099A UA106607C2 (uk) | 2009-02-18 | 2010-02-17 | Білки специфічного зв'язування і їх застосування |
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US (6) | US20100056762A1 (uk) |
EP (3) | EP2913344B1 (uk) |
JP (6) | JP5859314B2 (uk) |
KR (7) | KR101579769B1 (uk) |
CN (3) | CN105399829A (uk) |
AU (4) | AU2010216168B2 (uk) |
BR (1) | BRPI1012340B1 (uk) |
CA (1) | CA2752584C (uk) |
CL (2) | CL2011002003A1 (uk) |
CO (1) | CO6420350A2 (uk) |
CY (2) | CY1124849T1 (uk) |
DK (2) | DK2913344T3 (uk) |
DO (1) | DOP2020000032A (uk) |
EC (1) | ECSP11011335A (uk) |
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HK (3) | HK1206752A1 (uk) |
HR (2) | HRP20150656T1 (uk) |
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PL (2) | PL2913344T3 (uk) |
PT (2) | PT2398828E (uk) |
RU (3) | RU2673724C2 (uk) |
SG (3) | SG10201801945TA (uk) |
SI (2) | SI2398828T1 (uk) |
UA (2) | UA117807C2 (uk) |
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DK2163256T3 (en) | 2001-05-11 | 2015-12-07 | Ludwig Inst For Cancer Res Ltd | Specific binding proteins and use thereof |
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