PE20081238A1 - Piperidinas sustituidas como antagonistas de hdm2 - Google Patents

Piperidinas sustituidas como antagonistas de hdm2

Info

Publication number
PE20081238A1
PE20081238A1 PE2007000844A PE2007000844A PE20081238A1 PE 20081238 A1 PE20081238 A1 PE 20081238A1 PE 2007000844 A PE2007000844 A PE 2007000844A PE 2007000844 A PE2007000844 A PE 2007000844A PE 20081238 A1 PE20081238 A1 PE 20081238A1
Authority
PE
Peru
Prior art keywords
trifluoromethyl
carbonyl
heteroaryl
substituted
cyclyl
Prior art date
Application number
PE2007000844A
Other languages
English (en)
Inventor
Yao Ma
Brian Robert Lahue
Gerald W Shipps Jr
Yaolin Wang
Stephane L Bogen
Matthew E Voss
Latha G Nair
Yuan Tian
Ronald J Doll
Zhuyan Guo
Corey O Strickland
Rumin Zhang
Mark A Mccoy
Weidong Pan
Elise M Siegel
Craig R Gibeau
Original Assignee
Schering Corp
Albany Molecular Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Albany Molecular Res Inc filed Critical Schering Corp
Publication of PE20081238A1 publication Critical patent/PE20081238A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A COMPUESTOS PIPERIDINAS SUSTITUIDAS DE FORMULA (I), EN DONDE R1 ES HETEROCICLICO, HETEROCICLENILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON Z; A ES O, CR8R9, S, SO2, NR10 O CO; m ES 0-2; R2 ES ARILO, HETEROARILO, CICLILO, ENTRE OTROS; R3 ES ARILO, HETEROARILO, CICLILO, HETEROCICLILO, ENTRE OTROS; R4 O R4' SON INDEPENDIENTEMENTE H, ALQUILO, ALQUENILO, ENTRE OTROS O JUNTOS PUEDEN FORMAR UN ESPIROCICLILO, ESPIROHETEROCICLILO; R5, R5', R7 Y R7' SON INDEPENDIENTEMENTE H, ALQUILO, ALQUENILO, ENTRE OTROS; R6 O R6' SON NDEPENDIENTEMENTE, H, ALQUILO, ALQUENILO, ENTRE OTROS. SON SELECCIONADOS: (1,3,4,9-TETRAHIDRO-b-CARBONIL-2-IL)-[3-(4-TRIFLUOROMETIL-FENOXI)-1-(4-TRIFLUOROMETIL-PIRIDIN-3-CARBONIL)-PIPERIDIN-3-IL]-METANONA, [4-(2-METOXI-FENIL)-PIPERAZINI-1-IL]-[3-(4-TRIFLUOROMETIL-PIRIDIN-3-CARBONIL)-PIPERIDIN-3-IL]-METANONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA HDM2 O MDM2 (DOUBLE MINUTE 2 HUMANA), SIENDO UTILES EN EL TRATAMIENTO DE CANCER, ENFEREMEDADES QUE IMPLICAN PROLIFERACION CELULAR ANORMAL O CAUSADAS POR NIVELES DE P53 INADECUADOS
PE2007000844A 2006-06-30 2007-07-02 Piperidinas sustituidas como antagonistas de hdm2 PE20081238A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81775306P 2006-06-30 2006-06-30

Publications (1)

Publication Number Publication Date
PE20081238A1 true PE20081238A1 (es) 2008-09-04

Family

ID=38656615

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000844A PE20081238A1 (es) 2006-06-30 2007-07-02 Piperidinas sustituidas como antagonistas de hdm2

Country Status (17)

Country Link
US (1) US7884107B2 (es)
EP (1) EP2035416A1 (es)
JP (1) JP2009542666A (es)
KR (1) KR20090042779A (es)
CN (1) CN101595107A (es)
AR (1) AR061726A1 (es)
AU (1) AU2007269836A1 (es)
BR (1) BRPI0713119A2 (es)
CA (1) CA2656398A1 (es)
CO (1) CO6150158A2 (es)
IL (1) IL196152A0 (es)
MX (1) MX2009000285A (es)
NO (1) NO20090469L (es)
PE (1) PE20081238A1 (es)
TW (1) TW200808781A (es)
WO (1) WO2008005268A1 (es)
ZA (1) ZA200900204B (es)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546404B2 (en) * 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
US7807672B2 (en) * 2006-02-16 2010-10-05 Schering Corporation Compounds that are ERK inhibitors
CA2656393A1 (en) * 2006-06-30 2008-01-10 Schering Corporation Method of using substituted piperidines that increase p53 activity
US20080051380A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US20080051375A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
JP5649825B2 (ja) * 2007-01-31 2015-01-07 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 安定化させたｐ５３ペプチドおよびその使用法
KR101525754B1 (ko) 2007-03-28 2015-06-09 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
CA2690809A1 (en) 2007-06-15 2008-12-24 Microphage Incorporated Method of detection of microorganisms with enhanced bacteriophage amplification
WO2009009132A1 (en) * 2007-07-12 2009-01-15 Cougar Biotechnology, Inc. Use of 17alpha-hydroxylase/c17, 20-lyase inhibitors for the treatment of cancer
JP5562865B2 (ja) 2007-12-17 2014-07-30 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｔｒｐｖ１のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター
ES2556353T3 (es) * 2008-02-21 2016-01-15 Merck Sharp & Dohme Corp. Compuestos que son inhibidores de las ERK
EP3409762A1 (en) 2008-03-17 2018-12-05 The Scripps Research Institute Combined chemical and genetic approaches for generation of induced pluripotent stem cells
TW201011009A (en) * 2008-09-15 2010-03-16 Priaxon Ag Novel pyrrolidin-2-ones
RU2506257C2 (ru) * 2008-09-18 2014-02-10 Ф.Хоффманн-Ля Рош Аг Замещенные пирролидин-2-карбоксамиды
US8354444B2 (en) * 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
CN102317442B (zh) 2008-12-17 2014-08-13 斯克里普斯研究所 干细胞的产生和保持
US7928233B2 (en) 2009-02-10 2011-04-19 Hoffmann-La Roche Inc. Spiroindolinone pyridine derivatives
US8217051B2 (en) 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
US8017607B2 (en) 2009-10-14 2011-09-13 Hoffmann-La Roche Inc. N-substituted-pyrrolidines as inhibitors of MDM2-P-53 interactions
CN104945382B (zh) * 2009-10-14 2020-02-07 默沙东公司 提高p53活性的取代的哌啶和其用途
CN102741394B (zh) 2009-10-16 2016-05-04 斯克里普斯研究所 多能细胞的诱导
US8088815B2 (en) 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8288431B2 (en) 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
WO2011123572A1 (en) 2010-03-31 2011-10-06 The Scripps Research Institute Reprogramming cells
US8217044B2 (en) 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines
JO2998B1 (ar) * 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
CN103003416B (zh) 2010-06-15 2016-11-16 细胞动力学国际有限公司 从小体积的外周血产生诱导性多潜能干细胞
EP2601289B1 (en) 2010-08-04 2017-07-12 Cellular Dynamics International, Inc. Reprogramming immortalized b cells
CN108570097A (zh) 2010-08-13 2018-09-25 爱勒让治疗公司 拟肽大环化合物
FR2967072B1 (fr) 2010-11-05 2013-03-29 Univ Dundee Procede pour ameliorer la production de virus et semences vaccinales influenza
MX2013006739A (es) * 2010-12-16 2013-07-17 Roche Glycart Ag Terapia combinada de anticuerpo cd20 afucosilado con inhibidor de mdm2.
US9732319B2 (en) 2010-12-22 2017-08-15 Fate Therapeutics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
WO2012172555A1 (en) 2011-06-14 2012-12-20 Yeda Research And Development Co. Ltd. Combination therapy to prevent dcis formation and progression to breast cancer
CA2841165A1 (en) 2011-07-11 2013-01-17 Cellular Dynamics International, Inc. Methods for cell reprogramming and genome engineering
JP6093770B2 (ja) 2011-09-27 2017-03-08 アムジエン・インコーポレーテツド 癌の治療のためのｍｄｍ２阻害剤としての複素環化合物
MX358886B (es) 2011-10-18 2018-08-31 Aileron Therapeutics Inc Macrociclos peptidomimeticos.
WO2013062923A1 (en) * 2011-10-28 2013-05-02 Merck Sharp & Dohme Corp. MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF
US9062071B2 (en) 2011-12-21 2015-06-23 Merck Sharp & Dohme Corp. Substituted piperidines as HDM2 inhibitors
SG11201404648PA (en) * 2012-02-15 2014-09-26 Aileron Therapeutics Inc Peptidomimetic macrocycles
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US20130245089A1 (en) * 2012-03-19 2013-09-19 Hoffmann-La Roche Inc. Method for administration
CN102690826B (zh) * 2012-04-19 2014-03-05 山西医科大学 一种特异性降低人Aurora-A基因表达的shRNA及其应用
WO2014024993A1 (ja) * 2012-08-09 2014-02-13 国立大学法人京都大学 ピぺラジン誘導体およびその用途
US9603844B2 (en) * 2012-10-22 2017-03-28 Georgetown University Compositions and methods for treating mammary tumors
EP2914256B1 (en) 2012-11-01 2019-07-31 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CA2895504A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
EP2961735B1 (en) 2013-02-28 2017-09-27 Amgen Inc. A benzoic acid derivative mdm2 inhibitor for the treatment of cancer
AU2014236812B2 (en) 2013-03-14 2018-03-01 Amgen Inc. Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
PT3013833T (pt) * 2013-06-26 2019-03-20 Univ Do Porto Oxazoloisoindolinonas derivadas de triptofanol: ativadoras de molécula pequena da p53
PT3114214T (pt) 2014-03-04 2024-01-03 Fate Therapeutics Inc Métodos de reprogramação melhorados e plataformas de cultura celular
WO2016001376A1 (en) 2014-07-03 2016-01-07 Boehringer Ingelheim International Gmbh New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
JP2017533889A (ja) 2014-09-24 2017-11-16 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
CN112972378A (zh) 2014-09-24 2021-06-18 艾瑞朗医疗公司 拟肽大环化合物及其制剂
CN105597090B (zh) * 2014-11-14 2022-08-23 中国科学院上海营养与健康研究所 一种提高cd4阳性t淋巴细胞存活率和活性的试剂及其应用
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
AU2016221305B2 (en) 2015-02-18 2021-05-27 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
EP3294318A4 (en) 2015-03-20 2019-04-03 Aileron Therapeutics, Inc. PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
ES2863500T3 (es) 2015-04-10 2021-10-11 Capsugel Belgium Nv Formulaciones lipídicas de acetato de abiraterona
JP6803339B2 (ja) 2015-04-21 2020-12-23 エンリヴェックス セラピューティクス リミテッド 治療用のプールされた血液アポトーシス細胞調製物及びそれらの使用
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
WO2017060431A1 (en) 2015-10-09 2017-04-13 Boehringer Ingelheim International Gmbh Spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
JP7263005B2 (ja) 2015-10-16 2023-04-24 フェイト セラピューティクス，インコーポレイテッド 基底状態の多能性の誘導及び維持に関するプラットフォーム
AU2016343682A1 (en) 2015-10-30 2018-06-14 The Regents Of The University Of California Methods of generating T-cells from stem cells and immunotherapeutic methods using the T-cells
JP6884155B2 (ja) 2016-02-18 2021-06-09 エンリヴェックス セラピューティクス リミテッド 癌治療のための併用免疫療法及びサイトカイン制御療法
UA124972C2 (uk) 2016-07-29 2021-12-22 Янссен Фармацевтика Нв Способи лікування раку передміхурової залози
WO2018055527A1 (en) 2016-09-20 2018-03-29 Glaxosmithkline Intellectual Property (No.2) Limited Trpv4 antagonists
TW201825458A (zh) 2016-09-20 2018-07-16 英商葛蘭素史克智慧財產（第二）有限公司 Ｔｒｐｖ４拮抗劑
KR20190049865A (ko) 2016-09-20 2019-05-09 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Trpv4 길항제
WO2018185135A1 (en) 2017-04-05 2018-10-11 Boehringer Ingelheim International Gmbh Anticancer combination therapy
WO2019134070A1 (en) * 2018-01-02 2019-07-11 Rui Jin Hospital, Shanghai Jiao Tong University School Of Medicine Panda as novel therapeutic
CN108864113B (zh) * 2018-08-03 2021-08-13 南方科技大学 一种mdm2-hdac双靶点抑制剂、药物组合物及其制备和用途
CN109293630A (zh) * 2018-11-15 2019-02-01 山东大学 含取代吡唑类化合物及其制备方法与应用
CN110643557B (zh) * 2019-04-23 2021-12-31 天津科技大学 一种基因工程菌的构建及其在高效催化5α-雄烯二酮生产中的应用
CN113633642A (zh) * 2021-08-26 2021-11-12 山东第一医科大学附属青岛眼科医院(山东省眼科研究所、青岛眼科医院) Abt-263在制备抑制角膜移植免疫排斥反应的药物中的应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09249566A (ja) 1996-03-19 1997-09-22 Takeda Chem Ind Ltd ピペリジン化合物含有ケモカイン受容体拮抗剤
WO1998016527A1 (en) * 1996-10-15 1998-04-23 Fujisawa Pharmaceutical Co., Ltd. Benzoxepine derivatives which promote release of growth hormone
WO1998051687A1 (en) * 1997-05-14 1998-11-19 Fujisawa Pharmaceutical Co., Ltd. Piperidino derivatives which promote growth hormone release
EP0947494A1 (en) 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Derivatives of phenoxy acetic acid and phenoxymethyltetrazole having antitumor activity
SI1077941T1 (sl) * 1998-05-11 2010-01-29 Novo Nordisk As Spojine, ki imajo lastnost sproščanja rastnega hormona
GB9819860D0 (en) 1998-09-12 1998-11-04 Zeneca Ltd Chemical compounds
AR035312A1 (es) * 1999-01-27 2004-05-12 Wyeth Corp Compuestos de acido hidroxamico que contienen alquinilo como inhibidores de metaloproteinasa de matriz/tace, composicion farmaceutica que los comprenden y el uso de los mismos para la manufactura de un medicamento
UA73530C2 (uk) * 1999-11-10 2005-08-15 Ново Нордіск А/С Сполука з властивостями вивільнювати гормон росту
EP2301930B1 (en) * 2000-06-15 2016-01-06 Merck Sharp & Dohme Corp. Derivatives of hexahydrobenzofuranone useful for the treatment of (inter alia) auto-immune or inflammatory disorders
US6403584B1 (en) 2000-06-22 2002-06-11 Merck & Co., Inc. Substituted nipecotyl derivatives as inhibitors of cell adhesion
US20020099035A1 (en) * 2001-01-24 2002-07-25 Sandanayaka Vincent P. Method for preparing alpha-sulfonyl hydroxamic acid derivatives
ES2301717T3 (es) 2001-12-18 2008-07-01 F. Hoffmann-La Roche Ag Cis-2,4,5-trifenil-imidazolinas y su utilizacion para el tratamiento de tumores.
CN1182113C (zh) * 2002-07-19 2004-12-29 中国科学院上海有机化学研究所 2，5－cis－二取代的吡咯烷衍生物、合成方法及其用途
US6916833B2 (en) 2003-03-13 2005-07-12 Hoffmann-La Roche Inc. Substituted piperidines
US7632920B2 (en) * 2003-04-10 2009-12-15 Schering Corporation Soluble, stable form of HDM2, crystalline forms thereof and methods of use thereof
US7132421B2 (en) 2003-06-17 2006-11-07 Hoffmann-La Roche Inc. CIS-imidazoles
US7425638B2 (en) 2003-06-17 2008-09-16 Hoffmann-La Roche Inc. Cis-imidazolines
JP4814228B2 (ja) 2004-05-18 2011-11-16 エフ．ホフマン−ラ ロシュ アーゲー 新規ｃｉｓ−イミダゾリン
PL1966151T3 (pl) 2005-12-13 2012-02-29 Merck Sharp & Dohme Policykliczne pochodne indazoli jako inhibitory ERK

Also Published As

Publication number Publication date
AR061726A1 (es) 2008-09-17
MX2009000285A (es) 2009-06-08
KR20090042779A (ko) 2009-04-30
EP2035416A1 (en) 2009-03-18
AU2007269836A1 (en) 2008-01-10
CA2656398A1 (en) 2008-01-10
CO6150158A2 (es) 2010-04-20
IL196152A0 (en) 2009-09-22
JP2009542666A (ja) 2009-12-03
NO20090469L (no) 2009-03-27
CN101595107A (zh) 2009-12-02
WO2008005268A1 (en) 2008-01-10
US7884107B2 (en) 2011-02-08
ZA200900204B (en) 2010-01-27
TW200808781A (en) 2008-02-16
BRPI0713119A2 (pt) 2012-04-17
US20080004287A1 (en) 2008-01-03

Similar Documents

Publication Publication Date Title
PE20081238A1 (es) Piperidinas sustituidas como antagonistas de hdm2
PE20090952A1 (es) Compuestos de pirazol moduladores de raf
PE20120693A1 (es) Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2)
PE20080951A1 (es) DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS
PE20110328A1 (es) Compuestos heterociclicos fusionados como moduladores del receptor de la orexina
PE20090482A1 (es) Derivados heterociclicos como antagonistas del receptor ccr2
PE20080404A1 (es) Derivados bencil-amino-piperidina como inhibidores de cetp
EA200601849A1 (ru) 4-фениламинохиназолин-6-ил-амиды
PE20080344A1 (es) Compuestos 8-azabiciclo[3.2.1]oct-8-il-1,2,3,4-tetrahidroquinolina sustituidos como inhibidores 11b-hsd1
PE20080677A1 (es) Inhibidores de pirrolotriazina cinaza
PE20081845A1 (es) Nuevos derivados de aminopirimidina como inhibidores de plk1
PE20061436A1 (es) Derivados de amida sustituida como inhibidores de proteina quinasa
PE20070491A1 (es) Compuestos derivados de 9-azabiciclo[3.3.1]nonano como inhibidores de la recaptacion de neurotransmisores de monoamina
PE20070833A1 (es) Compuestos de pirimidinil benzotiofeno
PE20070490A1 (es) Compuestos derivados de bencimidazol-2-ona sustituidos con piperidina como agonistas del receptor muscarinico m1
PE20090816A1 (es) Derivados de pirrolopirimidinona como agentes ligandos de los receptores p2x3
PE20080925A1 (es) DERIVADOS DE PIRROLO[2,3-b]PIRIDINA COMO INHIBIDORES DE QUINASA, EN PARTICULAR INHIBIDORES IKK2 (O IKK BETA)
PE20091090A1 (es) Derivados de piperidina como agonistas de receptores muscarinicos
PE20091724A1 (es) Derivados de indol como moduladores del receptor nicotinico de acetilcolina alfa 7
PE20121172A1 (es) Piperidinas sustituidas con actividad en la hdm2
PE20061096A1 (es) Derivados de oxiindol como agonistas 5-ht4
PE20120031A1 (es) Compuestos aril metil benzoquinazolinona como moduladores alostericos positivos del receptor m1
PE20071177A1 (es) Derivados de 3,5-piridina como inhibidores de renina
PE20080275A1 (es) Derivados de 5h-benzo[4,5]ciclohepta[1,2]piridina como inhibidores de tirosina quinasa
DE602005021150D1 (de) 3-substituierte pyridinderivate als h3-antagonisten

Legal Events

Date Code Title Description
FC Refusal