NO20090469L - Substituerte piperidiner som oker P53-aktiviteten, og anvendelse derav - Google Patents
Substituerte piperidiner som oker P53-aktiviteten, og anvendelse deravInfo
- Publication number
- NO20090469L NO20090469L NO20090469A NO20090469A NO20090469L NO 20090469 L NO20090469 L NO 20090469L NO 20090469 A NO20090469 A NO 20090469A NO 20090469 A NO20090469 A NO 20090469A NO 20090469 L NO20090469 L NO 20090469L
- Authority
- NO
- Norway
- Prior art keywords
- activity
- increase
- compounds
- substituted piperidines
- hdm2 protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
Det beskrives forbindelser som er inhibitorer av HDM2-protein, fremgangsmåter for å fremstille slike forbindelser, farmasøytiske preparater som innbefatter én eller flere slike forbindelser, anvendelse ved behandling, forebyggelse eller inhibering av én eller flere sykdommer forbundet med HDM2-protein eller P53, ved å anvende slike forbindelser eller farmasøytiske preparater.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81775306P | 2006-06-30 | 2006-06-30 | |
PCT/US2007/014958 WO2008005268A1 (en) | 2006-06-30 | 2007-06-27 | Substituted piperidines that increase p53 activity and the uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20090469L true NO20090469L (no) | 2009-03-27 |
Family
ID=38656615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20090469A NO20090469L (no) | 2006-06-30 | 2009-01-29 | Substituerte piperidiner som oker P53-aktiviteten, og anvendelse derav |
Country Status (17)
Country | Link |
---|---|
US (1) | US7884107B2 (no) |
EP (1) | EP2035416A1 (no) |
JP (1) | JP2009542666A (no) |
KR (1) | KR20090042779A (no) |
CN (1) | CN101595107A (no) |
AR (1) | AR061726A1 (no) |
AU (1) | AU2007269836A1 (no) |
BR (1) | BRPI0713119A2 (no) |
CA (1) | CA2656398A1 (no) |
CO (1) | CO6150158A2 (no) |
IL (1) | IL196152A0 (no) |
MX (1) | MX2009000285A (no) |
NO (1) | NO20090469L (no) |
PE (1) | PE20081238A1 (no) |
TW (1) | TW200808781A (no) |
WO (1) | WO2008005268A1 (no) |
ZA (1) | ZA200900204B (no) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8546404B2 (en) * | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
US7807672B2 (en) * | 2006-02-16 | 2010-10-05 | Schering Corporation | Compounds that are ERK inhibitors |
CN101511361A (zh) * | 2006-06-30 | 2009-08-19 | 先灵公司 | 使用增强p53活性的取代哌啶的方法 |
US20080051380A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
CA2677045C (en) * | 2007-01-31 | 2016-10-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
KR101623985B1 (ko) | 2007-03-28 | 2016-05-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
US8455186B2 (en) | 2007-06-15 | 2013-06-04 | MicroPhage™ Incorporated | Method of detection of microorganisms with enhanced bacteriophage amplification |
US20090124587A1 (en) * | 2007-07-12 | 2009-05-14 | Auerbach Alan H | METHODS FOR TREATING CANCER USING 17alpha-HYDROXYLASE/C17,20-LYASE INHIBITORS |
PE20091102A1 (es) | 2007-12-17 | 2009-07-25 | Janssen Pharmaceutica Nv | Moduladores imidazolo-, oxazolo-, y tiazolopirimidina del trpv1 |
MY152271A (en) * | 2008-02-21 | 2014-09-15 | Merck Sharp & Dohme | Novel compounds that are erk inhibitors |
JP5951254B2 (ja) | 2008-03-17 | 2016-07-13 | ザ スクリプス リサーチ インスティテュート | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
TW201011009A (en) * | 2008-09-15 | 2010-03-16 | Priaxon Ag | Novel pyrrolidin-2-ones |
CN102159207B (zh) * | 2008-09-18 | 2015-02-04 | 霍夫曼-拉罗奇有限公司 | 取代的吡咯烷-2-甲酰胺类 |
US8354444B2 (en) | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
SG172160A1 (en) | 2008-12-17 | 2011-07-28 | Scripps Research Inst | Generation and maintenance of stem cells |
US7928233B2 (en) | 2009-02-10 | 2011-04-19 | Hoffmann-La Roche Inc. | Spiroindolinone pyridine derivatives |
US8217051B2 (en) | 2009-02-17 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
US8076482B2 (en) | 2009-04-23 | 2011-12-13 | Hoffmann-La Roche Inc. | 3,3′-spiroindolinone derivatives |
NZ599343A (en) * | 2009-10-14 | 2014-05-30 | Merck Sharp & Dohme | Substituted piperidines that increase p53 activity and the uses thereof |
US8017607B2 (en) | 2009-10-14 | 2011-09-13 | Hoffmann-La Roche Inc. | N-substituted-pyrrolidines as inhibitors of MDM2-P-53 interactions |
EP4206319A1 (en) | 2009-10-16 | 2023-07-05 | The Scripps Research Institute | Induction of pluripotent cells |
US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
US8288431B2 (en) | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
CN105176930B (zh) | 2010-03-31 | 2021-05-04 | 斯克里普斯研究所 | 重编程细胞 |
US8217044B2 (en) | 2010-04-28 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone pyrrolidines |
JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
AU2011267849B2 (en) | 2010-06-15 | 2015-02-05 | FUJIFILM Cellular Dynamics, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
WO2012018933A2 (en) | 2010-08-04 | 2012-02-09 | Cellular Dynamics International, Inc. | Reprogramming immortalized b cells |
CA2807685C (en) | 2010-08-13 | 2020-10-06 | Aileron Therapeutics, Inc. | P53 derived peptidomimetic macrocycle |
FR2967072B1 (fr) | 2010-11-05 | 2013-03-29 | Univ Dundee | Procede pour ameliorer la production de virus et semences vaccinales influenza |
KR20130088170A (ko) * | 2010-12-16 | 2013-08-07 | 로슈 글리카트 아게 | 비푸코실화 cd20 항체와 mdm2 저해제와의 조합 치료 |
CN103380212B (zh) | 2010-12-22 | 2017-04-05 | 菲特治疗公司 | 用于单细胞分选与增强ipsc重新编程的细胞培养平台 |
EP2720720B1 (en) | 2011-06-14 | 2018-02-28 | Yeda Research and Development Co. Ltd. | Combination therapy to prevent dcis formation and progression to breast cancer |
EP2732029B1 (en) | 2011-07-11 | 2019-01-16 | FUJIFILM Cellular Dynamics, Inc. | Methods for cell reprogramming and genome engineering |
EP2760845B1 (en) | 2011-09-27 | 2016-11-16 | Amgen Inc. | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer |
JP6342808B2 (ja) | 2011-10-18 | 2018-06-13 | エイルロン セラピューティクス,インコーポレイテッド | ペプチドミメティック大環状化合物 |
EP2771008A4 (en) * | 2011-10-28 | 2015-04-08 | Merck Sharp & Dohme | MACROCYCLES INCREASING P53 ACTIVITY AND USES THEREOF |
WO2013096150A1 (en) * | 2011-12-21 | 2013-06-27 | Merck Sharp & Dohme Corp. | Substituted piperidines as hdm2 inhibitors |
CN107216380A (zh) | 2012-02-15 | 2017-09-29 | 爱勒让治疗公司 | 拟肽大环化合物 |
AU2013221433B2 (en) | 2012-02-15 | 2018-01-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
US20130245089A1 (en) * | 2012-03-19 | 2013-09-19 | Hoffmann-La Roche Inc. | Method for administration |
CN102690826B (zh) * | 2012-04-19 | 2014-03-05 | 山西医科大学 | 一种特异性降低人Aurora-A基因表达的shRNA及其应用 |
WO2014024993A1 (ja) * | 2012-08-09 | 2014-02-13 | 国立大学法人京都大学 | ピぺラジン誘導体およびその用途 |
WO2014066330A1 (en) * | 2012-10-22 | 2014-05-01 | Georgetown University | Compositions and methods for treating mammary tumors |
CA2887285A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
CA2895504A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
CN105121407B (zh) | 2013-02-28 | 2017-07-18 | 美国安进公司 | 用于治疗癌症的苯甲酸衍生物mdm2抑制剂 |
JP6377123B2 (ja) | 2013-03-14 | 2018-08-22 | アムジエン・インコーポレーテツド | 癌の治療のためのmdm2阻害剤としてのヘテロアリール酸モルホリノン化合物 |
JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
US9732091B2 (en) | 2013-06-26 | 2017-08-15 | Universidade Do Porto | Tryptophanol-derived oxazoloisoindolinones: small-molecule P53 activators |
WO2015134652A1 (en) | 2014-03-04 | 2015-09-11 | Bahram Valamehr | Improved reprogramming methods and cell culture platforms |
US10576064B2 (en) | 2014-07-03 | 2020-03-03 | Boehringer Ingelheim International Gmbh | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors |
SG11201702175YA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
CN112245565A (zh) | 2014-09-24 | 2021-01-22 | 艾瑞朗医疗公司 | 拟肽大环化合物及其用途 |
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CA2976879A1 (en) | 2015-02-18 | 2016-08-25 | Enlivex Therapeutics Ltd. | Combination immune therapy and cytokine control therapy for cancer treatment |
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US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
WO2016170541A1 (en) | 2015-04-21 | 2016-10-27 | Enlivex Therapeutics Ltd. | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
MX2017011834A (es) | 2015-03-20 | 2018-04-11 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y usos de los mismos. |
EP3824908A1 (en) | 2015-04-10 | 2021-05-26 | Capsugel Belgium NV | Abiraterone acetate lipid formulations |
US10023613B2 (en) | 2015-09-10 | 2018-07-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of MCL-1 |
UA123905C2 (uk) | 2015-10-09 | 2021-06-23 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Спіро[3h-індол-3,2'-піролідин]-2(1h)-онові сполуки та похідні як інгібітори мdm2-p53 |
SG10202111851YA (en) | 2015-10-16 | 2021-12-30 | Fate Therapeutics Inc | Platform for the Induction & Maintenance of Ground State Pluripotency |
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WO2018055527A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
TW201825458A (zh) | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產(第二)有限公司 | Trpv4拮抗劑 |
WO2018055526A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
JP2020516604A (ja) | 2017-04-05 | 2020-06-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗がん併用療法 |
WO2019134070A1 (en) * | 2018-01-02 | 2019-07-11 | Rui Jin Hospital, Shanghai Jiao Tong University School Of Medicine | Panda as novel therapeutic |
CN108864113B (zh) * | 2018-08-03 | 2021-08-13 | 南方科技大学 | 一种mdm2-hdac双靶点抑制剂、药物组合物及其制备和用途 |
CN109293630A (zh) * | 2018-11-15 | 2019-02-01 | 山东大学 | 含取代吡唑类化合物及其制备方法与应用 |
CN110628735B (zh) * | 2019-04-23 | 2022-04-08 | 天津科技大学 | 一种5α-还原酶突变体,基因工程菌及其在高效催化5α-AD生产中的应用 |
CN113633642A (zh) * | 2021-08-26 | 2021-11-12 | 山东第一医科大学附属青岛眼科医院(山东省眼科研究所、青岛眼科医院) | Abt-263在制备抑制角膜移植免疫排斥反应的药物中的应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09249566A (ja) | 1996-03-19 | 1997-09-22 | Takeda Chem Ind Ltd | ピペリジン化合物含有ケモカイン受容体拮抗剤 |
JP2001502319A (ja) * | 1996-10-15 | 2001-02-20 | 藤沢薬品工業株式会社 | 成長ホルモンの放出を促進するベンズオキセピン誘導体 |
WO1998051687A1 (en) * | 1997-05-14 | 1998-11-19 | Fujisawa Pharmaceutical Co., Ltd. | Piperidino derivatives which promote growth hormone release |
EP0947494A1 (en) | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and phenoxymethyltetrazole having antitumor activity |
AU757217B2 (en) * | 1998-05-11 | 2003-02-06 | Helsinn Healthcare Sa | Compounds with growth hormone releasing properties |
GB9819860D0 (en) | 1998-09-12 | 1998-11-04 | Zeneca Ltd | Chemical compounds |
AR035312A1 (es) * | 1999-01-27 | 2004-05-12 | Wyeth Corp | Compuestos de acido hidroxamico que contienen alquinilo como inhibidores de metaloproteinasa de matriz/tace, composicion farmaceutica que los comprenden y el uso de los mismos para la manufactura de un medicamento |
UA73530C2 (uk) * | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
TWI302913B (en) * | 2000-06-15 | 2008-11-11 | Schering Corp | Thrombin receptor antagonists |
US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
US20020099035A1 (en) * | 2001-01-24 | 2002-07-25 | Sandanayaka Vincent P. | Method for preparing alpha-sulfonyl hydroxamic acid derivatives |
ATE389400T1 (de) | 2001-12-18 | 2008-04-15 | Hoffmann La Roche | Cis-2,4,5- triphenyl-imidazoline und ihre verwendung bei der behandlung von tumoren |
CN1182113C (zh) * | 2002-07-19 | 2004-12-29 | 中国科学院上海有机化学研究所 | 2,5-cis-二取代的吡咯烷衍生物、合成方法及其用途 |
US6916833B2 (en) | 2003-03-13 | 2005-07-12 | Hoffmann-La Roche Inc. | Substituted piperidines |
US7632920B2 (en) * | 2003-04-10 | 2009-12-15 | Schering Corporation | Soluble, stable form of HDM2, crystalline forms thereof and methods of use thereof |
US7425638B2 (en) * | 2003-06-17 | 2008-09-16 | Hoffmann-La Roche Inc. | Cis-imidazolines |
US7132421B2 (en) | 2003-06-17 | 2006-11-07 | Hoffmann-La Roche Inc. | CIS-imidazoles |
ES2314660T3 (es) | 2004-05-18 | 2009-03-16 | F. Hoffmann-La Roche Ag | Nuevas cis-imidazolinas. |
PL1966151T3 (pl) | 2005-12-13 | 2012-02-29 | Merck Sharp & Dohme | Policykliczne pochodne indazoli jako inhibitory ERK |
-
2007
- 2007-06-27 KR KR1020097001772A patent/KR20090042779A/ko not_active Application Discontinuation
- 2007-06-27 WO PCT/US2007/014958 patent/WO2008005268A1/en active Application Filing
- 2007-06-27 AU AU2007269836A patent/AU2007269836A1/en not_active Abandoned
- 2007-06-27 US US11/769,030 patent/US7884107B2/en active Active
- 2007-06-27 JP JP2009518257A patent/JP2009542666A/ja active Pending
- 2007-06-27 BR BRPI0713119-4A patent/BRPI0713119A2/pt not_active IP Right Cessation
- 2007-06-27 CA CA002656398A patent/CA2656398A1/en not_active Abandoned
- 2007-06-27 CN CNA2007800306960A patent/CN101595107A/zh active Pending
- 2007-06-27 MX MX2009000285A patent/MX2009000285A/es unknown
- 2007-06-27 EP EP07796521A patent/EP2035416A1/en not_active Withdrawn
- 2007-06-28 AR ARP070102892A patent/AR061726A1/es not_active Application Discontinuation
- 2007-06-29 TW TW096123818A patent/TW200808781A/zh unknown
- 2007-07-02 PE PE2007000844A patent/PE20081238A1/es not_active Application Discontinuation
-
2008
- 2008-12-23 IL IL196152A patent/IL196152A0/en unknown
-
2009
- 2009-01-09 ZA ZA200900204A patent/ZA200900204B/xx unknown
- 2009-01-29 NO NO20090469A patent/NO20090469L/no not_active Application Discontinuation
- 2009-01-30 CO CO09008866A patent/CO6150158A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2009542666A (ja) | 2009-12-03 |
CN101595107A (zh) | 2009-12-02 |
IL196152A0 (en) | 2009-09-22 |
EP2035416A1 (en) | 2009-03-18 |
US7884107B2 (en) | 2011-02-08 |
PE20081238A1 (es) | 2008-09-04 |
US20080004287A1 (en) | 2008-01-03 |
BRPI0713119A2 (pt) | 2012-04-17 |
CO6150158A2 (es) | 2010-04-20 |
AR061726A1 (es) | 2008-09-17 |
ZA200900204B (en) | 2010-01-27 |
WO2008005268A1 (en) | 2008-01-10 |
KR20090042779A (ko) | 2009-04-30 |
TW200808781A (en) | 2008-02-16 |
AU2007269836A1 (en) | 2008-01-10 |
CA2656398A1 (en) | 2008-01-10 |
MX2009000285A (es) | 2009-06-08 |
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