PE20070832A1 - Derivados de piridazinona como inhibidores de la tirosina quinasa - Google Patents

Derivados de piridazinona como inhibidores de la tirosina quinasa

Info

Publication number
PE20070832A1
PE20070832A1 PE2006001553A PE2006001553A PE20070832A1 PE 20070832 A1 PE20070832 A1 PE 20070832A1 PE 2006001553 A PE2006001553 A PE 2006001553A PE 2006001553 A PE2006001553 A PE 2006001553A PE 20070832 A1 PE20070832 A1 PE 20070832A1
Authority
PE
Peru
Prior art keywords
phenyl
atoms
inhibitors
kinase
naphthylus
Prior art date
Application number
PE2006001553A
Other languages
English (en)
Inventor
Dieter Dorsch
Oliver Schadt
Andree Blaukat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PE20070832A1 publication Critical patent/PE20070832A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES Ar1, Het; R2 ES Ar2, Het2; R3 ES H, A; A ES ALQUILO NO RAMIFICADO O RAMIFICADO QUE TIENE 1-10 ATOMOS DE C, EN DONE 1-7 ATOMOS DE H PUEDEN ESTAR REEMPLAZADOS POR F, Cl, ENTRE OTROS; Ar1 ES FENILO, NAFTILO, BIFENILO, ENTRE OTROS; Ar2 ES FENILO, NAFTILO, BIFENILO, ENTRE OTROS; Het Y Het2 SON CADA UNO HETEROCICLO SATURADO, INSATURADO O AROMATICO MONO-, BI- O TRICICLICO QUE TIENE 1-4 ATOMOS DE N, O, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-ETIL-3-{3-[3-(3-HIDROXIFENIL)-6-OXO-6H-PIRIDAZIN-1-ILMETIL]FENIL}UREA; 1-(3-{3-[3-(2-DIMETILAMINOETOXI)FENIL]-6-OXO-6H-PIRAZIDIN-1-ILMETIL}FENIL)-3-ETILUREA, CLORHIDRATO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS ACTUAN COMO INHIBIDORES DE LAS TIROSINA QUINASAS EN ESPECIAL LA MET-QUINASA, UTILES PAR EL TRATAMIENTO DE TUMORES
PE2006001553A 2005-12-05 2006-12-05 Derivados de piridazinona como inhibidores de la tirosina quinasa PE20070832A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005057924A DE102005057924A1 (de) 2005-12-05 2005-12-05 Pyridazinonderivate

Publications (1)

Publication Number Publication Date
PE20070832A1 true PE20070832A1 (es) 2007-08-27

Family

ID=37775213

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001553A PE20070832A1 (es) 2005-12-05 2006-12-05 Derivados de piridazinona como inhibidores de la tirosina quinasa

Country Status (28)

Country Link
US (1) US8173653B2 (es)
EP (1) EP1960370B1 (es)
JP (1) JP5210172B2 (es)
KR (1) KR101367447B1 (es)
CN (1) CN101326167B (es)
AR (1) AR057214A1 (es)
AT (1) ATE527241T1 (es)
AU (1) AU2006322364B2 (es)
BR (1) BRPI0619407A2 (es)
CA (1) CA2632217C (es)
CY (1) CY1112206T1 (es)
DE (1) DE102005057924A1 (es)
DK (1) DK1960370T3 (es)
EA (1) EA014667B1 (es)
EC (1) ECSP088598A (es)
ES (1) ES2373117T3 (es)
HK (1) HK1127489A1 (es)
IL (1) IL191832A (es)
MY (1) MY153261A (es)
NZ (1) NZ569568A (es)
PE (1) PE20070832A1 (es)
PL (1) PL1960370T3 (es)
PT (1) PT1960370E (es)
SI (1) SI1960370T1 (es)
TW (1) TWI395741B (es)
UA (1) UA95934C2 (es)
WO (1) WO2007065518A1 (es)
ZA (1) ZA200805877B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008013838A2 (en) * 2006-07-25 2008-01-31 Cephalon, Inc. Pyridizinone derivatives
DE102006037478A1 (de) * 2006-08-10 2008-02-14 Merck Patent Gmbh 2-(Heterocyclylbenzyl)-pyridazinonderivate
KR20090096690A (ko) * 2006-12-14 2009-09-14 아스텔라스세이야쿠 가부시키가이샤 Ｃｒｔｈ2 길항제 및 항알레르기제로 유용한 폴리사이클릭 산 화합물
US8283351B2 (en) * 2007-04-02 2012-10-09 Institute For Oneworld Health Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof
DE102007025717A1 (de) 2007-06-01 2008-12-11 Merck Patent Gmbh Arylether-pyridazinonderivate
DE102007025718A1 (de) * 2007-06-01 2008-12-04 Merck Patent Gmbh Pyridazinonderivate
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007038957A1 (de) * 2007-08-17 2009-02-19 Merck Patent Gmbh 6-Thioxo-pyridazinderivate
DE102007061963A1 (de) * 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
CN101538245B (zh) * 2008-03-18 2011-02-16 中国科学院上海药物研究所 一类哒嗪酮类化合物及其制备方法和制备药物的用途
DE102008019907A1 (de) * 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
DE102008037790A1 (de) 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
PT2361250E (pt) * 2008-12-22 2013-11-11 Merck Patent Gmbh Novas formas polimórficas de di-hidrogenofosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirimidin-2-il]-benzil}-2h-piridazin-3-ona e processos de fabrico das mesmas
DE102008062826A1 (de) 2008-12-23 2010-07-01 Merck Patent Gmbh Pyridazinonderivate
DE102009003954A1 (de) 2009-01-07 2010-07-08 Merck Patent Gmbh Pyridazinonderivate
WO2010078897A1 (en) 2009-01-08 2010-07-15 Merck Patent Gmbh Novel polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof
DE102009004061A1 (de) * 2009-01-08 2010-07-15 Merck Patent Gmbh Pyridazinonderivate
CN102731409A (zh) * 2011-04-08 2012-10-17 中国科学院上海药物研究所 一类哒嗪酮类化合物，其药物组合物、制备方法及用途
KR101842645B1 (ko) 2012-04-12 2018-03-29 한국화학연구원 신규한 히드라진온이 치환된 피리미딘 유도체 및 그의 용도
RS56485B1 (sr) * 2012-11-02 2018-01-31 Merck Patent Gmbh 6-okso-1,6-dihidro-piridazin derivat za upotrebu u tretmanu hepatocelularnog karcinoma (hcc)
CA2927567C (en) * 2013-10-18 2022-04-26 Celgene Quanticel Research, Inc. Bromodomain inhibitors
CN103772352B (zh) * 2014-01-16 2017-01-18 四川百利药业有限责任公司 哒嗪酮类衍生物及其制备方法和用途
CA2970394C (en) * 2014-12-11 2023-03-14 Merck Patent Gmbh Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a quinazoline derivative
AU2017348186A1 (en) * 2016-10-26 2019-05-16 Proteostasis Therapeutics, Inc Pyridazine derivatives, compositions and methods for modulating CFTR
CN107334767B (zh) * 2017-06-08 2019-03-05 中国医学科学院医药生物技术研究所 一种哒嗪酮类化合物在肿瘤治疗中的应用
CN111315735B (zh) 2017-09-04 2024-03-08 C4医药公司 二氢苯并咪唑酮
DK3877376T3 (da) 2018-11-06 2023-10-02 Edgewise Therapeutics Inc Pyridazinonforbindelser og anvendelser deraf
CN113272280A (zh) * 2018-11-06 2021-08-17 艾知怀斯治疗学公司 哒嗪酮化合物及其用途
CA3118908A1 (en) 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
CN113557235A (zh) 2019-03-06 2021-10-26 C4医药公司 用于药物治疗的杂环化合物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO79566A2 (ro) * 1980-05-28 1982-08-17 Institutul De Cercetari Chimico-Farmaceutice,Ro Substante din clasa 2-(3'-aril-piridazonil-1'5-metil-5-aril-(alchil)amino-tiadiazolului
RO79562A2 (ro) * 1980-05-29 1982-08-17 Institutul De Cercetari Chimico-Farmaceutice,Ro Substante din clasa 3-(3'-aril-piridazonil-1'5-metil-4-aril(alchil)-5-mercapto-1,2,4-triazolului si procedeu de obtinere a acestora
JPS5826802A (ja) * 1981-08-10 1983-02-17 Sankyo Co Ltd 農園芸用殺菌剤
DE3321012A1 (de) * 1983-06-10 1984-12-13 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 4,5-dihydro-6-(thien-2-yl)-3(2h)-pyridazinone und 6-(thien-2-yl)-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung
DE69131268T2 (de) * 1990-09-21 1999-12-30 Rohm & Haas Dihydropyridazinone und Pyridazinone als Fungizide
BR9104043A (pt) * 1990-09-21 1992-06-02 Rohm & Haas Composicao fungicida,processo para a producao de compostos di-hidropiridazinona e processo para a preparacao de materias de partida para a producao de compostos
IL115889A0 (en) * 1994-11-14 1996-01-31 Rohm & Haas Pyridazinones and their use as fungicides
US6121251A (en) * 1996-10-11 2000-09-19 Rohm And Haas Company Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides
EP1005460B1 (en) * 1997-08-22 2006-03-08 Abbott Laboratories Prostaglandin endoperoxide h synthase biosynthesis inhibitors
KR100626605B1 (ko) * 1997-11-19 2006-09-22 코와 가부시키가이샤 신규 피리다진 유도체 및 이를 유효성분으로 하는 의약
US7060822B1 (en) * 1999-07-30 2006-06-13 Abbott Gmbh & Co. Kg 2-pyrazolin-5-ones
CN1193026C (zh) * 1999-07-30 2005-03-16 艾博特股份有限两合公司 2－吡唑啉－5－酮
AUPR606401A0 (en) * 2001-07-02 2001-07-26 Fujisawa Pharmaceutical Co., Ltd. Pyrazolopyridine compound and pharmaceutical use thereof
HUP0401984A3 (en) * 2001-10-31 2005-06-28 Merck Patent Gmbh Use of type 4 phosphodiesterase inhibitors for preparation of pharmaceutical compositions and combination with other active ingredients
AU2003209321A1 (en) * 2002-01-18 2003-07-30 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
US20040067955A1 (en) * 2002-09-06 2004-04-08 Fujisawa Pharmaceutical Co. Ltd. Pyridazinone compound and pharmaceutical use thereof
JP4528722B2 (ja) * 2003-03-07 2010-08-18 興和株式会社 ベンゾフラン誘導体
CN101410120A (zh) * 2003-04-25 2009-04-15 吉里德科学公司 抗炎的膦酸酯化合物
KR20060028632A (ko) * 2003-04-25 2006-03-30 길리애드 사이언시즈, 인코포레이티드 항염증 포스포네이트 화합물
WO2006095666A1 (ja) * 2005-03-07 2006-09-14 Kyorin Pharmaceutical Co., Ltd. ピラゾロピリジン－４－イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤

Also Published As

Publication number Publication date
AR057214A1 (es) 2007-11-21
EP1960370A1 (de) 2008-08-27
ZA200805877B (en) 2009-07-29
NZ569568A (en) 2011-05-27
TW200804303A (en) 2008-01-16
CA2632217A1 (en) 2007-06-14
PT1960370E (pt) 2012-01-11
DK1960370T3 (da) 2012-01-02
CN101326167A (zh) 2008-12-17
EA200801428A1 (ru) 2008-10-30
CA2632217C (en) 2014-07-08
KR20080077664A (ko) 2008-08-25
CY1112206T1 (el) 2015-12-09
TWI395741B (zh) 2013-05-11
PL1960370T3 (pl) 2012-01-31
ES2373117T3 (es) 2012-01-31
JP5210172B2 (ja) 2013-06-12
SI1960370T1 (sl) 2011-12-30
MY153261A (en) 2015-01-29
CN101326167B (zh) 2011-03-09
IL191832A0 (en) 2008-12-29
JP2009518323A (ja) 2009-05-07
UA95934C2 (ru) 2011-09-26
AU2006322364B2 (en) 2012-01-12
WO2007065518A1 (de) 2007-06-14
DE102005057924A1 (de) 2007-06-06
EA014667B1 (ru) 2010-12-30
IL191832A (en) 2013-09-30
ATE527241T1 (de) 2011-10-15
BRPI0619407A2 (pt) 2011-10-04
ECSP088598A (es) 2008-08-29
EP1960370B1 (de) 2011-10-05
US8173653B2 (en) 2012-05-08
HK1127489A1 (en) 2009-09-25
AU2006322364A1 (en) 2007-06-14
KR101367447B1 (ko) 2014-02-25
US20080293719A1 (en) 2008-11-27

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