EA201070912A1 - Производные оксима в качестве ингибиторов hsp90 - Google Patents

Производные оксима в качестве ингибиторов hsp90

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Publication number
EA201070912A1
EA201070912A1 EA201070912A EA201070912A EA201070912A1 EA 201070912 A1 EA201070912 A1 EA 201070912A1 EA 201070912 A EA201070912 A EA 201070912A EA 201070912 A EA201070912 A EA 201070912A EA 201070912 A1 EA201070912 A1 EA 201070912A1
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EA
Eurasian Patent Office
Prior art keywords
oxima
derivatives
compounds
hsp90 inhibitors
present
Prior art date
Application number
EA201070912A
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English (en)
Other versions
EA019156B1 (ru
Inventor
Юн К. Чэнь
Эрик Ван Ко
Прасуна Гунтупалли
Джон Дэвид Лосон
Вольфганг Райнхард Людвиг Нотц
Джеффри А. Стаффорд
Хуонг-Тху Тон-Ну
Original Assignee
Такеда Фармасьютикал Компани Лимитед
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Publication of EA201070912A1 publication Critical patent/EA201070912A1/ru
Publication of EA019156B1 publication Critical patent/EA019156B1/ru

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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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Abstract

Настоящее изобретение относится к соединениям, ингибирующим HSP90, имеющим формулув которой переменные определены в настоящем описании. Настоящее изобретение также относится к фармацевтическим композициям, наборам и изделиям, включающим такие соединения; способам и промежуточным соединениям, полезным для получения таких соединений; а также способам использования таких соединений.
EA201070912A 2008-02-01 2009-01-30 Производные оксима в качестве ингибиторов hsp90 EA019156B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2572508P 2008-02-01 2008-02-01
US10159508P 2008-09-30 2008-09-30
PCT/US2009/032728 WO2009097578A1 (en) 2008-02-01 2009-01-30 Oxim derivatives as hsp90 inhibitors

Publications (2)

Publication Number Publication Date
EA201070912A1 true EA201070912A1 (ru) 2011-08-30
EA019156B1 EA019156B1 (ru) 2014-01-30

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US (4) US20110053873A1 (ru)
EP (1) EP2252595B1 (ru)
JP (1) JP5524084B2 (ru)
KR (1) KR20100116206A (ru)
CN (1) CN101983191B (ru)
AR (1) AR071452A1 (ru)
AU (1) AU2009208947B2 (ru)
BR (1) BRPI0906598A2 (ru)
CA (1) CA2713658C (ru)
CL (1) CL2009000228A1 (ru)
CR (1) CR11659A (ru)
DO (1) DOP2010000236A (ru)
EA (1) EA019156B1 (ru)
EC (1) ECSP10010434A (ru)
ES (1) ES2475206T3 (ru)
GE (1) GEP20125718B (ru)
IL (1) IL207227A0 (ru)
MA (1) MA32104B1 (ru)
MX (1) MX2010008269A (ru)
MY (1) MY150596A (ru)
NZ (1) NZ587207A (ru)
PE (1) PE20091371A1 (ru)
SG (1) SG187502A1 (ru)
TW (1) TW200946531A (ru)
WO (1) WO2009097578A1 (ru)
ZA (1) ZA201005435B (ru)

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CN112544621B (zh) * 2020-04-13 2021-10-15 辽宁先达农业科学有限公司 一种制备2-(4-氯苯氧基)-丙氧胺的方法
CN111671749A (zh) * 2020-06-12 2020-09-18 重庆医科大学 双香豆素在制备HBx蛋白稳定性抑制剂中的用途
CN112661668B (zh) * 2020-12-31 2023-07-28 辽宁先达农业科学有限公司 一种n-取代酰胺类化合物及其制备方法
CN114259564B (zh) * 2021-11-30 2023-03-14 清华大学 Hsp90抑制剂阻碍stat3线粒体转运和治疗哮喘的新应用
CN115073458A (zh) * 2022-07-04 2022-09-20 山东致泰医药技术有限公司 一种阿维巴坦钠的制备方法
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