PE20060398A1 - Compuestos derivados de pirimidina como inhibidores de quinasa de proteina - Google Patents
Compuestos derivados de pirimidina como inhibidores de quinasa de proteinaInfo
- Publication number
- PE20060398A1 PE20060398A1 PE2005000667A PE2005000667A PE20060398A1 PE 20060398 A1 PE20060398 A1 PE 20060398A1 PE 2005000667 A PE2005000667 A PE 2005000667A PE 2005000667 A PE2005000667 A PE 2005000667A PE 20060398 A1 PE20060398 A1 PE 20060398A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- phenyl
- alkyl
- benzamide
- imidazol
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I, DONDE m Y n SON 0, 1 O 2; R1 ES -XOR5, -XNR5R6, -XR5, ENTRE OTROS; R5 ES H, ALQUILO C1-C6, ARILO C1-C6, ENTRE OTROS; R6 ES H, ALQUILO C1-C6, ENTRE OTROS; R2 Y R4 SON HALOGENO, OH, ALQUILO C1-C4, ENTRE OTROS; R3 ES NR10R11, NR10C(O)R11, ENTRE OTROS; R10 ES H Y ALQUILO C1-C6; R11 ES ARILO C6-C10, CICLOALQUILO C3-C10, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N[4-METIL-3-(1-{6-[4-(2-MORFOLIN-4-IL-ETIL)-FENIL-AMINO]-PIRIMIDIN-4-IL}-1H-IMIDAZOL-2-ILAMINO)-FENIL]-3-TRIFLUORO-METIL-BENZAMIDA, N-{3-[1-(6-CICLOPROPIL-AMINO-PIRIMIDIN-4-IL)-1H-IMIDAZOL-2-ILAMINO]-4-METIL-FENIL}-3-(4-ETIL-PIPERAZIN-1-IL)-5-TRIFLUORO-METIL-BENZAMIDA, N-(4-METIL-3-{1-[6-(2-MORFOLIN-4-IL-ETIL-AMINO)-PIRIMIDIN-4-IL]-1H-IMIDAZOL-2-ILAMINO}-FENIL)-3-TRIFLUORO-METIL-BENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES O DESORDENES QUE INVOLUCREN LA ACTIVACION ANORMAL DE LAS QUINASAS Abl, BCR-Abl, PDGF-R, trkB, c-SRC, BMX, FGFR3, b-RAF, SGK, Tie2, Lck, JNK2a2, MKK4, c-RAF, MKK6, SAPKa Y SAPK2b
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57849104P | 2004-06-10 | 2004-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060398A1 true PE20060398A1 (es) | 2006-06-05 |
Family
ID=35509612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000667A PE20060398A1 (es) | 2004-06-10 | 2005-06-10 | Compuestos derivados de pirimidina como inhibidores de quinasa de proteina |
Country Status (21)
Country | Link |
---|---|
US (1) | US7745437B2 (es) |
EP (1) | EP1758892B1 (es) |
JP (1) | JP4688876B2 (es) |
CN (1) | CN1960988B (es) |
AR (1) | AR049511A1 (es) |
AU (1) | AU2005254982B2 (es) |
BR (1) | BRPI0511978A (es) |
CA (1) | CA2567662C (es) |
EC (1) | ECSP067070A (es) |
ES (1) | ES2396135T3 (es) |
IL (1) | IL179613A0 (es) |
MA (1) | MA28679B1 (es) |
MX (1) | MXPA06014247A (es) |
MY (1) | MY144044A (es) |
NO (1) | NO20070160L (es) |
PE (1) | PE20060398A1 (es) |
RU (1) | RU2401265C2 (es) |
TN (1) | TNSN06406A1 (es) |
TW (1) | TW200610762A (es) |
WO (1) | WO2005123719A1 (es) |
ZA (1) | ZA200609450B (es) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
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AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
WO2006064375A2 (en) * | 2004-12-16 | 2006-06-22 | Ab Science | Aminoaryl substituted five-membered ring heterocyclic compounds for the treatment of diseases |
US20080194606A1 (en) * | 2005-05-05 | 2008-08-14 | Astrazeneca | Pyrazolyl-Amino-Substituted Pyrimidines and Their Use in the Treatment of Cancer |
SI1879573T1 (sl) | 2005-05-10 | 2013-04-30 | Incyte Corporation Experimental Station | Modulatorji indolamin 2,3-dioksigenaze in postopki za uporabo le-te |
DK2348023T5 (da) | 2005-12-13 | 2017-05-15 | Incyte Holdings Corp | Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus-kinase-inhibitorer |
EP2574340A3 (en) * | 2006-04-07 | 2013-04-17 | Novartis AG | Combination comprising a pyrimidylaminobenzamide compound and a THR315LLEe kinase inhibitor |
ATE543498T1 (de) | 2006-09-08 | 2012-02-15 | Hoffmann La Roche | Benzotriazol kinasemodulatoren |
PT2068938E (pt) | 2006-09-22 | 2011-03-23 | Novartis Ag | Optimização do tratamento da leucemia filadélfia positiva com o inibidor de tirosina quinase abl imatinib |
KR101101675B1 (ko) * | 2006-10-02 | 2011-12-30 | 노파르티스 아게 | 단백질 키나제 억제제로서의 화합물 및 조성물 |
AU2007333536A1 (en) * | 2006-12-11 | 2008-06-19 | Irm Llc | Compounds and compositions as kinase inhibitors |
RS53245B2 (sr) | 2007-06-13 | 2022-10-31 | Incyte Holdings Corp | Soli inhibitora janus kinaze (r)-3-(4-(7h-pirolo(2,3-d) pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropan-nitrila |
KR101956261B1 (ko) | 2008-05-21 | 2019-03-08 | 어리어드 파마슈티칼스, 인코포레이티드 | 키나아제 억제제로서 포스포러스 유도체 |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
WO2009158432A2 (en) | 2008-06-27 | 2009-12-30 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
ES2524266T3 (es) | 2008-07-08 | 2014-12-04 | Incyte Corporation | 1,2,5-Oxadiazoles como inhibidores de la indoleamina 2,3-dioxigenasa |
WO2010100127A1 (en) * | 2009-03-04 | 2010-09-10 | Novartis Ag | Disubstituted imidazole derivatives as modulators of raf kinase |
AU2010249380B2 (en) | 2009-05-22 | 2015-08-20 | Incyte Holdings Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as Janus kinase inhibitors |
EP2432472B1 (en) | 2009-05-22 | 2019-10-02 | Incyte Holdings Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
JP6073677B2 (ja) | 2009-06-12 | 2017-02-01 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 縮合複素環式化合物およびそれらの使用 |
JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
CA2784807C (en) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
EP2536729A1 (en) | 2010-02-18 | 2012-12-26 | Incyte Corporation | Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors |
SI3354652T1 (sl) | 2010-03-10 | 2020-08-31 | Incyte Holdings Corporation | Derivati piperidin-4-il azetidina kot inhibitorji JAK1 |
MY178634A (en) | 2010-05-21 | 2020-10-19 | Incyte Corp | Topical formulation for a jak inhibitor |
JP2012102090A (ja) * | 2010-10-15 | 2012-05-31 | Sumitomo Chemical Co Ltd | ピリミジン化合物およびその有害生物防除用途 |
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RU2477723C2 (ru) | 2011-06-16 | 2013-03-20 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
EA201490042A1 (ru) | 2011-06-20 | 2014-10-30 | Инсайт Корпорейшн | Азетидинил-фенил-, пиридил- или пиразинилкарбоксамидные производные как ингибиторы jak |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
JP6150813B2 (ja) | 2011-11-11 | 2017-06-21 | ノバルティス アーゲー | 増殖性疾患の治療方法 |
US9382239B2 (en) | 2011-11-17 | 2016-07-05 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-terminal kinase (JNK) |
WO2013078264A1 (en) | 2011-11-23 | 2013-05-30 | Novartis Ag | Pharmaceutical formulations |
GB201204384D0 (en) | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
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EP1404669A2 (en) * | 2001-05-16 | 2004-04-07 | Vertex Pharmaceuticals Incorporated | Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases |
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AR049511A1 (es) | 2006-08-09 |
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WO2005123719A1 (en) | 2005-12-29 |
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MA28679B1 (fr) | 2007-06-01 |
RU2007100136A (ru) | 2008-07-20 |
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RU2401265C2 (ru) | 2010-10-10 |
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AU2005254982B2 (en) | 2008-11-27 |
AU2005254982A1 (en) | 2005-12-29 |
EP1758892B1 (en) | 2012-10-17 |
TW200610762A (en) | 2006-04-01 |
US20070225286A1 (en) | 2007-09-27 |
CN1960988A (zh) | 2007-05-09 |
JP2008502729A (ja) | 2008-01-31 |
US7745437B2 (en) | 2010-06-29 |
BRPI0511978A (pt) | 2008-01-22 |
JP4688876B2 (ja) | 2011-05-25 |
ZA200609450B (en) | 2008-05-28 |
CN1960988B (zh) | 2012-01-25 |
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