EA200970347A1 - Соединения и композиции в качестве ингибиторов протеинкиназ - Google Patents

Соединения и композиции в качестве ингибиторов протеинкиназ

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Publication number
EA200970347A1
EA200970347A1 EA200970347A EA200970347A EA200970347A1 EA 200970347 A1 EA200970347 A1 EA 200970347A1 EA 200970347 A EA200970347 A EA 200970347A EA 200970347 A EA200970347 A EA 200970347A EA 200970347 A1 EA200970347 A1 EA 200970347A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
proteinkinaz
inhibitors
compositions
raf
Prior art date
Application number
EA200970347A
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English (en)
Other versions
EA015751B1 (ru
Inventor
Памела Албо
Грегори С. Чопиук
Цян Дин
Шэньлинь Хуан
Цзошэн Лю
Шифенг Пан
Пинда Жэнь
Ся Ван
Син Ван
Юнпин Се
Чэньчжи Чжан
Цюн Чжан
Гобао Чжан
Дэниел Пун
Пол Ренхауэ
Мартин Сендцик
Original Assignee
АйАрЭм ЭлЭлСи
Новартис Аг
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Application filed by АйАрЭм ЭлЭлСи, Новартис Аг filed Critical АйАрЭм ЭлЭлСи
Publication of EA200970347A1 publication Critical patent/EA200970347A1/ru
Publication of EA015751B1 publication Critical patent/EA015751B1/ru

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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Данное изобретение предлагает новый класс соединений, фармацевтические композиции, содержащие указанные соединения, и способы применения указанных соединений для лечения или профилактики заболеваний или расстройств, связанных с аномальной или нарушенной киназной активностью, в частности, заболеваний или расстройств, которые включают аномальную активацию киназ Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 и TrkB.
EA200970347A 2006-10-02 2007-09-24 Соединения и композиции в качестве ингибиторов протеинкиназ EA015751B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82787306P 2006-10-02 2006-10-02
PCT/US2007/079340 WO2008042639A1 (en) 2006-10-02 2007-09-24 Compounds and compositions as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
EA200970347A1 true EA200970347A1 (ru) 2009-10-30
EA015751B1 EA015751B1 (ru) 2011-12-30

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ID=38955203

Family Applications (1)

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EA200970347A EA015751B1 (ru) 2006-10-02 2007-09-24 Соединения и композиции в качестве ингибиторов протеинкиназ

Country Status (22)

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US (1) US8202876B2 (ru)
EP (1) EP2057146A1 (ru)
JP (1) JP5153777B2 (ru)
KR (1) KR101101675B1 (ru)
CN (2) CN101522661A (ru)
AR (1) AR063099A1 (ru)
AU (1) AU2007305016B2 (ru)
BR (1) BRPI0719797A8 (ru)
CA (1) CA2663366C (ru)
CL (1) CL2007002836A1 (ru)
CO (1) CO6180440A2 (ru)
CR (1) CR10670A (ru)
EA (1) EA015751B1 (ru)
IL (1) IL197724A0 (ru)
MA (1) MA30772B1 (ru)
MX (1) MX2009003456A (ru)
NO (1) NO20091759L (ru)
PE (1) PE20080828A1 (ru)
SM (1) SMAP200900020A (ru)
TN (1) TN2009000105A1 (ru)
TW (1) TW200823200A (ru)
WO (1) WO2008042639A1 (ru)

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