ECSP066365A - Anilino purinas sustituidas en la posición 6 útiles como inhibidores de rtk - Google Patents
Anilino purinas sustituidas en la posición 6 útiles como inhibidores de rtkInfo
- Publication number
- ECSP066365A ECSP066365A EC2006006365A ECSP066365A ECSP066365A EC SP066365 A ECSP066365 A EC SP066365A EC 2006006365 A EC2006006365 A EC 2006006365A EC SP066365 A ECSP066365 A EC SP066365A EC SP066365 A ECSP066365 A EC SP066365A
- Authority
- EC
- Ecuador
- Prior art keywords
- purinas
- anilino
- replaced
- useful
- rtk inhibitors
- Prior art date
Links
- HSMPSHPWCOOUJH-UHFFFAOYSA-N anilinyl Chemical class [NH]C1=CC=CC=C1 HSMPSHPWCOOUJH-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 abstract 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 abstract 1
- 101150028321 Lck gene Proteins 0.000 abstract 1
- 101100272634 Mus musculus Bmx gene Proteins 0.000 abstract 1
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 abstract 1
- 101150056950 Ntrk2 gene Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención provee una clase novedosa de compuestos, composiciones farmacéuticas que comprenden a dichos compuestos y métodos para utilizar dichos compuestos para tratar o prevenir enfermedades o trastornos asociados con actividad de cSRC, Lck, FGFR3, Flt3, TrkB, Bmx, y/o PFGFRa cinasa.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49540603P | 2003-08-15 | 2003-08-15 | |
US52435703P | 2003-11-21 | 2003-11-21 | |
US56536704P | 2004-04-26 | 2004-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP066365A true ECSP066365A (es) | 2006-08-30 |
Family
ID=34198974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006365A ECSP066365A (es) | 2003-08-15 | 2006-02-14 | Anilino purinas sustituidas en la posición 6 útiles como inhibidores de rtk |
Country Status (16)
Country | Link |
---|---|
US (2) | US20050124637A1 (es) |
EP (1) | EP1656378A4 (es) |
JP (1) | JP2007502776A (es) |
AU (2) | AU2004264419B2 (es) |
BR (1) | BRPI0413563A (es) |
CA (1) | CA2535620A1 (es) |
CO (1) | CO5680404A2 (es) |
EC (1) | ECSP066365A (es) |
IL (1) | IL173392A0 (es) |
IS (1) | IS8345A (es) |
MA (1) | MA27997A1 (es) |
MX (1) | MXPA06001758A (es) |
NO (1) | NO20061074L (es) |
SG (1) | SG145748A1 (es) |
TN (1) | TNSN06053A1 (es) |
WO (1) | WO2005016528A2 (es) |
Families Citing this family (96)
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WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
DE102005017259A1 (de) * | 2005-04-14 | 2006-10-19 | Merck Patent Gmbh | Purinderivate |
AU2006247757B2 (en) * | 2005-05-13 | 2009-08-27 | Irm, Llc | Compounds and compositions as protein kinase inhibitors |
JP5108752B2 (ja) * | 2005-05-16 | 2012-12-26 | プロメティック・バイオサイエンスィズ・インコーポレーテッド | 自己免疫疾患を治療するための化合物とそれら化合物の使用 |
CN100526315C (zh) * | 2005-06-16 | 2009-08-12 | 浙江医药股份有限公司新昌制药厂 | N2-喹啉或异喹啉取代的嘌呤衍生物及其制备方法和其用途 |
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JP3290666B2 (ja) * | 1995-06-07 | 2002-06-10 | ファイザー・インコーポレーテッド | 複素環式の縮合環ピリミジン誘導体 |
CN1168138A (zh) * | 1995-11-14 | 1997-12-17 | 法玛西雅厄普约翰公司 | 芳基和杂芳基嘌呤化合物 |
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CA2379640C (en) * | 1999-09-30 | 2006-11-28 | Neurogen Corporation | Certain alkylene diamine-substituted heterocycles |
BR0207302A (pt) * | 2001-02-08 | 2004-02-10 | Memory Pharm Corp | Trifluorometilpurinas como inibidores da fosfodiesterase 4 |
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JP2005506350A (ja) * | 2001-10-18 | 2005-03-03 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | サイトカイン阻害薬としての1,4−二置換ベンゾ−縮合尿素化合物 |
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-
2004
- 2004-08-13 US US10/917,578 patent/US20050124637A1/en not_active Abandoned
- 2004-08-13 EP EP04781114A patent/EP1656378A4/en not_active Withdrawn
- 2004-08-13 AU AU2004264419A patent/AU2004264419B2/en not_active Ceased
- 2004-08-13 BR BRPI0413563-6A patent/BRPI0413563A/pt not_active IP Right Cessation
- 2004-08-13 MX MXPA06001758A patent/MXPA06001758A/es not_active Application Discontinuation
- 2004-08-13 WO PCT/US2004/026373 patent/WO2005016528A2/en active Application Filing
- 2004-08-13 CA CA002535620A patent/CA2535620A1/en not_active Abandoned
- 2004-08-13 SG SG200806062-6A patent/SG145748A1/en unknown
- 2004-08-13 JP JP2006523409A patent/JP2007502776A/ja active Pending
-
2006
- 2006-01-26 IL IL173392A patent/IL173392A0/en unknown
- 2006-02-14 TN TNP2006000053A patent/TNSN06053A1/en unknown
- 2006-02-14 EC EC2006006365A patent/ECSP066365A/es unknown
- 2006-02-17 MA MA28818A patent/MA27997A1/fr unknown
- 2006-02-20 CO CO06016491A patent/CO5680404A2/es not_active Application Discontinuation
- 2006-03-06 NO NO20061074A patent/NO20061074L/no not_active Application Discontinuation
- 2006-03-09 IS IS8345A patent/IS8345A/is unknown
-
2009
- 2009-04-15 AU AU2009201480A patent/AU2009201480A1/en not_active Abandoned
-
2010
- 2010-12-22 US US12/976,187 patent/US20110092491A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TNSN06053A1 (en) | 2007-10-03 |
AU2004264419B2 (en) | 2009-01-15 |
AU2004264419A1 (en) | 2005-02-24 |
MA27997A1 (fr) | 2006-07-03 |
EP1656378A2 (en) | 2006-05-17 |
IL173392A0 (en) | 2006-06-11 |
BRPI0413563A (pt) | 2006-10-17 |
WO2005016528A2 (en) | 2005-02-24 |
CA2535620A1 (en) | 2005-02-24 |
SG145748A1 (en) | 2008-09-29 |
US20050124637A1 (en) | 2005-06-09 |
MXPA06001758A (es) | 2006-08-11 |
US20110092491A1 (en) | 2011-04-21 |
CO5680404A2 (es) | 2006-09-29 |
EP1656378A4 (en) | 2011-05-11 |
NO20061074L (no) | 2006-03-06 |
JP2007502776A (ja) | 2007-02-15 |
IS8345A (is) | 2006-03-09 |
AU2009201480A1 (en) | 2009-05-14 |
WO2005016528A3 (en) | 2005-05-12 |
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