NO20070160L - Forbindelser og sammensetninger som proteinkinaseinhibitorer - Google Patents
Forbindelser og sammensetninger som proteinkinaseinhibitorerInfo
- Publication number
- NO20070160L NO20070160L NO20070160A NO20070160A NO20070160L NO 20070160 L NO20070160 L NO 20070160L NO 20070160 A NO20070160 A NO 20070160A NO 20070160 A NO20070160 A NO 20070160A NO 20070160 L NO20070160 L NO 20070160L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- compositions
- protein kinase
- kinase inhibitors
- raf
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Foreliggende oppfinnelse tilveiebringer en ny klasse forbindelser, farmasøytiske sammensetninger som innbefatter slike forbindelser og fremgangsmåter for anvendelse av slike forbindelser for å behandle eller hindre sykdommer eller forstyrrelser assosiert med abnorrnal eller deregulert kinaseaktivitet, særlig sykdommer eller forstyrrelser som involverer abnormal aktivering av Abl, BCR-Abl, PDGF-R, trkB, c-SRC, BMX, FGFR3, b-RAF, SGK, Tie2, Lck, JNK2A2, MKK4, c-RAF, MKK6, SAM2( og SAPK2( kinaser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57849104P | 2004-06-10 | 2004-06-10 | |
PCT/US2005/020371 WO2005123719A1 (en) | 2004-06-10 | 2005-06-09 | Compounds and compositions as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20070160L true NO20070160L (no) | 2007-01-09 |
Family
ID=35509612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20070160A NO20070160L (no) | 2004-06-10 | 2007-01-09 | Forbindelser og sammensetninger som proteinkinaseinhibitorer |
Country Status (21)
Country | Link |
---|---|
US (1) | US7745437B2 (no) |
EP (1) | EP1758892B1 (no) |
JP (1) | JP4688876B2 (no) |
CN (1) | CN1960988B (no) |
AR (1) | AR049511A1 (no) |
AU (1) | AU2005254982B2 (no) |
BR (1) | BRPI0511978A (no) |
CA (1) | CA2567662C (no) |
EC (1) | ECSP067070A (no) |
ES (1) | ES2396135T3 (no) |
IL (1) | IL179613A0 (no) |
MA (1) | MA28679B1 (no) |
MX (1) | MXPA06014247A (no) |
MY (1) | MY144044A (no) |
NO (1) | NO20070160L (no) |
PE (1) | PE20060398A1 (no) |
RU (1) | RU2401265C2 (no) |
TN (1) | TNSN06406A1 (no) |
TW (1) | TW200610762A (no) |
WO (1) | WO2005123719A1 (no) |
ZA (1) | ZA200609450B (no) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
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AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
TW200533357A (en) | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
WO2006064375A2 (en) * | 2004-12-16 | 2006-06-22 | Ab Science | Aminoaryl substituted five-membered ring heterocyclic compounds for the treatment of diseases |
JP2008540391A (ja) * | 2005-05-05 | 2008-11-20 | アストラゼネカ アクチボラグ | ピラゾリルアミノ置換ピリミジン、および癌の処置におけるそれらの使用 |
AU2006244068B9 (en) | 2005-05-10 | 2012-10-25 | Incyte Holdings Corporation | Modulators of indoleamine 2,3-dioxygenase and methods of using the same |
MY162590A (en) | 2005-12-13 | 2017-06-30 | Incyte Holdings Corp | Heteroaryl substituted pyrrolo[2,3-b] pyridines and pyrrolo[2,3-b] pyrimidines as janus kinase inhibitors |
KR20090023561A (ko) * | 2006-04-07 | 2009-03-05 | 노파르티스 아게 | a) 피리미딜아미노벤즈아미드 화합물과 b) Thr315Ile 키나제 억제제를 포함하는 조합물 |
JP5325783B2 (ja) | 2006-09-08 | 2013-10-23 | エフ.ホフマン−ラ ロシュ アーゲー | ベンゾトリアゾールキナーゼモジュレーター |
EP2251042A3 (en) | 2006-09-22 | 2012-05-02 | Novartis AG | Method of optimizing the treatment of philadelphia-positive leukemia with abl tyrosine kinase inhibitors |
CA2663366C (en) * | 2006-10-02 | 2012-02-07 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
BRPI0720059A2 (pt) * | 2006-12-11 | 2013-12-17 | Irm Llc | Compostos e composições como inibidores de cinase |
EP3495369B1 (en) | 2007-06-13 | 2021-10-27 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
CA2723961C (en) | 2008-05-21 | 2017-03-21 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
EP2671891A3 (en) | 2008-06-27 | 2014-03-05 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
KR101783004B1 (ko) | 2008-07-08 | 2017-09-28 | 인사이트 홀딩스 코포레이션 | 인돌아민 2,3-디옥시게나아제의 억제제로서의 1,2,5-옥사디아졸 |
WO2010100127A1 (en) * | 2009-03-04 | 2010-09-10 | Novartis Ag | Disubstituted imidazole derivatives as modulators of raf kinase |
EA025520B1 (ru) | 2009-05-22 | 2017-01-30 | Инсайт Холдингс Корпорейшн | N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ |
MX2011012262A (es) | 2009-05-22 | 2012-01-25 | Incyte Corp | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il] octano-o heptano-nitrilo como inhibidores de cinasas janus (jak). |
WO2010144909A1 (en) | 2009-06-12 | 2010-12-16 | Novartis Ag | Fused heterocyclic compounds and their uses |
JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
CA2784807C (en) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
EA023444B1 (ru) | 2010-02-18 | 2016-06-30 | Инсайт Холдингс Корпорейшн | Циклобутановые и метилциклобутановые производные, композиции на их основе и способы их применения |
SI3354652T1 (sl) | 2010-03-10 | 2020-08-31 | Incyte Holdings Corporation | Derivati piperidin-4-il azetidina kot inhibitorji JAK1 |
SG10201910912TA (en) | 2010-05-21 | 2020-01-30 | Incyte Corp | Topical Formulation for a JAK Inhibitor |
JP2012102090A (ja) * | 2010-10-15 | 2012-05-31 | Sumitomo Chemical Co Ltd | ピリミジン化合物およびその有害生物防除用途 |
BR112013012502A2 (pt) | 2010-11-19 | 2019-03-06 | Incyte Corporation | pirrolopiridina ciclobutil substituída e derivados de pirrolopirimidina derivativos como inibidores de jak |
US9034884B2 (en) | 2010-11-19 | 2015-05-19 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
CN103501612B (zh) | 2011-05-04 | 2017-03-29 | 阿里亚德医药股份有限公司 | 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物 |
RU2477723C2 (ru) | 2011-06-16 | 2013-03-20 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
MY165963A (en) | 2011-06-20 | 2018-05-18 | Incyte Holdings Corp | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
CA2855243C (en) | 2011-11-11 | 2020-04-14 | Novartis Ag | Method of treating a proliferative disease |
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CN105708819B (zh) | 2011-11-23 | 2020-12-29 | 诺华股份有限公司 | 医药制剂 |
GB201204384D0 (en) | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
WO2013169401A1 (en) | 2012-05-05 | 2013-11-14 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
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JP2002302445A (ja) * | 2001-02-02 | 2002-10-18 | Takeda Chem Ind Ltd | Jnk阻害剤 |
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JP4316893B2 (ja) * | 2001-05-16 | 2009-08-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | Srcおよび他のプロテインキナーゼのインヒビター |
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CA2567662A1 (en) | 2005-12-29 |
BRPI0511978A (pt) | 2008-01-22 |
CN1960988A (zh) | 2007-05-09 |
IL179613A0 (en) | 2007-05-15 |
TNSN06406A1 (en) | 2008-02-22 |
RU2007100136A (ru) | 2008-07-20 |
AU2005254982A1 (en) | 2005-12-29 |
ZA200609450B (en) | 2008-05-28 |
ES2396135T3 (es) | 2013-02-19 |
EP1758892A4 (en) | 2010-07-28 |
ECSP067070A (es) | 2007-01-26 |
AU2005254982B2 (en) | 2008-11-27 |
CA2567662C (en) | 2012-11-27 |
PE20060398A1 (es) | 2006-06-05 |
RU2401265C2 (ru) | 2010-10-10 |
EP1758892A1 (en) | 2007-03-07 |
MXPA06014247A (es) | 2007-03-12 |
MY144044A (en) | 2011-07-29 |
JP2008502729A (ja) | 2008-01-31 |
AR049511A1 (es) | 2006-08-09 |
CN1960988B (zh) | 2012-01-25 |
WO2005123719A1 (en) | 2005-12-29 |
EP1758892B1 (en) | 2012-10-17 |
US7745437B2 (en) | 2010-06-29 |
MA28679B1 (fr) | 2007-06-01 |
US20070225286A1 (en) | 2007-09-27 |
TW200610762A (en) | 2006-04-01 |
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