PE20050772A1 - Piperidinilcarbonil-pirrolidinas como agonistas de melanocortina - Google Patents
Piperidinilcarbonil-pirrolidinas como agonistas de melanocortinaInfo
- Publication number
- PE20050772A1 PE20050772A1 PE2005000122A PE2005000122A PE20050772A1 PE 20050772 A1 PE20050772 A1 PE 20050772A1 PE 2005000122 A PE2005000122 A PE 2005000122A PE 2005000122 A PE2005000122 A PE 2005000122A PE 20050772 A1 PE20050772 A1 PE 20050772A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- agonists
- terc
- difluorophenyl
- pyrrolidin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, CICLOALQUILO C3-C8, CICLOALQUENILO C5-C8, ARILO, ENTRE OTROS; R2 ES H, OH, OCH3; R3 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, CICLOALQUILO C3-C8, ENTRE OTROS; R4 ES H, ALQUILO C1-C4, ALQUENILO C2-C4, ENTRE OTROS; R5 SON ALQUILO C1-C4, ALQUENILO C2-C4, ALQUINILO C2-C4, ENTRE OTROS; R4 Y R5 JUNTOS FORMAN UN ANILLO SATURADO O IINSATURADO DE 5 A 7 MIEMBROS. SON COMPUESTOS PREFERIDOS: (3R,4R,5S)-1-{[(3s,4R)-1-TERC-BUTIL-4-(2,4-DIFLUOROFENIL)PIRROLIDIN-3-IL]CARBONIL}-3,5-DIMETIL-4-FENILPIPERIDIN-4-OL CONOCIDO COMO [1-TERC-BUTIL-4-(2,4-DIFLUOROFENIL)-PIRROLIDIN-3-IL]-(4-HIDROXI-3,5-DIMETIL-4-FENIL-PIPERIDIN-1-IL)-METANONA Y SALES DE ACIDOS FARMACEUTICAMENTE ACPETABLES, HIDRATOS O SOLVATOS DEL MISMO. SE REFIERE TAMBIEN A UN PROCESO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON AGONISTAS SELECTIVOS DE MELANOCORTINA CR4 (MCR4) UTILES EN EL TRATAMIENTO DE DISFUNCION SEXUAL
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0402492.3A GB0402492D0 (en) | 2004-02-04 | 2004-02-04 | Pharmaceutically active compounds |
GB0412417A GB0412417D0 (en) | 2004-06-03 | 2004-06-03 | Pharmaceutically active compounds |
GB0425530A GB0425530D0 (en) | 2004-11-19 | 2004-11-19 | Pharmaceutically active compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050772A1 true PE20050772A1 (es) | 2005-10-31 |
Family
ID=34864830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000122A PE20050772A1 (es) | 2004-02-04 | 2005-02-02 | Piperidinilcarbonil-pirrolidinas como agonistas de melanocortina |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1716135B1 (es) |
JP (1) | JP4031814B2 (es) |
KR (1) | KR100830763B1 (es) |
CN (1) | CN1930146A (es) |
AP (1) | AP2006003699A0 (es) |
AR (1) | AR048232A1 (es) |
AT (1) | ATE511507T1 (es) |
AU (1) | AU2005213538A1 (es) |
BR (1) | BRPI0507435A (es) |
CA (1) | CA2555800C (es) |
CR (1) | CR8545A (es) |
EA (1) | EA011159B1 (es) |
EC (1) | ECSP066751A (es) |
GB (1) | GB0402492D0 (es) |
GE (1) | GEP20084361B (es) |
IL (1) | IL177004A0 (es) |
MA (1) | MA28348A1 (es) |
NL (1) | NL1028193C2 (es) |
NO (1) | NO20063944L (es) |
PA (1) | PA8623101A1 (es) |
PE (1) | PE20050772A1 (es) |
TW (1) | TWI300066B (es) |
UY (1) | UY28737A1 (es) |
WO (1) | WO2005077935A1 (es) |
ZA (1) | ZA200606236B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1912968A1 (en) * | 2005-08-04 | 2008-04-23 | Pfizer Limited | Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds |
WO2007041052A2 (en) * | 2005-09-29 | 2007-04-12 | Merck & Co., Inc. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
WO2007047496A2 (en) * | 2005-10-18 | 2007-04-26 | Merck & Co., Inc. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
AP2008004602A0 (en) * | 2006-02-23 | 2008-10-31 | Pfizer Ltd | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines |
CN101426782B (zh) * | 2006-02-23 | 2012-10-31 | 辉瑞股份有限公司 | 黑皮质素4型受体激动剂哌啶羰基吡咯烷 |
DK2176220T3 (da) | 2007-08-07 | 2013-06-10 | Takeda Pharmaceutical | Pyrrolidin-2-on-derivater som androgenreceptormodulatorer. |
UA99555C2 (en) | 2008-11-12 | 2012-08-27 | Элджи Лайф Саенсез Лтд. | Melanocortin receptor agonists |
US8476227B2 (en) | 2010-01-22 | 2013-07-02 | Ethicon Endo-Surgery, Inc. | Methods of activating a melanocortin-4 receptor pathway in obese subjects |
US9044606B2 (en) | 2010-01-22 | 2015-06-02 | Ethicon Endo-Surgery, Inc. | Methods and devices for activating brown adipose tissue using electrical energy |
WO2015182723A1 (ja) | 2014-05-29 | 2015-12-03 | 田辺三菱製薬株式会社 | 新規ピロリジン化合物およびメラノコルチン受容体作動薬としての用途 |
US10092738B2 (en) | 2014-12-29 | 2018-10-09 | Ethicon Llc | Methods and devices for inhibiting nerves when activating brown adipose tissue |
US10080884B2 (en) | 2014-12-29 | 2018-09-25 | Ethicon Llc | Methods and devices for activating brown adipose tissue using electrical energy |
PE20180690A1 (es) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
EP3333165B1 (en) * | 2015-08-04 | 2019-09-18 | Astellas Pharma Inc. | Piperazine derivative |
CN112694436B (zh) * | 2020-12-30 | 2022-07-08 | 济南周行医药科技有限公司 | 一种槟榔碱的合成方法 |
CN114211258B (zh) * | 2021-11-04 | 2023-09-26 | 江阴市大久金属科技有限公司 | 高精密无缝钢管制备工艺 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60219295T2 (de) * | 2001-02-28 | 2008-01-03 | Merck & Co., Inc. | Acylierte piperidinderivate als melanocortin-4-rezeptoragonisten |
DE60215132T2 (de) * | 2001-02-28 | 2007-08-23 | Merck & Co., Inc. | Acylierte piperidin-derivate als melanocortin-4-rezeptor-agonisten |
-
2004
- 2004-02-04 GB GBGB0402492.3A patent/GB0402492D0/en not_active Ceased
-
2005
- 2005-01-26 CA CA2555800A patent/CA2555800C/en not_active Expired - Fee Related
- 2005-01-26 BR BRPI0507435-5A patent/BRPI0507435A/pt not_active IP Right Cessation
- 2005-01-26 GE GEAP20059564A patent/GEP20084361B/en unknown
- 2005-01-26 AU AU2005213538A patent/AU2005213538A1/en not_active Abandoned
- 2005-01-26 JP JP2006551945A patent/JP4031814B2/ja not_active Expired - Fee Related
- 2005-01-26 CN CNA2005800075736A patent/CN1930146A/zh active Pending
- 2005-01-26 WO PCT/IB2005/000208 patent/WO2005077935A1/en active Application Filing
- 2005-01-26 AT AT05702363T patent/ATE511507T1/de not_active IP Right Cessation
- 2005-01-26 EP EP05702363A patent/EP1716135B1/en active Active
- 2005-01-26 KR KR1020067015811A patent/KR100830763B1/ko not_active IP Right Cessation
- 2005-01-26 AP AP2006003699A patent/AP2006003699A0/xx unknown
- 2005-01-26 EA EA200601279A patent/EA011159B1/ru not_active IP Right Cessation
- 2005-02-02 PE PE2005000122A patent/PE20050772A1/es not_active Application Discontinuation
- 2005-02-03 UY UY28737A patent/UY28737A1/es not_active Application Discontinuation
- 2005-02-03 TW TW094103372A patent/TWI300066B/zh active
- 2005-02-03 AR ARP050100409A patent/AR048232A1/es not_active Application Discontinuation
- 2005-02-04 NL NL1028193A patent/NL1028193C2/nl not_active IP Right Cessation
- 2005-02-04 PA PA20058623101A patent/PA8623101A1/es unknown
-
2006
- 2006-07-20 IL IL177004A patent/IL177004A0/en unknown
- 2006-07-27 ZA ZA200606236A patent/ZA200606236B/xx unknown
- 2006-08-03 CR CR8545A patent/CR8545A/es not_active Application Discontinuation
- 2006-08-03 EC EC2006006751A patent/ECSP066751A/es unknown
- 2006-08-04 MA MA29242A patent/MA28348A1/fr unknown
- 2006-09-04 NO NO20063944A patent/NO20063944L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2555800A1 (en) | 2005-08-25 |
EA200601279A1 (ru) | 2006-12-29 |
CN1930146A (zh) | 2007-03-14 |
AU2005213538A1 (en) | 2005-08-25 |
KR100830763B1 (ko) | 2008-05-19 |
ZA200606236B (en) | 2008-04-30 |
CA2555800C (en) | 2010-06-15 |
TW200526625A (en) | 2005-08-16 |
JP4031814B2 (ja) | 2008-01-09 |
IL177004A0 (en) | 2006-12-10 |
NO20063944L (no) | 2006-10-31 |
BRPI0507435A (pt) | 2007-07-03 |
UY28737A1 (es) | 2005-09-30 |
GEP20084361B (en) | 2008-04-29 |
GB0402492D0 (en) | 2004-03-10 |
JP2007534668A (ja) | 2007-11-29 |
NL1028193A1 (nl) | 2005-08-08 |
NL1028193C2 (nl) | 2006-04-20 |
AP2006003699A0 (en) | 2006-08-31 |
WO2005077935A1 (en) | 2005-08-25 |
MA28348A1 (fr) | 2006-12-01 |
PA8623101A1 (es) | 2006-05-16 |
CR8545A (es) | 2007-09-03 |
EP1716135A1 (en) | 2006-11-02 |
EP1716135B1 (en) | 2011-06-01 |
ATE511507T1 (de) | 2011-06-15 |
AR048232A1 (es) | 2006-04-12 |
TWI300066B (en) | 2008-08-21 |
ECSP066751A (es) | 2006-11-16 |
KR20060127125A (ko) | 2006-12-11 |
EA011159B1 (ru) | 2009-02-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |