PT1636169E - PROCESSO PARA A DESIDRATAÆO DE COMPOSTOS SUBSTITUDOS DE 4-DIMETILAMINO-2-ARILBUTAN-2-OL E PROCESSO PARA A PRODUÆO DE COMPOSTOS SUBSTITUDOS DE DIMETIL-(3-ARILBUTIL)AMINA POR MEIO DE CATáLISE HETEROGéNEA - Google Patents

PROCESSO PARA A DESIDRATAÆO DE COMPOSTOS SUBSTITUDOS DE 4-DIMETILAMINO-2-ARILBUTAN-2-OL E PROCESSO PARA A PRODUÆO DE COMPOSTOS SUBSTITUDOS DE DIMETIL-(3-ARILBUTIL)AMINA POR MEIO DE CATáLISE HETEROGéNEA

Info

Publication number
PT1636169E
PT1636169E PT04740107T PT04740107T PT1636169E PT 1636169 E PT1636169 E PT 1636169E PT 04740107 T PT04740107 T PT 04740107T PT 04740107 T PT04740107 T PT 04740107T PT 1636169 E PT1636169 E PT 1636169E
Authority
PT
Portugal
Prior art keywords
aryl
substituted
compounds
butyl
butan
Prior art date
Application number
PT04740107T
Other languages
English (en)
Inventor
Utz-Peter Jagusch
Wolfgang Hilderich
Monika Wissler
Original Assignee
Gr Nenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gr Nenthal Gmbh filed Critical Gr Nenthal Gmbh
Publication of PT1636169E publication Critical patent/PT1636169E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT04740107T 2003-06-23 2004-06-21 PROCESSO PARA A DESIDRATAÆO DE COMPOSTOS SUBSTITUDOS DE 4-DIMETILAMINO-2-ARILBUTAN-2-OL E PROCESSO PARA A PRODUÆO DE COMPOSTOS SUBSTITUDOS DE DIMETIL-(3-ARILBUTIL)AMINA POR MEIO DE CATáLISE HETEROGéNEA PT1636169E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10328316A DE10328316A1 (de) 2003-06-23 2003-06-23 Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe

Publications (1)

Publication Number Publication Date
PT1636169E true PT1636169E (pt) 2010-07-21

Family

ID=33520871

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04740107T PT1636169E (pt) 2003-06-23 2004-06-21 PROCESSO PARA A DESIDRATAÆO DE COMPOSTOS SUBSTITUDOS DE 4-DIMETILAMINO-2-ARILBUTAN-2-OL E PROCESSO PARA A PRODUÆO DE COMPOSTOS SUBSTITUDOS DE DIMETIL-(3-ARILBUTIL)AMINA POR MEIO DE CATáLISE HETEROGéNEA

Country Status (12)

Country Link
US (2) US20060167318A1 (pt)
EP (1) EP1636169B1 (pt)
CN (2) CN101774932B (pt)
AT (1) ATE469877T1 (pt)
DE (2) DE10328316A1 (pt)
ES (1) ES2345658T3 (pt)
HK (1) HK1088598A1 (pt)
IL (1) IL172692A (pt)
PL (1) PL1636169T3 (pt)
PT (1) PT1636169E (pt)
SI (1) SI1636169T1 (pt)
WO (1) WO2005000788A1 (pt)

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DE10328316A1 (de) 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE102005052588A1 (de) 2005-11-02 2007-05-10 Grünenthal GmbH Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse
TWI401237B (zh) 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
US8138376B2 (en) 2006-07-24 2012-03-20 Janssen Pharmaceutica, Nv Preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine
TWI496762B (zh) * 2006-07-24 2015-08-21 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
CN102002065B (zh) * 2009-09-02 2014-09-10 上海特化医药科技有限公司 他喷他多的制备方法及其中间体
US8288592B2 (en) 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
PL2519100T3 (pl) * 2009-12-29 2017-09-29 Mapi Pharma Limited Związki pośrednie i sposoby wytwarzania tapentadolu i pokrewnych związków
CA2790519A1 (en) 2010-03-05 2011-09-09 Actavis Group Ptc Ehf Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
EP2556048A2 (en) 2010-04-05 2013-02-13 Actavis Group PTC EHF Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof
CN103168025B (zh) * 2010-06-15 2015-02-25 格吕伦塔尔有限公司 用于制备取代的3-(1-氨基-2-甲基戊烷-3-基)苯基化合物的方法
ES2860676T3 (es) * 2010-07-23 2021-10-05 Gruenenthal Gmbh Sales o cocristales de 3- (3-dimetilamino-1-etil-2-metil-propil) -fenol
WO2012023147A1 (en) 2010-08-16 2012-02-23 Indoco Remedies Limited Process for the preparation of tapentadol
US8552219B2 (en) 2010-09-20 2013-10-08 Ind-Swift Laboratories Limited Process for preparing L-phenyl-3-dimethylaminopropane derivative
US20130296608A1 (en) * 2011-01-27 2013-11-07 Symed Labs Limited Novel stereospecific synthesis of (-) (2s, 3s)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol
WO2012146978A2 (en) 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
WO2013105109A1 (en) 2011-11-09 2013-07-18 Indoco Remedies Limited Process for the preparation of tapentadol
WO2013090161A1 (en) 2011-12-12 2013-06-20 Boehringer Ingelheim International Gmbh Stereoselective synthesis of tapentadol and its salts
WO2013120466A1 (en) 2012-02-17 2013-08-22 Zentiva, K.S. A new solid form of tapentadol and a method of its preparation
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
US9090539B2 (en) 2013-05-24 2015-07-28 Ampac Fine Chemicals Llc Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
WO2015075678A1 (en) 2013-11-21 2015-05-28 Unimark Remedies Ltd. A novel process for the preparation of 1-phenyl-3-aminopropane derivatives
SI3083551T1 (en) 2013-12-16 2018-04-30 Farma Grs, D.O.O. CRYSTAL FORM INTERMEDIATE TAPENTADOL
CZ307492B6 (cs) 2014-02-04 2018-10-17 Zentiva, K.S. Pevná forma maleátu tapentadolu a způsob její přípravy
US9556108B2 (en) * 2014-07-10 2017-01-31 Mallinckrodt Llc Process for preparing substituted phenylalkanes
MX370658B (es) 2015-07-10 2019-12-19 SpecGx LLC Proceso en dos etapas para preparar fenilalquilaminas sustituidas en la posición 3.
WO2019238267A1 (en) * 2018-06-15 2019-12-19 Pharmathen S.A. A novel process for the preparation of tapentadol

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KR101057284B1 (ko) 2005-10-26 2011-08-16 일라이 릴리 앤드 캄파니 선택적 ｖｐａｃ２ 수용체 펩티드 작동제

Also Published As

Publication number Publication date
US20130060065A1 (en) 2013-03-07
PL1636169T3 (pl) 2010-11-30
US8704002B2 (en) 2014-04-22
DE502004011239D1 (de) 2010-07-15
ATE469877T1 (de) 2010-06-15
CN1809527B (zh) 2010-05-26
ES2345658T3 (es) 2010-09-29
US20060167318A1 (en) 2006-07-27
CN101774932A (zh) 2010-07-14
HK1088598A1 (en) 2006-11-10
SI1636169T1 (sl) 2010-09-30
WO2005000788A1 (de) 2005-01-06
IL172692A (en) 2011-03-31
IL172692A0 (en) 2006-04-10
CN101774932B (zh) 2013-10-30
EP1636169B1 (de) 2010-06-02
EP1636169A1 (de) 2006-03-22
CN1809527A (zh) 2006-07-26
DE10328316A1 (de) 2005-01-20

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