PT1636169E - PROCESSO PARA A DESIDRATAÃO DE COMPOSTOS SUBSTITUDOS DE 4-DIMETILAMINO-2-ARILBUTAN-2-OL E PROCESSO PARA A PRODUÃO DE COMPOSTOS SUBSTITUDOS DE DIMETIL-(3-ARILBUTIL)AMINA POR MEIO DE CATáLISE HETEROGéNEA - Google Patents
PROCESSO PARA A DESIDRATAÃO DE COMPOSTOS SUBSTITUDOS DE 4-DIMETILAMINO-2-ARILBUTAN-2-OL E PROCESSO PARA A PRODUÃO DE COMPOSTOS SUBSTITUDOS DE DIMETIL-(3-ARILBUTIL)AMINA POR MEIO DE CATáLISE HETEROGéNEAInfo
- Publication number
- PT1636169E PT1636169E PT04740107T PT04740107T PT1636169E PT 1636169 E PT1636169 E PT 1636169E PT 04740107 T PT04740107 T PT 04740107T PT 04740107 T PT04740107 T PT 04740107T PT 1636169 E PT1636169 E PT 1636169E
- Authority
- PT
- Portugal
- Prior art keywords
- aryl
- substituted
- compounds
- butyl
- butan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10328316A DE10328316A1 (de) | 2003-06-23 | 2003-06-23 | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1636169E true PT1636169E (pt) | 2010-07-21 |
Family
ID=33520871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT04740107T PT1636169E (pt) | 2003-06-23 | 2004-06-21 | PROCESSO PARA A DESIDRATAÃO DE COMPOSTOS SUBSTITUDOS DE 4-DIMETILAMINO-2-ARILBUTAN-2-OL E PROCESSO PARA A PRODUÃO DE COMPOSTOS SUBSTITUDOS DE DIMETIL-(3-ARILBUTIL)AMINA POR MEIO DE CATáLISE HETEROGéNEA |
Country Status (12)
Country | Link |
---|---|
US (2) | US20060167318A1 (pt) |
EP (1) | EP1636169B1 (pt) |
CN (2) | CN101774932B (pt) |
AT (1) | ATE469877T1 (pt) |
DE (2) | DE10328316A1 (pt) |
ES (1) | ES2345658T3 (pt) |
HK (1) | HK1088598A1 (pt) |
IL (1) | IL172692A (pt) |
PL (1) | PL1636169T3 (pt) |
PT (1) | PT1636169E (pt) |
SI (1) | SI1636169T1 (pt) |
WO (1) | WO2005000788A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10328316A1 (de) | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
DE102005052588A1 (de) | 2005-11-02 | 2007-05-10 | Grünenthal GmbH | Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse |
TWI401237B (zh) | 2006-07-24 | 2013-07-11 | 3-〔(1r,2r)-3-(二甲基氨基)-1-乙基-2-甲基丙基〕酚之製備 | |
US8138376B2 (en) | 2006-07-24 | 2012-03-20 | Janssen Pharmaceutica, Nv | Preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine |
TWI496762B (zh) * | 2006-07-24 | 2015-08-21 | 製備(1r,2r)-3-(3-二甲胺基-1-乙基-2-甲基-丙基)-酚之方法 | |
CN102002065B (zh) * | 2009-09-02 | 2014-09-10 | 上海特化医药科技有限公司 | 他喷他多的制备方法及其中间体 |
US8288592B2 (en) | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
PL2519100T3 (pl) * | 2009-12-29 | 2017-09-29 | Mapi Pharma Limited | Związki pośrednie i sposoby wytwarzania tapentadolu i pokrewnych związków |
CA2790519A1 (en) | 2010-03-05 | 2011-09-09 | Actavis Group Ptc Ehf | Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
EP2556048A2 (en) | 2010-04-05 | 2013-02-13 | Actavis Group PTC EHF | Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof |
CN103168025B (zh) * | 2010-06-15 | 2015-02-25 | 格吕伦塔尔有限公司 | 用于制备取代的3-(1-氨基-2-甲基戊烷-3-基)苯基化合物的方法 |
ES2860676T3 (es) * | 2010-07-23 | 2021-10-05 | Gruenenthal Gmbh | Sales o cocristales de 3- (3-dimetilamino-1-etil-2-metil-propil) -fenol |
WO2012023147A1 (en) | 2010-08-16 | 2012-02-23 | Indoco Remedies Limited | Process for the preparation of tapentadol |
US8552219B2 (en) | 2010-09-20 | 2013-10-08 | Ind-Swift Laboratories Limited | Process for preparing L-phenyl-3-dimethylaminopropane derivative |
US20130296608A1 (en) * | 2011-01-27 | 2013-11-07 | Symed Labs Limited | Novel stereospecific synthesis of (-) (2s, 3s)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol |
WO2012146978A2 (en) | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof |
WO2013105109A1 (en) | 2011-11-09 | 2013-07-18 | Indoco Remedies Limited | Process for the preparation of tapentadol |
WO2013090161A1 (en) | 2011-12-12 | 2013-06-20 | Boehringer Ingelheim International Gmbh | Stereoselective synthesis of tapentadol and its salts |
WO2013120466A1 (en) | 2012-02-17 | 2013-08-22 | Zentiva, K.S. | A new solid form of tapentadol and a method of its preparation |
EP2674414A1 (en) | 2012-06-15 | 2013-12-18 | Siegfried AG | Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds |
US9090539B2 (en) | 2013-05-24 | 2015-07-28 | Ampac Fine Chemicals Llc | Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds |
WO2015075678A1 (en) | 2013-11-21 | 2015-05-28 | Unimark Remedies Ltd. | A novel process for the preparation of 1-phenyl-3-aminopropane derivatives |
SI3083551T1 (en) | 2013-12-16 | 2018-04-30 | Farma Grs, D.O.O. | CRYSTAL FORM INTERMEDIATE TAPENTADOL |
CZ307492B6 (cs) | 2014-02-04 | 2018-10-17 | Zentiva, K.S. | Pevná forma maleátu tapentadolu a způsob její přípravy |
US9556108B2 (en) * | 2014-07-10 | 2017-01-31 | Mallinckrodt Llc | Process for preparing substituted phenylalkanes |
MX370658B (es) | 2015-07-10 | 2019-12-19 | SpecGx LLC | Proceso en dos etapas para preparar fenilalquilaminas sustituidas en la posición 3. |
WO2019238267A1 (en) * | 2018-06-15 | 2019-12-19 | Pharmathen S.A. | A novel process for the preparation of tapentadol |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE791133A (fr) | 1971-11-10 | 1973-05-09 | Calgon Corp | Nouveaux monomeres cationiques et leurs procedes de fabrication |
AT322534B (de) | 1972-03-16 | 1975-05-26 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen optisch aktiven 1-(4'-amino-3'-halogenphenyl)-2-aminoäthanolen und deren säureadditionssalzen |
US4012456A (en) * | 1974-11-19 | 1977-03-15 | Chaplits Donat N | Method for separation of isobutylene from C4 hydrocarbon fractions |
DD124521A1 (pt) | 1976-03-16 | 1977-03-02 | ||
US4276195A (en) * | 1979-12-20 | 1981-06-30 | Iowa State University Research Foundation, Inc. | Converting homogeneous to heterogeneous catalysts |
US6022637A (en) | 1984-10-23 | 2000-02-08 | Wilson; John T. R. | High temperature battery |
JPH0690934B2 (ja) | 1987-08-07 | 1994-11-14 | 日本電信電話株式会社 | 二次電池およびその製造方法 |
EP0612758B1 (de) | 1993-02-26 | 2003-04-09 | Syngenta Participations AG | Ferrocenyldiphosphine als Liganden für homogene Katalysatoren |
DE59408655D1 (de) | 1993-10-01 | 1999-09-30 | Novartis Ag | Mit Fluoralkyl substituierte Ferrocenyldiphosphine als Liganden für homogene Katalysatoren |
JPH07326372A (ja) | 1994-05-30 | 1995-12-12 | Yuasa Corp | 固体電解質電池 |
DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
ATE222932T1 (de) | 1995-02-24 | 2002-09-15 | Novartis Erfind Verwalt Gmbh | An seitenketten von polymeren gebundene diphosphine und deren metall-komplexe |
DE59605736D1 (de) | 1995-02-24 | 2000-09-21 | Novartis Ag | Silylierte Ferrocenyldiphosphine, an anorganische oder polymere organische Träger gebundene silylierte Ferrocenyldiphosphine sowie Metallkomplexe davon, ihre Herstellung und Verwendung |
DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
US6337156B1 (en) | 1997-12-23 | 2002-01-08 | Sri International | Ion battery using high aspect ratio electrodes |
JPH11345629A (ja) | 1998-03-31 | 1999-12-14 | Canon Inc | 二次電池及びその製造方法 |
DE19933421A1 (de) * | 1999-07-16 | 2001-01-25 | Gruenenthal Gmbh | 2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate |
DE10000311A1 (de) | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Aminomethyl-Phonyl-Cyclohexanonderivate |
JP4951809B2 (ja) | 2000-11-21 | 2012-06-13 | 日油株式会社 | 二次電池用電解質および二次電池 |
JP4777593B2 (ja) | 2002-11-29 | 2011-09-21 | 株式会社オハラ | リチウムイオン二次電池の製造方法 |
JP4366101B2 (ja) | 2003-03-31 | 2009-11-18 | キヤノン株式会社 | リチウム二次電池 |
EP1611114A2 (de) | 2003-04-07 | 2006-01-04 | Solvias AG | Amin-substituierte diphenyldiphosphine und deren verwendung in metallkomplexen für asymmetrische synthesen |
DE10326097A1 (de) | 2003-06-06 | 2005-01-05 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen |
DE10328316A1 (de) | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
KR101057284B1 (ko) | 2005-10-26 | 2011-08-16 | 일라이 릴리 앤드 캄파니 | 선택적 vpac2 수용체 펩티드 작동제 |
-
2003
- 2003-06-23 DE DE10328316A patent/DE10328316A1/de not_active Withdrawn
-
2004
- 2004-06-21 CN CN2009101611938A patent/CN101774932B/zh not_active Expired - Lifetime
- 2004-06-21 PT PT04740107T patent/PT1636169E/pt unknown
- 2004-06-21 ES ES04740107T patent/ES2345658T3/es not_active Expired - Lifetime
- 2004-06-21 DE DE502004011239T patent/DE502004011239D1/de not_active Expired - Lifetime
- 2004-06-21 CN CN2004800173486A patent/CN1809527B/zh not_active Expired - Lifetime
- 2004-06-21 WO PCT/EP2004/006666 patent/WO2005000788A1/de active Application Filing
- 2004-06-21 EP EP04740107A patent/EP1636169B1/de not_active Expired - Lifetime
- 2004-06-21 PL PL04740107T patent/PL1636169T3/pl unknown
- 2004-06-21 AT AT04740107T patent/ATE469877T1/de active
- 2004-06-21 SI SI200431479T patent/SI1636169T1/sl unknown
-
2005
- 2005-12-20 IL IL172692A patent/IL172692A/en active IP Right Grant
- 2005-12-22 US US11/313,937 patent/US20060167318A1/en not_active Abandoned
-
2006
- 2006-09-14 HK HK06110186.7A patent/HK1088598A1/xx not_active IP Right Cessation
-
2012
- 2012-11-02 US US13/667,110 patent/US8704002B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20130060065A1 (en) | 2013-03-07 |
PL1636169T3 (pl) | 2010-11-30 |
US8704002B2 (en) | 2014-04-22 |
DE502004011239D1 (de) | 2010-07-15 |
ATE469877T1 (de) | 2010-06-15 |
CN1809527B (zh) | 2010-05-26 |
ES2345658T3 (es) | 2010-09-29 |
US20060167318A1 (en) | 2006-07-27 |
CN101774932A (zh) | 2010-07-14 |
HK1088598A1 (en) | 2006-11-10 |
SI1636169T1 (sl) | 2010-09-30 |
WO2005000788A1 (de) | 2005-01-06 |
IL172692A (en) | 2011-03-31 |
IL172692A0 (en) | 2006-04-10 |
CN101774932B (zh) | 2013-10-30 |
EP1636169B1 (de) | 2010-06-02 |
EP1636169A1 (de) | 2006-03-22 |
CN1809527A (zh) | 2006-07-26 |
DE10328316A1 (de) | 2005-01-20 |
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