PE20020521A1 - Compuestos heterociclicos sustituidos para tratar la resistencia a multiples drogas - Google Patents
Compuestos heterociclicos sustituidos para tratar la resistencia a multiples drogasInfo
- Publication number
- PE20020521A1 PE20020521A1 PE2001001029A PE2001001029A PE20020521A1 PE 20020521 A1 PE20020521 A1 PE 20020521A1 PE 2001001029 A PE2001001029 A PE 2001001029A PE 2001001029 A PE2001001029 A PE 2001001029A PE 20020521 A1 PE20020521 A1 PE 20020521A1
- Authority
- PE
- Peru
- Prior art keywords
- heterocyclic compounds
- drug resistance
- multiple drug
- treat multiple
- substitute
- Prior art date
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
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- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
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- C07D263/12—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals containing only hydrogen and carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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- C07C2601/14—The ring being saturated
Abstract
SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA I DONDE s ES 1-3; A1 ES -(C(R1)2)x-D1-Oy-D2-R2; R1 ES H, OH, HIDROCARBURO, CARBOCICLO, HETEROCICLO, AROMATICO, HETEROAROMATICO; R2 ES HIDROCARBURO, CARBOCICLO, HETEROCICLO, AROMATICO, HETEROAROMATICO; R3 ES H, R2; O R2 Y R3 FORMAN UN ANILLO HETEROCICLO; y Y z SON 0-1; D1 Y D2 SON CO, NR3; CUANDO y=0; z=1; CUANDO z=0; y=1; CUANDO y=0; D1 ES NR3; D2 ES CO; CUANDO y=0; D2 ES NR3, D1 ES CO; x=0, D1 ES CO, y=0, D2 ES NR3, D3 ES CO, SO2; A3 ES D4-(C(R1)2)t-D5; t ES 1-6; D4 ES CO, CHR1; D5 ES NR6R7, OrR6, COR6; r ES 0-1; R6 ES HIDROCARBURO, CARBOCICLO, HETEROCICLO, AROMATICO, HETEROAROMATICO; R7 ES H, R6; CUANDO u ES 0; D3 Y D4 NO SON CO; A2 ES -(C(R1)u-D3-(C(R1)2)p-Ov-R5; p Y u SON 0-10; v ES 0-1; D3 ES SO2, CO, CR1OH; CUANDO D3 ES SO2; D1 ES CO, D2 ES NR3; R2 Y R3 FORMAN UN ANILLO; D3 ES CO, v ES 0; R5 ES CO; p ES DIFERENTE DE 0; R5 ES UN HIDROCARBURO OPCIONALMENTE SUSTITUIDO CON GRUPO AROMATICO HETEROAROMATICO. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS AGENTES TERAPEUTICOS, ANTIBACTERIANOS, ANTIVIRAL, ANTIFUNGICO. LOS COMPUESTOSSON INHIBIDORES DE LA PROTEINA DE TRANSPORTE CELULAR GLICOPROTEINA P Y PUEDEN SER UTILES PARA INHIBIR LA RESISTENCIA A MULTIPLES DROGAS
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US09/740,391 US6693099B2 (en) | 2000-10-17 | 2000-12-19 | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
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-
2000
- 2000-12-19 US US09/740,391 patent/US6693099B2/en not_active Expired - Lifetime
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2001
- 2001-10-16 CA CA2420996A patent/CA2420996C/en not_active Expired - Fee Related
- 2001-10-16 PE PE2001001029A patent/PE20020521A1/es not_active Application Discontinuation
- 2001-10-16 JP JP2002536058A patent/JP4515027B2/ja not_active Expired - Fee Related
- 2001-10-16 AT AT01981711T patent/ATE553086T1/de active
- 2001-10-16 EP EP01981711A patent/EP1326840B1/en not_active Expired - Lifetime
- 2001-10-16 MX MXPA03003480A patent/MXPA03003480A/es not_active Application Discontinuation
- 2001-10-16 AU AU2002213336A patent/AU2002213336A1/en not_active Abandoned
- 2001-10-16 WO PCT/US2001/032422 patent/WO2002032874A2/en active Application Filing
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US20040132722A1 (en) | 2004-07-08 |
CA2420996C (en) | 2010-06-22 |
ATE553086T1 (de) | 2012-04-15 |
US6693099B2 (en) | 2004-02-17 |
EP1326840B1 (en) | 2012-04-11 |
JP4515027B2 (ja) | 2010-07-28 |
WO2002032874A8 (en) | 2003-11-13 |
JP2004513097A (ja) | 2004-04-30 |
CA2420996A1 (en) | 2002-04-25 |
MXPA03003480A (es) | 2003-07-14 |
EP1326840A2 (en) | 2003-07-16 |
US20020123498A1 (en) | 2002-09-05 |
WO2002032874A3 (en) | 2002-07-25 |
WO2002032874A2 (en) | 2002-04-25 |
AU2002213336A1 (en) | 2002-04-29 |
US7304053B2 (en) | 2007-12-04 |
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