IT1255704B - Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree - Google Patents

Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree

Info

Publication number
IT1255704B
IT1255704B ITMI922263A ITMI922263A IT1255704B IT 1255704 B IT1255704 B IT 1255704B IT MI922263 A ITMI922263 A IT MI922263A IT MI922263 A ITMI922263 A IT MI922263A IT 1255704 B IT1255704 B IT 1255704B
Authority
IT
Italy
Prior art keywords
asthma
therapy
airway inflammation
heterocyclic amines
amines useful
Prior art date
Application number
ITMI922263A
Other languages
English (en)
Inventor
Giorgio Long
Silvano Spinelli
Antonella Rozzi
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Publication of ITMI922263A0 publication Critical patent/ITMI922263A0/it
Priority to ITMI922263A priority Critical patent/IT1255704B/it
Priority to KR1019950701200A priority patent/KR100270977B1/ko
Priority to ES93919147T priority patent/ES2111175T3/es
Priority to DE69315085T priority patent/DE69315085T2/de
Priority to AT93919147T priority patent/ATE159937T1/de
Priority to US08/406,900 priority patent/US5607930A/en
Priority to PCT/EP1993/002264 priority patent/WO1994007856A1/en
Priority to JP50861694A priority patent/JP3268524B2/ja
Priority to AU49518/93A priority patent/AU680626B2/en
Priority to CA002145775A priority patent/CA2145775C/en
Priority to RU95112577A priority patent/RU2119913C1/ru
Priority to EP93919147A priority patent/EP0662957B1/en
Priority to CN93118154A priority patent/CN1043141C/zh
Priority to ZA937147A priority patent/ZA937147B/xx
Priority to TW082107968A priority patent/TW238305B/zh
Publication of ITMI922263A1 publication Critical patent/ITMI922263A1/it
Application granted granted Critical
Publication of IT1255704B publication Critical patent/IT1255704B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Si descrivono composti di formula generale (I): (FORMULA I) dove Ra, Rb, B e D hanno i significati riportati nella descrizione; procedimenti per la loro preparazione.I composti dell'invenzione sono dotati di attività antiasmatica e antiinfiammatoria delle vie aeree.
ITMI922263A 1992-09-30 1992-09-30 Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree IT1255704B (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
ITMI922263A IT1255704B (it) 1992-09-30 1992-09-30 Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree
AU49518/93A AU680626B2 (en) 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract
RU95112577A RU2119913C1 (ru) 1992-09-30 1993-08-24 1,4-дизамещенные пиперазины, пригодные при лечении астмы и воспаления дыхательных путей, способ их получения, лекарственные препараты на их основе и способ их получения
DE69315085T DE69315085T2 (de) 1992-09-30 1993-08-24 1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege
AT93919147T ATE159937T1 (de) 1992-09-30 1993-08-24 1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege
US08/406,900 US5607930A (en) 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract
PCT/EP1993/002264 WO1994007856A1 (en) 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract
JP50861694A JP3268524B2 (ja) 1992-09-30 1993-08-24 気道のぜん息および炎症の治療に有用な１，４‐ジ置換されたピペラジン
KR1019950701200A KR100270977B1 (ko) 1992-09-30 1993-08-24 호흡기의 천식과 염증치료에 유용한 1,4-이치환된 피페라진
CA002145775A CA2145775C (en) 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract
ES93919147T ES2111175T3 (es) 1992-09-30 1993-08-24 Piperazinas 1,4-disustituidas utiles en el tratamiento del asma y de inflamaciones de las vias respiratorias.
EP93919147A EP0662957B1 (en) 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract
CN93118154A CN1043141C (zh) 1992-09-30 1993-09-27 杂环胺化合物,其制备方法、含它们的药物组合物及其医药用途
ZA937147A ZA937147B (en) 1992-09-30 1993-09-27 Heterocyclic amines useful in the therapy of the asthma and of the inflammation of the respiratory tract
TW082107968A TW238305B (it) 1992-09-30 1993-09-27

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922263A IT1255704B (it) 1992-09-30 1992-09-30 Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree

Publications (3)

Publication Number Publication Date
ITMI922263A0 ITMI922263A0 (it) 1992-09-30
ITMI922263A1 ITMI922263A1 (it) 1994-03-30
IT1255704B true IT1255704B (it) 1995-11-10

Family

ID=11364040

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI922263A IT1255704B (it) 1992-09-30 1992-09-30 Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree

Country Status (15)

Country Link
US (1) US5607930A (it)
EP (1) EP0662957B1 (it)
JP (1) JP3268524B2 (it)
KR (1) KR100270977B1 (it)
CN (1) CN1043141C (it)
AT (1) ATE159937T1 (it)
AU (1) AU680626B2 (it)
CA (1) CA2145775C (it)
DE (1) DE69315085T2 (it)
ES (1) ES2111175T3 (it)
IT (1) IT1255704B (it)
RU (1) RU2119913C1 (it)
TW (1) TW238305B (it)
WO (1) WO1994007856A1 (it)
ZA (1) ZA937147B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601697D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
US6809093B2 (en) 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
ATE456559T1 (de) * 2001-10-22 2010-02-15 Pfizer Prod Inc Piperazinderivate mit ccr1-rezeptor- antagonistischer wirkung
CA2580857A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP1807085B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
JP5043668B2 (ja) 2004-09-20 2012-10-10 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体および治療薬としてのそれらの使用
JP5094398B2 (ja) 2004-09-20 2012-12-12 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環式誘導体およびステアロイル−ＣｏＡデサチュラーゼのメディエータとしてのそれらの使用
BRPI0515489A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados heterocìclicos e sua utilização como inibidores de estearoil-coa desaturase
US7919496B2 (en) 2004-09-20 2011-04-05 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
CN101083992A (zh) 2004-09-20 2007-12-05 泽农医药公司 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物
WO2007130075A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
EP2209376B1 (en) * 2007-10-11 2013-03-06 GlaxoSmithKline LLC Novel seh inhibitors and their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288575A4 (en) * 1986-10-27 1990-10-10 Yoshitomi Pharmaceutical Industries, Ltd. Piperazine compounds and their medicinal use
FR2663026B1 (fr) * 1990-06-07 1992-08-07 Synthelabo Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.
IT1245712B (it) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
JPH08291987A (ja) * 1995-04-20 1996-11-05 Hitachi Ltd 冷蔵庫

Also Published As

Publication number Publication date
WO1994007856A1 (en) 1994-04-14
JP3268524B2 (ja) 2002-03-25
EP0662957B1 (en) 1997-11-05
RU95112577A (ru) 1997-01-10
KR100270977B1 (ko) 2000-11-01
ITMI922263A0 (it) 1992-09-30
RU2119913C1 (ru) 1998-10-10
US5607930A (en) 1997-03-04
ES2111175T3 (es) 1998-03-01
CA2145775A1 (en) 1994-04-14
CN1088580A (zh) 1994-06-29
ATE159937T1 (de) 1997-11-15
AU4951893A (en) 1994-04-26
ITMI922263A1 (it) 1994-03-30
CN1043141C (zh) 1999-04-28
CA2145775C (en) 2002-10-08
DE69315085D1 (de) 1997-12-11
JPH08501573A (ja) 1996-02-20
AU680626B2 (en) 1997-08-07
DE69315085T2 (de) 1998-03-26
ZA937147B (en) 1994-05-18
EP0662957A1 (en) 1995-07-19
TW238305B (it) 1995-01-11

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970929