OA12498A - Reconstitutable parenteral composition containing a cox-2 inhibitor. - Google Patents

Reconstitutable parenteral composition containing a cox-2 inhibitor. Download PDF

Info

Publication number: OA12498A
Authority: OA; OAPI
Prior art keywords: composition; parecoxib; sodium; therapeutic agent; sait
Prior art date: 2001-04-03

Application number

OA1200300254A

Other languages

English (en)

Inventor

Tugrul T Kararli

Aziz Karim

Sandeep Nema

Original Assignee

Pharmacia Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-03

Filing date

2002-04-02

Publication date

2006-05-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23075770&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA12498(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-04-02 Application filed by Pharmacia Corp filed Critical Pharmacia Corp

2006-05-24 Publication of OA12498A publication Critical patent/OA12498A/en

Links

239000000203 mixture Substances 0.000 title claims abstract description 150
229940111134 coxibs Drugs 0.000 title description 2
239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title description 2
239000003814 drug Substances 0.000 claims abstract description 77
229940124597 therapeutic agent Drugs 0.000 claims abstract description 42
102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 claims abstract description 39
108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 claims abstract description 39
239000000843 powder Substances 0.000 claims abstract description 26
239000000651 prodrug Substances 0.000 claims abstract description 26
229940002612 prodrug Drugs 0.000 claims abstract description 26
239000006172 buffering agent Substances 0.000 claims abstract description 25
230000002401 inhibitory effect Effects 0.000 claims abstract description 24
229960003925 parecoxib sodium Drugs 0.000 claims abstract description 24
ICJGKYTXBRDUMV-UHFFFAOYSA-N trichloro(6-trichlorosilylhexyl)silane Chemical compound Cl[Si](Cl)(Cl)CCCCCC[Si](Cl)(Cl)Cl ICJGKYTXBRDUMV-UHFFFAOYSA-N 0.000 claims abstract description 24
239000007788 liquid Substances 0.000 claims abstract description 15
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 13
239000002904 solvent Substances 0.000 claims abstract description 13
150000003839 salts Chemical class 0.000 claims abstract description 11
229940102223 injectable solution Drugs 0.000 claims abstract description 7
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
229960004662 parecoxib Drugs 0.000 claims description 67
TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 claims description 67
229960002004 valdecoxib Drugs 0.000 claims description 54
LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 claims description 54
239000000243 solution Substances 0.000 claims description 36
238000000034 method Methods 0.000 claims description 32
-1 desracoxib Chemical compound 0.000 claims description 31
238000011282 treatment Methods 0.000 claims description 29
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 21
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LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 5
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239000003125 aqueous solvent Substances 0.000 claims 2
AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical compound OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 claims 1
MJGRAMHMDHOEPN-UHFFFAOYSA-N 2,4-dichloro-2-(trifluoromethyl)chromene-3-carboxylic acid Chemical compound C1=CC=C2OC(C(F)(F)F)(Cl)C(C(=O)O)=C(Cl)C2=C1 MJGRAMHMDHOEPN-UHFFFAOYSA-N 0.000 claims 1
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244000182067 Fraxinus ornus Species 0.000 claims 1
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OA1200300254A 2001-04-03 2002-04-02 Reconstitutable parenteral composition containing a cox-2 inhibitor. OA12498A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28105801P	2001-04-03	2001-04-03

Publications (1)

Publication Number	Publication Date
OA12498A true OA12498A (en)	2006-05-24

Family

ID=23075770

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200300254A OA12498A (en)	2001-04-03	2002-04-02	Reconstitutable parenteral composition containing a cox-2 inhibitor.

Country Status (46)

Country	Link
US (1)	US7695736B2 (es)
EP (1)	EP1372645B1 (es)
JP (1)	JP4511792B2 (es)
KR (1)	KR100980685B1 (es)
CN (3)	CN107115302A (es)
AP (1)	AP1776A (es)
AR (1)	AR033688A1 (es)
AT (1)	ATE310516T1 (es)
AU (1)	AU2002256031B2 (es)
BG (1)	BG66367B1 (es)
BR (1)	BRPI0208652B8 (es)
CA (1)	CA2442906C (es)
CZ (1)	CZ299623B6 (es)
DE (1)	DE60207535T2 (es)
DK (1)	DK1372645T3 (es)
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- 2002-04-02 UA UA2003108945A patent/UA77173C2/xx unknown
- 2002-04-02 CA CA002442906A patent/CA2442906C/en not_active Expired - Fee Related
- 2002-04-02 GE GE5312A patent/GEP20063775B/en unknown
- 2002-04-02 CN CNA028107659A patent/CN1512882A/zh active Pending
- 2002-04-02 DE DE60207535T patent/DE60207535T2/de not_active Expired - Lifetime
- 2002-04-02 EP EP02725471A patent/EP1372645B1/en not_active Expired - Lifetime
- 2002-04-03 TW TW091106757A patent/TWI314867B/zh not_active IP Right Cessation
- 2002-04-03 PA PA20028542701A patent/PA8542701A1/es unknown
- 2002-04-03 EG EG2002040352A patent/EG24345A/xx active
- 2002-04-03 TN TNTNSN02039A patent/TNSN02039A1/en unknown
- 2002-04-03 GT GT200200065A patent/GT200200065A/es unknown
- 2002-04-03 JO JO200231A patent/JO2337B1/en active
- 2002-04-03 SV SV2002000969A patent/SV2002000969A/es active IP Right Grant
- 2002-04-03 AR ARP020101224A patent/AR033688A1/es not_active Application Discontinuation
2003
- 2003-07-08 TN TNPCT/US2002/010252A patent/TNSN03085A1/fr unknown
- 2003-09-30 ZA ZA200307630A patent/ZA200307630B/en unknown
- 2003-09-30 IS IS6972A patent/IS2408B/is unknown
- 2003-10-01 IL IL158209A patent/IL158209A/en active IP Right Grant
- 2003-10-01 BG BG108221A patent/BG66367B1/bg unknown
- 2003-10-01 HR HRP20030793AA patent/HRP20030793B1/hr not_active IP Right Cessation
- 2003-10-02 MA MA27332A patent/MA27008A1/fr unknown
- 2003-10-02 NO NO20034415A patent/NO333381B1/no not_active IP Right Cessation
- 2003-10-03 EC EC2003004789A patent/ECSP034789A/es unknown
2018
- 2018-02-28 HK HK18102864.9A patent/HK1243338A1/zh unknown
- 2018-03-27 HK HK18104186.6A patent/HK1244690A1/zh unknown

Also Published As

Publication number	Publication date
UA77173C2 (en)	2006-11-15
SK12282003A3 (sk)	2005-03-04
BG108221A (bg)	2010-08-31
TNSN03085A1 (fr)	2005-12-23
CN107213121A (zh)	2017-09-29
NO20034415L (no)	2003-12-02
PL205658B1 (pl)	2010-05-31
US7695736B2 (en)	2010-04-13
BR0208652A (pt)	2004-03-02
ECSP034789A (es)	2004-07-23
AP2003002879A0 (en)	2003-12-31
WO2002080912A1 (en)	2002-10-17
BG66367B1 (bg)	2013-10-31
MXPA03009013A (es)	2004-02-12
GT200200065A (es)	2002-11-15
AP1776A (en)	2007-08-28
SI1372645T1 (sl)	2006-06-30
CA2442906A1 (en)	2002-10-17
HK1244690A1 (zh)	2018-08-17
HUP0303750A3 (en)	2006-02-28
NO20034415D0 (no)	2003-10-02
SK287754B6 (sk)	2011-08-04
BRPI0208652B8 (pt)	2021-05-25
JO2337B1 (en)	2006-06-28
MA27008A1 (fr)	2004-12-20
HU229264B1 (en)	2013-10-28
JP2004525949A (ja)	2004-08-26
HRP20030793A2 (en)	2005-10-31
DE60207535D1 (de)	2005-12-29
CZ20032651A3 (cs)	2004-07-14
TWI314867B (en)	2009-09-21
YU85803A (sh)	2006-05-25
JP4511792B2 (ja)	2010-07-28
BR0208652B1 (pt)	2017-10-31
IL158209A0 (en)	2004-05-12
ES2252448T3 (es)	2006-05-16
GEP20063775B (en)	2006-03-27
HRP20030793B1 (hr)	2013-05-31
DE60207535T2 (de)	2006-07-20
AU2002256031B2 (en)	2006-05-18
AR033688A1 (es)	2004-01-07
EA006554B1 (ru)	2006-02-24
RS50430B (sr)	2009-12-31
PA8542701A1 (es)	2002-10-28
CZ299623B6 (cs)	2008-09-24
DK1372645T3 (da)	2006-02-13
HK1243338A1 (zh)	2018-07-13
EP1372645B1 (en)	2005-11-23
CN1512882A (zh)	2004-07-14
PL368597A1 (en)	2005-04-04
SV2002000969A (es)	2002-12-13
KR100980685B1 (ko)	2010-09-07
KR20030087058A (ko)	2003-11-12
CA2442906C (en)	2010-01-12
IS6972A (is)	2003-09-30
EA200301004A1 (ru)	2004-04-29
ZA200307630B (en)	2004-09-30
IL158209A (en)	2010-05-31
ATE310516T1 (de)	2005-12-15
HUP0303750A2 (hu)	2004-03-01
EG24345A (en)	2009-02-11
CN107115302A (zh)	2017-09-01
NO333381B1 (no)	2013-05-21
MEP56908A (en)	2011-05-10
US20030078266A1 (en)	2003-04-24
MY137736A (en)	2009-03-31
NZ528547A (en)	2005-09-30
EP1372645A1 (en)	2004-01-02
TNSN02039A1 (en)	2005-12-23
PE20021017A1 (es)	2002-11-24
IS2408B (is)	2008-09-15

Publication	Publication Date	Title
EP1372645B1 (en)	2005-11-23	Reconstitutable parenteral composition containing a cox-2 inhibitor
AU2002256031A1 (en)	2003-04-10	Reconstitutable parenteral composition containing a COX-2 inhibitor
US6579895B2 (en)	2003-06-17	Use of a celecoxib composition for fast pain relief
US20030161867A1 (en)	2003-08-28	Skin-permeable selective cyclooxygenase-2 inhibitor composition
EP1814517B1 (en)	2010-08-11	Nonaqueous liquid parenteral aceclofenac formulation
EP1446118B1 (en)	2008-01-09	Oral dosage form of parecoxib
MXPA05000011A (es)	2005-04-08	Formulacion parenteral liquida estable de parecoxib.
KR20050072823A (ko)	2005-07-12	셀레콕시브 전구약물