FR2769311B1 - Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique - Google Patents

Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique

Info

Publication number
FR2769311B1
FR2769311B1 FR9712459A FR9712459A FR2769311B1 FR 2769311 B1 FR2769311 B1 FR 2769311B1 FR 9712459 A FR9712459 A FR 9712459A FR 9712459 A FR9712459 A FR 9712459A FR 2769311 B1 FR2769311 B1 FR 2769311B1
Authority
FR
France
Prior art keywords
diarylthiazolin
novel
processes
preparation
therapeutic uses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9712459A
Other languages
English (en)
Other versions
FR2769311A1 (fr
Inventor
Eric Sartori
Jean-Marie Charles Teulon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNION PHARMA SCIENT APPL
UPSA SAS
Original Assignee
UNION PHARMA SCIENT APPL
UPSA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNION PHARMA SCIENT APPL, UPSA SAS filed Critical UNION PHARMA SCIENT APPL
Priority to FR9712459A priority Critical patent/FR2769311B1/fr
Priority to US08/962,256 priority patent/US5859036A/en
Priority to TW087114980A priority patent/TW520365B/zh
Priority to CO98056357A priority patent/CO4980887A1/es
Priority to PE1998000920A priority patent/PE120099A1/es
Priority to ZA988921A priority patent/ZA988921B/xx
Priority to CA002306245A priority patent/CA2306245A1/fr
Priority to AU94462/98A priority patent/AU747221B2/en
Priority to ARP980104976A priority patent/AR017172A1/es
Priority to PCT/FR1998/002128 priority patent/WO1999018093A1/fr
Priority to EP98947607A priority patent/EP1023277A1/fr
Priority to JP2000514904A priority patent/JP2001519343A/ja
Publication of FR2769311A1 publication Critical patent/FR2769311A1/fr
Application granted granted Critical
Publication of FR2769311B1 publication Critical patent/FR2769311B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
FR9712459A 1997-10-07 1997-10-07 Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique Expired - Fee Related FR2769311B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR9712459A FR2769311B1 (fr) 1997-10-07 1997-10-07 Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique
US08/962,256 US5859036A (en) 1997-10-07 1997-10-31 3,4-diarylthiazolin-2-one or -2-thione derivatives, their methods of preparation and their uses in their methods of preparation and their uses in therapeutics
TW087114980A TW520365B (en) 1997-10-07 1998-09-09 Novel 3,4-diarylthiazolin-2-one or -2-thione derivatives, their methods of preparation and their uses in therapeutics
CO98056357A CO4980887A1 (es) 1997-10-07 1998-09-28 Nueva 3,4-diariltiazolina-2-uno o 2-tiono derivados, sus metodos de preparacion y su uso terapeutico
PE1998000920A PE120099A1 (es) 1997-10-07 1998-09-28 Nueva 3,4-diariltiazolina-2-ona o 2-tiona derivados, sus metodos de preparacion y su uso terapeutico
ZA988921A ZA988921B (en) 1997-10-07 1998-09-30 3,4-diarylthiazolin-2-one or -2-thione derivatives their methods of preparation and their uses in therapeutics
CA002306245A CA2306245A1 (fr) 1997-10-07 1998-10-06 Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique
AU94462/98A AU747221B2 (en) 1997-10-07 1998-10-06 Novel 3,4-diarylthiazolin-2-one or -2-thione derivatives, preparation methods and uses in therapy
ARP980104976A AR017172A1 (es) 1997-10-07 1998-10-06 Compuestos derivados de 3,4-diariltiazolina-2-ona o 2-tiona un metodo para su preparacion y composiciones farmaceuticas que los comprenden
PCT/FR1998/002128 WO1999018093A1 (fr) 1997-10-07 1998-10-06 Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique
EP98947607A EP1023277A1 (fr) 1997-10-07 1998-10-06 Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique
JP2000514904A JP2001519343A (ja) 1997-10-07 1998-10-06 新規な３，４−ジアリールチアゾリン−２−オン又は−２−チオン誘導体、その調製方法及び治療用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9712459A FR2769311B1 (fr) 1997-10-07 1997-10-07 Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique

Publications (2)

Publication Number Publication Date
FR2769311A1 FR2769311A1 (fr) 1999-04-09
FR2769311B1 true FR2769311B1 (fr) 1999-12-24

Family

ID=9511893

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9712459A Expired - Fee Related FR2769311B1 (fr) 1997-10-07 1997-10-07 Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique

Country Status (12)

Country Link
US (1) US5859036A (fr)
EP (1) EP1023277A1 (fr)
JP (1) JP2001519343A (fr)
AR (1) AR017172A1 (fr)
AU (1) AU747221B2 (fr)
CA (1) CA2306245A1 (fr)
CO (1) CO4980887A1 (fr)
FR (1) FR2769311B1 (fr)
PE (1) PE120099A1 (fr)
TW (1) TW520365B (fr)
WO (1) WO1999018093A1 (fr)
ZA (1) ZA988921B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
US6649645B1 (en) 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
US20040122011A1 (en) * 1998-12-23 2004-06-24 Pharmacia Corporation Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
SK12672001A3 (sk) * 1999-12-08 2002-04-04 Pharmacia Corporation Zloženia inhibítora cyklooxygenázy-2 s rýchlym nástupom terapeutického účinku
WO2001081332A2 (fr) * 2000-04-25 2001-11-01 Pharmacia Corporation Composes de 2-fluorobenzenesulfonyle utilises pour le traitement d'inflammations
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
JP2004503601A (ja) * 2000-07-13 2004-02-05 ファルマシア・コーポレーション 眼のｃｏｘ−２媒介疾患の処置及び予防におけるｃｏｘ−２阻害剤の使用法
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
EP1363669A2 (fr) * 2001-02-02 2003-11-26 Pharmacia Corporation Methode d'utilisation d'un inhibiteur de la cyclooxygenase-2 et de steroides sexuels dans une polytherapie pour traiter et prevenir la dysmenorrhee
MY137736A (en) 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
KR100804827B1 (ko) * 2002-05-17 2008-02-20 씨제이제일제당 (주) 티아졸리딘-4-온 유도체, 그 제조방법 및 약제학적 조성물
KR100465455B1 (ko) * 2002-06-24 2005-01-13 씨제이 주식회사 2-티옥소티아졸 유도체, 그 제조방법 및 약제학적 조성물
CN1309717C (zh) * 2003-06-03 2007-04-11 李小虎 4－芳基－5h－噻吩－2－酮衍生物、其制法和用途
WO2022195579A1 (fr) 2021-03-15 2022-09-22 Saul Yedgar Dipalmitoyl-phosphatidyl-éthanol-amine conjuguée à l'acide hyaluronique en combinaison avec des médicaments anti-inflammatoires non stéroïdiens (ains) pour traiter ou soulager des maladies inflammatoires

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2050439A1 (de) * 1970-10-14 1972-04-20 Farbenfabriken Bayer Ag, 5090 Leverkusen Thiazolon-(2)-Derivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
CN1061036C (zh) * 1993-11-30 2001-01-24 G·D·瑟尔公司 用于治疗炎症的取代的吡唑基苯磺酰胺类化合物
US5616601A (en) * 1994-07-28 1997-04-01 Gd Searle & Co 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors

Also Published As

Publication number Publication date
CA2306245A1 (fr) 1999-04-15
FR2769311A1 (fr) 1999-04-09
AU9446298A (en) 1999-04-27
AR017172A1 (es) 2001-08-22
ZA988921B (en) 1999-04-12
CO4980887A1 (es) 2000-11-27
US5859036A (en) 1999-01-12
AU747221B2 (en) 2002-05-09
PE120099A1 (es) 1999-12-19
EP1023277A1 (fr) 2000-08-02
JP2001519343A (ja) 2001-10-23
WO1999018093A1 (fr) 1999-04-15
TW520365B (en) 2003-02-11

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20150630