FR2751964B1 - Nouveaux derives diarylmethylene carbocycliques, leurs procedes de preparation, et leurs utilisations en therapeutique - Google Patents
Nouveaux derives diarylmethylene carbocycliques, leurs procedes de preparation, et leurs utilisations en therapeutiqueInfo
- Publication number
- FR2751964B1 FR2751964B1 FR9609742A FR9609742A FR2751964B1 FR 2751964 B1 FR2751964 B1 FR 2751964B1 FR 9609742 A FR9609742 A FR 9609742A FR 9609742 A FR9609742 A FR 9609742A FR 2751964 B1 FR2751964 B1 FR 2751964B1
- Authority
- FR
- France
- Prior art keywords
- processes
- preparation
- therapeutic uses
- novel carbocyclic
- diarylmethylene derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9609742A FR2751964B1 (fr) | 1996-08-01 | 1996-08-01 | Nouveaux derives diarylmethylene carbocycliques, leurs procedes de preparation, et leurs utilisations en therapeutique |
US08/723,449 US5686460A (en) | 1996-08-01 | 1996-10-07 | Carbocyclic diarylmethylene derivatives, processes for their preparation and their uses in therapeutics |
CA002262223A CA2262223A1 (fr) | 1996-08-01 | 1997-07-31 | Nouveaux derives diarylmethylene carbocycliques, leurs procedes de preparation et leurs utilisations en therapeutique |
PCT/FR1997/001431 WO1998005643A1 (fr) | 1996-08-01 | 1997-07-31 | Nouveaux derives diarylmethylene carbocycliques, leurs procedes de preparation et leurs utilisations en therapeutique |
JP10507673A JP2000515161A (ja) | 1996-08-01 | 1997-07-31 | 新規の炭素環式ジアリールメチレン誘導体、その製造方法及びその治療上の使用 |
AU39443/97A AU729453B2 (en) | 1996-08-01 | 1997-07-31 | Novel carbocyclic diarylmethylene derivatives, methods for preparing same, and therapeutical uses thereof |
EP97936719A EP0915850A1 (fr) | 1996-08-01 | 1997-07-31 | Nouveaux derives diarylmethylene carbocycliques, leurs procedes de preparation et leurs utilisations en therapeutique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9609742A FR2751964B1 (fr) | 1996-08-01 | 1996-08-01 | Nouveaux derives diarylmethylene carbocycliques, leurs procedes de preparation, et leurs utilisations en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2751964A1 FR2751964A1 (fr) | 1998-02-06 |
FR2751964B1 true FR2751964B1 (fr) | 1998-10-30 |
Family
ID=9494744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9609742A Expired - Fee Related FR2751964B1 (fr) | 1996-08-01 | 1996-08-01 | Nouveaux derives diarylmethylene carbocycliques, leurs procedes de preparation, et leurs utilisations en therapeutique |
Country Status (7)
Country | Link |
---|---|
US (1) | US5686460A (fr) |
EP (1) | EP0915850A1 (fr) |
JP (1) | JP2000515161A (fr) |
AU (1) | AU729453B2 (fr) |
CA (1) | CA2262223A1 (fr) |
FR (1) | FR2751964B1 (fr) |
WO (1) | WO1998005643A1 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001518087A (ja) * | 1997-04-02 | 2001-10-09 | メルク フロスト カナダ アンド カンパニー | 選択的シクロオキシゲナーゼ−2阻害薬としてのα−メチレン−γ−ラクトン類 |
US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
US6649645B1 (en) | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
NZ513960A (en) | 1999-12-08 | 2004-02-27 | Pharmacia Corp | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
JP2004503601A (ja) * | 2000-07-13 | 2004-02-05 | ファルマシア・コーポレーション | 眼のcox−2媒介疾患の処置及び予防におけるcox−2阻害剤の使用法 |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
EP1363669A2 (fr) * | 2001-02-02 | 2003-11-26 | Pharmacia Corporation | Methode d'utilisation d'un inhibiteur de la cyclooxygenase-2 et de steroides sexuels dans une polytherapie pour traiter et prevenir la dysmenorrhee |
PE20021017A1 (es) | 2001-04-03 | 2002-11-24 | Pharmacia Corp | Composicion parenteral reconstituible |
UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
PT1534305E (pt) * | 2003-05-07 | 2007-02-28 | Osteologix As | Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis |
PT1622630E (pt) * | 2003-05-07 | 2012-10-11 | Osteologix As | Combinações de estrôncio para a profilaxia/tratamento de patologias da cartilagem e/ou do osso |
MXPA06001094A (es) * | 2003-07-28 | 2006-04-11 | Smithkline Beecham Corp | Compuestos quimicos. |
WO2008137740A1 (fr) * | 2007-05-03 | 2008-11-13 | Emory University | Analogues de fulvène et fulvalène et leur utilisation dans le traitement des cancers |
IL305573A (en) | 2021-03-15 | 2023-10-01 | Saul Yedgar | Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0311899A3 (fr) * | 1987-10-14 | 1990-06-27 | Air Products And Chemicals, Inc. | Bis-aryldiamines alcényl alpha, bêta insaturées pour utilisation dans la préparation d'un polymère de condensation réticulant |
US5344991A (en) * | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
ES2133740T3 (es) * | 1994-02-10 | 1999-09-16 | Searle & Co | Espiro-compuestos sustituidos para el tratamiento de la inflamacion. |
WO1995030652A1 (fr) * | 1994-05-04 | 1995-11-16 | G.D. Searle & Co. | Spirodienes substitues utilises pour le traitement d'inflammations |
-
1996
- 1996-08-01 FR FR9609742A patent/FR2751964B1/fr not_active Expired - Fee Related
- 1996-10-07 US US08/723,449 patent/US5686460A/en not_active Expired - Lifetime
-
1997
- 1997-07-31 CA CA002262223A patent/CA2262223A1/fr not_active Abandoned
- 1997-07-31 JP JP10507673A patent/JP2000515161A/ja active Pending
- 1997-07-31 AU AU39443/97A patent/AU729453B2/en not_active Ceased
- 1997-07-31 WO PCT/FR1997/001431 patent/WO1998005643A1/fr not_active Application Discontinuation
- 1997-07-31 EP EP97936719A patent/EP0915850A1/fr not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0915850A1 (fr) | 1999-05-19 |
JP2000515161A (ja) | 2000-11-14 |
AU729453B2 (en) | 2001-02-01 |
US5686460A (en) | 1997-11-11 |
AU3944397A (en) | 1998-02-25 |
FR2751964A1 (fr) | 1998-02-06 |
WO1998005643A1 (fr) | 1998-02-12 |
CA2262223A1 (fr) | 1998-02-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |
Effective date: 20160429 |