OA10850A - Quinoxalinediones - Google Patents

Quinoxalinediones Download PDF

Info

Publication number: OA10850A
Authority: OA; OAPI
Prior art keywords: triazol; methyl; pyridin; crc4; alkyl
Prior art date: 1996-03-09

Application number

OA9800155A

Other languages

English (en)

Inventor

David John Bull

Michael Jonathan Fray

Charles Eric Mowbray

Christopher Lee Carr

Elisabeth Colette Loui Gautier

Alan Stobie

Original Assignee

Pfizer Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-09

Filing date

1998-08-28

Publication date

2001-08-16

1998-08-28 Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev

2001-08-16 Publication of OA10850A publication Critical patent/OA10850A/en

Links

SEPKUNXLGWMPHL-UHFFFAOYSA-N quinoxaline-2,3-dione Chemical class C1=CC=CC2=NC(=O)C(=O)N=C21 SEPKUNXLGWMPHL-UHFFFAOYSA-N 0.000 title claims abstract description 6
150000001875 compounds Chemical class 0.000 claims abstract description 144
239000000203 mixture Substances 0.000 claims abstract description 101
125000003118 aryl group Chemical group 0.000 claims abstract description 46
125000005843 halogen group Chemical group 0.000 claims abstract description 39
125000001309 chloro group Chemical group Cl* 0.000 claims abstract description 37
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 34
125000001424 substituent group Chemical group 0.000 claims abstract description 24
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 19
229910052799 carbon Inorganic materials 0.000 claims abstract description 15
125000004104 aryloxy group Chemical group 0.000 claims abstract description 13
125000001072 heteroaryl group Chemical group 0.000 claims abstract description 11
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 8
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims abstract description 8
125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 7
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims abstract description 7
125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims abstract description 6
125000001246 bromo group Chemical group Br* 0.000 claims abstract description 6
125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 6
125000001153 fluoro group Chemical group F* 0.000 claims abstract description 6
208000012902 Nervous system disease Diseases 0.000 claims abstract description 4
230000001154 acute effect Effects 0.000 claims abstract description 4
125000002947 alkylene group Chemical group 0.000 claims abstract description 4
230000001684 chronic effect Effects 0.000 claims abstract description 4
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 16
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 8
125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract 7
125000000000 cycloalkoxy group Chemical group 0.000 claims abstract 4
125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 3
-1 CrC4 aikoxy Chemical group 0.000 claims description 171
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 62
125000000217 alkyl group Chemical group 0.000 claims description 59
238000000034 method Methods 0.000 claims description 44
125000003545 alkoxy group Chemical group 0.000 claims description 29
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 15
238000006243 chemical reaction Methods 0.000 claims description 14
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
125000000714 pyrimidinyl group Chemical group 0.000 claims description 14
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
125000004076 pyridyl group Chemical group 0.000 claims description 12
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 11
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims description 10
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims description 10
125000002098 pyridazinyl group Chemical group 0.000 claims description 10
125000001425 triazolyl group Chemical group 0.000 claims description 10
239000005557 antagonist Substances 0.000 claims description 9
201000010099 disease Diseases 0.000 claims description 9
125000003373 pyrazinyl group Chemical group 0.000 claims description 9
125000000168 pyrrolyl group Chemical group 0.000 claims description 9
125000001113 thiadiazolyl group Chemical group 0.000 claims description 9
125000001544 thienyl group Chemical group 0.000 claims description 9
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 8
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
125000003226 pyrazolyl group Chemical group 0.000 claims description 8
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 8
239000011734 sodium Substances 0.000 claims description 8
229910052708 sodium Inorganic materials 0.000 claims description 8
125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 7
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 7
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
125000002883 imidazolyl group Chemical group 0.000 claims description 7
125000003831 tetrazolyl group Chemical group 0.000 claims description 7
125000000335 thiazolyl group Chemical group 0.000 claims description 7
125000001786 isothiazolyl group Chemical group 0.000 claims description 6
125000000842 isoxazolyl group Chemical group 0.000 claims description 6
125000002971 oxazolyl group Chemical group 0.000 claims description 6
125000001305 1,2,4-triazol-3-yl group Chemical group [H]N1N=C([*])N=C1[H] 0.000 claims description 5
230000002378 acidificating effect Effects 0.000 claims description 5
150000001721 carbon Chemical group 0.000 claims description 5
125000002541 furyl group Chemical group 0.000 claims description 5
125000001715 oxadiazolyl group Chemical group 0.000 claims description 5
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 5
125000001401 1,2,4-triazol-4-yl group Chemical group N=1N=C([H])N([*])C=1[H] 0.000 claims description 4
125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims description 4
125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 4
125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 4
208000028867 ischemia Diseases 0.000 claims description 4
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 4
125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims description 4
125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims description 4
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 3
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 3
125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims description 3
206010019196 Head injury Diseases 0.000 claims description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
230000000694 effects Effects 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
125000001624 naphthyl group Chemical group 0.000 claims description 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 claims description 3
230000000472 traumatic effect Effects 0.000 claims description 3
125000001506 1,2,3-triazol-5-yl group Chemical group [H]N1N=NC([H])=C1[*] 0.000 claims description 2
125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims description 2
208000032109 Transient ischaemic attack Diseases 0.000 claims description 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
239000003085 diluting agent Substances 0.000 claims description 2
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims description 2
125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 claims description 2
SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 5
241000124008 Mammalia Species 0.000 claims 3
125000003342 alkenyl group Chemical group 0.000 claims 3
125000003710 aryl alkyl group Chemical group 0.000 claims 2
125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 1
125000004399 C1-C4 alkenyl group Chemical group 0.000 claims 1
230000007062 hydrolysis Effects 0.000 claims 1
238000006460 hydrolysis reaction Methods 0.000 claims 1
125000000336 imidazol-5-yl group Chemical group [H]N1C([H])=NC([H])=C1[*] 0.000 claims 1
125000000369 oxido group Chemical group [*]=O 0.000 claims 1
230000001052 transient effect Effects 0.000 claims 1
238000002360 preparation method Methods 0.000 abstract description 41
150000003839 salts Chemical class 0.000 abstract description 12
239000000543 intermediate Substances 0.000 abstract description 8
230000015572 biosynthetic process Effects 0.000 abstract description 3
230000000626 neurodegenerative effect Effects 0.000 abstract description 3
238000003786 synthesis reaction Methods 0.000 abstract description 3
229940127523 NMDA Receptor Antagonists Drugs 0.000 abstract description 2
208000025966 Neurological disease Diseases 0.000 abstract description 2
125000004432 carbon atom Chemical group C* 0.000 abstract description 2
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 138
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 115
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 90
239000007787 solid Substances 0.000 description 83
239000000243 solution Substances 0.000 description 68
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 46
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 45
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 45
XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 description 42
229940093499 ethyl acetate Drugs 0.000 description 38
235000019439 ethyl acetate Nutrition 0.000 description 38
238000010992 reflux Methods 0.000 description 31
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 30
238000005481 NMR spectroscopy Methods 0.000 description 30
238000003818 flash chromatography Methods 0.000 description 25
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 24
229910052943 magnesium sulfate Inorganic materials 0.000 description 23
235000019341 magnesium sulphate Nutrition 0.000 description 23
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 22
239000002253 acid Substances 0.000 description 22
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 21
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 21
238000001914 filtration Methods 0.000 description 20
239000000725 suspension Substances 0.000 description 20
ZMXDDKWLCZADIW-UHFFFAOYSA-N dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 19
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
238000004458 analytical method Methods 0.000 description 18
239000000284 extract Substances 0.000 description 17
239000000741 silica gel Substances 0.000 description 17
229910002027 silica gel Inorganic materials 0.000 description 17
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 16
238000010828 elution Methods 0.000 description 15
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 14
239000000499 gel Substances 0.000 description 14
229960000443 hydrochloric acid Drugs 0.000 description 13
235000011167 hydrochloric acid Nutrition 0.000 description 13
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 13
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 12
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 12
HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 12
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 12
239000012267 brine Substances 0.000 description 12
229910052739 hydrogen Inorganic materials 0.000 description 12
239000000047 product Substances 0.000 description 12
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 12
238000005160 1H NMR spectroscopy Methods 0.000 description 11
WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 10
125000004356 hydroxy functional group Chemical group O* 0.000 description 10
239000008346 aqueous phase Substances 0.000 description 9
238000004587 chromatography analysis Methods 0.000 description 9
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 8
239000004471 Glycine Substances 0.000 description 8
CFHGBZLNZZVTAY-UHFFFAOYSA-N lawesson's reagent Chemical compound C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 description 7
239000012071 phase Substances 0.000 description 7
239000002904 solvent Substances 0.000 description 7
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 6
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 6
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
229960000583 acetic acid Drugs 0.000 description 6
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
102000005962 receptors Human genes 0.000 description 6
108020003175 receptors Proteins 0.000 description 6
229920006395 saturated elastomer Polymers 0.000 description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 5
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 5
239000000706 filtrate Substances 0.000 description 5
150000004678 hydrides Chemical class 0.000 description 5
239000010410 layer Substances 0.000 description 5
239000002244 precipitate Substances 0.000 description 5
238000000746 purification Methods 0.000 description 5
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
JSFLFNPZGIDUBV-UHFFFAOYSA-N 3-(2-amino-3-hydroxy-5-methyl-3h-1,2-oxazol-4-yl)propanoic acid Chemical compound CC1=C(CCC(O)=O)C(O)N(N)O1 JSFLFNPZGIDUBV-UHFFFAOYSA-N 0.000 description 4
QCXRMHQLFIXXOV-UHFFFAOYSA-N 6,7-dichloro-2,3-dimethoxyquinoxalin-5-amine Chemical compound ClC1=C(Cl)C(N)=C2N=C(OC)C(OC)=NC2=C1 QCXRMHQLFIXXOV-UHFFFAOYSA-N 0.000 description 4
ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 4
OKJPEAGHQZHRQV-UHFFFAOYSA-N Triiodomethane Natural products IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 4
210000004556 brain Anatomy 0.000 description 4
239000006260 foam Substances 0.000 description 4
238000009472 formulation Methods 0.000 description 4
229960002989 glutamic acid Drugs 0.000 description 4
238000011065 in-situ storage Methods 0.000 description 4
INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 4
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 4
CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 4
238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 4
239000002287 radioligand Substances 0.000 description 4
239000012312 sodium hydride Substances 0.000 description 4
229910000104 sodium hydride Inorganic materials 0.000 description 4
238000003756 stirring Methods 0.000 description 4
238000012360 testing method Methods 0.000 description 4
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
FMCGSUUBYTWNDP-ONGXEEELSA-N (1R,2S)-2-(dimethylamino)-1-phenyl-1-propanol Chemical compound CN(C)[C@@H](C)[C@H](O)C1=CC=CC=C1 FMCGSUUBYTWNDP-ONGXEEELSA-N 0.000 description 3
FMCGSUUBYTWNDP-MWLCHTKSSA-N (1s,2r)-2-(dimethylamino)-1-phenylpropan-1-ol Chemical compound CN(C)[C@H](C)[C@@H](O)C1=CC=CC=C1 FMCGSUUBYTWNDP-MWLCHTKSSA-N 0.000 description 3
NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 3
125000001359 1,2,3-triazol-4-yl group Chemical group [H]N1N=NC([*])=C1[H] 0.000 description 3
IIKGGZYZFWEFFR-UHFFFAOYSA-N 2,3,7-trichloro-6-methyl-5-nitroquinoxaline Chemical compound N1=C(Cl)C(Cl)=NC2=C([N+]([O-])=O)C(C)=C(Cl)C=C21 IIKGGZYZFWEFFR-UHFFFAOYSA-N 0.000 description 3
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 3
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 3
150000001408 amides Chemical class 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
239000003054 catalyst Substances 0.000 description 3
238000007796 conventional method Methods 0.000 description 3
239000002027 dichloromethane extract Substances 0.000 description 3
208000035475 disorder Diseases 0.000 description 3
150000002148 esters Chemical class 0.000 description 3
125000004494 ethyl ester group Chemical group 0.000 description 3
235000013922 glutamic acid Nutrition 0.000 description 3
239000004220 glutamic acid Substances 0.000 description 3
IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 3
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
239000012528 membrane Substances 0.000 description 3
229910052753 mercury Inorganic materials 0.000 description 3
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
238000002156 mixing Methods 0.000 description 3
239000003921 oil Substances 0.000 description 3
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
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Psychology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Luminescent Compositions (AREA)
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OA9800155A 1996-03-09 1998-08-28 Quinoxalinediones OA10850A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9605027.3A GB9605027D0 (en)	1996-03-09	1996-03-09	Quinoxalinediones

Publications (1)

Publication Number	Publication Date
OA10850A true OA10850A (en)	2001-08-16

Family

ID=10790134

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9800155A OA10850A (en)	1996-03-09	1998-08-28	Quinoxalinediones

Country Status (42)

Country	Link
US (1)	US6376490B1 (zh)
EP (1)	EP0885212B1 (zh)
JP (1)	JP3110467B2 (zh)
KR (1)	KR100288099B1 (zh)
CN (1)	CN1103770C (zh)
AP (1)	AP767A (zh)
AR (1)	AR006119A1 (zh)
AT (1)	ATE208773T1 (zh)
AU (1)	AU717972B2 (zh)
BG (1)	BG63340B1 (zh)
BR (1)	BR9707851A (zh)
CA (1)	CA2248366C (zh)
CO (1)	CO4770976A1 (zh)
CZ (1)	CZ292792B6 (zh)
DE (1)	DE69708269T2 (zh)
DK (1)	DK0885212T3 (zh)
DZ (1)	DZ2188A1 (zh)
EA (1)	EA001730B1 (zh)
ES (1)	ES2163742T3 (zh)
GB (1)	GB9605027D0 (zh)
HN (1)	HN1998000034A (zh)
HR (1)	HRP970132A2 (zh)
HU (1)	HUP9900975A3 (zh)
ID (1)	ID18112A (zh)
IL (1)	IL125491A (zh)
IS (1)	IS4811A (zh)
MA (1)	MA26422A1 (zh)
NO (1)	NO984058L (zh)
NZ (1)	NZ331060A (zh)
OA (1)	OA10850A (zh)
PE (2)	PE43398A1 (zh)
PL (1)	PL329032A1 (zh)
PT (1)	PT885212E (zh)
SI (1)	SI0885212T1 (zh)
SK (1)	SK283467B6 (zh)
TN (1)	TNSN97044A1 (zh)
TR (1)	TR199801782T2 (zh)
TW (1)	TW454004B (zh)
UY (1)	UY24482A1 (zh)
WO (1)	WO1997032873A1 (zh)
YU (2)	YU39698A (zh)
ZA (1)	ZA971987B (zh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69827614T2 (de) *	1997-02-27	2005-11-10	Pfizer Inc.	Chinoxalindionen
AP982A (en)	1997-02-27	2001-07-16	Pfizer	Quinoxalinediones.
US6340758B1 (en) *	1997-05-16	2002-01-22	Warner-Lambert Company	Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents
DE10005150A1 (de)	2000-02-07	2001-08-09	Merck Patent Gmbh	Verfahren zur Herstellung von 5-Arylnicotinaldehyden
KR100776119B1 (ko) *	2000-05-19	2007-11-16	아스텔라스세이야쿠 가부시키가이샤	트리아졸 유도체
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
WO2005006945A2 (en) *	2003-07-03	2005-01-27	The Salk Institute For Biological Studies	Methods for treating neural disorders and compounds useful therefor
MY145368A (en) *	2004-01-13	2012-01-31	Nissan Chemical Ind Ltd	Aminoquinoxaline compounds and polyaminoquinoxaline compounds, and use thereof
EP1713101B1 (en)	2004-02-06	2012-10-31	Yamaguchi University	Electrode for energy storage device and process for producing the same
JP2007223901A (ja) *	2004-03-24	2007-09-06	Takeda Chem Ind Ltd	複素環化合物およびその用途
US20060211739A1 (en) *	2005-02-08	2006-09-21	Arturo Perez-Medrano	Use of selective P2X7 receptor antagonists
WO2007112347A1 (en) *	2006-03-28	2007-10-04	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
EP2089383B1 (en)	2006-11-09	2015-09-16	Probiodrug AG	3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
JP5523107B2 (ja)	2006-11-30	2014-06-18	プロビオドルグエージー	グルタミニルシクラーゼの新規阻害剤
EP2150248A4 (en) *	2007-01-16	2011-06-29	Univ Johns Hopkins	GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE
ZA200905537B (en)	2007-03-01	2010-10-27	Probiodrug Ag	New use of glutaminyl cyclase inhibitors
ES2533484T3 (es)	2007-04-18	2015-04-10	Probiodrug Ag	Derivados de tiourea como inhibidores de la glutaminil ciclasa
WO2008143019A1 (en) *	2007-05-17	2008-11-27	Semiconductor Energy Laboratory Co., Ltd.	Triazole derivative, and light-emitting element, light-emitting device, and electronic device with the use of triazole derivative
DK2475428T3 (en)	2009-09-11	2015-09-28	Probiodrug Ag	Heterocyclic derivatives as glutaminylcyklaseinhibitorer
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
CN102791704B (zh)	2010-03-10	2015-11-25	前体生物药物股份公司	谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂
JP5945532B2 (ja)	2010-04-21	2016-07-05	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
ES2570167T3 (es)	2011-03-16	2016-05-17	Probiodrug Ag	Derivados de benzimidazol como inhibidores de glutaminil ciclasa
CA2900300A1 (en) *	2013-02-07	2014-08-14	Merck Patent Gmbh	Substituted acetylene derivatives and their use as positive allosteric modulators of mglur4
EP3461819B1 (en)	2017-09-29	2020-05-27	Probiodrug AG	Inhibitors of glutaminyl cyclase
CN111548320B (zh) *	2019-10-09	2023-03-24	贵州大学	一类1，3，4-噁二唑酰肼类化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2150417T3 (es) *	1990-11-06	2000-12-01	Yamanouchi Pharma Co Ltd	Derivados de pirazina fusionados.
DE4217952A1 (de) *	1992-05-30	1993-12-02	Basf Ag	Chinoxalin-2,3(1H,4H)-dione
GB9418443D0 (en)	1994-09-13	1994-11-02	Pfizer Ltd	Therapeutic agents
DE4439492A1 (de) *	1994-10-25	1996-05-02	Schering Ag	Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE69827614T2 (de) *	1997-02-27	2005-11-10	Pfizer Inc.	Chinoxalindionen

1996
- 1996-03-09 GB GBGB9605027.3A patent/GB9605027D0/en active Pending
1997
- 1997-02-05 TW TW086101412A patent/TW454004B/zh not_active IP Right Cessation
- 1997-02-27 ES ES97908156T patent/ES2163742T3/es not_active Expired - Lifetime
- 1997-02-27 EP EP97908156A patent/EP0885212B1/en not_active Expired - Lifetime
- 1997-02-27 PT PT97908156T patent/PT885212E/pt unknown
- 1997-02-27 TR TR1998/01782T patent/TR199801782T2/xx unknown
- 1997-02-27 AU AU20231/97A patent/AU717972B2/en not_active Ceased
- 1997-02-27 CZ CZ19982864A patent/CZ292792B6/cs not_active IP Right Cessation
- 1997-02-27 SI SI9730225T patent/SI0885212T1/xx unknown
- 1997-02-27 CN CN97192923A patent/CN1103770C/zh not_active Expired - Fee Related
- 1997-02-27 AT AT97908156T patent/ATE208773T1/de not_active IP Right Cessation
- 1997-02-27 BR BR9707851A patent/BR9707851A/pt not_active Application Discontinuation
- 1997-02-27 DE DE69708269T patent/DE69708269T2/de not_active Expired - Fee Related
- 1997-02-27 SK SK1214-98A patent/SK283467B6/sk unknown
- 1997-02-27 KR KR1019980707063A patent/KR100288099B1/ko not_active IP Right Cessation
- 1997-02-27 DK DK97908156T patent/DK0885212T3/da active
- 1997-02-27 CA CA002248366A patent/CA2248366C/en not_active Expired - Fee Related
- 1997-02-27 PL PL97329032A patent/PL329032A1/xx unknown
- 1997-02-27 IL IL12549197A patent/IL125491A/xx not_active IP Right Cessation
- 1997-02-27 WO PCT/EP1997/000995 patent/WO1997032873A1/en active IP Right Grant
- 1997-02-27 YU YU39698A patent/YU39698A/sh unknown
- 1997-02-27 HU HU9900975A patent/HUP9900975A3/hu unknown
- 1997-02-27 EA EA199800702A patent/EA001730B1/ru not_active IP Right Cessation
- 1997-02-27 NZ NZ331060A patent/NZ331060A/xx unknown
- 1997-02-27 JP JP09531429A patent/JP3110467B2/ja not_active Expired - Fee Related
- 1997-03-05 TN TNTNSN97044A patent/TNSN97044A1/fr unknown
- 1997-03-05 DZ DZ970034A patent/DZ2188A1/fr active
- 1997-03-05 AR ARP970100888A patent/AR006119A1/es unknown
- 1997-03-05 MA MA24514A patent/MA26422A1/fr unknown
- 1997-03-06 PE PE1997000162A patent/PE43398A1/es not_active Application Discontinuation
- 1997-03-06 UY UY24482A patent/UY24482A1/es not_active IP Right Cessation
- 1997-03-06 AP APAP/P/1997/000947A patent/AP767A/en active
- 1997-03-07 HR HR9605027.3A patent/HRP970132A2/xx not_active Application Discontinuation
- 1997-03-07 ID IDP970725A patent/ID18112A/id unknown
- 1997-03-07 ZA ZA971987A patent/ZA971987B/xx unknown
- 1997-03-10 CO CO97012901A patent/CO4770976A1/es unknown
1998
- 1998-02-19 HN HN1998000034A patent/HN1998000034A/es unknown
- 1998-02-23 PE PE1998000128A patent/PE58199A1/es not_active Application Discontinuation
- 1998-02-24 YU YU41199A patent/YU41199A/sh unknown
- 1998-07-27 IS IS4811A patent/IS4811A/is unknown
- 1998-08-28 OA OA9800155A patent/OA10850A/en unknown
- 1998-09-03 NO NO984058A patent/NO984058L/no unknown
- 1998-09-04 US US09/157,806 patent/US6376490B1/en not_active Expired - Fee Related
- 1998-09-09 BG BG102760A patent/BG63340B1/bg unknown

Also Published As

Publication number	Publication date
NO984058D0 (no)	1998-09-03
YU39698A (sh)	1999-03-04
DE69708269T2 (de)	2002-07-25
TW454004B (en)	2001-09-11
PT885212E (pt)	2002-02-28
AP767A (en)	1999-09-29
DK0885212T3 (da)	2002-03-25
CZ286498A3 (cs)	1999-07-14
IL125491A0 (en)	1999-03-12
HUP9900975A2 (hu)	1999-07-28
CA2248366C (en)	2002-06-04
CN1213369A (zh)	1999-04-07
SI0885212T1 (en)	2002-02-28
AU717972B2 (en)	2000-04-06
AR006119A1 (es)	1999-08-11
SK121498A3 (en)	2000-10-09
ZA971987B (en)	1998-09-07
CZ292792B6 (cs)	2003-12-17
ATE208773T1 (de)	2001-11-15
PE58199A1 (es)	1999-06-11
NZ331060A (en)	2000-01-28
EA001730B1 (ru)	2001-08-27
PE43398A1 (es)	1998-08-29
EP0885212A1 (en)	1998-12-23
GB9605027D0 (en)	1996-05-08
NO984058L (no)	1998-11-06
JPH11506123A (ja)	1999-06-02
DE69708269D1 (de)	2001-12-20
TR199801782T2 (xx)	1998-12-21
HRP970132A2 (en)	1998-06-30
KR100288099B1 (ko)	2001-05-02
SK283467B6 (sk)	2003-08-05
HN1998000034A (es)	1999-02-09
CN1103770C (zh)	2003-03-26
JP3110467B2 (ja)	2000-11-20
EP0885212B1 (en)	2001-11-14
PL329032A1 (en)	1999-03-01
CA2248366A1 (en)	1997-09-12
IL125491A (en)	2003-07-06
DZ2188A1 (fr)	2002-12-02
US6376490B1 (en)	2002-04-23
BG63340B1 (bg)	2001-10-31
AU2023197A (en)	1997-09-22
ES2163742T3 (es)	2002-02-01
ID18112A (id)	1998-03-05
KR19990087614A (ko)	1999-12-27
WO1997032873A1 (en)	1997-09-12
UY24482A1 (es)	2000-09-29
MA26422A1 (fr)	2004-12-20
BR9707851A (pt)	1999-07-27
BG102760A (en)	1999-09-30
YU41199A (sh)	2001-09-28
TNSN97044A1 (fr)	2005-03-15
IS4811A (is)	1998-07-27
AP9700947A0 (en)	1997-04-30
HUP9900975A3 (en)	2001-12-28
CO4770976A1 (es)	1999-04-30
EA199800702A1 (ru)	1999-04-29

Publication	Publication Date	Title
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KR20230163501A (ko)	2023-11-30	Mk2 저해제 및 이의 용도
US20010018438A1 (en)	2001-08-30	Substituted 1H-pyridinyl-2-ones as GABAA alpha 2/3 ligands
EP0208518B1 (en)	1991-09-11	6-phenyl-pyridazinyl compounds
AU2011342039B2 (en)	2015-06-11	Continuous arycyclic compound
KR20210005593A (ko)	2021-01-14	화합물 및 이의 용도
EP0201988B1 (en)	1991-08-07	Dihydropyridazinone derivatives
AU5435599A (en)	2000-03-21	Triazolopyridazine derivatives for enhancing cognition
JPH05194429A (ja)	1993-08-03	アゾール化合物、その製造法および用途