ES2150417T3 - Derivados de pirazina fusionados. - Google Patents
Derivados de pirazina fusionados.Info
- Publication number
- ES2150417T3 ES2150417T3 ES91918943T ES91918943T ES2150417T3 ES 2150417 T3 ES2150417 T3 ES 2150417T3 ES 91918943 T ES91918943 T ES 91918943T ES 91918943 T ES91918943 T ES 91918943T ES 2150417 T3 ES2150417 T3 ES 2150417T3
- Authority
- ES
- Spain
- Prior art keywords
- represent
- alkyl
- nitro
- cycloalkyl
- alternatively
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
UN DERIVADO DE PIRAZINA QUE INHIBE EL RECEPTOR DE GLUTAMATO, REPRESENTADO POR LA FORMULA GENERAL (IA) DONDE Z REPRESENTA C O N, SIEMPRE QUE DOS Z NO SEAN ATOMOS DE N AL MISMO TIEMPO; R1 REPRESENTA (1A) DONDE X REPRESENTA N O R8C, R6 REPRESENTA H O ALQUILO, Y R7 Y R8 REPRESENTAN CADA UNO H,ALQUILO, NITRO O FENILO, O ALTERNATIVAMENTE R7 Y R8 ESTAN COMBINADOS CONJUNTAMENTE PARA REPRESENTAR BUTADIENILENO O 1,4 PRESENTAN CADA UNO H, F, CIANO, ACILO, NITRO, ALQUILO, MORFOLINA O R1; R4 Y R5 REPRESENTAN CADA UNO H, HIDROXI, ALQUILO, CICLOALQUILO, HETEROCICLO, FERRILO O ALQUILO Y SUSTITUIDO; Y REPRESENTA HIDROXI, ACILOXI, METILO F SUSTITUIDO, CICLOALQUILO, TETRAHIDROFURILO, CARBOXILO, ALCOXICARBONILO O NR9R10; Y R9 Y R10 REPRESENTAN H O ALQUILO, O ALTERNATIVAMENTE R9 Y R10 ESTAN COMBINADOS CONJUNTAMENTE PARA REPRESENTAR UN GRUPO CICLICO DE 5 O 6 MIEMBROS QUE PUEDE CONTENER ATOMO(S) DE OXIGENO.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30087990 | 1990-11-06 | ||
JP6959291 | 1991-01-11 | ||
JP13382891 | 1991-03-29 | ||
JP18324891 | 1991-06-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2150417T3 true ES2150417T3 (es) | 2000-12-01 |
Family
ID=27465151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91918943T Expired - Lifetime ES2150417T3 (es) | 1990-11-06 | 1991-11-01 | Derivados de pirazina fusionados. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5283244A (es) |
EP (1) | EP0556393B1 (es) |
JP (1) | JP2550456B2 (es) |
KR (1) | KR0132903B1 (es) |
AT (1) | ATE194985T1 (es) |
AU (1) | AU656154B2 (es) |
CA (1) | CA2095444C (es) |
DE (1) | DE69132340T2 (es) |
DK (1) | DK0556393T3 (es) |
ES (1) | ES2150417T3 (es) |
GR (1) | GR3034629T3 (es) |
HU (2) | HU221425B (es) |
RU (1) | RU2095352C1 (es) |
WO (1) | WO1992007847A1 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK162491D0 (da) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
US6057304A (en) | 1992-10-26 | 2000-05-02 | Schering Aktiengesellschaft | Quinoxaline-phosphonic acid derivatives |
DE4217952A1 (de) * | 1992-05-30 | 1993-12-02 | Basf Ag | Chinoxalin-2,3(1H,4H)-dione |
ES2313714T3 (es) * | 1992-06-22 | 2009-03-01 | The Regents Of The University Of California | Antagonistas de receptores de glicina y uso de los mismos. |
EP0664807B1 (en) | 1992-10-13 | 1997-09-10 | Warner-Lambert Company | Quinoxalinedione derivatives as eaa antagonists |
PH31122A (en) * | 1993-03-31 | 1998-02-23 | Eisai Co Ltd | Nitrogen-containing fused-heterocycle compounds. |
IL109397A0 (en) * | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
US5631373A (en) * | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
DE4340045A1 (de) * | 1993-11-24 | 1995-06-01 | Basf Ag | Neue Chinoxaline und Arzneimittel daraus |
AU1599395A (en) * | 1994-01-03 | 1995-08-01 | Cocensys, Inc. | 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/nmda receptor |
AU688459B2 (en) * | 1994-04-08 | 1998-03-12 | Shionogi & Co., Ltd. | Oxopyridinylquinoxaline derivative |
DE4428152A1 (de) * | 1994-06-22 | 1996-01-04 | Basf Ag | Neue Amido-chinoxalindione, ihrer Herstellung und Verwendung |
GB9419318D0 (en) * | 1994-09-24 | 1994-11-09 | Pfizer Ltd | Therapeutic agents |
DK0784054T3 (da) * | 1994-09-27 | 2002-03-25 | Yamanouchi Pharma Co Ltd | 1,2,3,4-tetrahydroquinoxalinderivater og deres anvendelse som glutamatreceptorantagonister |
DE4436852A1 (de) * | 1994-10-14 | 1996-04-18 | Basf Ag | Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung |
US5801183A (en) * | 1995-01-27 | 1998-09-01 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists |
US6110911A (en) * | 1995-06-07 | 2000-08-29 | Warner-Lambert Company | Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
DE19521058A1 (de) * | 1995-06-09 | 1996-12-12 | Basf Ag | Verfahren zur Herstellung von Aromaten enthaltenden Polyetherpolyolen |
DE19532050A1 (de) * | 1995-08-31 | 1997-03-06 | Basf Ag | Pyrrolyl-tetrahydrochinoxalindione, ihre Herstellung und Verwendung zur Bekämpfung von Krankheiten |
GB9605027D0 (en) * | 1996-03-09 | 1996-05-08 | Pfizer Ltd | Quinoxalinediones |
ZA973884B (en) | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
TW448171B (en) * | 1996-06-06 | 2001-08-01 | Yamanouchi Pharma Co Ltd | Imidazole-substituted quinoxalinedione derivatives |
US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
US5824662A (en) * | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
DE19624808A1 (de) | 1996-06-21 | 1998-01-02 | Basf Ag | Pyrrolylchinoxalindione, ihre Herstellung und Verwendung |
KR20000036227A (ko) | 1996-09-27 | 2000-06-26 | 토마스 씨. 서 | 날라다아제조성물, 글루탐산염 이상 치료법 및 동물내의 뉴우런활성법 |
WO1998017672A1 (de) * | 1996-10-24 | 1998-04-30 | Novartis Ag | Substituierte aminoalkanphosphonsäuren |
AP982A (en) * | 1997-02-27 | 2001-07-16 | Pfizer | Quinoxalinediones. |
ATE282608T1 (de) * | 1997-02-27 | 2004-12-15 | Pfizer | Chinoxalindionen |
TW403740B (en) | 1997-06-10 | 2000-09-01 | Novartis Ag | Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide |
US6015800A (en) * | 1997-09-03 | 2000-01-18 | Warner-Lambert Company | Substituted quinoxaline-2-ones as glutamate receptor antagonists |
KR20010031983A (ko) | 1997-11-11 | 2001-04-16 | 우에노 도시오 | 축합 피라진 화합물 |
WO2001055110A1 (en) | 2000-01-24 | 2001-08-02 | Neurosearch A/S | Isatine derivatives with neurotrophic activity |
EP1904481B1 (en) | 2005-06-23 | 2016-02-17 | Array Biopharma, Inc. | Process for preparing benzimidazole compounds |
ES2366239T3 (es) * | 2006-04-21 | 2011-10-18 | Pfizer Products Inc. | Piridin[3,4-b]pirazinonas. |
US7601716B2 (en) * | 2006-05-01 | 2009-10-13 | Cephalon, Inc. | Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors |
NZ578078A (en) | 2007-01-16 | 2011-11-25 | Purdue Pharma Lp | Heterocyclic-substituted piperidine as orl-1 ligands |
CA2686816A1 (en) | 2007-01-16 | 2008-07-24 | The Johns Hopkins University | Use of various glutamate receptor antagonists for delaying or preventing platelet activity or for treating or preventing a thrombotic disease or disorder |
JP5554709B2 (ja) | 2007-08-31 | 2014-07-23 | パーデュー、ファーマ、リミテッド、パートナーシップ | 置換キノキサリンタイプピペリジン化合物とその使用 |
WO2010053757A1 (en) * | 2008-10-29 | 2010-05-14 | Gilead Palo Alto, Inc. | 2 -oxoquinoxalin blockers of the late sodium channel |
US20100113514A1 (en) | 2008-10-30 | 2010-05-06 | Gilead Palo Alto, Inc. | Fused heterocyclic compounds as ion channel modulators |
EP2338492A1 (en) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
JPWO2023042887A1 (es) | 2021-09-15 | 2023-03-23 | ||
EP4403185A1 (en) | 2021-09-15 | 2024-07-24 | University of The Ryukyus | Pharmaceutical composition for treating cognitive decline or for treating overweightness or obesity |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE66149B1 (en) * | 1986-09-16 | 1995-12-13 | Novo Nordisk As | Quinoxaline compounds and their preparation and use |
NO179551C (no) * | 1987-11-10 | 1996-10-30 | Novo Nordisk As | Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser |
CA2002864C (en) * | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
GB8827822D0 (en) * | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
DK715888D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
-
1991
- 1991-11-01 EP EP91918943A patent/EP0556393B1/en not_active Expired - Lifetime
- 1991-11-01 JP JP3517229A patent/JP2550456B2/ja not_active Expired - Fee Related
- 1991-11-01 AU AU87666/91A patent/AU656154B2/en not_active Ceased
- 1991-11-01 RU RU93033484/04A patent/RU2095352C1/ru not_active IP Right Cessation
- 1991-11-01 DE DE69132340T patent/DE69132340T2/de not_active Expired - Fee Related
- 1991-11-01 CA CA002095444A patent/CA2095444C/en not_active Expired - Fee Related
- 1991-11-01 WO PCT/JP1991/001498 patent/WO1992007847A1/ja active IP Right Grant
- 1991-11-01 DK DK91918943T patent/DK0556393T3/da active
- 1991-11-01 US US08/050,225 patent/US5283244A/en not_active Expired - Lifetime
- 1991-11-01 ES ES91918943T patent/ES2150417T3/es not_active Expired - Lifetime
- 1991-11-01 HU HU9301298A patent/HU221425B/hu unknown
- 1991-11-01 AT AT91918943T patent/ATE194985T1/de not_active IP Right Cessation
-
1993
- 1993-05-04 KR KR1019930701342A patent/KR0132903B1/ko not_active IP Right Cessation
-
1995
- 1995-06-30 HU HU95P/P00644P patent/HU211310A9/hu unknown
-
2000
- 2000-10-16 GR GR20000402315T patent/GR3034629T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1992007847A1 (en) | 1992-05-14 |
KR0132903B1 (ko) | 1998-04-17 |
GR3034629T3 (en) | 2001-01-31 |
DE69132340D1 (de) | 2000-08-31 |
AU8766691A (en) | 1992-05-26 |
US5283244A (en) | 1994-02-01 |
DK0556393T3 (da) | 2000-10-16 |
EP0556393A1 (en) | 1993-08-25 |
EP0556393A4 (en) | 1994-04-13 |
JP2550456B2 (ja) | 1996-11-06 |
AU656154B2 (en) | 1995-01-27 |
HU221425B (en) | 2002-10-28 |
HUT64324A (en) | 1993-12-28 |
HU211310A9 (en) | 1995-11-28 |
CA2095444A1 (en) | 1992-05-07 |
EP0556393B1 (en) | 2000-07-26 |
DE69132340T2 (de) | 2001-02-08 |
RU2095352C1 (ru) | 1997-11-10 |
CA2095444C (en) | 2001-06-19 |
HU9301298D0 (en) | 1993-09-28 |
ATE194985T1 (de) | 2000-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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