YU41199A - Hinoksalindioni - Google Patents

Hinoksalindioni

Info

Publication number
YU41199A
YU41199A YU41199A YU41199A YU41199A YU 41199 A YU41199 A YU 41199A YU 41199 A YU41199 A YU 41199A YU 41199 A YU41199 A YU 41199A YU 41199 A YU41199 A YU 41199A
Authority
YU
Yugoslavia
Prior art keywords
preparation
quinoxalinediones
solvate
compounds
processes
Prior art date
Application number
YU41199A
Other languages
English (en)
Inventor
Alan Stobie
Elisabeth Colette L. Gautier
David Charles Waite
Robert James Crook
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9715783.8A external-priority patent/GB9715783D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU41199A publication Critical patent/YU41199A/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Dati pronalazak obezbedjuje suštinski čisto jedinjenje formule (I), ili njegovu farmaceutski prihvatljivu so ili solvat, zajedno sa kompozicijama koje ih sadrže, upotrebom, postupcima dobijanja i intermedijarima upotrebljenim u dobijanjima takvih jedinjenja.[The present invention provides a substantially pure compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, together with compositions containing, uses of, processes for the preparation of and intermediates used in the preparation of such compounds.
YU41199A 1996-03-09 1998-02-24 Hinoksalindioni YU41199A (sh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9605027.3A GB9605027D0 (en) 1996-03-09 1996-03-09 Quinoxalinediones
PCT/EP1997/000995 WO1997032873A1 (en) 1996-03-09 1997-02-27 Quinoxalinediones
GBGB9715783.8A GB9715783D0 (en) 1997-02-27 1997-07-25 Quinoxalinediones

Publications (1)

Publication Number Publication Date
YU41199A true YU41199A (sh) 2001-09-28

Family

ID=10790134

Family Applications (2)

Application Number Title Priority Date Filing Date
YU39698A YU39698A (sh) 1996-03-09 1997-02-27 Hinoksalindioni
YU41199A YU41199A (sh) 1996-03-09 1998-02-24 Hinoksalindioni

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU39698A YU39698A (sh) 1996-03-09 1997-02-27 Hinoksalindioni

Country Status (42)

Country Link
US (1) US6376490B1 (sh)
EP (1) EP0885212B1 (sh)
JP (1) JP3110467B2 (sh)
KR (1) KR100288099B1 (sh)
CN (1) CN1103770C (sh)
AP (1) AP767A (sh)
AR (1) AR006119A1 (sh)
AT (1) ATE208773T1 (sh)
AU (1) AU717972B2 (sh)
BG (1) BG63340B1 (sh)
BR (1) BR9707851A (sh)
CA (1) CA2248366C (sh)
CO (1) CO4770976A1 (sh)
CZ (1) CZ292792B6 (sh)
DE (1) DE69708269T2 (sh)
DK (1) DK0885212T3 (sh)
DZ (1) DZ2188A1 (sh)
EA (1) EA001730B1 (sh)
ES (1) ES2163742T3 (sh)
GB (1) GB9605027D0 (sh)
HN (1) HN1998000034A (sh)
HR (1) HRP970132A2 (sh)
HU (1) HUP9900975A3 (sh)
ID (1) ID18112A (sh)
IL (1) IL125491A (sh)
IS (1) IS4811A (sh)
MA (1) MA26422A1 (sh)
NO (1) NO984058L (sh)
NZ (1) NZ331060A (sh)
OA (1) OA10850A (sh)
PE (2) PE43398A1 (sh)
PL (1) PL329032A1 (sh)
PT (1) PT885212E (sh)
SI (1) SI0885212T1 (sh)
SK (1) SK283467B6 (sh)
TN (1) TNSN97044A1 (sh)
TR (1) TR199801782T2 (sh)
TW (1) TW454004B (sh)
UY (1) UY24482A1 (sh)
WO (1) WO1997032873A1 (sh)
YU (2) YU39698A (sh)
ZA (1) ZA971987B (sh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP982A (en) * 1997-02-27 2001-07-16 Pfizer Quinoxalinediones.
WO1998038186A1 (en) * 1997-02-27 1998-09-03 Pfizer Limited Quinoxalinediones
US6340758B1 (en) * 1997-05-16 2002-01-22 Warner-Lambert Company Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents
DE10005150A1 (de) 2000-02-07 2001-08-09 Merck Patent Gmbh Verfahren zur Herstellung von 5-Arylnicotinaldehyden
CZ20023763A3 (cs) * 2000-05-19 2003-03-12 Merck Patent Gmbh Derivát triazolu
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
WO2005006945A2 (en) * 2003-07-03 2005-01-27 The Salk Institute For Biological Studies Methods for treating neural disorders and compounds useful therefor
MY145368A (en) * 2004-01-13 2012-01-31 Nissan Chemical Ind Ltd Aminoquinoxaline compounds and polyaminoquinoxaline compounds, and use thereof
WO2005076295A1 (ja) 2004-02-06 2005-08-18 Yamaguchi University エネルギー貯蔵デバイス用電極及びその製造方法
JP2007223901A (ja) * 2004-03-24 2007-09-06 Takeda Chem Ind Ltd 複素環化合物およびその用途
US20060211739A1 (en) * 2005-02-08 2006-09-21 Arturo Perez-Medrano Use of selective P2X7 receptor antagonists
WO2007112347A1 (en) * 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
WO2008065141A1 (en) 2006-11-30 2008-06-05 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
EP2150248A4 (en) * 2007-01-16 2011-06-29 Univ Johns Hopkins GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
CN101679383B (zh) * 2007-05-17 2014-10-29 株式会社半导体能源研究所 ***衍生物,和使用***衍生物的发光元件、发光器件和电子器件
SG178953A1 (en) 2009-09-11 2012-04-27 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
ES2481823T3 (es) 2010-03-10 2014-07-31 Probiodrug Ag Inhibidores heterocíclicos de glutaminil ciclasa (QC, EC 2.3.2.5)
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
CN104955809B (zh) * 2013-02-07 2018-12-11 普雷斯特威克化学公司 取代的乙炔衍生物及其作为mGluR4的正变构调节剂的用途
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
CN111548320B (zh) * 2019-10-09 2023-03-24 贵州大学 一类1,3,4-噁二唑酰肼类化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69132340T2 (de) * 1990-11-06 2001-02-08 Yamanouchi Pharma Co Ltd Kondensiertes pyrazinderivat
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
DE4439492A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
WO1998038186A1 (en) * 1997-02-27 1998-09-03 Pfizer Limited Quinoxalinediones

Also Published As

Publication number Publication date
CZ286498A3 (cs) 1999-07-14
BG102760A (en) 1999-09-30
DZ2188A1 (fr) 2002-12-02
OA10850A (en) 2001-08-16
AU717972B2 (en) 2000-04-06
IS4811A (is) 1998-07-27
CA2248366C (en) 2002-06-04
UY24482A1 (es) 2000-09-29
EA001730B1 (ru) 2001-08-27
MA26422A1 (fr) 2004-12-20
CZ292792B6 (cs) 2003-12-17
AP767A (en) 1999-09-29
DE69708269T2 (de) 2002-07-25
DE69708269D1 (de) 2001-12-20
HUP9900975A3 (en) 2001-12-28
HN1998000034A (es) 1999-02-09
TNSN97044A1 (fr) 2005-03-15
SI0885212T1 (en) 2002-02-28
EP0885212B1 (en) 2001-11-14
EP0885212A1 (en) 1998-12-23
BG63340B1 (bg) 2001-10-31
PL329032A1 (en) 1999-03-01
CN1213369A (zh) 1999-04-07
ID18112A (id) 1998-03-05
KR100288099B1 (ko) 2001-05-02
HRP970132A2 (en) 1998-06-30
YU39698A (sh) 1999-03-04
CN1103770C (zh) 2003-03-26
AR006119A1 (es) 1999-08-11
ZA971987B (en) 1998-09-07
BR9707851A (pt) 1999-07-27
SK121498A3 (en) 2000-10-09
JPH11506123A (ja) 1999-06-02
PT885212E (pt) 2002-02-28
WO1997032873A1 (en) 1997-09-12
AP9700947A0 (en) 1997-04-30
NZ331060A (en) 2000-01-28
ES2163742T3 (es) 2002-02-01
NO984058D0 (no) 1998-09-03
CA2248366A1 (en) 1997-09-12
PE43398A1 (es) 1998-08-29
NO984058L (no) 1998-11-06
TW454004B (en) 2001-09-11
PE58199A1 (es) 1999-06-11
DK0885212T3 (da) 2002-03-25
JP3110467B2 (ja) 2000-11-20
TR199801782T2 (xx) 1998-12-21
EA199800702A1 (ru) 1999-04-29
CO4770976A1 (es) 1999-04-30
ATE208773T1 (de) 2001-11-15
IL125491A (en) 2003-07-06
GB9605027D0 (en) 1996-05-08
US6376490B1 (en) 2002-04-23
SK283467B6 (sk) 2003-08-05
AU2023197A (en) 1997-09-22
IL125491A0 (en) 1999-03-12
KR19990087614A (ko) 1999-12-27
HUP9900975A2 (hu) 1999-07-28

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