NO930926L - 2-oksokinolinderivater - Google Patents
2-oksokinolinderivaterInfo
- Publication number
- NO930926L NO930926L NO93930926A NO930926A NO930926L NO 930926 L NO930926 L NO 930926L NO 93930926 A NO93930926 A NO 93930926A NO 930926 A NO930926 A NO 930926A NO 930926 L NO930926 L NO 930926L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- cooh
- cooa
- oxo
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
2-oksokinolinderivater med formel I hvor R er og R1 er H, A. OA eller SA; R2 er H, COOH, COOA, CN. NO,. NH-, NHCOR7, NHSO-R7 eller lH-5-tetrazolyi; R; og R4 er hver H eller A; R- og R'- er hver K, A, COOH, COOA, cyan-alkyl, HOOC-elkyl, AOOC- alkyl, H.NCO-alkyl, ANKCO-alkyl, A,NCO- alkyl, cyan-alkenyl. HOOC-alkenyl, AOOC-alkenyi , 1H- 5-re-crazoiyl -alkyl , 2- okso-oksazoiiGinyl-aikyl, Ar-alkyl, AO- alkyl, ArO-alkyl, Ar-alkyl-0-alkyl, formyl-alkyl, okso-alkyl, HOOC-okso- alkyl, AOOC-okso-alkyl, oksimino-alkyl, O-alkyl-oksimino-alky:, HO-alkyl eller R6R5N-alkyl; R3 og R- kan til sammen også være en binding; R7 er alkyl med 1-6 C-atomer, hvor også ert eller flere K-atom(er) kan være erstattet med F; R£er H eller A; R9 er H, A, A-CO, Ar-CO, COOA, CONH,, CONHA, CONHAr, CON(A), eller CONAAr; X mangler eller er -NH- CO-, -CO-NH-, -O-CH(COOH)-, -NH-CH- (COOH)-, -NA-CH(COOH)-, -CH=C(COOH)-, -CH=C(CN)- eller -CH=C(lH-5-tetrazol- yl)-; A er alkyl med 1-6 C-atomer; Ar er en usubstituert eller en med R7, OR7, Hal, COOH, COOA, CN, N02, NH2, NHA, N(A)2, NHCOR7, NHSO,R7 eller 1H-5- tetrazolyl monosubsrituert fenylgruppe; og Hal er F, Cl, Br eller I; og alkyl- delen eller alkenyldelen i de nevnte grupper hver inneholder inntil 6 C- atomer, samt salter derav. Derivatene oppviser angiotensin Il-antagonistiske egenskaper og virker blant annet blod- trykkssenkende.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4208304A DE4208304A1 (de) | 1992-03-16 | 1992-03-16 | 2-oxochinolinderivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO930926D0 NO930926D0 (no) | 1993-03-15 |
| NO930926L true NO930926L (no) | 1993-09-17 |
Family
ID=6454136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93930926A NO930926L (no) | 1992-03-16 | 1993-03-15 | 2-oksokinolinderivater |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5371226A (no) |
| EP (1) | EP0561252A1 (no) |
| JP (1) | JPH0625174A (no) |
| KR (1) | KR930019631A (no) |
| CN (1) | CN1077192A (no) |
| AU (1) | AU663358B2 (no) |
| CA (1) | CA2092671A1 (no) |
| CZ (1) | CZ42193A3 (no) |
| DE (1) | DE4208304A1 (no) |
| HU (1) | HUT70038A (no) |
| MX (1) | MX9301404A (no) |
| NO (1) | NO930926L (no) |
| PL (1) | PL298080A1 (no) |
| ZA (1) | ZA931876B (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9125485D0 (en) * | 1991-11-29 | 1992-01-29 | Merck Sharp & Dohme | Therapeutic agents |
| DE4341453A1 (de) * | 1993-12-06 | 1995-06-08 | Merck Patent Gmbh | Imidazopyridine |
| DE19528418A1 (de) * | 1995-08-02 | 1997-02-06 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| US5776482A (en) * | 1996-03-29 | 1998-07-07 | University Of Iowa Research Foundation | Tetrahydroquinoline analogues for use in glaucoma treatment |
| AU4719799A (en) * | 1998-06-30 | 2000-01-17 | Du Pont Pharmaceuticals Company | Substituted quinolin-2(1h)-ones useful as hiv reverse transcriptase inhibitors |
| US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| ES2318899T3 (es) * | 1998-07-06 | 2009-05-01 | Bristol-Myers Squibb Company | Bifenil sulfonamidas como antagonistas duales de los receptores de angiotensina y endotelina. |
| DE19839499A1 (de) * | 1998-08-29 | 2000-03-02 | Merck Patent Gmbh | 2-Oxo-2H-chinolinderivate |
| EP1198231A1 (en) * | 1999-07-21 | 2002-04-24 | American Home Products Corporation | Bicyclic antagonists selective for the(alpha)v(beta)3 integrin |
| US7939545B2 (en) * | 2006-05-16 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| EA201200631A1 (ru) | 2007-11-16 | 2012-11-30 | Джилид Сайенсиз, Инк. | Ингибиторы репликации вируса иммунодефицита человека |
| CA2819106C (en) * | 2010-12-01 | 2015-12-29 | Pfizer Inc. | Kat ii inhibitors |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3406329A1 (de) * | 1984-02-22 | 1985-08-22 | Merck Patent Gmbh, 6100 Darmstadt | Pyridone |
| US4760064A (en) * | 1984-12-18 | 1988-07-26 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds, compositions containing same and processes for preparing same |
| US5036048A (en) * | 1986-03-07 | 1991-07-30 | Schering Corporation | Angiotensin II receptor blockers as antiglaucoma agents |
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| CA2020073A1 (en) * | 1989-07-03 | 1991-01-04 | Eric E. Allen | Substituted quinazolinones as angiotensin ii antagonists |
| US5100897A (en) * | 1989-08-28 | 1992-03-31 | Merck & Co., Inc. | Substituted pyrimidinones as angiotensin ii antagonists |
| US5064837A (en) * | 1989-11-13 | 1991-11-12 | Schering Corporation | 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions |
| EP0430709A3 (en) * | 1989-12-01 | 1992-02-12 | Glaxo Group Limited | Benzthiophen derivatives |
| US5140037A (en) * | 1990-03-20 | 1992-08-18 | E. I. Du Pont De Nemours And Company | Treatment of central nervous system disorders with imidazole angiotensin-ii receptor antagonists |
| AU653734B2 (en) * | 1990-06-19 | 1994-10-13 | Meiji Seika Kabushiki Kaisha | Substituted 4-biphenylmethoxypyridine derivatives |
| IL100917A0 (en) * | 1991-02-16 | 1992-11-15 | Fisons Plc | Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them |
| US5283241A (en) * | 1992-08-28 | 1994-02-01 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
| US5284841A (en) * | 1993-02-04 | 1994-02-08 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
-
1992
- 1992-03-16 DE DE4208304A patent/DE4208304A1/de not_active Withdrawn
-
1993
- 1993-03-09 AU AU34067/93A patent/AU663358B2/en not_active Ceased
- 1993-03-09 EP EP93103710A patent/EP0561252A1/de not_active Ceased
- 1993-03-11 JP JP5050944A patent/JPH0625174A/ja active Pending
- 1993-03-12 CA CA002092671A patent/CA2092671A1/en not_active Abandoned
- 1993-03-15 CN CN93102568A patent/CN1077192A/zh not_active Withdrawn
- 1993-03-15 KR KR1019930003903A patent/KR930019631A/ko not_active Application Discontinuation
- 1993-03-15 PL PL29808093A patent/PL298080A1/xx unknown
- 1993-03-15 MX MX9301404A patent/MX9301404A/es unknown
- 1993-03-15 NO NO93930926A patent/NO930926L/no unknown
- 1993-03-16 HU HU9300744A patent/HUT70038A/hu unknown
- 1993-03-16 CZ CZ93421A patent/CZ42193A3/cs unknown
- 1993-03-16 US US08/031,977 patent/US5371226A/en not_active Expired - Fee Related
- 1993-03-16 ZA ZA931876A patent/ZA931876B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0561252A1 (de) | 1993-09-22 |
| CA2092671A1 (en) | 1993-09-17 |
| CN1077192A (zh) | 1993-10-13 |
| DE4208304A1 (de) | 1993-09-23 |
| US5371226A (en) | 1994-12-06 |
| HUT70038A (en) | 1995-09-28 |
| AU663358B2 (en) | 1995-10-05 |
| HU9300744D0 (en) | 1993-05-28 |
| CZ42193A3 (en) | 1994-01-19 |
| AU3406793A (en) | 1993-09-23 |
| JPH0625174A (ja) | 1994-02-01 |
| PL298080A1 (en) | 1993-10-18 |
| ZA931876B (en) | 1993-10-06 |
| KR930019631A (ko) | 1993-10-18 |
| NO930926D0 (no) | 1993-03-15 |
| MX9301404A (es) | 1993-09-01 |
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