ATE323717T1 - Piperazin-4-phenyl-derivate als inhibitoren der wechselwirkung zwischen mdm2 und mdm2 - Google Patents
Piperazin-4-phenyl-derivate als inhibitoren der wechselwirkung zwischen mdm2 und mdm2Info
- Publication number
- ATE323717T1 ATE323717T1 AT99944688T AT99944688T ATE323717T1 AT E323717 T1 ATE323717 T1 AT E323717T1 AT 99944688 T AT99944688 T AT 99944688T AT 99944688 T AT99944688 T AT 99944688T AT E323717 T1 ATE323717 T1 AT E323717T1
- Authority
- AT
- Austria
- Prior art keywords
- 4alkyl
- mdm2
- formula
- piperazine
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9819860.9A GB9819860D0 (en) | 1998-09-12 | 1998-09-12 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323717T1 true ATE323717T1 (de) | 2006-05-15 |
Family
ID=10838741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99944688T ATE323717T1 (de) | 1998-09-12 | 1999-09-07 | Piperazin-4-phenyl-derivate als inhibitoren der wechselwirkung zwischen mdm2 und mdm2 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6770627B1 (de) |
| EP (1) | EP1112284B1 (de) |
| JP (1) | JP2002524570A (de) |
| AT (1) | ATE323717T1 (de) |
| AU (1) | AU5751299A (de) |
| DE (1) | DE69930947T2 (de) |
| GB (1) | GB9819860D0 (de) |
| WO (1) | WO2000015657A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| JP2005511475A (ja) | 2001-03-02 | 2005-04-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモジュレーターとして有用な化合物及びそれを含む製薬組成物 |
| WO2003075917A1 (en) | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
| GB0215650D0 (en) * | 2002-07-05 | 2002-08-14 | Cyclacel Ltd | Bisarylsufonamide compounds |
| AU2004212928A1 (en) | 2003-02-13 | 2004-09-02 | Bioveris Corporation | Deazaflavin compounds and methods of use thereof |
| US6916833B2 (en) | 2003-03-13 | 2005-07-12 | Hoffmann-La Roche Inc. | Substituted piperidines |
| WO2005112922A2 (en) * | 2004-04-22 | 2005-12-01 | Samaritan Pharmaceuticals | Benzamide compounds |
| CN101300241A (zh) * | 2005-10-21 | 2008-11-05 | 埃科特莱茵药品有限公司 | 作为抗疟疾剂的哌嗪衍生物 |
| EP2001868B1 (de) | 2006-03-22 | 2013-07-17 | Janssen Pharmaceutica N.V. | Inhibitoren der wechselwirkung zwischen mdm2 und p53 |
| US8088795B2 (en) | 2006-03-22 | 2012-01-03 | Janssen Pharmaceutica N.V. | Cyclic-alkylamine derivatives as inhibitors of the interaction between MDM2 and p53 |
| BRPI0713119A2 (pt) | 2006-06-30 | 2012-04-17 | Schering Corp | piperidinas substituìdas que aumentam a atividade de p53 e os usos destas |
| US8470785B2 (en) | 2006-07-28 | 2013-06-25 | St. Jude Children's Research Hospital | Method for treating ocular cancer |
| WO2008014216A1 (en) | 2006-07-28 | 2008-01-31 | St. Jude Children's Research Hospital | Method for treating ocular cancer |
| JP2010500341A (ja) * | 2006-08-10 | 2010-01-07 | コリア リサーチインスティテュート オブ バイオサイエンス アンド バイオテクノロジー | 新規の窒素原子含有ヘテロ環化合物またはその薬学的に許容可能な塩、その製造方法およびそれを含む癌治療用薬学組成物 |
| BRPI0717266A2 (pt) * | 2006-09-21 | 2014-12-09 | Hoffmann La Roche | Derivados de oxindol |
| CN101605798A (zh) | 2006-12-14 | 2009-12-16 | 第一三共株式会社 | 咪唑并噻唑衍生物 |
| US7723372B2 (en) * | 2008-03-19 | 2010-05-25 | Hoffman-La Roche Inc. | Spiroindolinone derivatives |
| WO2009151069A1 (ja) | 2008-06-12 | 2009-12-17 | 第一三共株式会社 | ４，７－ジアザスピロ［２．５］オクタン環構造を有するイミダゾチアゾール誘導体 |
| BR112012008849A2 (pt) | 2009-10-14 | 2015-09-22 | Schering Corp | composto, composição farmacêutica, e, uso de um composto |
| US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
| US8889688B2 (en) | 2010-01-05 | 2014-11-18 | Actelion Pharmaceuticals Ltd. | Piperazines as antimalarial agents |
| US8288431B2 (en) | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
| US8217044B2 (en) | 2010-04-28 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone pyrrolidines |
| WO2013062923A1 (en) | 2011-10-28 | 2013-05-02 | Merck Sharp & Dohme Corp. | MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF |
| WO2013096150A1 (en) | 2011-12-21 | 2013-06-27 | Merck Sharp & Dohme Corp. | Substituted piperidines as hdm2 inhibitors |
| CN105073746B (zh) | 2012-12-20 | 2017-03-22 | 默沙东公司 | 作为hdm2抑制剂的取代的咪唑并吡啶 |
| EP2951180B1 (de) | 2013-01-30 | 2018-05-02 | Merck Sharp & Dohme Corp. | 2,6,7,8-substituierte purine als hdm2-inhibitoren |
| BR112015023560A8 (pt) | 2013-03-15 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Novos derivados de acrilamida como agentes antimaláricos |
| WO2015004610A1 (en) | 2013-07-11 | 2015-01-15 | Adamed Sp. Z O.O. | 1,5-dihydropyrrol-2-one derivatives as inhibitors of p53-mdm2/mdm4 protein-protein interaction |
| CN103954601A (zh) * | 2014-05-20 | 2014-07-30 | 中国科学技术大学 | 一种mdm2拮抗剂的检验试剂盒及其制备方法 |
| EP3458101B1 (de) | 2016-05-20 | 2020-12-30 | H. Hoffnabb-La Roche Ag | Protac-antikörper-konjugate und verfahren zur verwendung |
| CN110183348B (zh) * | 2019-06-18 | 2022-06-03 | 中国医科大学 | N-(3-硝基-4-烷氧基苯甲酰基)氨基酸类化合物、制备方法及其用途 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE423858C (de) | 1925-05-11 | 1926-01-11 | Raduner & Co Akt Ges Fa | Verfahren zum Appretieren von Faserstoffen |
| FR2518088B1 (fr) | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
| JP2769578B2 (ja) | 1989-10-13 | 1998-06-25 | 大塚製薬株式会社 | バソプレシン拮抗剤 |
| DK0488345T3 (da) | 1990-11-30 | 2000-01-24 | Fujirebio Kk | Optisk aktive 1,4-dihydropyridinderivater og fremgangsmåder til fremstilling deraf |
| US5411860A (en) | 1992-04-07 | 1995-05-02 | The Johns Hopkins University | Amplification of human MDM2 gene in human tumors |
| JPH05294915A (ja) | 1992-04-21 | 1993-11-09 | Yamanouchi Pharmaceut Co Ltd | タキキニン拮抗剤 |
| EP0610487B1 (de) * | 1992-09-03 | 1999-11-10 | Boehringer Ingelheim Pharma KG | Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen |
| WO1994007496A1 (en) | 1992-10-07 | 1994-04-14 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| SK142696A3 (en) | 1994-05-07 | 1997-06-04 | Boehringer Ingelheim Kg | Amino acids derivative, method for preparation thereof, pharmaceutical compositions containing said compounds (ii) and their use |
| US5777112A (en) | 1994-06-13 | 1998-07-07 | Merck & Co., Inc | Piperazine compounds promote release of growth hormone |
| US5770377A (en) | 1994-07-20 | 1998-06-23 | University Of Dundee | Interruption of binding of MDM2 and P53 protein and therapeutic application thereof |
| US5607936A (en) | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| KR0173034B1 (ko) | 1995-04-28 | 1999-03-30 | 성재갑 | 선택적 트롬빈 억제제 |
| FR2738151B1 (fr) | 1995-09-04 | 1997-09-26 | Rhone Poulenc Rorer Sa | Antagonistes de l'activite oncogenique de la proteine mdm2, et leur utilisation dans le traitement des cancers |
| ES2193615T3 (es) | 1995-10-25 | 2003-11-01 | Senju Pharma Co | .nhibidor de la angiogenesis. |
| GB9601724D0 (en) | 1996-01-29 | 1996-03-27 | Merck Sharp & Dohme | Therapeutic agents |
| ATE229946T1 (de) | 1996-04-05 | 2003-01-15 | Sod Conseils Rech Applic | Alpha-1 adrenergischer rezeptor antagonisten |
| EP0958305B1 (de) * | 1996-07-05 | 2008-06-04 | Cancer Research Technology Limited | Hemmer der interaktion zwischen p53 und mdm2 |
| NZ334543A (en) | 1996-09-10 | 2000-06-23 | Thomae Gmbh Dr K | Modified amino acids for production of antibodies and labelled compounds suitable for RIA and ELISA assays |
| WO1998025617A1 (en) | 1996-12-13 | 1998-06-18 | Merck & Co., Inc. | Substituted aryl piperazines as modulators of chemokine receptor activity |
-
1998
- 1998-09-12 GB GBGB9819860.9A patent/GB9819860D0/en not_active Ceased
-
1999
- 1999-09-07 AT AT99944688T patent/ATE323717T1/de not_active IP Right Cessation
- 1999-09-07 DE DE69930947T patent/DE69930947T2/de not_active Expired - Fee Related
- 1999-09-07 EP EP99944688A patent/EP1112284B1/de not_active Expired - Lifetime
- 1999-09-07 WO PCT/GB1999/002957 patent/WO2000015657A1/en active IP Right Grant
- 1999-09-07 AU AU57512/99A patent/AU5751299A/en not_active Abandoned
- 1999-09-07 JP JP2000570195A patent/JP2002524570A/ja active Pending
- 1999-09-07 US US09/786,702 patent/US6770627B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB9819860D0 (en) | 1998-11-04 |
| US6770627B1 (en) | 2004-08-03 |
| JP2002524570A (ja) | 2002-08-06 |
| EP1112284B1 (de) | 2006-04-19 |
| DE69930947D1 (de) | 2006-05-24 |
| DE69930947T2 (de) | 2006-12-28 |
| WO2000015657A1 (en) | 2000-03-23 |
| EP1112284A1 (de) | 2001-07-04 |
| AU5751299A (en) | 2000-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |