NO327982B1 - C(7)-estersubstituerte taxaner, farmasoytiske preparater som omfatter taxanene, preparater for oral administrering som omfatter taxanene, samt anvendelse av taxanene til fremstilling av orale farmasoytiske preparater for inhibering av tumorvekst hos pattedyr - Google Patents

C(7)-estersubstituerte taxaner, farmasoytiske preparater som omfatter taxanene, preparater for oral administrering som omfatter taxanene, samt anvendelse av taxanene til fremstilling av orale farmasoytiske preparater for inhibering av tumorvekst hos pattedyr Download PDF

Info

Publication number: NO327982B1
Authority: NO; Norway
Prior art keywords: ethyl; butyl; taxanes; xio; solution
Prior art date: 2000-02-02

Application number

NO20014759A

Other languages

English (en)

Norwegian (no)

Other versions

NO20014759D0 (no

NO20014759L (no

Inventor

Robert A Holton

Original Assignee

Univ Florida State Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-02

Filing date

2001-10-01

Publication date

2009-11-02

2001-10-01 Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found

2001-10-01 Publication of NO20014759D0 publication Critical patent/NO20014759D0/no

2001-11-29 Publication of NO20014759L publication Critical patent/NO20014759L/no

2009-11-02 Publication of NO327982B1 publication Critical patent/NO327982B1/no

Links

229940123237 Taxane Drugs 0.000 title claims description 41
238000002360 preparation method Methods 0.000 title claims description 40
239000000825 pharmaceutical preparation Substances 0.000 title claims description 17
241000124008 Mammalia Species 0.000 title claims description 5
230000004614 tumor growth Effects 0.000 title claims description 4
239000008183 oral pharmaceutical preparation Substances 0.000 title claims description 3
230000005764 inhibitory process Effects 0.000 title description 3
-1 tert-amyl Chemical group 0.000 claims description 35
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 31
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 29
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 23
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 11
125000000217 alkyl group Chemical group 0.000 claims description 10
239000003937 drug carrier Substances 0.000 claims description 6
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 6
125000002541 furyl group Chemical group 0.000 claims description 4
230000002401 inhibitory effect Effects 0.000 claims description 3
125000001544 thienyl group Chemical group 0.000 claims description 3
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 2
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 13
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 11
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 5
125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 4
125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 3
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 3
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
239000000243 solution Substances 0.000 description 102
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235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
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229920001451 polypropylene glycol Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
239000013630 prepared media Substances 0.000 description 1
XVSSGIXTKVRGAR-UHFFFAOYSA-N prop-2-enoxycarbonyl prop-2-enyl carbonate Chemical compound C=CCOC(=O)OC(=O)OCC=C XVSSGIXTKVRGAR-UHFFFAOYSA-N 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
238000001226 reprecipitation Methods 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
239000004248 saffron Substances 0.000 description 1
235000013974 saffron Nutrition 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
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229910002027 silica gel Inorganic materials 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
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235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
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235000017550 sodium carbonate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
229940082004 sodium laurate Drugs 0.000 description 1
229940001584 sodium metabisulfite Drugs 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
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239000012177 spermaceti Substances 0.000 description 1
229940032094 squalane Drugs 0.000 description 1
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TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000000707 stereoselective effect Effects 0.000 description 1
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239000004094 surface-active agent Substances 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
150000003892 tartrate salts Chemical class 0.000 description 1
150000003505 terpenes Chemical class 0.000 description 1
235000007586 terpenes Nutrition 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
150000003538 tetroses Chemical class 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
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235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
125000004665 trialkylsilyl group Chemical group 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003641 trioses Chemical class 0.000 description 1
229960004418 trolamine Drugs 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
150000004670 unsaturated fatty acids Chemical class 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
235000019386 wax ester Nutrition 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000002023 wood Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20014759A 2000-02-02 2001-10-01 C(7)-estersubstituerte taxaner, farmasoytiske preparater som omfatter taxanene, preparater for oral administrering som omfatter taxanene, samt anvendelse av taxanene til fremstilling av orale farmasoytiske preparater for inhibering av tumorvekst hos pattedyr NO327982B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17979400P	2000-02-02	2000-02-02
PCT/US2001/003385 WO2001057027A1 (en)	2000-02-02	2001-02-02	C7 ester substituted taxanes as antitumor agents

Publications (3)

Publication Number	Publication Date
NO20014759D0 NO20014759D0 (no)	2001-10-01
NO20014759L NO20014759L (no)	2001-11-29
NO327982B1 true NO327982B1 (no)	2009-11-02

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NO20014759A NO327982B1 (no)	2000-02-02	2001-10-01	C(7)-estersubstituerte taxaner, farmasoytiske preparater som omfatter taxanene, preparater for oral administrering som omfatter taxanene, samt anvendelse av taxanene til fremstilling av orale farmasoytiske preparater for inhibering av tumorvekst hos pattedyr

Country Status (35)

Country	Link
US (3)	US6610860B2 (de)
EP (1)	EP1183253B8 (de)
JP (1)	JP2003522167A (de)
KR (1)	KR100784161B1 (de)
CN (1)	CN1362955A (de)
AR (1)	AR030188A1 (de)
AT (1)	ATE396188T1 (de)
AU (1)	AU776051B2 (de)
BG (1)	BG65279B1 (de)
BR (1)	BR0104749A (de)
CA (1)	CA2368993C (de)
CO (1)	CO5280224A1 (de)
CZ (1)	CZ298484B6 (de)
DE (1)	DE60134094D1 (de)
DK (1)	DK1183253T3 (de)
ES (1)	ES2307588T3 (de)
GE (1)	GEP20043322B (de)
HK (1)	HK1047938A1 (de)
HU (1)	HUP0200917A3 (de)
IL (1)	IL145641A0 (de)
MX (1)	MXPA01009901A (de)
MY (1)	MY137637A (de)
NO (1)	NO327982B1 (de)
NZ (1)	NZ514409A (de)
PL (1)	PL202668B1 (de)
PT (1)	PT1183253E (de)
RO (1)	RO121777B1 (de)
RU (1)	RU2265017C2 (de)
SA (1)	SA01220045B1 (de)
SK (1)	SK13712001A3 (de)
TR (1)	TR200102856T1 (de)
TW (1)	TWI291873B (de)
UA (1)	UA75573C2 (de)
WO (1)	WO2001057027A1 (de)
ZA (1)	ZA200108060B (de)

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2001
- 2001-01-31 CO CO01007075A patent/CO5280224A1/es not_active Application Discontinuation
- 2001-01-31 AR ARP010100463A patent/AR030188A1/es not_active Application Discontinuation
- 2001-02-02 RO ROA200101085A patent/RO121777B1/ro unknown
- 2001-02-02 CN CN01800306A patent/CN1362955A/zh active Pending
- 2001-02-02 MX MXPA01009901A patent/MXPA01009901A/es active IP Right Grant
- 2001-02-02 DK DK01905349T patent/DK1183253T3/da active
- 2001-02-02 GE GE4514A patent/GEP20043322B/en unknown
- 2001-02-02 WO PCT/US2001/003385 patent/WO2001057027A1/en active IP Right Grant
- 2001-02-02 SK SK1371-2001A patent/SK13712001A3/sk unknown
- 2001-02-02 NZ NZ514409A patent/NZ514409A/xx unknown
- 2001-02-02 CZ CZ20013503A patent/CZ298484B6/cs not_active IP Right Cessation
- 2001-02-02 MY MYPI20010481A patent/MY137637A/en unknown
- 2001-02-02 DE DE60134094T patent/DE60134094D1/de not_active Expired - Fee Related
- 2001-02-02 CA CA002368993A patent/CA2368993C/en not_active Expired - Fee Related
- 2001-02-02 ES ES01905349T patent/ES2307588T3/es not_active Expired - Lifetime
- 2001-02-02 AT AT01905349T patent/ATE396188T1/de not_active IP Right Cessation
- 2001-02-02 PL PL350026A patent/PL202668B1/pl not_active IP Right Cessation
- 2001-02-02 TR TR2001/02856T patent/TR200102856T1/xx unknown
- 2001-02-02 UA UA2001106734A patent/UA75573C2/uk unknown
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- 2001-02-02 AU AU33239/01A patent/AU776051B2/en not_active Ceased
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- 2001-02-02 RU RU2001129507/04A patent/RU2265017C2/ru not_active IP Right Cessation
- 2001-02-02 JP JP2001557859A patent/JP2003522167A/ja active Pending
- 2001-02-02 US US09/775,851 patent/US6610860B2/en not_active Expired - Fee Related
- 2001-02-02 KR KR1020017012600A patent/KR100784161B1/ko not_active IP Right Cessation
- 2001-02-02 EP EP01905349A patent/EP1183253B8/de not_active Expired - Lifetime
- 2001-02-02 BR BR0104749-3A patent/BR0104749A/pt not_active IP Right Cessation
- 2001-02-02 PT PT01905349T patent/PT1183253E/pt unknown
- 2001-03-06 TW TW090102237A patent/TWI291873B/zh active
- 2001-04-11 SA SA1220045A patent/SA01220045B1/ar unknown
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- 2001-10-01 NO NO20014759A patent/NO327982B1/no not_active IP Right Cessation
- 2001-10-01 BG BG105967A patent/BG65279B1/bg unknown
2003
- 2003-01-07 HK HK03100173.6A patent/HK1047938A1/zh unknown
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Also Published As

Publication number	Publication date
CA2368993C (en)	2009-10-20
CZ20013503A3 (cs)	2002-03-13
CN1362955A (zh)	2002-08-07
UA75573C2 (en)	2006-05-15
BG105967A (en)	2002-08-30
PL202668B1 (pl)	2009-07-31
PL350026A1 (en)	2002-10-21
US20040014979A1 (en)	2004-01-22
TR200102856T1 (tr)	2002-06-21
DK1183253T3 (da)	2008-09-22
MY137637A (en)	2009-02-27
CZ298484B6 (cs)	2007-10-17
DE60134094D1 (de)	2008-07-03
EP1183253B8 (de)	2009-01-07
ES2307588T3 (es)	2008-12-01
MXPA01009901A (es)	2003-07-28
NO20014759D0 (no)	2001-10-01
EP1183253B1 (de)	2008-05-21
GEP20043322B (en)	2003-12-10
US6610860B2 (en)	2003-08-26
ATE396188T1 (de)	2008-06-15
EP1183253A1 (de)	2002-03-06
PT1183253E (pt)	2008-08-04
US20070249708A1 (en)	2007-10-25
BR0104749A (pt)	2001-12-26
TWI291873B (en)	2008-01-01
IL145641A0 (en)	2002-06-30
CO5280224A1 (es)	2003-05-30
HU0200917D0 (en)	2002-04-29
NZ514409A (en)	2004-03-26
ZA200108060B (en)	2003-12-01
AU776051B2 (en)	2004-08-26
AR030188A1 (es)	2003-08-13
BG65279B1 (bg)	2007-11-30
WO2001057027A1 (en)	2001-08-09
HUP0200917A2 (en)	2002-08-28
SA01220045B1 (ar)	2008-06-07
CA2368993A1 (en)	2001-08-09
KR100784161B1 (ko)	2007-12-12
US20020013346A1 (en)	2002-01-31
RO121777B1 (ro)	2008-04-30
HUP0200917A3 (en)	2004-07-28
AU3323901A (en)	2001-08-14
HK1047938A1 (zh)	2003-03-14
KR20010111583A (ko)	2001-12-19
US7186849B2 (en)	2007-03-06
SK13712001A3 (sk)	2002-05-09
RU2265017C2 (ru)	2005-11-27
NO20014759L (no)	2001-11-29
JP2003522167A (ja)	2003-07-22

Legal Events

Date	Code	Title	Description
2010-09-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO327982B1 (no)	2009-11-02	C(7)-estersubstituerte taxaner, farmasoytiske preparater som omfatter taxanene, preparater for oral administrering som omfatter taxanene, samt anvendelse av taxanene til fremstilling av orale farmasoytiske preparater for inhibering av tumorvekst hos pattedyr
US20070249707A1 (en)	2007-10-25	Taxanes having c7 hydroxy and c10 heterosubstituted acetate substituents
US20050143446A1 (en)	2005-06-30	C7 heterosubstituted acetate taxane compositions
US20050165051A1 (en)	2005-07-28	Taxanes having a C7 carbonate substituent
NO327910B1 (no)	2009-10-19	Taxaner, farmasoytiske preparater som omfatter disse, preparater for oral administrering som omfatter taxanene, samt anvendelse av taxanene til fremstilling av orale farmasoytiske preparater for inhibering av tumorvekst hos pattedyr
US6750245B2 (en)	2004-06-15	C7 carbamate substituted taxanes
US7160919B2 (en)	2007-01-09	C7 lactyloxy-substituted taxanes
CA2354486A1 (en)	2003-01-31	C7 ester substituted taxanes