CO5280224A1 - Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen - Google Patents
Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienenInfo
- Publication number
- CO5280224A1 CO5280224A1 CO01007075A CO01007075A CO5280224A1 CO 5280224 A1 CO5280224 A1 CO 5280224A1 CO 01007075 A CO01007075 A CO 01007075A CO 01007075 A CO01007075 A CO 01007075A CO 5280224 A1 CO5280224 A1 CO 5280224A1
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- taxans
- ester
- useful
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un taxano que tiene la fórmula:<EMI FILE="01007075_1" ID="1" IMF=JPEG >Ac es acetilo;Bz es benzoilo;R7 es RaCOO-;R10 es hidroxi;X3 es alquilo, alquenilo, alquinilo sustituido o no sustituido, o heterociclo;X5 es -COX10, -COOX10 ó CONHX10;X10 es hidrocarbilo, hidrocarbilo sustituido, o heterociclo en donde dicho hidrocarbilo o hidrocarbilo sustituido contiene átomos de carbono en las posiciones alfa y beta relativos al carbono del cual Ra es sustituyente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17979400P | 2000-02-02 | 2000-02-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5280224A1 true CO5280224A1 (es) | 2003-05-30 |
Family
ID=22658029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO01007075A CO5280224A1 (es) | 2000-02-02 | 2001-01-31 | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
Country Status (35)
Country | Link |
---|---|
US (3) | US6610860B2 (es) |
EP (1) | EP1183253B8 (es) |
JP (1) | JP2003522167A (es) |
KR (1) | KR100784161B1 (es) |
CN (1) | CN1362955A (es) |
AR (1) | AR030188A1 (es) |
AT (1) | ATE396188T1 (es) |
AU (1) | AU776051B2 (es) |
BG (1) | BG65279B1 (es) |
BR (1) | BR0104749A (es) |
CA (1) | CA2368993C (es) |
CO (1) | CO5280224A1 (es) |
CZ (1) | CZ298484B6 (es) |
DE (1) | DE60134094D1 (es) |
DK (1) | DK1183253T3 (es) |
ES (1) | ES2307588T3 (es) |
GE (1) | GEP20043322B (es) |
HK (1) | HK1047938A1 (es) |
HU (1) | HUP0200917A3 (es) |
IL (1) | IL145641A0 (es) |
MX (1) | MXPA01009901A (es) |
MY (1) | MY137637A (es) |
NO (1) | NO327982B1 (es) |
NZ (1) | NZ514409A (es) |
PL (1) | PL202668B1 (es) |
PT (1) | PT1183253E (es) |
RO (1) | RO121777B1 (es) |
RU (1) | RU2265017C2 (es) |
SA (1) | SA01220045B1 (es) |
SK (1) | SK13712001A3 (es) |
TR (1) | TR200102856T1 (es) |
TW (1) | TWI291873B (es) |
UA (1) | UA75573C2 (es) |
WO (1) | WO2001057027A1 (es) |
ZA (1) | ZA200108060B (es) |
Families Citing this family (37)
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JP2003521545A (ja) * | 2000-02-02 | 2003-07-15 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 改良された溶解性を有するタキサン製剤 |
CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
CA2354486A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C7 ester substituted taxanes |
SG125889A1 (en) * | 2001-08-01 | 2006-10-30 | Univ Florida State Res Found | C7 ester subsituted taxanes |
KR100819578B1 (ko) * | 2001-08-01 | 2008-04-04 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | C7 에스테르 치환된 탁산 |
US20030082229A1 (en) * | 2001-11-01 | 2003-05-01 | Board Of Regents, The University Of Texas Systems | Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use |
US8012950B2 (en) * | 2003-08-29 | 2011-09-06 | Wisconsin Alumni Research Foundation | Method to diagnose and treat degenerative joint disease |
EP1894921A3 (en) * | 2003-09-25 | 2008-03-12 | Tapestry Pharmaceuticals, Inc. | 9, 10-Alpha, Alpha-Oh-Taxane analogs and methods for production thereof |
ATE377593T1 (de) | 2003-09-25 | 2007-11-15 | Tapestry Pharmaceuticals Inc | 9,10-alpha,alpha-oh-taxananaloga und verfahren zu deren herstellung |
JP2007527432A (ja) * | 2004-03-05 | 2007-09-27 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | C7ラクチルオキシ置換タキサン |
TW200533339A (en) * | 2004-03-16 | 2005-10-16 | Bristol Myers Squibb Co | Therapeutic synergy of anti-cancer compounds |
EP1812864A2 (en) * | 2004-10-07 | 2007-08-01 | Emory University | Multifunctional nanoparticles conjugates and their use |
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US20060216767A1 (en) * | 2005-03-22 | 2006-09-28 | Saladax Biomedical Inc. | Docetaxel immunoassay |
PL217731B1 (pl) | 2006-06-01 | 2014-08-29 | Tomasz Byrski | Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi |
US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
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US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
EP2118079A1 (en) | 2007-02-07 | 2009-11-18 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Synthetic macrocyclic compounds for treating cancer |
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CA2732290A1 (en) | 2008-07-31 | 2010-02-04 | Ziopharm Oncology, Inc. | Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof |
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WO2010138686A1 (en) | 2009-05-29 | 2010-12-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mdri-inverse agents |
WO2011112867A1 (en) | 2010-03-10 | 2011-09-15 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas |
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ES2718812T3 (es) | 2011-07-11 | 2019-07-04 | Us Health | Conjugados de anticuerpo-fluoróforo fotosensibilizantes |
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ES2764833T3 (es) | 2013-10-11 | 2020-06-04 | The United States Of America Represented By The Sec Dep Of Health And Human Services | Anticuerpos contra TEM8 y su uso |
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WO2019099615A1 (en) | 2017-11-17 | 2019-05-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of copeptin to modulate the immune response and hematopoiesis, and stimulate bone growth |
JP2021521135A (ja) | 2018-04-10 | 2021-08-26 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | がん細胞を標的とする近赤外光線免疫療法および宿主免疫活性化の組合せ |
EA202290208A1 (ru) | 2019-07-02 | 2022-03-25 | Дзе Юнайтед Стейтс Оф Эмерика, Эз Репрезентед Бай Дзе Секретэри, Дипартмент Оф Хелт Энд Хьюман Сервисиз | МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТ EGFRvIII, И ИХ ПРИМЕНЕНИЕ |
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WO2024006965A1 (en) | 2022-06-30 | 2024-01-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cd25-specific antibodies and uses thereof |
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-
2001
- 2001-01-31 CO CO01007075A patent/CO5280224A1/es not_active Application Discontinuation
- 2001-01-31 AR ARP010100463A patent/AR030188A1/es not_active Application Discontinuation
- 2001-02-02 AT AT01905349T patent/ATE396188T1/de not_active IP Right Cessation
- 2001-02-02 MY MYPI20010481A patent/MY137637A/en unknown
- 2001-02-02 EP EP01905349A patent/EP1183253B8/en not_active Expired - Lifetime
- 2001-02-02 BR BR0104749-3A patent/BR0104749A/pt not_active IP Right Cessation
- 2001-02-02 RU RU2001129507/04A patent/RU2265017C2/ru not_active IP Right Cessation
- 2001-02-02 HU HU0200917A patent/HUP0200917A3/hu unknown
- 2001-02-02 CN CN01800306A patent/CN1362955A/zh active Pending
- 2001-02-02 DE DE60134094T patent/DE60134094D1/de not_active Expired - Fee Related
- 2001-02-02 IL IL14564101A patent/IL145641A0/xx unknown
- 2001-02-02 US US09/775,851 patent/US6610860B2/en not_active Expired - Fee Related
- 2001-02-02 PL PL350026A patent/PL202668B1/pl not_active IP Right Cessation
- 2001-02-02 UA UA2001106734A patent/UA75573C2/uk unknown
- 2001-02-02 WO PCT/US2001/003385 patent/WO2001057027A1/en active IP Right Grant
- 2001-02-02 RO ROA200101085A patent/RO121777B1/ro unknown
- 2001-02-02 MX MXPA01009901A patent/MXPA01009901A/es active IP Right Grant
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- 2001-02-02 CA CA002368993A patent/CA2368993C/en not_active Expired - Fee Related
- 2001-02-02 ES ES01905349T patent/ES2307588T3/es not_active Expired - Lifetime
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- 2001-02-02 CZ CZ20013503A patent/CZ298484B6/cs not_active IP Right Cessation
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- 2001-02-02 KR KR1020017012600A patent/KR100784161B1/ko not_active IP Right Cessation
- 2001-02-02 AU AU33239/01A patent/AU776051B2/en not_active Ceased
- 2001-02-02 JP JP2001557859A patent/JP2003522167A/ja active Pending
- 2001-02-02 DK DK01905349T patent/DK1183253T3/da active
- 2001-02-02 SK SK1371-2001A patent/SK13712001A3/sk unknown
- 2001-03-06 TW TW090102237A patent/TWI291873B/zh active
- 2001-04-11 SA SA1220045A patent/SA01220045B1/ar unknown
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- 2001-10-01 NO NO20014759A patent/NO327982B1/no not_active IP Right Cessation
- 2001-10-01 BG BG105967A patent/BG65279B1/bg unknown
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2003
- 2003-01-07 HK HK03100173.6A patent/HK1047938A1/zh unknown
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2007
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