ES2149800T3 - Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermediarios en la preparacion de taxanos. - Google Patents

Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermediarios en la preparacion de taxanos.

Info

Publication number
ES2149800T3
ES2149800T3 ES93300241T ES93300241T ES2149800T3 ES 2149800 T3 ES2149800 T3 ES 2149800T3 ES 93300241 T ES93300241 T ES 93300241T ES 93300241 T ES93300241 T ES 93300241T ES 2149800 T3 ES2149800 T3 ES 2149800T3
Authority
ES
Spain
Prior art keywords
taxanes
preparation
resolution
intermediaries
compounds useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93300241T
Other languages
English (en)
Inventor
Ramesh N Patel
Laszlo J Szarka
Richard A Partyka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of ES2149800T3 publication Critical patent/ES2149800T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

LA INVENCION SE REFIERE A METODOS PARA LA RESOLUCION ENZIMATICA DE MEZCLAS DE ENANTIOMEROS, TALES COMO COMPUESTOS BETA ARACION DE TAXANOS, TALES COMO TAXOL, QUE ES DE UTILIDAD EN EL CAMPO FARMACEUTICO.
ES93300241T 1992-01-15 1993-01-15 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermediarios en la preparacion de taxanos. Expired - Lifetime ES2149800T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82201592A 1992-01-15 1992-01-15

Publications (1)

Publication Number Publication Date
ES2149800T3 true ES2149800T3 (es) 2000-11-16

Family

ID=25234887

Family Applications (2)

Application Number Title Priority Date Filing Date
ES93300241T Expired - Lifetime ES2149800T3 (es) 1992-01-15 1993-01-15 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermediarios en la preparacion de taxanos.
ES99124119T Expired - Lifetime ES2230790T3 (es) 1992-01-15 1993-01-15 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99124119T Expired - Lifetime ES2230790T3 (es) 1992-01-15 1993-01-15 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos.

Country Status (11)

Country Link
US (2) US5567614A (es)
EP (2) EP1001036B1 (es)
JP (1) JP3184350B2 (es)
AT (2) ATE195973T1 (es)
CA (2) CA2087359A1 (es)
DE (2) DE69329304T2 (es)
DK (2) DK1001036T3 (es)
ES (2) ES2149800T3 (es)
GR (1) GR3034942T3 (es)
HK (1) HK1027130A1 (es)
PT (2) PT552041E (es)

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US6335362B1 (en) * 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
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US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
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DE4420751A1 (de) * 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
US5602272A (en) * 1994-06-21 1997-02-11 Bristol-Myers Squibb Company Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
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US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
DE69813053T2 (de) * 1997-01-24 2004-02-19 Sumitomo Chemical Co., Ltd. Verfahren zur Herstellung von optisch aktiven Azetidin-2-Carbonsäurederivaten
GB9714877D0 (en) * 1997-07-15 1997-09-17 Chiroscience Ltd Microorganism and its use
EP0933360A1 (en) 1997-12-22 1999-08-04 Pharmachemie B.V. Synthesis of new beta-lactams
US5919672A (en) * 1998-10-02 1999-07-06 Schering Corporation Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone
KR100567108B1 (ko) * 1999-07-16 2006-03-31 에스케이 주식회사 효소적 방법에 의한 트랜스-(1ｓ,2ｓ)-1-아지도 2-인단올 및 트랜스-(1ｒ,2ｒ)-1-아지도 2-인다닐 아세테이트의 제조방법
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6548293B1 (en) 1999-10-18 2003-04-15 Fsu Research Foundation, Inc. Enzymatic process for the resolution of enantiomeric mixtures of β-lactams
BR0104351A (pt) 2000-02-02 2002-01-02 Univ Florida State Res Found Taxanos substituìdos com carbonato c7 como agentes antitumor
AU782028B2 (en) * 2000-02-02 2005-06-30 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes as antitumor agents
CA2368534A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
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JP2003522173A (ja) 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カルバモイルオキシ置換タキサン
EP1165549B1 (en) * 2000-02-02 2008-04-16 Florida State University Research Foundation, Inc. C7 carbamoyloxy substituted taxanes as antitumor agents
CO5280224A1 (es) * 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
DE10004926A1 (de) * 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
CA2399062C (en) * 2000-02-11 2010-01-12 Shire Biochem Inc. Stereoselective synthesis of nucleoside analogues
JP4142444B2 (ja) * 2001-03-07 2008-09-03 第一三共株式会社 ２−アゼチジノン誘導体の製造方法
US6653501B2 (en) 2001-06-27 2003-11-25 Napro Biotherapeutics, Inc. Chiral resolution method for producing compounds useful in the synthesis of taxanes
US7063977B2 (en) * 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
HUP0600533A2 (en) 2001-11-30 2006-11-28 Bristol Myers Squibb Co Paclitaxel solvates
KR100433633B1 (ko) * 2002-04-18 2004-05-31 학교법인 포항공과대학교 무용매 이상계 시스템을 이용한 효소적 광학분할 방법
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
HN2005000054A (es) * 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
TW200540164A (en) 2004-03-05 2005-12-16 Univ Florida State Res Found C7 lactyloxy-substituted taxanes
PE20061090A1 (es) * 2005-02-14 2006-10-12 Univ Florida State Res Found Preparaciones de taxanos sustituidos con esteres de ciclopropilo en c10
WO2009118750A1 (en) * 2008-03-26 2009-10-01 Council Of Scientific & Industrial Research Stereoselective hydrolysis for the resolution of racemic mixtures of (+/-) -cis-s-acetoxy-l- (4-methoxyphenyl) -4- (2-furyl) -2-azetidinone, (+/-) -cis-s-acetoxy-l- (4-methoxyphenyl) -4- (2-thienyl) -2-azetidinone, or
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Also Published As

Publication number Publication date
EP0552041A3 (en) 1994-10-05
ES2230790T3 (es) 2005-05-01
JPH05308996A (ja) 1993-11-22
US5811292A (en) 1998-09-22
US5567614A (en) 1996-10-22
ATE280240T1 (de) 2004-11-15
JP3184350B2 (ja) 2001-07-09
DE69329304T2 (de) 2001-01-04
CA2434312A1 (en) 1993-07-16
DE69333675T2 (de) 2006-02-02
EP1001036B1 (en) 2004-10-20
PT552041E (pt) 2000-12-29
EP1001036A2 (en) 2000-05-17
CA2087359A1 (en) 1993-07-16
ATE195973T1 (de) 2000-09-15
EP0552041A2 (en) 1993-07-21
DE69333675D1 (de) 2004-11-25
EP0552041B1 (en) 2000-08-30
DE69329304D1 (de) 2000-10-05
PT1001036E (pt) 2005-01-31
EP1001036A3 (en) 2000-08-02
HK1027130A1 (en) 2001-01-05
GR3034942T3 (en) 2001-02-28
DK1001036T3 (da) 2004-11-29
DK0552041T3 (da) 2000-10-09

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