NO319503B1 - Anvendelse av et salt for fremstilling av et farmasoytisk eller dermatologisk preparat - Google Patents
Anvendelse av et salt for fremstilling av et farmasoytisk eller dermatologisk preparat Download PDFInfo
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- NO319503B1 NO319503B1 NO19964515A NO964515A NO319503B1 NO 319503 B1 NO319503 B1 NO 319503B1 NO 19964515 A NO19964515 A NO 19964515A NO 964515 A NO964515 A NO 964515A NO 319503 B1 NO319503 B1 NO 319503B1
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- agents
- preparation
- salt
- stated
- salts
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Description
Foreliggende oppfinnelse vedrører anvendelse av i det minste ett lantanid-, yttrium-, barium- eller strontiumsalt i et dermatologisk eller farmasøytisk preparat som subsans P antagonist, for fremstillingen av et farmasøytisk eller dermatologisk preparat for å behandle smerte forbundet med minst en av de følgende hudlidelser, inkluderende hodebunnen og slimhinner: zona, postzostersmerter, forbrenning, demodicidose, hudulcus, fibrose og/eller for å regulere hypertrofisk arrdannelse og/eller for å behandle acne rosacea.
Polypeptider som tilhører takykinin-familien eksisterer i pattedyr som induserer raske kontraksjoner av de glatte muskelfibre. Blant forbindelsene i denne familie skal det nevnes p-nevrokinin, a-nevrokinin og substans P.
Substans P er en polypeptid-kjemisk-bestanddel (undecapeptid) som dannes og frigis ved en nerveende. Lokaliseringen av substans P er spesifikk for nevronene, både i sentralnervesystemet og i de perifere organer. Svært mange organer eller vev mottar således afferenser av substans P nevroner, og disse er særlig spyttkjertlene, magesekk, pankreas, tarm (i den sistnevnte er fordelingen av substans P avleiret på den indre Meissners og Auerbachs nerve-plexus), det kardiovaskulære system, tyreoida, hud, iris og ciliær-legemer, blære og selvsagt sentralnervesystemet og det perifere nervesystem.
På grunn av den ubikvitære fordeling av substans P, er svært mange lidelser forbundet med en alt for stor syntese og/eller frigivelse av substans P.
Substans P er særlig involvert i transmisjon av smerte (dental, kutan, tympanisk) og i sykdommer i sentralnervesystemet (f.eks. angst, psykoser, nevropatier, nevrodegenerative lidelser av typen Alzheimers senil demens, demens hos aidspasienter, Parkinsons sykdom, Downs syndrom, Korsakoffs syndrom, multippel sklerose, schizofreni, psykotiske lidelser), i respirasjonssykdommer (f.eks. bronko-pneumoni, hoste, emfysem, bronkiolitt) og inflammatoriske sykdommer, (som f.eks. revmatoid artritt), i allergiske syndromer (f.eks. astma, allergisk rhinitt, allergisk faryngitt, urtikaria, eksematøs dermatitt)( i gastro-intestinale lidelser (som f.eks. ulcus, kolitt, Crohns sykdom, gastritt, gastroenteritt, intestinale spastisiteter), i hudlidelser (f.eks. psoriasis, pruriginøse lidelser, herpes, fotodermatose, atopisk dermatitt, kontaktdermatitt, lichen, prurigo, pruritus, rosacea, følsom hud, ringorm, solerytem og emosjonelt erytem, insektstikk), i fibroser og andre kollagenmaturasjons-lidelser (som f.eks. skleroderma) i kardiovaskulære sykdommer, vasospastiske lidelser (som f.eks. migrene, Raynauds sykdom), i immunologiske lidelser, i lidelser i urinrør og/eller genitalia (som f.eks. inkonti-nens, cystitt), i revmatiske lidelser, i enkelte dermatologiske lidelser (som eksem) og i oftalmologiske tilstander (som f.eks. konjunktivitt, uveitt, okulær pruritus, blefaritt, irritasjoner og okulær smerte).
Anvendelsen av en substans P antagonist er ett av de terapeutiske alternativer som er effektivt ved alle de tilstander som er nevnt i det foregående.
Substans P antagonist skal forstås til å bety enhver forbindelse som er i stand til delvis, eller til og med fullstendig, å inhibere den biologiske effekt av substans P. For at en substans skal oppfattes som en substans P antagonist, bør den spesielt indusere en koherent farmakologisk respons (som eventuelt inkluderer dens binding til substans P reseptoren) i særlig en av følgende tester: antagonistsubstansen bør redusere ekstravasasjonen av plasma over den vaskulære vegg indusert ved capsaicin
eller ved en antidrom nervestimulering, eller alternativt antagonistsubstansen bør bevirke inhibering av kontraksjonen av den glatte muskulatur indusert ved administrering av substans P.
Opp til nå har substans P antagonister blitt anvendt til å behandle lidelsene som indikert i det foregående og som nevnt i en rekke dokumenter.
Ingen av disse dokumenter lærer eller foreslår imidlertid at et lantanid-, sink-, yttrium-, tinn-, kobolt-, barium- eller strontiumsalt kan ha en substans P antagonistaktivitet som definert i det foregående og som derfor særlig kan anvendes for å behandle smerte forbundet med hudlidelsene som indikert i det foregående.
I tillegg er et medikament inneholdende kresoler og strontiumklorid for å øke de anti-bakterielle og anti-mikrobielle egenskaper til disse kresoler kjent fra dokumentet FR-M-5394. Dette dokument hverken beskriver eller foreslår imidlertid at strontiumklorid alene kan nedsette eller i realiteten eliminere symptomer som irritasjon, smerte, kløe eller svie som bevirket ved en hvilken som helst sykdom, heller ikke nedsette eller i realiteten eliminere de samme symptomer som bevirket ved et irriterende produkt.
Man har funnet at et salt valgt fra lantanid-, mangan-, tinn-, sink-, yttrium-, kobolt-, barium- eller strontiumsalter svarer til de egenskaper som er definert som kjennetegnende for en substans P antagonist.
Oppfinnelsen vedrører anvendelsen av minst ett salt valgt fra yttrium-, lantan-, cerium-, praseodym-, neodym-, prometium-, samarium-, europium-, gadolinium-, terbium-, dysprosium-, holmium-, erbium-, thulium-, ytterbium-, lutetium-, barium-eller strontiumsalter og en kombinasjon derav for fremstillingen av et farmasøytisk eller dermatologisk preparat for å behandle smerte forbundet med minst en av de følgende hudlidelser: zona, postzoster smerter, forbrenning, demodicidosis, hudulcus, fibrose og/eller for å regulere hypertrofisk arrdannelse og/eller for å behandle acne rosacea.
Med lantanid skal forstås elementene med atomtall z som strekker seg fra 57 til 71, dvs. lantan, cerium, praseodym, neodym, prometium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium og lutetium.
Oppfinnelsen er anvendbar i forbindelse med alle de ovennevnte hudlidelser som er forbundet med overdreven syntese og/eller frigivelse av substans P.
Saltene som anvendes kan f.eks. være karbonater, bikarbo-nater, sulfater, glycerofosfater, borater, klorider, nitrater, acetater, hydroksyder, persulfater såvel som salter av a-hydroksysyrer (citrater, tartrater, laktater, malater) eller av fruktsyrer, eller alternativt salter av aminosyrer (aspartat, arginat, glykocholat, fumarat) eller salter av fettsyrer (palmitat, oleat, kaseinat, behenat).
Saltene kan fordelaktig velges fra barium-, yttrium- og strontiumsalter og blandinger derav.
Foretrukket anvendes klorider og nitrater av særlig gadolinium, yttrium og strontium. Saltet er foretrukket et strontiumsalt.
I henhold til oppfinnelsen kan saltet anvendes i en mengde som strekker seg fra 10"<5>% til 20% av totalvekten av preparatet og foretrukket i en mengde fra 10"<2>% til 15% av totalvekten av preparatet, og ytterligere foretrukket fra 0,5% til 8% av totalvekten av preparatet.
Saltet kan anvendes i et preparat som skal inntas oralt, som skal injiseres lokalt eller påføres huden {på et hvilket som helst hudområde på kroppen), i håret eller på neglene. I henhold til administreringsmåten, kan preparatet tilveiebringes i en hvilken som helst galenisk form som normalt anvendes.
For topisk påføring på huden kan preparatet særlig være i form av en vandig, vandig-alkoholisk eller en oljeaktig oppløsning eller av en oljeaktig suspensjon eller av en dispersjon av typen lotion eller serum, av emulsjoner av flytende eller halv-flytende konsistens av typen melk, som oppnås ved å dispergere en fettfase i en vandig fase (O/V) eller omvendt (V/0), eller av suspensjoner eller emulsjoner med myk konsistens av typen vandig eller vannfri krem eller gel, av mikroemulsjoner eller alternativt av mikrokapsler eller mikropartikler, eller av vesikulære dispersjoner av typen ionisk- og/eller ikke-ionisk. Disse preparater er fremstilt i henhold til vanlig anvendte metoder.
De kan også anvendes for håret i form av vandige, alkoholiske eller vandig-alkoholiske oppløsninger, eller i form av kremer, geler, emulsjoner eller skum.
For lokal injeksjon kan preparatet være tilveiebragt i form av en vandig lotion, en oljeaktig suspensjon eller i form av et serum. For øynene kan det tilveiebringes i form av dråper og for oralt inntak kan det tilveiebringes i form av kapsler, granuler, siruper eller tabletter.
Mengdene av de forskjellige bestanddeler i preparatene er dem som vanlig anvendes innen de områder som studeres.
Disse preparater utgjør spesielt rensekremer, beskyttelses-kremer, kremer for behandling eller pleie av ansiktet, i forbindelse med hendene, føttene, for store anatomiske folder eller for kroppen (f.eks. dagkremer, nattkremer, underlagskremer, solbeskyttelseskremer), fluide underlagskremer, kroppsmelk for beskyttelse eller pleie, "aftersun" melk, lotioner, geler eller skum for hudpleie, som renselotioner, "aftersun" lotioner, badepreparater, deodorantpreparater omfattende et baktericid middel, etterbarberingsgeler eller lotioner, preparater mot insektbitt, anti-smertepreparater, preparater for å behandle visse hudsykdommer som eksem, rosacea, psoriasis, lichen, alvorlig pruritus og dem angitt i det foregående.
Preparatene kan også utgjøres av faste preparater som omfatter rensestykker eller såper.
Preparatene kan også være emballert i form av et aerosol-preparat som også omfatter et trykksatt drivmiddel.
Saltet som anvendes i henhold til oppfinnelsen kan også være innlemmet i forskjellige preparater for hårpleie, særlig sjampo, behandlingslotioner og restrukturerings-lotioner for håret, lotioner og/eller geler for å forhindre hårtap, anti-parasitt sjampoer o.l.
Når preparatet er en emulsjon, kan andelen av fettfasen være fra 5 til 80 vekt%, foretrukket fra 5 til 50 vekt% i forhold til totalvekten av preparatet. Oljene, voksene, emulgeringsmidlene og ko-emulgeringsmidlene som anvendes i preparatet i form av en emulsjon velges fra dem som vanligvis anvendes innen det farmasøytiske området. Emulgeringsmidlet og ko-emulgeringsmidlet er tilstede i preparatet i en andel som strekker seg fra 0,3 til 3 0 vekt%, foretrukket fra 0,5 til 2 0 vekt% i forhold til totalvekten av preparatet. Emulsjonen kan i tillegg inneholde lipidvesikler.
Når preparatet er en oljeaktig gel eller oppløsning, kan fettfasen representere mer enn 90% av totalvekten av preparatet.
Som vanlig kjent kan preparatet også inneholde adjuvanser som normalt anvendes innen det farmasøytiske området, som hydrofile eller lipofile geleringsmidler, hydrofile eller lipofile tilsetningsstoffer, konserveringsmidler, anti-oksydanter, løsningsmidler, parfymer, fyllstoffer, sol-beskyttende midler, odør-absorbsjonsmidler og fargestoffer. Mengden av disse forskjellige adjuvanser er dem som vanligvis anvendes innen det farmasøytiske området, og er f.eks. fra 0.01 til 20% av totalvekten av preparatet. Disse adjuvanser, avhengig av deres natur, kan innføres i fettfasen, i vann-fasen og/eller i lipidkulene.
Som oljer eller vokser som kan anvendes i forbindelse med oppfinnelsen, skal det nevnes mineraloljer (vaselin), vegetabilske oljer, (flytende fraksjon av bassiasmør, solsikkeolje), animalske oljer (perhydroskvalen), syntetiske oljer (Purcellinolje), silikonoljer eller vokser (cyklo-metikon) og fluorerte oljer (perfluorpolyetere), bivoks, karnaubavoks eller paraffin. Fettalkoholer, fettsyrer, stearinsyre, bivoks, karnaubavoks og paraffin kan tilsettes til disse oljer.
Som emulgeringsmiddel som kan anvendes i forbindelse med oppfinnelsen skal nevnes f.eks. glycerolstearat, polysorbat 60 og en blanding av PEG-6/PEG-32/glykolstearat solgt under handelsnavnet Tefose 63 av selskapet Gattefosse.
Som løsningsmidler som kan anvendes i forbindelse med oppfinnelsen skal man nevne lavere alkoholer, særlig etanol og isopropanol og propylenglykol.
Som hydrofile geleringsmidler som kan anvendes i forbindelse med oppfinnelsen skal man nevne karboksyvinylpolymerer (karbomer), akrylkopolymerer som akrylat/alkylakrylat-kopolymerer, polyakrylamider, polysakkarider som hydroksy-propyl-cellulose, naturlige gummier og leirer, og som lipofile geleringsmidler skal man nevne modifiserte leirer som bentonitter, metallsalter av fettsyrer som aluminium-stearater og hydrofobt silika, etylcellulose og polyetylen.
Preparatene kan inneholde andre hydrofile aktive midler som proteiner eller proteinhydrolysater, aminosyrer, polyoler, urea, allantoin, sukkere og sukkerderivater, vannoppløselige vitaminer, vegetabilske eller bakterie-ekstrakter og stivelse.
Som lipofile aktive midler kan det anvendes retinol (vitamin A) og dets derivater, tokoferol (vitamin E) og dets derivater, essensielle fettsyrer, ceramider, eteriske oljer. I henhold til oppfinnelsen kan det bl.a. med lantanid-, yttrium-, barium- og strontiumsaltene kombineres andre aktive midler som særlig er beregnet for forebygging og/eller behandling av hudtilstander. Blant disse aktive midler kan man som eksempel nevne: modulerende midler for hudpigmentering og/eller
proliferasjon og/eller differensiering slik som retinolsyre og dens isomerer, retinol og dens estere, vitamin D og dens derivater, østrogener som østradiol,
kojisyre eller hydrokinon,
anti-bakterielle midler som klindamycinfosfat, erytromycin
eller antibiotika av tetracyklinklassen,
anti-parasitt midler,særlig metronidazol, krotamiton eller
pyretrinoider,
anti-soppmidler, særlig forbindelsene som tilhører imidazolklassen som ekonazol, ketokonazol eller mikonazol eller deres salter, polyenforbindelser som amfotericin B, forbindelser av allylaminfamilien som terbinafin, eller
alternativt oktopirox,
antivirus midler som acyklovir,
steroide anti-inflammatoriske midler som hydrokortison,
betametasonvalerat eller klobetasolpropionat, eller ikke-steroide anti-inflammatoriske midler som ibuprofen og dets salter, diklofenak og dets salter, acetylsalisylsyre,
acetaminofen eller glycyrrhetinsyre,
anestesimidler som lidokainhydroklorid og dets derivater, anti-kløe midler som tenaldin, trimeprazin eller
cyproheptadin,
keratolytiske midler som alfa- og beta-hydroksykarboksyl-eller beta-ketokarboksylsyrer, deres salter, amider eller estere og mer spesielt hydroksysyrene som glykolsyre, melkesyre, salisylsyre, sitronsyre og, generelt,
fruktsyrer, og n-oktanoyl-5-salisylsyre,
midler mot frie radikaler som alfa-tokoferol og dens estere, superoksyddismutaser, visse metallchelatorer eller
askorbinsyre og dens estere,
anti-seboreiske midler som progesteron,
anti-flassmidler som oktopirox eller sinkpyrition, anti-aknemidler som retinolsyre eller benzoylperoksyd,
antiseptiske midler,
antimetabolitter.
I henhold til en spesifikk utførelse vedrører oppfinnelsen anvendelsen av minst ett salt valgt fra lantanid-, yttrium-, barium- og strontiumsalter og blandinger derav i et preparat som omfatter minst ett middel valgt fra anti-bakterielle midler, anti-parasitt midler, anti-soppmidler, anti-virus midler, anti-inflammatoriske midler, anti-kløe midler, anestesimidler, keratolytiske midler, midler mot frie radikaler, anti-seboreiske midler, anti-flassmidler eller anti-aknemidler og/eller modulerende midler for hudpigmentering og/eller proliferasjon og/eller differensiering.
Minst ett lantanid-, yttrium-, barium- eller strontiumsalt kan fordelaktig være kombinert med produkter som har en irriterende effekt og som er vanlig anvendt innen det dermatologisk eller farmasøytiske område, og hvor disse produkter noen ganger er dermatologiske eller farmasøytisk aktive midler. Tilstedeværelsen av en substans P antagonist i form av minst ett lantanid-, yttrium-, barium- eller strontiumsalt i eller for fremstillingen av et dermatologisk eller farmasøytisk preparat som omfatter et produkt med en irriterende effekt gjør det mulig å vesentlig svekke eller til og med undertrykke denne irriterende effekt. Dette gjør det i tillegg mulig å øke mengden aktivt middel som har en irriterende effekt i forhold til mengden av aktivt middel som normalt anvendes, for en økt effektivitet.
Oppfinnelsen kan spesielt gjennomføres ved anvendelse av de hygieniske, dermatologiske eller farmasøytiske preparater som definert i det foregående i henhold til den vanlig anvendte teknikk for anvendelse av disse preparater, som for eksempel anvendelse av kremer, geler, serumer, lotioner eller "aftersun" preparater på huden eller i tørt hår, anvendelse av en hårlotion i vått hår, eller anvendelse av sjampo.
De etterfølgende eksempler og preparater illustrerer oppfinnelsen. I preparatene er andelene som indikert vekt%-andeler.
Rensekrem ( Oppskrift A)
Rensemelk (Oppskrift B)
Pleiende lotion ( Oppskrift C ) Pleiende krem (Oppskrift D)
Ansiktspleiegel (Oppskrift E)
Pleiende krem for solerytem ( olje- i- vann emulsjon)
(Oppskrift F)
Lotion for å fjerne arr ( Oppskrift G)
Claims (10)
1. Anvendelse av minst ett salt valgt fra yttrium-, lantan-, cerium-, praseodym-, neodym-, prometium-, samarium-, europium-, gadolinium-, terbium-, dysprosium-, holmium-, erbium-, thulium-, ytterbium-, lutetium-, barium- eller strontiumsalter og en kombinasjon derav for fremstillingen av et farmasøytisk eller dermatologisk preparat for å behandle smerte forbundet med minst en av de følgende hudlidelser: zona, postzoster smerter, forbrenning, demodicidosis, hudulcus, fibrose og/eller for å regulere hypertrofisk arrdannelse og/eller for å behandle acne rosacea.
2. Anvendelse som angitt i krav 1 hvor saltet er valgt fra barium-, yttrium- eller strontiumsalter og en blanding derav.
3. Anvendelse som angitt i ett eller flere av de foregående krav hvor saltet er et strontiumsalt.
4. Anvendelse som angitt i krav 1 til 3, hvor saltene omfatter ioner valgt fra klorid-, borat-, bikarbonat-, karbo-nat-, nitrat-, hydroksyd-, sulfat- og glycerofosfationer, fruktsyrer og aminosyrer.
5. Anvendelse som angitt i ett eller flere av de foregående krav hvor ionene er klorid- eller nitrationer.
6. Anvendelse som angitt i ett eller flere av de foregående krav hvor saltet anvendes i en mengde fra 10"<5>% til 2 0% av totalvekten av preparatet.
7. Anvendelse som angitt i ett eller flere av de foregående krav hvor saltet anvendes i en mengde fra 10"<2>% til 15% av totalvekten av preparatet.
8. Anvendelse som angitt i ett eller flere av de foregående krav hvor preparatet i tillegg omfatter minst ett dermatologisk eller farmasøytisk aktivt middel som er forskjellig fra saltene.
9. Anvendelse som angitt i krav 8 hvor preparatet i tillegg inneholder minst ett middel valgt fra anti-bakterielle midler, anti-parasitt midler, anti-sopp midler, anti-virus midler, anti-inflammatoriske midler, anti-kløe midler, anestesimidler, keratolytiske midler, midler mot frie radikaler, anti-seboréiske midler, anti-flassmidler eller anti-akne midler, og/eller modulerende midler for hudpigmentering og/eller proliferasjon og/eller differensiering.
10. Anvendelse som angitt i ett eller flere av de foregående krav hvor preparatet er tilveiebragt i form en vandig, oljeaktig eller vandig-alkoholisk oppløsning, en olje-i-vann eller vann-i-olje emulsjon, mikroemulsjon, en vandig eller vannfri gel, et serum eller en dispersjon av vesikler.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9512656A FR2740341B1 (fr) | 1995-10-26 | 1995-10-26 | Utilisation de sel de lanthanide, d'etain, de zinc, de manganese, d'yttrium, de cobalt, de baryum, de strontium dans une composition pour la peau |
Publications (3)
Publication Number | Publication Date |
---|---|
NO964515D0 NO964515D0 (no) | 1996-10-24 |
NO964515L NO964515L (no) | 1997-04-28 |
NO319503B1 true NO319503B1 (no) | 2005-08-22 |
Family
ID=9483957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19964515A NO319503B1 (no) | 1995-10-26 | 1996-10-24 | Anvendelse av et salt for fremstilling av et farmasoytisk eller dermatologisk preparat |
Country Status (9)
Country | Link |
---|---|
US (1) | US5866168A (no) |
EP (1) | EP0775492B1 (no) |
JP (1) | JPH09169657A (no) |
AT (1) | ATE198276T1 (no) |
CA (1) | CA2188688C (no) |
DE (1) | DE69611343T2 (no) |
ES (1) | ES2155179T3 (no) |
FR (1) | FR2740341B1 (no) |
NO (1) | NO319503B1 (no) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6203803B1 (en) | 1994-12-14 | 2001-03-20 | Societe L'oreal S.A. | Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained |
US7404967B2 (en) * | 1994-12-21 | 2008-07-29 | Cosmederm, Inc. | Topical product formulations containing strontium for reducing skin irritation |
US6139850A (en) * | 1994-12-21 | 2000-10-31 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
FR2740340B1 (fr) * | 1995-10-30 | 1997-12-05 | Oreal | Utilisation d'acides carboxyliques porteurs d'une fonction soufree pour favoriser la desquamation de la peau ou stimuler le renouvellement epidermique |
US6168798B1 (en) * | 1997-02-03 | 2001-01-02 | Bristol-Myers Squibb Company | Non-irritating composition for treating acne and other skin conditions |
US6248370B1 (en) * | 1997-07-24 | 2001-06-19 | Leroy Harris | Skin treatment and methods |
AT405017B (de) * | 1997-10-06 | 1999-04-26 | Jakoby Marie Luise | Mittel zur stimulation der körpereigenen abwehr |
FR2774285B1 (fr) * | 1998-02-03 | 2001-06-15 | Roche Posay Lab Pharma | Utilisation d'une composition cosmetique pour le traitement et la prevention de la rosacee |
WO2001003712A1 (en) * | 1999-07-09 | 2001-01-18 | Astion Development Aps | Composition containing extracts of butyrospermum parkii and the use as medicament or dietary supplement |
DE10043466A1 (de) * | 2000-09-04 | 2002-03-28 | Johannes Wohlrab | Manganverbindungen enthaltende Zubereitung zur topischen Applikation und deren Verwendungen |
ES2181586B1 (es) * | 2001-05-03 | 2004-06-16 | Alfonso Blanco Cobo | Producto farmaceutico para el tratamiento de tumores cancerigenos. |
NO20014746D0 (no) * | 2001-09-28 | 2001-09-28 | Clas M Kjoelberg | Smertelindrende middel |
US7879365B2 (en) * | 2002-02-07 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
JP2005527601A (ja) * | 2002-04-30 | 2005-09-15 | 久光製薬株式会社 | 二糖類及び金属イオンによる、刺激の阻止のための方法及び組成物 |
US7081247B2 (en) * | 2002-05-20 | 2006-07-25 | Nidaria Technology Ltd. | Composition and method for inhibiting polar capsule discharge and protecting a subject from nematocyst sting |
FR2846558B1 (fr) * | 2002-11-05 | 2006-07-14 | Servier Lab | Utilisation du sel distrontique de l'acide 2-n,n-di(carboxymethyl)amino-3-cyano-4-carboxymethyl- thiophene-5-carboxylique pour l'obtention de medicaments destines au traitement des douleurs gastro-duodenales |
AU2002365172A1 (en) * | 2002-12-09 | 2004-06-30 | Evgeny Nikolaevich Ananiev | Pharmaceutical or cosmetic composition, preventing or reducing itch and local reaction from stings of insects |
EP2995312A1 (en) * | 2003-03-27 | 2016-03-16 | SantoSolve AS | Anti-inflammatory composition based on strontium compounds |
ATE342722T1 (de) * | 2003-05-07 | 2006-11-15 | Osteologix As | Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen |
AU2004237438B2 (en) * | 2003-05-07 | 2011-01-20 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
WO2005009352A2 (en) * | 2003-07-17 | 2005-02-03 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositons containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof |
EP1523985B1 (en) * | 2003-10-17 | 2010-03-10 | Oy Neurofood Ab | Non-radioactive strontium agent for treating cancer |
WO2005053613A2 (en) * | 2003-11-26 | 2005-06-16 | Combinatorx, Inc. | Combinations for the treatment of fungal infections |
US7258875B2 (en) * | 2003-12-04 | 2007-08-21 | Chiou Consulting, Inc. | Compositions and methods for topical treatment of skin infection |
FR2866810B1 (fr) * | 2004-03-01 | 2006-04-28 | Oreal | Utilisation d'au moins un inhibiteur des canaux calciques pour prevenir et/ou traiter la peau grasse. |
GB0517043D0 (en) * | 2005-08-19 | 2005-09-28 | York Pharma Plc | Improvements in pharmaceutical compositions |
US20070154448A1 (en) | 2005-11-22 | 2007-07-05 | Ted Reid | Methods and compositions using Substance P to promote wound healing |
JP2010501551A (ja) * | 2006-08-25 | 2010-01-21 | テウン イーエルエス インコーポレイテッド | 毛髪改善のための希土類元素の用途 |
KR100769260B1 (ko) * | 2006-08-25 | 2007-10-22 | 주식회사 태웅이엘에스 | 희토원소를 함유하는 모발 개선용 조성물 |
GB0617191D0 (en) * | 2006-08-31 | 2006-10-11 | York Pharma Plc | Improvements in pharmaceutical compositions |
WO2013142383A1 (en) | 2012-03-21 | 2013-09-26 | Cosmederm Bioscience, Inc. | Topically administered strontium-containing complexes for treating pain, pruritis and inflammation |
WO2016141219A1 (en) * | 2015-03-05 | 2016-09-09 | Cosmederm Bioscience, Inc. | Strontium based compositions and formulations for pain, pruritus, and inflammation |
US11235002B2 (en) | 2015-08-21 | 2022-02-01 | Galleon Labs Llc | Strontium based compositions and formulations for pain, pruritus, and inflammation |
WO2020091699A1 (en) | 2018-10-31 | 2020-05-07 | Yeditepe Universitesi | Use of nano-sized lanthanide borate (dysprosium borate and erbium borate) compounds for wound healing purposes and production method thereof |
EP3999076A4 (en) * | 2019-07-18 | 2023-08-09 | The Regents of the University of California | COMPOSITIONS AND METHODS FOR TREATING SKIN CONDITIONS |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE297062C (no) * | ||||
GB997975A (en) * | 1964-01-31 | 1965-07-14 | Aristotelis Papageorgiou Lambo | Pharmaceutical compositions containing a cresol or a mixture of cresols |
GB1072355A (en) * | 1964-06-17 | 1967-06-14 | Michael Collin | Antiseptic and anti-pruretic solution containing camphor |
US3519711A (en) * | 1967-09-01 | 1970-07-07 | Robert E Svigals | Composition and method of treating pruritic conditions of the skin |
IE35991B1 (en) * | 1971-01-22 | 1976-07-21 | Comprehensive Pharmaceuticals | Improvements in or relating to the treatment of diseases of the skin and mucosa |
LU65373A1 (no) * | 1972-05-17 | 1973-11-23 | ||
US3888976A (en) * | 1972-09-21 | 1975-06-10 | William P Mlkvy | Zinc and strontium ion containing effervescent mouthwash tablet |
US3772431A (en) * | 1972-09-21 | 1973-11-13 | W Mlkvy | Effervescent mouthwash tablet |
US4477439A (en) * | 1981-04-13 | 1984-10-16 | Walter J. Monacelli | Treatment of irritated and excoriated areas around the stoma of ostomy patients |
JPS58501675A (ja) * | 1981-10-09 | 1983-10-06 | フエ−リング・ア−ベ− | 物質p「きつ」抗質からなる薬材 |
AU556817B2 (en) * | 1982-02-03 | 1986-11-20 | Efamol Limited | Topical application of a lithium salt and dihomo-alpha- linolenic acid |
GB8320203D0 (en) * | 1983-07-27 | 1983-09-01 | Horrobin D F | Anti-viral compositions |
DE3338957A1 (de) * | 1983-10-27 | 1985-05-15 | Keyhan Dipl.-Ing. 6908 Wiesloch Ghawami | Enthaarungsmittel |
US4711780A (en) * | 1984-06-11 | 1987-12-08 | Fahim Mostafa S | Composition and process for promoting epithelial regeneration |
IT1214611B (it) * | 1985-05-22 | 1990-01-18 | Schiena Ricerche | Composti per uso cosmetico dermatologico e relative composizioni. |
US4837026A (en) * | 1985-10-03 | 1989-06-06 | Rajakhyaksha Vithal J | Transdermal and systemic preparation and method |
ATE69954T1 (de) * | 1985-10-08 | 1991-12-15 | Psori Med Ag | Salzmischung zur behandlung der schuppenflechte (psoriasis) und anderer hautkrankheiten. |
US4735802A (en) * | 1986-05-05 | 1988-04-05 | Le Bich N | Topical dermatological composition and method of treatment |
FR2599967B1 (fr) * | 1986-06-16 | 1989-03-31 | Bfb Etudes Rech Experimentale | Utilisation de sel de zinc et de la vitamine b6 pour enrayer les processus alopeciques et/ou seborrheiques. |
US4986981A (en) * | 1986-07-07 | 1991-01-22 | Den Mat Corporation | Toothpaste having low abrasion |
US5091171B2 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
SE8701372L (sv) * | 1987-04-02 | 1988-10-03 | Boliden Ab | Foerfarande och medel foer konservering av hoe |
DE3929411A1 (de) * | 1988-09-22 | 1990-03-29 | Siegfried Natterer | Pharmazeutische zubereitung sowie verfahren zu ihrer herstellung |
FR2644063B1 (fr) * | 1989-03-13 | 1991-06-14 | Fabre Pierre Cosmetique | Compositions dermatologiques et cosmetologiques a base d'alcoylcarboxamide et de sel de zinc utiles dans le traitement de la dermite seborrheique et/ou des troubles de la seborrhee |
CA2014201A1 (en) * | 1989-04-26 | 1990-10-26 | Albemarle Corporation | Solid non-hygroscopic trialkylamine oxides |
DE69007486T2 (de) * | 1989-07-31 | 1994-08-11 | Massachusetts Institute Of Technology, Cambridge, Mass. | Verwendung von calciumantagonisten für die behandlung von narben. |
US5132119A (en) * | 1989-07-31 | 1992-07-21 | Massachusetts Institute Of Technology | Treatment of hypertrophic wound healing disorders with calcium channel blockers |
IL95393A0 (en) * | 1989-08-18 | 1991-06-30 | John Morris Co | Odor-masked and stabilized compositions for treating keratinous tissue,skin conditions,and promoting wound healing |
US5202130A (en) * | 1989-08-31 | 1993-04-13 | The Johns Hopkins University | Suppression of eczematous dermatitis by calcium transport inhibition |
US5296476A (en) * | 1989-09-08 | 1994-03-22 | Henderson Esther G | Skin care compositions |
EP0439640B1 (de) * | 1990-01-29 | 1993-09-15 | WOGEPHARM GmbH | Verfahren zur Herstellung von Mitteln zur Therapie von Hauterkrankungen |
EP0451300B1 (fr) * | 1990-04-10 | 1994-10-26 | Romuald Dr. Kowalski | Composition contenant une dispersion colloidale de sulfate de baryum |
FR2662607B1 (fr) * | 1990-05-30 | 1992-08-28 | Oreal | Composition destinee a etre utilisee pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives d'alkyl-2 amino-4 (ou dialkyl-2-4) pyrimidine oxyde-3 . |
ATE133657T1 (de) * | 1991-07-05 | 1996-02-15 | Merck Sharp & Dohme | Aromatische verbindungen, diese enthaltende pharmazeutische zusammensetzungen und ihre therapeutische anwendung |
DE69208089T2 (de) * | 1991-07-10 | 1996-08-22 | Merck Sharp & Dohme | Aromatische verbindungen diese enthaltende pharmazeutische zusammensetzungen und ihre therapeutische verwendung |
RU2038072C1 (ru) * | 1991-11-01 | 1995-06-27 | Государственный российский научно-исследовательский институт органической химии и технологии | Крем для защиты кожи от химических веществ и способ его получения |
GB9201179D0 (en) * | 1992-01-21 | 1992-03-11 | Glaxo Group Ltd | Chemical compounds |
DE9211006U1 (de) * | 1992-08-17 | 1993-12-16 | Kao Corporation GmbH, 40472 Düsseldorf | Mittel zur Haarbehandlung |
GB9222486D0 (en) * | 1992-10-26 | 1992-12-09 | Merck Sharp & Dohme | Therapeutic agents |
WO1994009798A1 (en) * | 1992-10-29 | 1994-05-11 | C-P Technology Limited Partnership | Mixtures or complexes containing calcium and sulfate |
US5593992A (en) * | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
WO1996019182A1 (en) * | 1994-12-21 | 1996-06-27 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
US5716625A (en) * | 1994-12-21 | 1998-02-10 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
ES2192586T3 (es) * | 1994-12-21 | 2003-10-16 | Cosmederm Technologies | Formulaciones y procedimientos para reducir la irritacion de la piel. |
DE4446521A1 (de) * | 1994-12-24 | 1996-06-27 | Estee Lauder Inc | Mascara-Bürstchen |
-
1995
- 1995-10-26 FR FR9512656A patent/FR2740341B1/fr not_active Expired - Fee Related
-
1996
- 1996-10-14 AT AT96402180T patent/ATE198276T1/de active
- 1996-10-14 DE DE69611343T patent/DE69611343T2/de not_active Expired - Fee Related
- 1996-10-14 EP EP96402180A patent/EP0775492B1/fr not_active Expired - Lifetime
- 1996-10-14 ES ES96402180T patent/ES2155179T3/es not_active Expired - Lifetime
- 1996-10-23 CA CA002188688A patent/CA2188688C/fr not_active Expired - Fee Related
- 1996-10-24 NO NO19964515A patent/NO319503B1/no unknown
- 1996-10-25 JP JP8284316A patent/JPH09169657A/ja active Pending
- 1996-10-28 US US08/740,311 patent/US5866168A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2740341B1 (fr) | 1997-12-19 |
NO964515D0 (no) | 1996-10-24 |
DE69611343D1 (de) | 2001-02-01 |
CA2188688A1 (fr) | 1997-04-27 |
ES2155179T3 (es) | 2001-05-01 |
CA2188688C (fr) | 2002-12-17 |
US5866168A (en) | 1999-02-02 |
ATE198276T1 (de) | 2001-01-15 |
DE69611343T2 (de) | 2001-04-26 |
FR2740341A1 (fr) | 1997-04-30 |
NO964515L (no) | 1997-04-28 |
JPH09169657A (ja) | 1997-06-30 |
EP0775492A1 (fr) | 1997-05-28 |
EP0775492B1 (fr) | 2000-12-27 |
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