NO20061302L - Derivater av hydroksaminsyre som metalloproteinseinbitorer - Google Patents

Derivater av hydroksaminsyre som metalloproteinseinbitorer

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Publication number
NO20061302L
NO20061302L NO20061302A NO20061302A NO20061302L NO 20061302 L NO20061302 L NO 20061302L NO 20061302 A NO20061302 A NO 20061302A NO 20061302 A NO20061302 A NO 20061302A NO 20061302 L NO20061302 L NO 20061302L
Authority
NO
Norway
Prior art keywords
derivatives
hydroxamic acid
metalloproteinase inhibitors
metalloproteinase
inhibitors
Prior art date
Application number
NO20061302A
Other languages
English (en)
Inventor
Agnes Bombrun
Stephen John Davies
Gilles Pain
Original Assignee
Vernalis Oxford Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0319917A external-priority patent/GB0319917D0/en
Priority claimed from GB0328632A external-priority patent/GB0328632D0/en
Application filed by Vernalis Oxford Ltd filed Critical Vernalis Oxford Ltd
Publication of NO20061302L publication Critical patent/NO20061302L/no

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Forbindelser med formel (I) er inhibitorer for matriksmetallo-proteinaser, og har anvendelse ved behandlingen av f.eks. fibrotisk sykdom, multippel sklerose, emfysem, bronkitt og astma: hvor Ar er en eventuelt substituert aryl-, heteroaryl-, C3-C8-sykloalkyl-eller heterosykloakylgruppe; R er hydrogen, C1-C6-alkyl eller C3-C6-syklo-alkyl; Alk er et toverdig C1-C5-alkylen-eller C2-C5-alkenylenradikal; og R1 og R2 danner sammen med nitrogenatomet som de er bundet til, en første heterosykloalkylring som eventuelt er kondensert til en andre C3-C8-sykloalkyl-eller -heterosykloalkylring, idet den første og andre ringen eventuelt er substituert med minst en gruppe med formel (II): hvor m, p og n uavhengig av hverandre er 0 eller 1; Z er hydrogen eller en eventuelt substituert karbosyklisk eller heterosyklisk ring med 5-7 ringatomer som eventuelt er kondensert til en annen eventuelt substituert karbosyklisk eller heterosyklisk ring med 5-7 ringatomer; Alk1 og Alk2 er uavhengig av hverandre eventuelt substituerte toverdige C1-C3-alkylenradikaler; X er -O-, -S-, -S(O)-, -S(O2)-, -C(=O)-, -NH-, -NR3-, -S(O2)NH-, -S(O2)NR3-, -NHS(O2)- eller -NR3S(O2)-, hvor R3 er Cl-C3-alkyl.
NO20061302A 2003-08-23 2006-03-22 Derivater av hydroksaminsyre som metalloproteinseinbitorer NO20061302L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0319917A GB0319917D0 (en) 2003-08-23 2003-08-23 Metalloproteinase inhibitors
GB0328632A GB0328632D0 (en) 2003-12-10 2003-12-10 Metalloproteinase inhibitors
PCT/GB2004/003558 WO2005019194A1 (en) 2003-08-23 2004-08-18 Derivatives of hydroxamic acid as metalloproteinase inhibitors

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NO20061302L true NO20061302L (no) 2006-05-19

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US (2) US7786121B2 (no)
EP (1) EP1660471B1 (no)
JP (1) JP4921167B2 (no)
KR (1) KR20060037446A (no)
AT (1) ATE508121T1 (no)
AU (1) AU2004266896B2 (no)
CA (1) CA2536576C (no)
DE (1) DE602004032548D1 (no)
DK (1) DK1660471T3 (no)
HK (1) HK1104925A1 (no)
NO (1) NO20061302L (no)
PL (2) PL1660471T3 (no)
PT (1) PT1660471E (no)
WO (1) WO2005019194A1 (no)

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US7638513B2 (en) 2004-06-02 2009-12-29 Schering Corporation Compounds for the treatment of inflammatory disorders
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EP1660471B1 (en) 2011-05-04
DE602004032548D1 (de) 2011-06-16
AU2004266896A1 (en) 2005-03-03
PL379863A1 (pl) 2006-11-27
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US20060281920A1 (en) 2006-12-14
KR20060037446A (ko) 2006-05-03
EP1660471A1 (en) 2006-05-31
PT1660471E (pt) 2011-08-03
US20100280018A1 (en) 2010-11-04
US7786121B2 (en) 2010-08-31
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ATE508121T1 (de) 2011-05-15
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